Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05534906Recruiting
Detecting very early liver cancer and tracking its natural course
This study looks at how well doctors can detect small, early liver cancer and then follow how it changes over time. It may help your care team choose the best next steps based on earlier, clearer detection.
Oxford, OxfordshireAges 18–100 - NCT05536089Recruiting
Testing blood methylation to predict colorectal cancer relapse
This trial checks a blood test for “ctDNA methylation” to see who may be at higher risk of colorectal cancer returning after surgery. It may help doctors better judge whether adjuvant chemotherapy is working or needed.
Hangzhou, ZhejiangAges 18 years+ - NCT05536102RecruitingPhase 2
Surgery-plus chemo and immunotherapy for HER2-negative gastric cancer
This Phase 2 trial studies whether adding two medicines (XELOX and tislelizumab) and another chemotherapy drug (PLD) around the time of surgery works better and is safe for people with stage III gastric (stomach) cancer. It is designed for tumors that are HER2-negative and PD-1/L1 positive.
ShanghaiAges 18–75 - NCT05537129Recruiting
Laparoscopic vs open stomach surgery for stomach cancer
This trial compares two ways surgeons remove the entire stomach (total gastrectomy): laparoscopic (small keyhole cuts) versus open surgery (one larger cut). It’s testing which approach is safer and works better for people with certain stages of stomach cancer.
Shanghai, Shanghai MunicipalityAges 20–80 - NCT05539677Recruiting
Research biobank and patient registry for aggressive solid tumors
This study builds a biobank and patient registry using tumor samples and blood. It helps researchers better understand aggressive cancers and may improve future treatments by testing immune (defense) responses.
Saint PetersburgAges 1 year+ - NCT05541601Recruiting
Study to detect liver cancer early in people with cirrhosis
This study follows people with cirrhosis to see how best to detect liver cancer early. If you qualify, you may receive regular monitoring that could help find liver cancer sooner, when treatment is more likely to work.
Oxford, OxfordshireAges 18–100 - NCT05544019RecruitingPhase 1
Testing an investigational drug for mature B-cell cancers
This early (Phase 1) study tests SGR-1505, an experimental treatment, in people with certain mature B-cell cancers. It’s mainly designed to see how the drug works in the body and to check safety, and it may offer an option if standard treatments aren’t enough.
Gilbert, ArizonaAges 18 years+ - NCT05544097Recruiting
Listening to bowel sounds in very early preterm babies
This study listens to bowel sounds in very early preterm babies to see if sound patterns can predict a serious gut problem called enterocolitis. If you qualify, your baby may get monitored with harmless sound checks to help doctors catch problems earlier.
AmiensAges Up to 7 months - NCT05546086Recruiting
Beijing health study for adults who live in Beijing
This study collects health information from adults (18+) who are permanent residents of Beijing. It aims to learn patterns about health in the local population and how different factors may affect outcomes over time.
BeijingAges 18 years+ - NCT05547529RecruitingPhase 3
Chemo and radiation before surgery versus chemo alone for esophageal cancer
This trial studies whether adding radiation to chemotherapy before surgery works better for people with operable (resectable) squamous cell esophageal cancer. It aims to improve outcomes by comparing two different treatment plans before the operation.
MoscowAges 18–70 - NCT05547919Recruiting
PSMA scan study for newly diagnosed gut cancer
This study looks at a specific body scan target (PSMA) in newly diagnosed gut cancers to better understand the tumor and guide future care. You may be asked to provide tumor tissue and get a PSMA PET/CT scan, and the results could help identify who may benefit from PSMA-based treatments.
Würzburg, BavariaAges 18 years+ - NCT05550194RecruitingPhase 4
Study of an antiviral to treat achalasia-related nerve inflammation
This trial looks at whether the antiviral medicine valacyclovir, plus Shingrix vaccine, can change disease affecting the gut’s nerve system in people with achalasia. If you’re eligible, you would complete specific swallow and pressure tests and then take the medicines for about two months.
Nashville, TennesseeAges 18–75 - NCT05551299RecruitingPhase 4
Non-surgical treatment for bile duct cancer using heat or light
This trial tests whether treating hilar bile duct cancer with either radiofrequency ablation (heat) or photodynamic therapy (light-activated medicine) can help patients when surgery isn’t an option. It aims to treat the tumor directly without planned surgery soon.
AachenAges 18 years+ - NCT05551416Recruiting
Study to detect and prevent early stomach cancer
This study looks for early warning changes in the stomach and aims to improve early detection and prevention. Depending on your situation, you may be grouped as having stomach symptoms, early lesions that might be removed, already-diagnosed stomach cancer, or a comparison group without stomach problems.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT05552287RecruitingPhase 4
Infliximab drug levels in children with Crohn’s disease
This study measures how infliximab (a medicine that calms immune inflammation) moves through the body in children with Crohn’s disease. It mainly helps doctors understand dosing and drug levels, especially when treatment is newly starting.
RotterdamAges 1–15 - NCT05552755RecruitingPhase 1/Phase 2
Drug trial for FAP to reduce pre-cancer growth
This early-phase trial studies REC-4881 in adults with familial adenomatous polyposis (FAP), a condition that causes many colon/rectum and duodenal polyps. It aims to see whether the treatment can safely help control or shrink polyp growth in people who have had bowel surgery.
Scottsdale, ArizonaAges 18 years+ - NCT05554224Recruiting
Personalized treatment based on obesity-related fatty liver tests
This study uses multiple types of health data (“multi-omics”) to help choose a personalized treatment plan for people with obesity-related fatty liver disease. It may help match treatment to your biology to improve outcomes.
Reus, TarragonaAges 18 years+ - NCT05556473RecruitingPhase 1
Tryptophan PET/CT scan study for different tumors
This early-phase study tests a special PET/CT scan using labeled tryptophan to help doctors see how different tumors behave. The goal is to learn whether this scan can better identify and measure cancers in the brain or elsewhere.
Detroit, MichiganAges 18 years+ - NCT05557448RecruitingPhase 2
N-Acetylcysteine treatment for serious acetaminophen overdose
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Taipei, Beitou DistrictAges 20 years+ - NCT05561114RecruitingPhase 3
Paclitaxel balloon to widen stubborn benign food pipe narrowing
This study tests whether a paclitaxel-coated balloon can keep the esophagus (food pipe) open longer in people with a stubborn benign narrowing. It aims to improve swallowing by reducing how often the narrowing needs repeat stretching.
Birmingham, AlabamaAges 22 years+ - NCT05561504Recruiting
Study of stomach bacteria resistance in adults
This study looks at how common a stomach bacteria infection is and which antibiotics still work. You may help researchers by providing consent for related study participation and sample tracking.
MunichAges 18 years+ - NCT05561647Recruiting
Survey of GATTEX knowledge for patients and prescribers
This study uses a survey to check how much people and doctors know about using GATTEX. It may help improve education and support for safer, more informed use of the medicine.
Cambridge, MassachusettsAges 18 years+ - NCT05561907Recruiting
Endoscopic vs. surgical bypass for stomach blockage from cancer
This trial compares two ways to bypass a blockage in your stomach caused by cancer near the pancreas or duodenum. Both approaches create a new connection so food can pass through, but one uses a camera-guided tube (endoscopic) and the other is surgical. The study will see which works better for your symptoms and quality of life.
New Brunswick, New JerseyAges 18 years+ - NCT05563766RecruitingPhase 2
Itraconazole added for treatable esophageal cancer before surgery
This study tests whether adding itraconazole (an anti-fungal medicine) to standard chemo-radiation before surgery increases the chance of complete tumor response. It’s for people with esophageal (or GE junction) cancer that can be removed with curative surgery after treatment.
Palo Alto, CaliforniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.