Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06126419Recruiting
High-dose insulin for liver function after surgery
This trial tests if high-dose insulin can help your liver work better and heal faster after a major liver surgery for colorectal cancer that has spread to the liver.
Montreal, QuebecAges 18 years+ - NCT06126406RecruitingPhase 1
CEA-targeting CAR-T cell therapy for advanced solid tumors
This trial tests a new immune cell therapy (CAR-T) designed to attack cancer cells that make a protein called CEA. It may be an option for people with advanced colorectal, esophageal, gastric, or pancreatic cancer who have already tried at least two standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT06128252Recruiting
Taurine with chemotherapy and immunotherapy for gastric cancer
This trial tests whether adding taurine to standard chemo-immunotherapy before surgery helps treat locally advanced gastric cancer. It may be an option for patients whose tumors are PD-L1 positive and can be fully removed with surgery.
Wuhan, HubeiAges 18–75 - NCT06129474Recruiting
Reducing unnecessary high-dose heartburn medication in adults
This study tests whether it is safe and helpful to reduce or stop daily high-dose heartburn medications (called PPIs) in patients who might not need them anymore. It is for adults who take a strong PPI every day and can communicate in German.
BernAges 18 years+ - NCT06130280RecruitingPhase 2
MRI-guided radiation for liver tumors from colorectal cancer
This trial tests a single, high-dose radiation treatment (SBRT) guided by MRI for people with colorectal cancer that has spread to the liver. The goal is to see if this precise, one-time treatment can effectively control liver tumors while protecting nearby organs.
Basking Ridge, New JerseyAges 18 years+ - NCT06133101RecruitingPhase 2
Can soymilk help kids with fatty liver disease?
This study tests if drinking soymilk can improve liver health in children with non-alcoholic fatty liver disease (NAFLD). It may offer a simple dietary change to help manage the condition.
Cincinnati, OhioAges 5–12 - NCT06134388RecruitingPhase 3
Sulfasalazine for metastatic colorectal cancer
This trial tests whether adding the drug sulfasalazine to standard chemotherapy can help people with metastatic colorectal cancer live longer. It is for patients whose cancer has spread and who are healthy enough for chemotherapy.
Tanta, El-Gharbia GovernorateAges 18–65 - NCT06134687Recruiting
New stiffening tube for colon lesion removal
This trial tests a new flexible tube that becomes stiff to help doctors remove large or complex colon lesions during an endoscopic procedure. It may help people with certain types of flat or scarred growths that are harder to remove safely.
Houston, TexasAges 22 years+ - NCT06135571Recruiting
Lymph node patterns in left colon and rectal cancer
This study looks at how colon and rectal cancer on the left side spreads to nearby lymph nodes (No.253). It is for people who have had laparoscopic surgery and whose cancer is still only in the colon or rectum. The goal is to better understand these patterns to help guide future treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT06136949Recruiting
STARD3 study for colorectal cancer patients
This study looks at a marker called STARD3 in colorectal cancer to understand its role and potential for targeted treatment. It may help find new ways to treat the disease.
Aviano, PordenoneAges 18 years+ - NCT06136845Recruiting
Esophageal cancer microbiome and leak after surgery
This study looks at bacteria in esophageal cancer tumors and whether certain bacteria are linked to leaks that can happen after surgery to remove the esophagus. It may help doctors understand how to prevent these leaks in the future.
HaifaAges 18–85 - NCT06137014RecruitingPhase 1/Phase 2
Fortified rehydration drink for childhood diarrhea
This study tests a new type of oral rehydration drink for children with diarrhea. It aims to help kids recover faster at home without needing a hospital stay.
New Brunswick, New JerseyAges 6 months–5 years - NCT06138028RecruitingPhase 2/Phase 3
Sintilimab plus chemo and radiation for advanced esophageal cancer
This trial tests a combination of an immunotherapy drug (sintilimab) plus chemotherapy followed by radiation therapy for advanced esophageal cancer that has spread. The goal is to see if this sequence can help shrink tumors and improve outcomes.
Qingdao, ShandongAges 18–80 - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT06139042Recruiting
Early detection of liver, bile duct, and pancreas cancers
This study aims to find new ways to detect liver, bile duct, and pancreatic cancers early using a blood test. It may help doctors diagnose these cancers sooner, when they are easier to treat.
Hangzhou, ZhejiangAges 40–75 - NCT06141031RecruitingPhase 1
TTI-101 plus radiation for borderline or locally advanced pancreatic cancer
This trial tests a new oral drug (TTI-101) combined with targeted radiation (SBRT) for people with pancreatic cancer that is not removable by surgery. It aims to see if this combination helps shrink tumors that are borderline resectable or locally advanced.
Aurora, ColoradoAges 18 years+ - NCT06141369Recruiting
Personalized mRNA vaccine for advanced endocrine tumors
This trial tests a personalized mRNA vaccine made from your tumor's genetic information. It is for people with advanced endocrine tumors who have no standard treatment options left, and aims to help the immune system fight the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06144593Recruiting
Carb cutting for people with type 2 diabetes
This study looks at whether cutting carbs on certain days can improve metabolism for people with type 2 diabetes. It may help if you have mild to moderate diabetes and are overweight or obese.
HvidovreAges 35–75 - NCT06144762Recruiting
Precision imaging for early detection and treatment monitoring in pancreatic cancer
This trial uses advanced imaging to detect pancreatic cancer early and track how well treatment is working. It may help if you have pancreatic cancer that can be surgically removed, either right away or after chemotherapy.
MontpellierAges 18 years+ - NCT06145074RecruitingPhase 2
Testing propranolol before surgery for pancreatic cancer
This trial tests if taking propranolol (a blood pressure medication) before surgery helps treat pancreatic cancer that can be removed. It aims to see if the drug is safe and works well.
CopenhagenAges 18 years+ - NCT06146816Recruiting
Infrared light therapy for Crohn's disease
This trial tests a new infrared light treatment to see if it can reduce inflammation and symptoms in people with Crohn's disease. It's for those who have active disease despite current treatments or who are not on therapy.
Tel AvivAges 18–80 - NCT06147635RecruitingPhase 2
Tributyrin for early acute pancreatitis
This trial tests a supplement called tributyrin (related to butyrate) to see if it can help prevent complications from acute pancreatitis when given early after diagnosis. It is for people having their first episode of pancreatitis, not for those with certain causes or weakened immune systems.
Delft, South HollandAges 18 years+ - NCT06147414Recruiting
Blood test for genetic disorders in pregnancy
This study tests a safer blood test to check for certain genetic disorders during pregnancy, instead of an invasive procedure like amniocentesis. It's for pregnant women who are at risk of passing on a known genetic condition.
ParisAges 18 years+ - NCT06148402RecruitingPhase 2
A new combination therapy for advanced colorectal cancer
This trial tests a new combination of three drugs (fruquintinib, camrelizumab, and capecitabine) for people with colorectal cancer that has spread or cannot be removed and has stopped responding to a standard first chemotherapy. It is for those whose cancer progressed after a specific first treatment called FOLFOXIRI.
Guangzhou, GuangdongAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.