Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06888791Recruiting
Hydro dissection for frozen shoulder: ultrasound vs X-ray guidance
This trial compares two ways to guide a fluid injection for frozen shoulder—one using ultrasound and one using X-ray. The goal is to see which technique works better to reduce pain and improve movement.
AnkaraAges 18–80 - NCT06888908Recruiting
Blood volume changes during hip replacement surgery
This trial measures how blood volume and fluids shift in the body during and after hip replacement surgery. It helps doctors better understand fluid management for patients having this procedure.
CopenhagenAges 18 years+ - NCT06888934Recruiting
Testing a new toe implant for arthritis and crooked toes
This study tests a new implant called Lync® to fix arthritis or crooked toes (like hammer, claw, or mallet toes). The implant helps straighten the toe bone and may reduce pain.
LyonAges 18 years+ - NCT04342234Recruiting
Neural network tool to measure cleft palate from scans
This trial studies a computer “neural network” that uses existing dental impressions, scans, and photos to measure cleft palate features. The goal is to reduce the amount of repeated cleft lip and palate clinic work for patients and families.
BaselAges Any age - NCT06244511Recruiting
Balance Exercises for Chronic Ankle Instability
This study compares two types of balance exercises (standing on one leg vs. standing on both legs) to see which works better for people with long-term ankle instability. If you have chronic ankle weakness after a sprain at least 6 months ago, this trial may help improve your balance and confidence.
IstanbulAges 18–50 - NCT06598683Recruiting
Brain stimulation for muscle stiffness after stroke
This study tests whether a gentle, non-invasive brain stimulation (tDCS) can help reduce muscle stiffness and improve arm or leg movement in people who had a stroke. If you have tight or stiff muscles after your stroke, this might be a good option to explore.
Rawalpindi, Punjab ProvinceAges 30–70 - NCT06653634RecruitingPhase 4
Optimizing treatment for kids with JIA in remission
This trial tests whether children with juvenile idiopathic arthritis (JIA) who have been doing well for over a year can safely reduce their medications. The goal is to find the best way to keep arthritis under control while avoiding unnecessary treatments.
BergenAges 2–17 - NCT07275164Recruiting
High-intensity interval exercise for shoulder pain
This trial tests if high-intensity interval training (short bursts of intense exercise) can help people with long-term shoulder pain caused by rotator cuff problems or frozen shoulder.
WilrijkAges 18 years+ - NCT07278609Recruiting
Safer medication use for older adults with rheumatic conditions
This study tests a program to help doctors choose safer medications for people aged 60 and older who have arthritis or other rheumatic conditions. It aims to reduce the use of potentially harmful drugs and improve overall medication safety.
Montreal, QuebecAges 60 years+ - NCT07278323RecruitingPhase 4
Hormone therapy for frozen shoulder
This study tests if hormone replacement therapy can help treat frozen shoulder. It is designed for people with frozen shoulder in just one shoulder who are not currently using hormones and have no history of hormone-sensitive cancer.
San Francisco, CaliforniaAges 40 years+ - NCT07274267Recruiting
Breathing muscle training for muscle inflammation patients
This study tests whether special breathing exercises can help people with inflammatory myopathy. You would learn and practice breathing techniques using a device that strengthens your breathing muscles.
WarsawAges 18 years+ - NCT07278570Recruiting
Tracking muscle stiffness with MRI during hands-on therapy for low back pain
This study uses a special MRI scan to see if hands-on therapy (manual therapy) helps reduce muscle stiffness and pain in people with chronic low back pain. It aims to find a better way to measure how well this treatment works.
Rochester, MinnesotaAges 18 years+ - NCT07270276Recruiting
Dry needling for shoulder muscle pain
This study tests if dry needling (a therapy that uses thin needles to release muscle knots) can help with shoulder muscle pain. It uses special tests to measure how the treatment affects your muscles and pain.
Boston, MassachusettsAges 18–80 - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT07274124Recruiting
Pain education and nerve stimulation for rheumatoid arthritis
This study tests whether combining pain education with a mild nerve stimulation device can improve pain and recovery in people with rheumatoid arthritis. It may help you manage long-term pain better.
Istanbul, FatihAges 20–65 - NCT07269925Recruiting
How different electrical frequencies affect muscle strength and pain
This study tests whether changing the electrical frequency during a type of nerve stimulation (percutaneous neuromodulation) can improve muscle strength and reduce pain sensitivity in people with a hidden muscle knot (trigger point) in the shoulder blade area.
Krakow, PolandAges 18–65 - NCT07271771RecruitingPhase 4
Denosumab for muscle and insulin in diabetes
This study tests whether denosumab, a medication that strengthens bones, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes who take metformin.
AarhusAges 40 years+ - NCT07273123Recruiting
Chewing gum and fatigue in jaw joint health
This study tests if chewing sugar-free gum for a while can affect how tired you feel and how your jaw muscles work. It compares people with and without jaw joint problems (TMJ disorders).
Milan, MilanAges 19–35 - NCT07278050Recruiting
Comparing two nerve blocks for shoulder surgery
This trial compares two types of nerve blocks (interscalene and serratus posterior superior intercostal plane block) for pain relief during shoulder surgery. If you are having arthroscopic shoulder surgery under general anesthesia, you may be able to join.
Istanbul, BagcilarAges 18–75 - NCT07274423Recruiting
Deep learning for clearer ankle MRI scans
This study tests if a new deep learning technology can improve the quality of ankle MRI images. It may help people with ankle injuries get a more accurate diagnosis.
Wuhan, HubeiAges 18 years+ - NCT07275983Recruiting
Knee replacement recovery: spinal vs. general anesthesia
This study looks at recovery after total knee replacement surgery. It compares people who had spinal anesthesia (numbing the lower body) to those who had general anesthesia (being fully asleep) to see which group recovers better.
StrasbourgAges 18 years+ - NCT07276061Recruiting
Outpatient vs. in-hospital knee replacement recovery study
This study compares recovery after total knee replacement when patients go home the same day versus staying overnight in the hospital. It aims to see if outpatient surgery leads to similar or better recovery.
StrasbourgAges 18 years+ - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85 - NCT00512239Recruiting
Tests outcomes in early inflammatory joint arthritis
This study looks at how early inflammatory joint diseases behave over time, especially early rheumatoid arthritis. It may help doctors better predict prognosis and tailor care for people with new symptoms.
Sherbrooke, QuebecAges 18–90
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.