Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05563922RecruitingPhase 2
Testing a plan to preserve the anus after rectal chemo-radiation
This Phase 2 study tests a “total neoadjuvant” (chemo plus radiation before the main treatment) plan to see if some people with low rectal cancer can keep their anus. It may help you avoid permanent colostomy if your cancer responds well and you meet the study rules.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05566249Recruiting
Safety study of ArtiSential during rectal cancer surgery
This trial checks whether a tool called ArtiSential can be used safely and practically during planned rectal cancer operations. It may help the surgical team prepare and perform the operation more smoothly, but the main goal is safety and feasibility.
SeoulAges 18–80 - NCT05570448Recruiting
Endoscopy treatment using APC for chronic reflux disease
This trial studies whether an endoscopy procedure using APC (a type of heat/energy treatment) can improve symptoms in people with chronic GERD and confirmed acid reflux. It may help reduce reflux-related discomfort for people who meet specific testing and safety requirements.
Kansas City, MissouriAges 18–80 - NCT05571644RecruitingPhase 2
Study compares two pre-surgery treatments for locally advanced rectal cancer
This Phase 2 trial tests whether a newer combination chemotherapy plus an immunotherapy medicine (cadonilimab/AK104) works better than standard chemotherapy before surgery for locally advanced colorectal cancer. The goal is to shrink the tumor and improve how well treatment works after surgery.
Guangzhou, GuangdongAges 18–70 - NCT05572801Recruiting
Tumor DNA blood tests to guide follow-up after anal cancer
This study tests whether regular blood tests looking for “tumor DNA” can help guide your follow-up care after anal cancer treatment. It may help doctors decide what type of monitoring you need during check-ups.
Herlev, Capital Region of DenmarkAges 18 years+ - NCT05574387RecruitingPhase 2
Metformin added to treatment for ulcerative colitis
This Phase 2 study tests whether adding metformin to usual care can help people with mild to moderate ulcerative colitis. The goal is to see if it improves symptoms and disease control compared with standard therapy alone.
Al MansurahAges 18–75 - NCT05575505RecruitingPhase 2
Pentoxifylline added to ulcerative colitis treatment
This trial tests whether adding the medicine pentoxifylline to standard care can help people with ulcerative colitis. It’s designed to see if this combination improves symptoms by changing inflammation.
Al MansurahAges 18–75 - NCT05576038Recruiting
Tryptophan to help celiac symptoms improve
This trial tests whether tryptophan (a natural amino acid) can improve symptoms in people with celiac disease who still have symptoms despite following a gluten-free diet. It may help by supporting an internal body signal pathway researchers believe is impaired in some people with celiac disease.
Hamilton, OntarioAges 18–75 - NCT05576480RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for rectal cancer without mismatch repair
This Phase 2 study tests penpulimab (an immunotherapy medicine) given with CAPEOX chemotherapy before surgery for rectal cancer that is “MSS” (not the mismatch-repair type). It aims to shrink the tumor and improve outcomes by treating before the operation.
Shanghai, None SelectedAges 18–75 - NCT05577143Recruiting
Blood test screening for colorectal cancer
This study checks whether a blood test can help identify colorectal cancer or precancerous growths. You would have a planned colonoscopy, and researchers compare the blood test results to what the colonoscopy finds.
LilleAges 18–75 - NCT05577845Recruiting
Ramosetron vs loperamide for bowel symptoms after rectal surgery
This trial compares two medicines—ramosetron and loperamide—to see which works better for severe bowel control problems after low anterior rectal surgery. It may help people with major LARS (low anterior resection syndrome) choose a safer, more effective treatment.
Seoul, Jongro-guAges 19 years+ - NCT05578235Recruiting
Surgery for Crohn’s: hand-sewn vs stapled bowel connection
This trial compares two ways of reconnecting the bowel after removing diseased intestine in people with Crohn’s disease. The goal is to see which method works better for healing and short- and longer-term outcomes.
Almere Stad, FlevolandAges 16 years+ - NCT05579353Recruiting
Study stool and blood markers in colorectal cancer treatment planning
This study looks at special tiny cell-signal particles (called exosomes) and related pathways to understand colorectal cancer. Your results from samples may help researchers learn how these signals relate to the disease after surgery.
Jinan, LixiaAges 18–80 - NCT05579392Recruiting
Bright light therapy for gut inflammation in Crohn’s or colitis
This trial studies whether daily bright light can improve gut barrier “leakiness” and reduce inflammation in adults with Crohn’s disease or ulcerative colitis. It compares bright light versus dim light in a crossover design, meaning you may receive both.
Chicago, IllinoisAges 18 years+ - NCT05582174RecruitingPhase 4
IV medicine versus pills to stop bleeding stomach ulcers
This trial compares an IV “acid-suppressing” medicine (PPI infusion) with acid pills (oral PPIs) after doctors treat a bleeding peptic ulcer endoscopically. It may help prevent re-bleeding by keeping stomach acid low while the ulcer heals.
Guangzhou, GuangdongAges 18 years+ - NCT05591040Recruiting
Biofeedback to help swallow problems after stroke
This trial studies whether using “biofeedback” (seeing your body’s muscle signals on a screen) along with standard care can improve swallowing after a stroke. You might be eligible if you have ongoing swallow trouble and can safely do the training sessions.
Venice-LidoAges 18–89 - NCT05592886Recruiting
Oral probiotic-and-prebiotic drink to prevent colon polyps returning
This study tests whether an oral synbiotic (a probiotic plus a prebiotic) can reduce the chance that advanced colon growths come back after they were removed. It also looks at changes in stool-related bacterial “gene markers” that may signal lower risk over time.
Hohhot, Inner MongoliaAges 18–90 - NCT05593458RecruitingPhase 3
Stomach cancer surgery before chemo: artery-based or drip chemo
This trial compares two ways of giving chemotherapy before surgery for locally advanced stomach or stomach–esophagus cancer: chemo sent through an artery versus chemo given through an IV line. It also studies adding PD-1 immunotherapy to see which approach works better and is safer.
Hangzhou, ZhejiangAges 18–75 - NCT05594927RecruitingPhase 3
Test icaritin vs huachansu for advanced liver cancer with poor health
This Phase 3 trial compares two medicines—icaritin soft capsules versus huachansu tablets—as first treatment for unresectable hepatocellular carcinoma (HCC) that has “poor prognosis” blood test markers. It aims to see which option works better and is safer for people who can’t use standard first-line treatments or don’t want them.
Nanchang, JiangxiAges 18 years+ - NCT05597904Recruiting
Study differences in celiac disease and related skin rash
This study looks at why celiac disease (and a related skin condition called dermatitis herpetiformis) can look different from person to person. It may help researchers understand these “phenotypes” (different patterns) so future care can be better targeted.
TampereAges 18 years+ - NCT05603897Recruiting
Testing dysphagia screening methods after recent stroke
This study compares two ways of checking for swallowing problems (dysphagia) in people who were recently hospitalized for an acute ischemic stroke. If the new screening method works better, it could help catch swallowing issues earlier and improve safety.
Miami, FloridaAges 18 years+ - NCT05604846Recruiting
Probiotic drops for very preterm babies in Scandinavia
This trial studies whether giving probiotic supplements to extremely preterm newborns helps improve health outcomes. It’s meant for babies born very early, and the results could help guide safer early nutrition and care.
Solna, Stockholm CountyAges 5 months–6 months - NCT05604716Recruiting
Surgery Patients: Digestive and Social Function Follow-Up Study
This study checks how your digestion and daily social functioning may change after surgery. It looks at results from completed questionnaires filled out after your diagnosis to understand what issues patients face.
Beijing, Beijing MunicipalityAges Any age - NCT05606822Recruiting
Vacuum endoscopy for leaks after esophagus stomach surgery
This trial studies an endoscopic vacuum treatment (a suction device placed through an endoscope) to help heal a leak after surgery where food/drink pathways were connected (an anastomosis). If you had an esophago-gastric leak, this treatment may be part of your care plan and is being studied for effectiveness and safety.
AmsterdamAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.