Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT06918626Recruiting
Comparing two bile duct stone removal approaches during gallbladder surgery
This trial compares two ways of checking for and removing stones from the main bile duct during gallbladder surgery. One method uses a special scope (SpyGlass) during the operation, and the other does an MRI first. The goal is to see which approach is better for people with gallstone-related inflammation of the gallbladder who might have stones in the bile duct.
Pavia, PaviaAges 18 years+ - NCT06918652Recruiting
Surgery or endoscopy for high-risk gallbladder inflammation
This trial compares two minimally invasive treatments for people with severe gallbladder inflammation caused by gallstones. It aims to see which approach better helps the immune system and reduces risks for those who are too sick for standard surgery.
Pavia, PaviaAges 18 years+ - NCT06251297Recruiting
Reflexology to prevent nerve damage from chemotherapy
This study tests if foot reflexology can help prevent nerve damage caused by a chemotherapy drug called oxaliplatin in people with colorectal cancer. If it works, it could reduce pain, tingling, or numbness in the hands and feet.
Toulouse, CHU de ToulouseAges 18 years+ - NCT06678919Recruiting
A registry for metastatic colorectal cancer beyond second line
This study tracks people with metastatic colorectal cancer who have already tried at least two standard treatments. It aims to collect real-world data on how well newer treatments work in later lines of therapy.
LinzAges 18 years+ - NCT06718543RecruitingPhase 2
Short-course radiation with AK112 for rectal cancer before surgery
This trial tests whether combining short-course radiation with an immune therapy drug (AK112) plus chemotherapy before surgery is better than radiation alone for locally advanced rectal cancer. It aims to shrink tumors and improve outcomes without needing stronger treatments later.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06921668Recruiting
Energy use before and after esophagus surgery
This study measures how your body uses energy before and after scheduled esophagus removal surgery to understand recovery needs. It may help doctors provide better nutritional support during your hospital stay.
AmiensAges 18 years+ - NCT06921161Recruiting
TongueFit therapy for swallowing problems in children
This study tests a new device called TongueFit that helps children strengthen their tongue muscles to improve swallowing. If your child has trouble swallowing due to weak tongue muscles, this therapy may help.
Jakarta, Jakarta Special Capital RegionAges 3–16 - NCT02781870Recruiting
3D laparoscopic groin hernia repair with special mesh fix
This study looks at a laparoscopic (keyhole) operation to repair a groin (inguinal) hernia using a 3D “visible” mesh, with or without an added fixation method. If you have a first-time hernia on one side and are planning a laparoscopic repair, this trial may be an option to discuss with your surgical team.
GhentAges 18–80 - NCT06215404Recruiting
Fluid management during liver transplant for less blood loss
This trial tests different ways of managing fluids during liver transplant surgery to see if it can reduce blood loss. It may be helpful for patients with end-stage liver disease who are waiting for a transplant.
TaipeiAges 18–75 - NCT06685887RecruitingPhase 2
Chemo, Immunotherapy, and Heated Belly Chemo for Stomach Cancer Spread
This trial tests combining standard chemotherapy and immunotherapy (tirelizumab) with heated chemotherapy given directly into the belly. It aims to treat stomach cancer that has spread to the abdominal lining, and may help shrink or control the cancer.
Wuhan, HubeiAges 18–75 - NCT06216041RecruitingPhase 1
Safety study of IMM-H014 in healthy adults
This trial tests a new drug called IMM-H014 in healthy volunteers to see if it is safe and how the body processes it. It also checks if food changes how the drug works. You may join if you are generally healthy and meet the age and weight requirements.
Changchun, JilinAges 18–45 - NCT06214572RecruitingPhase 2/Phase 3
Radiation Therapy for Advanced Gallbladder Cancer
This trial tests a type of radiation therapy for people with advanced gallbladder cancer that cannot be removed by surgery. It is for those whose cancer has not spread to other parts of the body and has stayed stable or improved after initial chemotherapy.
Mumbai, MaharashtraAges 18 years+ - NCT06923150Recruiting
MiniGo vs. standard care for bowel symptoms after rectal cancer surgery
This trial tests a small, portable device called MiniGo that uses a gentle water rinse to help control bowel symptoms after rectal cancer surgery. It may be an option for people who still have bothersome bowel problems despite trying other treatments.
AmiensAges 18 years+ - NCT06923449Recruiting
Gastric cancer surgery and tumor board performance study
This study looks at how tumor board discussions affect outcomes for people having surgery to cure gastric cancer. If you have gastric adenocarcinoma and are scheduled for curative surgery, you may be able to join.
Rome, ITAges 18 years+ - NCT06687265RecruitingPhase 2
Metformin for reducing liver pressure in cirrhosis
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Clichy, FranceAges 18 years+ - NCT06406062Recruiting
AI-assisted colonoscopy study
This trial tests an artificial intelligence (AI) system during colonoscopy to help doctors see polyps or other issues more clearly. It may help improve detection of problems in the colon.
Wuhan, HubeiAges 50 years+ - NCT06847126RecruitingPhase 3
Oral vs IV antibiotics for liver abscess treatment
This trial compares two antibiotic treatments for liver abscess: one given through an IV (into a vein) and one taken as pills by mouth. The goal is to see if the oral treatment works just as well, which could make treatment easier and more convenient for patients.
ChandigarhAges 18 years+ - NCT07210580Recruiting
Tracking symptoms to improve quality of life for veterans with IBD
This study tests whether a structured approach to tracking symptoms and adjusting care (called measurement-based care) can improve quality of life for veterans with IBD. It is for veterans whose IBD symptoms affect their daily life and who receive care at one of the four participating VA hospitals.
Decatur, GeorgiaAges 18 years+ - NCT07208786Recruiting
Vacuum therapy to prevent leaks after colorectal cancer surgery
This trial tests whether using a special vacuum device inside the surgical connection (anastomosis) right after surgery can help prevent leaks. If you are having surgery for colorectal cancer, this treatment might reduce your risk of a serious complication.
Nanchong, SichuanAges 18–85 - NCT06925594RecruitingPhase 3
Cell injection for Crohn's-related anal fistulas
This trial tests a new cell injection (TH-SC01) to treat anal fistulas caused by Crohn's disease. It aims to see if the injection can heal fistulas and lower infection risk.
Nanjing, JiangsuAges 18–70 - NCT07209813RecruitingPhase 2
Immunotherapy plus TACE for liver cancer
This trial tests a new immunotherapy drug (GKL-006) combined with a standard treatment called TACE (which blocks blood flow to the tumor) for people with liver cancer that cannot be removed by surgery. The goal is to see if adding this drug helps shrink tumors more than TACE alone.
Beijing, Beijing MunicipalityAges 18–80 - NCT07205926RecruitingPhase 1
Testing a new Shigella vaccine in healthy adults
This trial tests a new Shigella vaccine in healthy adults to see if it is safe and creates a good immune response. It is a first-in-human study, meaning this is the first time the vaccine is given to people.
Cincinnati, OhioAges 18–49 - NCT06844604Recruiting
Comparing carbon footprint of robotic, laparoscopic, and open colorectal surgery
This study measures the environmental impact (carbon footprint) of different surgical techniques for removing part of the colon or rectum. It aims to find which approach is more sustainable without compromising patient care.
BaselAges 18 years+ - NCT05169073Recruiting
Virtual reality practice for gallbladder removal surgery
This trial tests whether virtual reality training can help surgeons perform laparoscopic gallbladder removal more effectively. It is meant for people scheduled for planned (non-emergency) gallbladder surgery due to gallstones or long-term gallbladder inflammation.
BaselAges 22–45
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.