Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT06915389Recruiting
Gastric cancer: predicting immune therapy side effects
This trial studies whether blood tests before treatment can predict side effects from immunotherapy (PD-1/PD-L1 inhibitors) in people with gastric cancer. If you are about to start this type of treatment, your participation could help doctors manage side effects better.
Xining, QinghaiAges 18–80 - NCT06917716Recruiting
Chinese pain survey for chronic pancreatitis patients
This study is testing a new questionnaire to better measure pain in people with chronic pancreatitis. It aims to help doctors understand and treat your pain more effectively.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06913998Recruiting
NUDT15 gene study for Taiwanese IBD patients
This study looks at how certain gene changes (NUDT15) affect people with inflammatory bowel disease (IBD) in Taiwan. It aims to help doctors better understand and treat IBD.
TaipeiAges 1–25 - NCT07220239Recruiting
Menstrual cup for early cancer detection in Lynch syndrome
This study tests whether a menstrual cup can collect cells from the uterus to detect early endometrial cancer in women with Lynch syndrome. If you have Lynch syndrome and are due for a routine biopsy, you may be able to use a menstrual cup instead.
Boston, MassachusettsAges 18 years+ - NCT07213271Recruiting
Exercise study for obese breast cancer survivors
This study tests whether a physical exercise program can improve metabolism, gut health, fitness, and quality of life in obese women who have completed breast cancer treatment at least one year ago.
BratislavaAges 25–70 - NCT07215624Recruiting
Survey on blood clot prevention after cancer surgery
This study surveys surgeons and surgical advanced practice providers about how they prevent blood clots (deep vein thrombosis) in patients after cancer surgery. It aims to understand current practices and improve future care.
Kingman, ArizonaAges 18 years+ - NCT07214298RecruitingPhase 1/Phase 2
Combination treatment for advanced pancreatic cancer
This trial tests a new drug, pegcetacoplan, combined with a standard chemotherapy regimen called modified FOLFIRINOX, for people with pancreatic cancer that has spread to other parts of the body. The goal is to see if the combination helps control the cancer better than chemotherapy alone.
Buffalo, New YorkAges 18 years+ - NCT07216521Recruiting
Study of why surgery was done for an IPMN cyst
This study looks at why doctors decided to do surgery for a certain type of pancreatic cyst (IPMN) and how well patients did after. If you had surgery for an IPMN between 2015 and 2025, you may be able to help doctors learn more.
Phoenix, ArizonaAges 18 years+ - NCT07219784Enrolling by invitation
Abdominal binders for feeding in preterm babies on breathing support
This study tests whether a soft abdominal binder (a wrap around the belly) helps preterm babies on breathing support keep their milk feeds going without interruptions. It might help reduce pauses in feeding and support growth.
Albany, New YorkAges Up to 1 year - NCT07220369Recruiting
Gut mini-pill study: testing a new capsule
This trial tests a special mini-pill that may help your gut health. You'll take the pill and provide stool samples while eating provided meals.
Boston, MassachusettsAges 50–75 - NCT07213557RecruitingPhase 2
Simvastatin with immunotherapy for ARID1A-mutated stomach cancer
This trial tests whether adding the cholesterol drug simvastatin to standard immunotherapy and chemotherapy can help people with a specific type of gastroesophageal cancer (ARID1A mutated, HER2 negative). It is for patients who have not had prior treatment for advanced disease.
Naples, ItaliaAges 18 years+ - NCT07213570RecruitingPhase 2
Second-line regorafenib for advanced RAS-mutant colorectal cancer
This trial tests regorafenib as a second-line treatment for people with advanced colorectal cancer that has a RAS mutation. It aims to see if this targeted therapy can help when the first treatment stopped working.
Naples, ItalyAges 18 years+ - NCT07212933RecruitingPhase 2
RAK cell therapy for advanced stomach cancer
This trial tests a new type of immune cell therapy called RAK cells for people with late-stage stomach cancer that has spread and stopped responding to standard treatments. The goal is to see if it is safe and helps control the cancer.
Beijing, Beijing MunicipalityAges 18–70 - NCT07219537Recruiting
Imaging the lower gut with a new capsule
This trial tests a new type of camera capsule that takes pictures of the lower part of your digestive tract. It may be an option for people who are healthy or have Lynch Syndrome and have had a recent normal colonoscopy.
Boston, MassachusettsAges 18–75 - NCT07220382RecruitingPhase 4
Botox injections before large hernia surgery
This trial tests if getting Botox shots in the belly muscles before hernia surgery makes the repair easier and more successful. It is for adults who need a planned, open surgery for a large ventral hernia.
Cleveland, OhioAges 18 years+ - NCT07216014RecruitingPhase 4
IL-23 antibody for inflammatory bowel disease
This trial tests a new antibody drug (IL-23 inhibitor) for people with Crohn's disease or ulcerative colitis. It aims to see if the drug is safe and effective. You may be able to join if you have moderate to severe disease and have not had certain bowel surgeries or infections.
Guangzhou, GuangdongAges 18–65 - NCT07212491Enrolling by invitation
Gentle cell sampling to check for early signs of esophageal cancer
This study tests less invasive ways to detect high-grade dysplasia (very abnormal cells) and esophageal cancer in people with Barrett's esophagus, a condition that can increase cancer risk. It looks for these changes using cell samples taken during a routine endoscopy, which may be quicker and more comfortable than standard biopsies.
Scottsdale, ArizonaAges 18–90 - NCT07213323Recruiting
Probiotics for Digestion During Weight-Loss Treatment
This study tests whether taking a probiotic (a type of 'good' bacteria) can improve digestion and gut health in people who are starting a GLP-1 RA medicine for weight loss. You would take the probiotic daily and answer questions about your digestive symptoms.
Pierre-BéniteAges 18–75 - NCT07217938RecruitingPhase 2
Testing statins for swallowing problems after radiation
This study tests whether a common cholesterol-lowering drug (pravastatin, a type of statin) can reduce swallowing problems caused by past radiation for head and neck cancer. If you have had radiation at least 2 years ago and still have trouble swallowing, this trial may help find a new way to ease those symptoms.
Melbourne, VictoriaAges 18 years+ - NCT07221058RecruitingPhase 1
Adaptive radiation boost study for rectal cancer
This study tests whether giving an extra, targeted radiation dose (adaptive radiation boost) after standard treatment can improve outcomes for people with rectal cancer. You may be eligible if you have stage T2-3 N0-1 rectal cancer and can undergo MRI scans and certain chemotherapies.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07215000RecruitingPhase 4
Better Colonoscopy Prep Options for Comfort
This trial compares different colonoscopy prep methods to see which one patients tolerate best. It aims to make the cleaning process before a colonoscopy more comfortable and acceptable.
Atlanta, GeorgiaAges 18 years+ - NCT04706234Recruiting
Check swallowing and voice function in neurodegenerative diseases
This study looks at how well the throat and voice-related functions work in people with certain long-term brain or nerve conditions. It uses a specific throat exam during FEES to better understand swallowing and laryngopharyngeal (throat-area) function.
Innsbruck, TyrolAges 18 years+ - NCT06621563RecruitingPhase 1
Study of HS-20117 Combination Therapy for Advanced Solid Tumors
This early-phase trial tests a new drug (HS-20117) combined with other drugs for people with advanced solid tumors. It aims to see if the combination is safe and effective, especially for cancers that have not responded to other treatments.
TianjinAges 18–75 - NCT06740357Recruiting
Shared decision-making for rectal cancer organ preservation
This trial tests a program that helps you and your doctor decide together whether to avoid surgery and keep your rectum after chemo and radiation. It's for people with early-stage rectal cancer who have not had prior treatment for this cancer.
DijonAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.