Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT05551299RecruitingPhase 4
Non-surgical treatment for bile duct cancer using heat or light
This trial tests whether treating hilar bile duct cancer with either radiofrequency ablation (heat) or photodynamic therapy (light-activated medicine) can help patients when surgery isn’t an option. It aims to treat the tumor directly without planned surgery soon.
AachenAges 18 years+ - NCT05804331Recruiting
Endoscopy treatment study for large upper stomach/throat lesions
This trial studies a specialized endoscopy procedure to remove larger abnormal growths in the upper digestive tract. It may help people whose lesion size and depth make certain removal techniques a better fit.
Sydney, New South WalesAges 18 years+ - NCT06888843RecruitingPhase 2
Chemotherapy for colorectal cancer in patients 70+
This trial tests two chemotherapy drugs, capecitabine alone or with oxaliplatin, in people aged 70 or older after surgery for stage III colorectal cancer. The goal is to find out which treatment works better to prevent cancer from coming back.
Nizhny NovgorodAges 70–90 - NCT06754189Recruiting
Study of UCon Patch Electrode for bladder or bowel control
This trial tests a new patch electrode placed on the skin to treat overactive bladder or bowel dysfunction. It aims to see if the device is safe and works well.
AarhusAges 18 years+ - NCT05935124Recruiting
White light or narrow-band imaging for colon polyp detection
This trial compares two camera light styles during screening colonoscopy to see which one better finds polyps on the right side of the colon. If you’re having a routine screening and have no concerning symptoms, the results may help improve how doctors spot polyps early.
Sydney, New South WalesAges 18 years+ - NCT06899867Recruiting
Comparing heart monitoring methods during liver transplant
This trial compares two ways to monitor how well your heart is pumping during liver transplant surgery. One method uses a thin tube in your blood vessels, and the other uses an ultrasound probe placed in your food pipe.
France, LyonAges 18 years+ - NCT03506893Recruiting
Alfapump device to reduce stubborn belly fluid in liver disease
This study looks at whether placing an Alfapump under the skin can better manage “refractory ascites,” which is stubborn belly fluid buildup in people with cirrhosis. It also evaluates the medical and economic impact of this care, and who benefits most.
AmiensAges 18 years+ - NCT05784688RecruitingPhase 1/Phase 2
TU2218 with Keytruda for advanced solid tumors
This trial studies TU2218 taken with Keytruda (pembrolizumab) in adults with advanced solid cancers that have limited treatment options. The goal is to see if the combination can shrink tumors and is safe enough to keep using.
San Antonio, TexasAges 18 years+ - NCT05678023Recruiting
Study of contrast dye in certain bowel blockage cases
This trial studies whether using contrast dye (a special substance seen on scans) helps in treating people with a specific type of small-bowel blockage. It may help doctors make better decisions without needing emergency surgery.
Tartu, TartuAges 18 years+ - NCT06293625RecruitingPhase 3
Chemotherapy before surgery for colon cancer in older adults
This trial tests whether giving 6 weeks of chemotherapy (FOLFOX) before surgery can help people aged 70 and older with locally advanced colon cancer. It aims to make treatment safer and more effective for older adults.
DijonAges 70 years+ - NCT07249788RecruitingPhase 4
Resmetirom for MASH: A study on safety and effectiveness
This trial tests if resmetirom can help people with MASH, a type of fatty liver disease linked to metabolic issues like diabetes or obesity. It looks at how safe and effective the drug is over time.
Rawalpindi, Punjab ProvinceAges 18–75 - NCT07252232RecruitingPhase 3
A pill to prevent pancreatic cancer recurrence after surgery
This trial tests an experimental daily pill, daraxonrasib, in people with pancreatic cancer that has been surgically removed. It’s for those who also had chemotherapy and have a specific DNA change called a RAS mutation. The goal is to see if the pill helps prevent the cancer from coming back.
Phoenix, ArizonaAges 18 years+ - NCT07254208Enrolling by invitation
Long-term study for those who took PBGENE-HBV
This study follows people who have already received the experimental gene therapy PBGENE-HBV for hepatitis B. It aims to monitor long-term safety and health outcomes.
Boston, MassachusettsAges 19–80 - NCT07255404RecruitingPhase 2
Testing pumitamig with chemotherapy for untreated pancreatic cancer
This trial tests an experimental drug called pumitamig combined with standard chemotherapy for people with advanced pancreatic cancer that has spread and has not been treated yet. The goal is to see if this combination is safe and effective.
Bedford ParkAges 18 years+ - NCT07255664RecruitingPhase 1/Phase 2
TIL therapy for advanced colorectal or prostate cancer
This trial tests a new type of immunotherapy that uses your own white blood cells (TILs) to fight advanced colorectal or prostate cancer. You will have surgery to remove a tumor, then your TIL cells are grown in a lab and given back to you along with other treatments to boost your immune system.
FrankfurtAges 18 years+ - NCT07259317RecruitingPhase 2
Relacorilant plus chemo for metastatic pancreatic cancer
This trial tests adding a drug called relacorilant to standard chemotherapy (nab-paclitaxel and gemcitabine) for people with pancreatic cancer that has spread. The goal is to see if this combination works better than chemo alone.
Scottsdale, ArizonaAges 18 years+ - NCT06755554RecruitingPhase 3
Green dye to guide lymph node removal in stomach cancer surgery
This trial tests whether a special green dye (indocyanine green) injected during minimally invasive stomach cancer surgery helps doctors remove more lymph nodes, which may improve treatment. It is for people with stomach adenocarcinoma that has not spread to distant organs.
KyivAges 18 years+ - NCT06881511Recruiting
Betaine for autoimmune gastritis
This study tests whether betaine hydrochloride, a supplement that helps with digestion, can improve symptoms in people with autoimmune gastritis. It is for adults who have been diagnosed with this condition and have high gastrin levels or a related stomach history.
Hangzhou, ZhejiangAges 18–80 - NCT07251140Recruiting
Swallowing study with a new microphone device
This study tests a new microphone device to see if it can help find swallowing problems in people who have had a stroke. If you are already scheduled for a swallowing test, you may be able to take part.
Atlanta, GeorgiaAges 40–85 - NCT07252115Recruiting
Comparing two surgeries for hiatal hernia and stubborn GERD
This trial compares two surgical approaches (a 'partial wrap' and a 'full wrap' of the stomach around the esophagus) to fix a hiatal hernia and treat severe, hard-to-control reflux (GERD). It may be a good option if your reflux hasn't improved with medication and you have a hiatal hernia.
BeijingAges 18–85 - NCT07252427Recruiting
Gut bacteria in IBD with or without depression
This study looks at how the bacteria in your gut (gut microbiome) may differ between people with IBD who also have depression and those who don't. It aims to help understand the link between gut health and mood.
Jinan, ShandongAges 18 years+ - NCT07250113Enrolling by invitation
WeCareToFeedDysphagia study for care partners of older adults
This trial tests a program to help care partners of older adults with Alzheimer's disease and swallowing problems. It aims to reduce stress and improve care at home.
Manhasset, New YorkAges 18 years+ - NCT07250347Recruiting
AI-assisted detection of gastric cancer on CT scans
This trial uses artificial intelligence to analyze contrast-enhanced CT scans of patients with gastric cancer. It aims to improve how doctors detect and stage the disease, which may lead to better treatment decisions.
Nanjing, JiangsuAges 18–85 - NCT07252323Recruiting
Carbon ion radiotherapy for liver cancer after TARE
This trial tests a new type of radiation therapy (carbon ion radiotherapy) for people with liver cancer that has not been fully controlled after prior TARE treatment. It aims to see if it is safe and effective for treating the remaining or returning cancer.
SeoulAges 20 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.