Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07281586RecruitingPhase 4
Switching from Prolia to a different osteoporosis drug
This trial tests if it's safe to switch from a long-term osteoporosis medication called Prolia to another treatment. It may help women and men who have been on Prolia for at least 3 years.
Douliu, TaiwanAges 50–85 - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT07282392Recruiting
Emotional awareness therapy for lupus and fibromyalgia pain
This study tests if a therapy called Emotional Awareness and Expression Therapy (EAET) can help people with lupus and fibromyalgia or chronic widespread pain feel better by addressing emotional factors that may worsen their pain. You would attend sessions to learn how to understand and express your emotions in healthy ways.
Salt Lake City, UtahAges 18–65 - NCT07282782RecruitingPhase 4
Vancomycin for knee replacement surgery
This trial is testing the antibiotic vancomycin to prevent infections after total knee replacement. It may help if you are having your first knee replacement and are not severely overweight or diabetic.
San Diego, CaliforniaAges 18 years+ - NCT07280741RecruitingPhase 4
Shingles vaccine study for people with rheumatic diseases
This study tests the recombinant shingles vaccine in adults with autoimmune rheumatic diseases who are on certain mild medications. It aims to see if the vaccine is safe and effective for them.
São Paulo, São PauloAges 18 years+ - NCT07284615Recruiting
Nerve Block vs. Wound Injection for Hip Replacement Pain
This trial compares two pain-relief methods after hip replacement surgery: a nerve block (numbing the hip area) versus a numbing injection into the wound. The goal is to see which provides better pain control.
Cinisello Balsamo, MilanoAges 18 years+ - NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT07279688RecruitingPhase 3
Baricitinib plus steroids for polymyalgia rheumatica
This trial tests if adding baricitinib (a pill that calms inflammation) to standard steroids works better than steroids alone for people with polymyalgia rheumatica. It aims to improve symptoms and reduce steroid side effects.
Aix-en-ProvenceAges 50 years+ - NCT07283887RecruitingPhase 4
Romosozumab and Denosumab for Postmenopausal Osteoporosis
This trial compares two osteoporosis drugs (romosozumab and denosumab) given alone or together to see which works better for improving bone density. It may help if you are a postmenopausal woman with osteoporosis and have not taken strong bone medications recently.
Douliu, TaiwanAges 50–80 - NCT07286565Recruiting
Remote motor development study for early-diagnosed DMD or SMA
This study remotely tracks motor development in children with Duchenne muscular dystrophy or spinal muscular atrophy who were diagnosed at birth or before symptoms started. It aims to see if early monitoring helps improve long-term care and outcomes.
LiègeAges 4 months+ - NCT07283276Recruiting
Core training vs cognitive training for ankle instability
This study tests whether special core exercises or mental training can help improve your balance and control after repeated ankle sprains. If you have chronic ankle instability, this could help you find which type of training works best.
CairoAges 18–30 - NCT07286435Recruiting
Vibration therapy after botox for stroke spasticity
This trial tests if adding whole-body vibration therapy to botulinum toxin A (Botox) injections can improve muscle stiffness, balance, and walking in stroke survivors. It may help reduce spasticity and make daily activities easier.
Bursa, BursaAges 18–75 - NCT07282522Recruiting
Sensory and function in cervical disc herniation
This study looks at how cervical disc herniation affects sensation and daily function. If you have had neck pain for at least 3 months and have been diagnosed with cervical disc herniation, researchers want to compare your results to people without neck pain.
Iğdır, IğdirAges 18–65 - NCT07287215Recruiting
Motor imagery and daily function in diplegic cerebral palsy
This study tests whether imagining movements (motor imagery) can help improve everyday skills like walking and playing in children with diplegic cerebral palsy. It compares the effects of motor imagery training with standard physical therapy.
BingoelAges 5–18 - NCT05299762Recruiting
INFUSE bone graft for lower back fusion: patient follow-up study
This study tracks patients who receive INFUSE bone graft during a specific type of lower back fusion surgery. It helps confirm how the device performs in real-world care and monitors safety and outcomes after surgery.
SeoulAges 18 years+ - NCT05643079Recruiting
Bone screw and tendon transfer for heel bone realignment
This trial studies a specific surgical technique for people who need heel bone realignment along with a tendon transfer. It tests whether using a human donor bone screw helps the bone heal and the tendon work after surgery.
ViennaAges 18 years+ - NCT06885411Recruiting
Hearing loss from metal-on-metal hip implants
This study looks at whether metal-on-metal hip replacements can affect hearing. It aims to understand if there is a link between these implants and hearing loss.
DelftAges Any age - NCT04181970Recruiting
Study of sarcoma care quality across Europe and Latin America
This observational study looks at information from people with sarcoma to understand how care is delivered across different centers. It does not test a new treatment, but may help improve future care and planning.
Buenos AiresAges 18–120 - NCT07277335Recruiting
Muscle Performance in Young Mexican Weightlifters
This study looks at how muscles and movement affect performance in young Mexican weightlifters. It will help understand how to train better and prevent injuries.
San Luis Potosí City, San Luis PotosíAges 13–23 - NCT06888544Recruiting
High-intensity interval training for bone health in older women
This trial tests whether high-intensity interval training (short bursts of intense exercise) can improve bone health in women aged 60 to 74 with osteopenia (low bone density, but not osteoporosis). Participation involves supervised exercise sessions and bone density measurements.
China, Hong KongAges 60–74 - NCT07276334Enrolling by invitation
Same-day discharge vs. hospital stay for wrist fracture surgery
This trial compares going home the same day after wrist fracture surgery versus staying in the hospital. It aims to see if same-day discharge is safe and effective for recovery.
Ẕerifin, IsraelAges 18–120 - NCT07270380Recruiting
Antibiotic device for bone infection in the arms or legs
This trial tests a dissolvable antibiotic implant placed during surgery to treat long-standing bone infections (osteomyelitis) that haven't healed with antibiotics alone. It may help people who need surgery to remove infected bone.
San Diego, CaliforniaAges 18 years+ - NCT07276958RecruitingPhase 1
Study of LY4298445 for lupus and rheumatoid arthritis
This study tests an investigational drug called LY4298445 in healthy people and in people with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). It aims to see if the drug is safe and how the body handles it.
BrisbaneAges 18–55 - NCT07276581RecruitingPhase 2
Testing AZD1163 for active rheumatoid arthritis
This study tests a new medication called AZD1163 for people with rheumatoid arthritis (RA) that hasn't responded well enough to standard treatments. It aims to see if the drug can safely reduce joint swelling and pain.
Glendale, ArizonaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.