Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07479472Recruiting
A study of digestive tract cancers in young adults
This study observes people aged 18-49 with a new gastrointestinal cancer (colorectal, stomach/esophageal, or pancreatic) to learn how their lifestyle habits and tumor characteristics affect their health. By participating, you help researchers understand why these cancers occur in younger adults.
Bologna, BOAges 18–49 - NCT07473583Recruiting
Hernia surgery study on gas timing and blood changes
This study looks at how long the gas used during laparoscopic hernia surgery affects bicarbonate levels in the blood. It may help doctors understand how to better manage your body's chemistry during this type of hernia repair.
IstanbulAges 18 years+ - NCT07475052Enrolling by invitation
Heart rate monitoring to predict biologic therapy response in IBD
This study tests whether a wearable heart rate monitor can help predict how well biologic medications work for people with Crohn's disease or ulcerative colitis. If you are starting infliximab or vedolizumab for the first time, you may be eligible.
Xi'an, ShaanxiAges 18–75 - NCT07476703Recruiting
Extended study on the SCAPIS Stockholm reexamined group
This trial studies data and samples from people already taking part in the main SCAPIS reexamination study in Stockholm. It looks for new findings to help understand heart and lung health.
StockholmAges 56–74 - NCT07477496Recruiting
Anal fistula surgery recovery study
This study follows people having surgery for an anal fistula to see how well they recover. It uses your feedback to measure results, and you'll have check-ins for a year.
AthensAges 18 years+ - NCT07473375Recruiting
Factors affecting portal vein clot reopening in cirrhosis
This study looks at factors that help open up blood clots in the main vein to the liver (portal vein) in people with cirrhosis and varices. It might help guide treatment to improve blood flow.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07478029Recruiting
PEG bowel preparation study for appendectomy patients
This study tests if a bowel-cleaning solution (PEG) works well before colonoscopy. It compares people who have had their appendix removed to those who haven't.
Wuhan, HubeiAges 18–75 - NCT07478185Recruiting
Prehab before pancreatic cancer surgery
This trial tests a pre-surgery exercise program (prehab) for people with pancreatic cancer who plan to have chemotherapy first. The goal is to see if getting stronger before surgery helps with recovery.
Worester, MassachusettsAges 18 years+ - NCT07475026RecruitingPhase 3
Combination therapy before surgery for high-risk liver cancer
This trial tests whether a combination of two drugs (tislelizumab and lenvatinib) given before surgery can lower the risk of liver cancer coming back in people with early-stage but high-risk disease.
TianjinAges 18–75 - NCT07474324RecruitingPhase 2
Targeted therapy plus chemo vs chemo alone for stage 3 stomach cancer
This trial tests adding disitamab vedotin (a drug that targets HER2) to standard chemotherapy (SOX) after surgery for stage 3 stomach cancer. The goal is to see if the combination works better than chemo alone to prevent cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT07478731RecruitingPhase 2
Combination therapy for advanced rectal cancer before surgery
This trial tests a new drug called SHR-1701 combined with standard chemotherapy and radiation for people with locally advanced rectal cancer. The goal is to shrink the tumor before surgery, making it easier to remove completely.
Wuhan, HubeiAges 18–75 - NCT07475286RecruitingPhase 2
Chemo for stomach cancer that has spread to the abdomen lining
This trial tests giving chemotherapy into the abdomen during surgery for stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen (peritoneal carcinomatosis). It aims to see if this approach can help control the disease better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06784557RecruitingPhase 4
Study of ezetimibe's effect on gut bacteria
This trial tests whether ezetimibe, a cholesterol-lowering drug, changes the bacteria in your gut. It may help people with heart disease or high cholesterol who are already on a statin.
SeoulAges 19–80 - NCT06784986RecruitingPhase 4
Low-pressure gas system for robotic prostate surgery
This trial tests whether a special gas system (Airseal) used with very low air pressure during robotic prostate removal surgery can help patients recover better. It compares this to standard methods for men with prostate cancer.
Salvador, Estado de BahiaAges 18–65 - NCT06782880Recruiting
Fecal transplant to prevent infections after liver transplant
This study tests if giving a fecal transplant (a procedure that transfers healthy bacteria from a donor's stool into your gut) before a liver transplant can lower the risk of serious infections after the surgery. It might help strengthen your immune system to fight off germs.
BolognaAges 18 years+ - NCT06783894Recruiting
Elliptical Exercise for Sexual Health in Men with IBS
This study looks at whether regular elliptical exercise can help improve sexual function in married men who have both irritable bowel syndrome (IBS) and erectile dysfunction. It may be an option if you are looking for a drug-free way to manage these issues.
Dokki, Giza GovernorateAges 30–50 - NCT06782594RecruitingPhase 2
Mosapride injection for bowel recovery after surgery
This trial tests an injectable medicine, mosapride citrate, to help the gut start working again after laparoscopic intestinal surgery. It may reduce bloating, pain, and time to first bowel movement.
Feixian, ShandongAges 18–75 - NCT06782555RecruitingPhase 1/Phase 2
Study of experimental drug combo for advanced cancers
This trial tests a new combination of three drugs—evofosfamide, zalifrelimab, and balstilimab—in people with advanced prostate, pancreatic, or certain head and neck cancers that have stopped responding to standard treatments.
Houston, TexasAges 18 years+ - NCT05530070Recruiting
Study diet effects on heart risk in celiac disease
This study looks at how celiac disease and gluten-free (GFD) or gluten-containing diets affect blood and cardiovascular (heart and blood vessel) risk factors. It may help researchers understand which diet habits are most important for heart health in people with celiac disease.
Pécs, BaranyaAges 18 years+ - NCT06334965Recruiting
Studying liver cancer response to targeted radiation therapy
This trial is for people with liver cancer (hepatocellular carcinoma) who are about to receive a type of internal radiation therapy called TARE (also known as radioembolization). Researchers want to learn more about how the cancer responds to this treatment using scans and biopsies. You might be a good fit if you have not had any prior treatment for your liver cancer.
ClichyAges 18 years+ - NCT06322680Recruiting
Drain tubes to prevent pancreas leak after Whipple surgery
This trial is testing whether draining the main pancreatic and bile ducts during a Whipple procedure can lower the risk of a pancreatic leak. The study focuses on people with a higher chance of this complication.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06489197RecruitingPhase 2
AK112 plus chemo for advanced esophageal cancer
This trial tests a new immunotherapy drug (AK112) combined with chemotherapy as a first treatment for advanced esophageal cancer that has spread or cannot be removed. It aims to see if this combination helps shrink tumors and controls the disease longer than chemotherapy alone.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06499324RecruitingPhase 3
Surgery plus Botox for large incisional hernia
This trial tests whether adding Botox injections to surgery helps repair large incisional hernias. It may lower the chance of the hernia coming back.
Colombes, FranceAges 18–79 - NCT06601075Recruiting
FDG and FAPI PET Scans for Advanced Colorectal Cancer
This trial uses two types of PET/CT scans (FDG and FAPI) to better see and track colorectal cancer that has spread to the belly lining (peritoneum). It aims to help doctors choose the best treatment by improving how they detect and monitor the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.