Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05714124Recruiting
Testing liver procedures to treat tumors when surgery isn’t possible
This trial studies different ways to place treatments inside the liver to control liver tumors when they can’t be removed with surgery or ablation. It may help certain people by improving how well the tumor is treated while keeping liver function safer.
MilanAges 18 years+ - NCT05717738Recruiting
Immunotherapy plus targeted drugs after TACE for liver cancer
This trial tests a combination of blood-vessel–targeting medicine and immunotherapy after a liver-directed treatment called TACE for advanced hepatocellular carcinoma (HCC). It aims to control tumor growth when surgery or ablation isn’t suitable, and to see if this “conversion therapy” helps patients do better than standard pathways.
Quanzhou, FujianAges 18 years+ - NCT05718440Recruiting
Checking risk factors for urinary and related issues
This study looks at why some adults with spinal dysraphism develop problems with bladder, bowel, and/or sexual function. It gathers information during a one-day visit to help doctors better understand risk factors.
ParisAges 18 years+ - NCT05718492Recruiting
Tested HAIC for liver cancer after prior immunotherapy
This trial studies HAIC, a type of targeted treatment delivered into the liver, for advanced hepatocellular carcinoma (liver cancer) that has already been treated with immune and anti-blood-vessel therapies. It aims to see whether HAIC can help control the cancer safely after those earlier treatments.
Guangzhou, GuangdongAges 18–75 - NCT05719246Recruiting
Yoga and meditation for teens with IBS stress
This study tests a structured yoga and meditation program to help reduce stress symptoms in teens with irritable bowel syndrome (IBS). It may help your teen learn calming practices that could ease how stress affects IBS.
Camden, New JerseyAges 12–21 - NCT05720338RecruitingPhase 3
Does everyone need a drain after distal pancreas surgery?
This study compares whether patients need an internal abdominal drain after removing part of the pancreas (a distal pancreatectomy). It aims to see if skipping the drain is as safe and may reduce drain-related problems.
Cleveland, OhioAges 18 years+ - NCT05721742Recruiting
Virtual diet education for irritable bowel symptom management
This trial tests whether adding online (virtual) diet education to a step-by-step irritable bowel (IBS) care plan can improve symptoms like belly pain and stool changes. You may be asked to make diet changes and use a device to join the virtual education.
Halifax, N.S.Ages 18–65 - NCT05720663Recruiting
Predicting liver outcomes in fatty liver cirrhosis
This study looks at how to predict future outcomes in adults who have fatty-liver disease (NAFLD) that has progressed to cirrhosis. It may help doctors better estimate risk and plan care, using information from liver tests and scans.
Rochester, MinnesotaAges 18 years+ - NCT05722275Recruiting
Predicting peritoneal spread in advanced stomach cancer
This trial uses CT scan images and a look inside the abdomen (laparoscopy) to predict whether advanced stomach cancer has spread to the lining of the abdomen (the peritoneum). It may help your care team better identify who already has peritoneal spread and who might not.
BeijingAges 18 years+ - NCT05722236Recruiting
Peer support program to help people manage stress from IBD
This trial tests a “peer-to-peer” support program to help adults with inflammatory bowel disease (IBD) manage psychological distress (stress and emotional strain). It may help you cope better during major life or treatment changes related to IBD.
Halifax, N.S.Ages 18–99 - NCT05723718Recruiting
Testing body-water measurements in people with stomach cancer
This trial uses a painless machine to measure your body composition (mainly fluid and muscle) using bioelectrical impedance. It’s looking at people with stage II–III stomach cancer who are receiving standard “multi-treatment” care, to see whether these measurements are useful during treatment.
LublinAges 18–100 - NCT05723445Recruiting
Low glycemic diet test for diabetes and body changes in CF
This trial studies whether a low glycemic load (a specific way of choosing carbohydrates) improves blood sugar control and body composition in adults with cystic fibrosis–related diabetes. It may help reduce blood sugar problems and support healthier weight and body measurements.
Boston, MassachusettsAges 18–70 - NCT05723107RecruitingPhase 1
Testing an endoscopic treatment for pancreatic cancer that can't be removed
This early-phase trial is testing a new endoscopic (from inside the stomach) approach for pancreatic ductal adenocarcinoma that is locally advanced and cannot be removed with surgery. It may help some people who have already tried first chemotherapy and still have a tumor confined to the pancreas area (no spread).
New York, New YorkAges 18 years+ - NCT05724992Recruiting
Study genetic testing in families at pancreatic cancer risk
This program invites people whose families are followed in a pancreatic cancer registry to do a saliva swab genetic test. It helps researchers learn how to identify genetic risk in families and may guide future care.
VeronaAges 18–80 - NCT05725200RecruitingPhase 2
Personalized treatment plan for metastatic colon or rectal cancer
This Phase 2 trial tests an individualized treatment chosen from your tumor’s lab testing (genetic and RNA profile plus a drug-sensitivity test from your tumor cells). It may help by matching you to targeted anti-cancer drugs that are most likely to work for your specific cancer.
OsloAges 18 years+ - NCT05725590Recruiting
External pancreatic duct stents after pancreatic surgery
This study tests whether placing an external pancreatic duct stent after pancreaticoduodenectomy can lower the risk of pancreatic leak (pancreatic fistula). If you had this surgery with a specific connection technique, you may be able to help find a safer way to prevent complications.
HangzhouAges 18–75 - NCT05725876RecruitingPhase 1
Imaging ustekinumab medicine movement in Crohn’s and psoriasis
This Phase 1 study uses a special camera to track how ustekinumab (a common biologic medicine) spreads in inflamed tissue. It aims to help researchers understand where the drug goes in Crohn’s disease and psoriasis, especially when standard treatments haven’t worked.
GroningenAges 18 years+ - NCT05726136RecruitingPhase 4
Test fluid dosing during laparoscopic abdominal surgery
This trial tests a “fluid challenge” approach during surgery to better control your body’s fluid level. It may help guide how much fluid is safely given during longer laparoscopic abdominal operations.
Norrköping, Östergötland CountyAges 18–85 - NCT05726396RecruitingPhase 2
Microbiome therapy for steroid-resistant immune colitis
This Phase 2 pilot study tests a “restorative microbiota therapy” (RMT) to treat colitis caused by immune checkpoint inhibitors when standard treatments like steroids are not working. It aims to see if this approach is safe and practical, and may improve diarrhea and gut inflammation.
Brainerd, MinnesotaAges 18 years+ - NCT05727020Recruiting
Breath test study for pancreatic cancer and related conditions
This study checks whether breathing out certain chemicals (volatile organic compounds) can help identify pancreatic ductal adenocarcinoma (pancreatic cancer) or related pancreas problems. You may qualify if you’re an adult with suspected/confirmed pancreatic conditions and can safely take part in breath testing or surgery-related tissue collection.
LondonAges 18 years+ - NCT05727722RecruitingPhase 1
Micro-packaged liver cell transplant for adult liver failure
This Phase 1 study tests a new way to place liver cells (in small protective “micro-packages”) inside the belly to treat liver failure. It aims to see whether the treatment is safe and potentially helps liver function in adults with worsening chronic or acute-on-chronic liver failure.
ShanghaiAges 18–65 - NCT05727787Recruiting
Radiation trial for liver cancer that cannot be removed
This Phase I study tests a specific radiation approach (vGRID SBRT) for hepatocellular carcinoma (and some mixed types) that is advanced and cannot be cured with surgery or transplant. It aims to control tumors while staying within safety limits for the liver and nearby organs.
Kansas City, KansasAges 18 years+ - NCT05728697Recruiting
Test a liver ultrasound method to measure fat and stiffness
This trial tests a special ultrasound technique during an endoscopy to see how well it can detect changes in the liver from non-alcoholic fatty liver disease. It may help improve non-invasive assessment before or alongside a follow-up liver biopsy.
Boston, MassachusettsAges 18 years+ - NCT05729438Recruiting
Nutritional assessment in people with liver cirrhosis
This study focuses on assessing nutrition in adults living with liver cirrhosis. The goal is to understand nutritional needs and how assessment may support care.
Bucharest, București - Sector1Ages 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.