Cancer clinical trials

Adebrelimab With Famitinib and Chemotherapy as Neoadjuvant Therapy for ESCC

Investigational cell therapy for advanced solid tumors

This trial tests a new immune cell therapy called LEU011 for people with solid tumors that have not responded to standard treatments. It aims to see if the therapy is safe and helps shrink tumors. It may be an option if standard treatments are no longer working.

Sequencing test to guide care after CD19 CAR T in kids

This study checks a DNA-based lab test (next-generation sequencing, or NGS) to monitor B-cell recovery after CD19 CAR T treatment in children and young adults. The goal is to see whether the test can help guide management while looking for remission and safe recovery.

Laser therapy for vaginal dryness in breast cancer survivors

This trial tests whether laser therapy can help women who have had breast cancer and now experience vaginal dryness. It aims to see if this treatment can reduce dryness and improve comfort.

ctDNA-MRD Monitoring for Stage I-III Resectable Colon Adenocarcinoma With Oncogenic Driver Mutations: A Multicenter Prospective Cohort Study

VS-7375 for KRAS G12D pancreatic cancer

This study tests a new drug called VS-7375, combined with cetuximab, for pancreatic cancer patients whose tumors have a specific genetic mutation called KRAS G12D. The goal is to see if this combination can shrink tumors and help patients live longer.

Remote activity program for breast cancer survivors

This trial tests a new program to help breast cancer survivors become more active. The program is delivered remotely using a smartphone app, and it adjusts based on your progress. It may be a good fit if you finished treatment less than 5 years ago and are not very active yet.

High-dose vitamin C with standard therapy for newly diagnosed AML

This trial tests adding high-dose vitamin C (ascorbate) to the standard two-drug treatment (azacitidine and venetoclax) for people with newly diagnosed acute myeloid leukemia who are not candidates for intensive chemo. The goal is to see if the vitamin C makes the standard treatment work better and helps control the leukemia.

New cancer drug combo for advanced cervical cancer

This trial tests if giving the immunotherapy drug pembrolizumab before and after standard chemoradiation works better than the standard approach for people with high-risk cervical cancer that has spread locally.

Testing an investigational drug for advanced prostate cancer

This Phase 1 trial tests HRS-5041 in people with metastatic castration-resistant prostate cancer (prostate cancer that keeps growing despite lower testosterone). It aims to see if the drug can be given safely and whether it may help control the cancer after prior standard treatments.

MRG003 plus pucotenlimab vs chemo for advanced nasopharyngeal cancer

This trial tests whether combining an experimental antibody-drug conjugate (MRG003) with an immunotherapy (pucotenlimab) works better than standard chemotherapy for people with nasopharyngeal cancer that has come back or spread. If you have tried at least one prior treatment and are generally in good health, you may be able to join.

Comparing treatment lengths for venetoclax in older adults with newly diagnosed acute myeloid leukemia

This study tests whether a shorter or longer course of the drug venetoclax works better for older adults with a type of blood cancer called acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. The goal is to find the best treatment duration to control the cancer while reducing side effects.

Testing CTIM-76 for recurrent ovarian and other advanced cancers

This trial tests a new drug, CTIM-76, in people whose ovarian, testicular, or endometrial cancer has come back and is not responding to standard treatments. It aims to see if the drug can shrink tumors or stop them from growing.

Hormone therapy with or without chemo for early breast cancer

This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.

New drug vs chemo for advanced endometrial cancer

This trial tests a new drug (mocertatug rezetecan) compared to standard chemotherapy for people with endometrial cancer that has progressed after platinum-based chemo and immunotherapy. It may help if your tumor has a protein called B7-H4.

Study of Lonitoclax and azacitidine for AML

This trial tests a new drug called Lonitoclax combined with azacitidine for people with AML that has come back or not responded to prior treatment. The study will see if the combination is safe and can help control the leukemia.

Nivolumab plus chemotherapy for early-stage Hodgkin lymphoma in young people

This study tests a combination of a newer immunotherapy drug (nivolumab) with standard chemotherapy (AVD) in children, teens, and young adults with newly diagnosed, early-stage Hodgkin lymphoma—a blood cancer affecting lymph nodes. The goal is to see if adding immunotherapy improves outcomes while being tolerable for this age group.

Mammogram decision help for women in rural areas

This trial tests a shared decision-making tool to help women aged 39-49 talk with their doctor about whether to get a mammogram. It aims to make the choice clearer for patients in rural settings.

New targeted drug study for EGFR-mutated lung cancer

This trial tests a new targeted drug (HS-10504) for people with advanced EGFR-mutated non-small cell lung cancer that has worsened after previous EGFR inhibitor therapy. The study aims to see if this drug can help shrink tumors or slow cancer growth.

Supportive clinic for advanced or metastatic cancer

This study offers a supportive care clinic for people with advanced or metastatic cancer. The goal is to help manage symptoms and improve quality of life during treatment.

Cesium implant radiation for recurrent cervical or uterine cancer

This study tests a type of internal radiation (cesium implant) to treat cancer that has come back in the vagina after previous pelvic radiation. The goal is to save the organ while treating the cancer.

Cema-cel for high-risk lymphoma after first treatment

This trial tests a new treatment called cema-cel for people with large B-cell lymphoma who are in remission after first-line therapy but still have tiny amounts of cancer detected by a sensitive blood test. The goal is to prevent the cancer from coming back.

Ipsilateral Versus Bilateral Systematic Biopsy Combined With MRI/Ultrasound Cognitive Fusion Targeted Biopsy for Prostate Cancer Diagnosis

Keytruda with or without Sac-TMT for advanced squamous lung cancer

This trial tests the combination of pembrolizumab (Keytruda) with or without a new drug, sacituzumab tirumotecan (Sac-TMT), as initial treatment for advanced squamous non-small cell lung cancer. It aims to see if adding Sac-TMT after initial treatment helps keep cancer under control longer.