Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07538024Recruiting
Reduced-dose radiation for spine cancer spread
This trial tests whether lower radiation doses work well for treating cancer that has spread to the spine. If you have a few spine tumors that are stable or causing symptoms, this study might help doctors find safer, faster treatment options.
Negrar, VeronaAges 18 years+ - NCT07584941Recruiting
Upper-Limb Training Methods for Improving Tennis Serve Power
This study compares two different arm-training approaches—plyometric exercises (explosive, bouncy movements) versus traditional strength training—to see which better improves serve speed and arm power in competitive tennis players. If you're an experienced competitive player, this research could help you understand which training method works best for your serve.
IslamabadAges 18–30 - NCT07555899Recruiting
Bone marrow scaffold for ankle cartilage damage repair
This study tests whether a scaffold (a support structure) filled with cells from your bone marrow can help heal deep ankle joint damage when combined with a surgical technique called retrograde drilling. The goal is to regenerate damaged bone and cartilage in the ankle.
BolognaAges 18–55 - NCT07544264Recruiting
Five-Year Knee Replacement Outcomes Study
This study follows patients who receive a new knee joint replacement for severe knee arthritis or similar conditions. Researchers will track how well the artificial knee works and how patients recover over 5 years to ensure the replacement lasts and improves quality of life.
BolognaAges 50–85 - NCT07579936RecruitingPhase 2
SAL056 bone-strengthening treatment for postmenopausal osteoporosis
This study tests a new injectable medication called SAL056 to strengthen bones and prevent fractures in postmenopausal women with osteoporosis. Researchers want to find the best dose and how often to give it.
Beijing, Beijing MunicipalityAges 45–80 - NCT06628895Recruiting
Modified Poco-Poco exercise for pre-frailty
This study tests whether a special exercise routine called Modified Poco-Poco can improve frailty and certain biological markers (DNA changes, GDF15, and Lamin A). It may help people who are beginning to feel weaker and want to try a gentle exercise program.
Bandung, West JavaAges 60 years+ - NCT06748885Recruiting
Mpact 3D metal hip replacement study
This trial tests a new 3D-printed metal hip implant for people who need a first-time hip replacement. It aims to see how well the implant works and helps you recover.
NantesAges 18–75 - NCT07576192Recruiting
Massage treatments for heel pain in pregnant women
This study compares two hands-on massage techniques to relieve plantar fasciitis (heel pain) in pregnant women during the second trimester. The goal is to find the most effective, safe way to reduce pain without medication.
Lahore, Punjab ProvinceAges 18–40 - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT05288803Recruiting
Personalized rehab plans for veterans after knee replacement
This study tests whether customizing a recovery plan (“trajectory”) can improve rehabilitation for veterans after total knee replacement surgery. You may be eligible if you start outpatient rehab soon after surgery at participating clinics.
Aurora, ColoradoAges 40–90 - NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT07067697Recruiting
Exercise and nutrition for older adults in the hospital
This study tests whether a supervised exercise program, combined with oral nutritional supplements, helps hospitalized older adults who are malnourished or at risk. It aims to improve strength and recovery during their hospital stay.
Pamplona, NavarreAges 75 years+ - NCT06905691Recruiting
Eccentric training after ACL reconstruction
This study tests if a specific exercise (eccentric training) helps people recover better after ACL surgery. You may join if you are between 18 and 40 and are scheduled for this surgery.
Veranópolis, Rio Grande do SulAges 18–40 - NCT06752551Recruiting
Apprehension training vs standard physical therapy for shoulder dislocation in military
This study compares a new type of training focused on controlling shoulder 'apprehension' (the feeling that your shoulder might pop out) with standard physical therapy. It is for military personnel who have had a shoulder dislocation and may help you regain trust in your shoulder without surgery.
Be’er Ya‘aqovAges 18–39 - NCT06753110Recruiting
Long-term safety of OPRA implant for arm amputees
This study checks the long-term safety and how well the OPRA implant (a bone-anchored prosthetic) works for people who have an arm amputation. It is for those who already have the implant and had their second surgery at least six months ago.
Melbourne, VictoriaAges Any age - NCT06960343Recruiting
Shoulder repair with fat tissue for better healing
This trial tests whether adding a small amount of your own fat tissue to standard shoulder surgery helps the torn tendons heal better and last longer. It is for people with a full-thickness tear of the supraspinatus and infraspinatus tendons that needs arthroscopic repair.
Milan, ItalyAges 18 years+ - NCT06430762Recruiting
Study of risk factors for jaw bone damage from certain drugs
This study looks at people who have jaw bone damage (osteonecrosis) caused by medications. Researchers want to understand what treatments and risk factors are linked to this condition to help improve care.
IstanbulAges 18–110 - NCT07726511Recruiting
Hard gum chewing and facial shape changes
This study looks at how chewing a hard gum for 4 weeks might change the shape of your face and jaw muscles. It is for healthy adults aged 20–40 with no jaw problems or missing teeth.
Farmington, ConnecticutAges 20–40 - NCT07516769RecruitingPhase 3
Nicorandil to reduce inflammation in active rheumatoid arthritis
This study tests whether nicorandil, a heart medication with anti-inflammatory properties, can help reduce joint inflammation and swelling in people with active rheumatoid arthritis who are already taking conventional disease-modifying drugs. The goal is to see if it provides additional relief from symptoms.
Tanta, Gharbia GovernorateAges 18–70 - NCT07724470Recruiting
Stretching techniques for neck and arm pain
This study tests two types of stretching to see which one works better for neck pain that spreads into the arm. If you have had this pain for more than a month, this trial might help find a way to move better and feel less pain.
Lahore, Punjab ProvinceAges 30–60 - NCT07499973Recruiting
Core muscle strength and knee stability for injury prevention
This study looks at how your core (abdominal muscles) affects knee stability. It will test a training program to see if it helps prevent injuries. You will be randomly assigned to either the training group or a control group for 8 weeks.
Villaviciosa de Odón, MadridAges 18–35 - NCT07526051Recruiting
Stretching techniques for lower back pain and muscle tightness
This study compares two stretching methods to help relieve lower back pain caused by muscle imbalances. You'll be tested to confirm the pattern of muscle tightness, then receive one of two types of stretching therapy to see which works better for your pain.
Islamabad, Punjab ProvinceAges 25–50 - NCT07719699Recruiting
Vibration and Pilates for chronic low back pain
This study tests if whole-body vibration or Pilates exercises can reduce pain and improve balance and movement in people with long-lasting low back pain. It aims to find a helpful treatment for chronic back pain that has lasted more than 12 weeks.
Lahore, Punjab ProvinceAges 18–40 - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.