Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT06769828Recruiting
Ga-68-FAPI-46 PET scan for colorectal cancer recurrence with rising CEA
This trial tests a new type of PET scan called Ga-68-FAPI-46 to help find if your colorectal cancer has returned when your CEA levels are rising. It might offer a more accurate way to detect recurrence early.
Taipei, BeitouAges 20–100 - NCT06787625Recruiting
Growing tumor models from colorectal cancer and liver metastases
This study takes samples from colorectal cancer that has spread to the liver and grows them in the lab. The goal is to create models that can help researchers understand the cancer better and find new treatments.
RomeAges 18 years+ - NCT06786169Recruiting
Stress and treatment results in stomach cancer
This study looks at how psychological stress affects treatment success and long-term outcomes in people with stomach cancer. It includes three different groups of patients at various stages of the disease.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06786793Recruiting
AI in colonoscopy screening study
This study tests whether artificial intelligence can help doctors find polyps or other issues during a colonoscopy. It may lead to better detection and earlier treatment.
Krakow, Lesser PoladnAges 50–65 - NCT07469306RecruitingPhase 2
Comparing two radiation plans with chemo and immunotherapy for rectal cancer
This study compares two ways of giving radiation therapy for advanced rectal cancer, combined with a chemotherapy pill and an immunotherapy drug. One approach uses a shorter course of radiation before surgery, and the other uses a longer course; researchers want to see which is more effective and safer.
Fuzhou, FujianAges 18–75 - NCT07463183RecruitingPhase 2
Study of MK-8690 for moderate to severe ulcerative colitis
This trial tests an investigational drug called MK-8690 for people with moderate to severe ulcerative colitis (UC) who haven't responded well to other treatments or can't tolerate them. The study aims to see if the drug can help control UC symptoms safely.
Anaheim, CaliforniaAges 18–75 - NCT07463573RecruitingPhase 3
New drug vs chemotherapy for advanced esophageal cancer
This trial tests a new drug, QLC5508, against standard chemotherapy for people with advanced esophageal cancer that has already been treated. It aims to see if the new drug works better.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07471490Enrolling by invitation
Stool test study for inflammatory bowel disease vs. irritable bowel syndrome
This study collects stool samples and health information to help develop a new test that may tell the difference between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). If you have not been diagnosed with a chronic gut disorder, you may be able to join.
Minneapolis, MinnesotaAges 2 years+ - NCT07466602Recruiting
Using DNA to detect liver cancer return
This trial uses a blood test to check for signs of liver cancer coming back after treatment. It may help find recurrence earlier than standard scans.
Wuhan, HubeiAges 18 years+ - NCT07465705RecruitingPhase 3
Comparing two bowel prep options for colonoscopy the same day
This trial compares two different bowel cleansing preparations taken the same day as your colonoscopy: mannitol vs Plenvu. It aims to see which one works best and is safe.
AnderlechtAges 18 years+ - NCT07465718RecruitingPhase 3
Once-daily trientine for first-line Wilson's disease treatment
This trial tests a once-daily trientine pill as the first treatment for Wilson's disease, a condition where copper builds up in the body. It may help if you've never been treated for Wilson's disease or have only had zinc therapy briefly.
Denver, ColoradoAges 8 years+ - NCT07462923RecruitingPhase 1
A study of HS-20093 for advanced stomach or gastroesophageal cancer
This trial tests a new drug, HS-20093, in people with advanced stomach or gastroesophageal junction cancer that has not responded to other treatments. The goal is to see if it can help shrink or slow the growth of the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07470879RecruitingPhase 2
Etrasimod for Children with Ulcerative Colitis
This trial tests if the medicine etrasimod can help children with moderate to severe ulcerative colitis. You may still be able to join even if you are already taking other treatments for your condition.
New York, New YorkAges 2–11 - NCT06790134Recruiting
AI-assisted pancreas ultrasound training study
This study tests whether an AI tool can help doctors perform and learn pancreatic ultrasound exams better. If you need a pancreas ultrasound, you may be able to join.
ChangshaAges 18–80 - NCT06306755Recruiting
Risk-based screening for esophageal and gastric cancer
This study tests a new way of screening for esophagus and stomach cancer by using a risk-based approach. It aims to see if this works better than standard screening, and is offered to people in certain villages in China.
Beijing, Beijing MunicipalityAges 50–69 - NCT04932577RecruitingPhase 2/Phase 3
Fecal transplant to treat complications of liver cirrhosis
This trial studies whether transferring healthy gut bacteria (from a donor sample) can improve outcomes for people with liver cirrhosis who have worsening complications. It may help by changing the gut microbiome, which can influence inflammation and liver health.
AarhusAges 18–75 - NCT06778174Recruiting
Treating progressive familial intrahepatic cholestasis
This study tracks treatments and outcomes for people with a confirmed genetic form of PFIC, a rare liver disease. It helps doctors learn which treatments work best for each type.
GroningenAges Any age - NCT07464600Recruiting
CRP testing to predict leaks after colon surgery
This trial checks if a simple blood test for CRP (a marker of inflammation) after colorectal surgery can help predict if a patient might develop a leak where the bowel is reconnected. If you are having planned colon or rectal surgery, this study might be for you.
AmiensAges 18 years+ - NCT07465614Recruiting
Nerve stimulation study for children with cyclic vomiting syndrome
This study tests whether a gentle nerve stimulation device placed on the ear can reduce vomiting episodes in children with cyclic vomiting syndrome (CVS). It aims to find a safe, non-drug option for managing symptoms.
Milwaukee, WisconsinAges 5–18 - NCT07464626Recruiting
Art therapy for anxiety and sleep in colorectal cancer patients
This study compares virtual and in-person art therapy to help reduce anxiety, improve psychological well-being, and enhance sleep quality for people with colorectal cancer who are receiving chemotherapy.
Izmir, BalçovaAges 18 years+ - NCT07468630RecruitingPhase 2
Tocilizumab plus chemoimmunotherapy for advanced colon cancer
This study tests a new combination of medications for people with locally advanced colon cancer. It aims to see if adding tocilizumab to standard chemo-immunotherapy can help shrink or control the tumor.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07467928Recruiting
AI colonoscopy's long-term effect on advanced polyps
This study looks at how well AI-assisted colonoscopy prevents new advanced polyps from forming over the long term. It's for people who were in our earlier AI colonoscopy study and are healthy enough for a follow-up scope.
Hong KongAges 18 years+ - NCT07463287Recruiting
Fatty liver and colorectal polyp risk study
This study looks at whether certain gene activity in people with fatty liver disease can predict the risk of developing colorectal polyps. It may help doctors find high-risk patients earlier.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07467434Recruiting
Chemo before surgery for rectal cancer with liver spread
This trial tests if giving FOLFIRINOX chemotherapy first can improve outcomes for people with rectal cancer that has spread to the liver but can still be removed by surgery.
Le Kremlin-BicêtreAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.