Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06111105Recruiting
Comparing blood tests to guide colon cancer treatment
This study compares different blood tests to find the best way to detect tiny bits of cancer DNA after surgery for stage III colorectal cancer. It aims to help doctors decide if additional chemotherapy is needed to prevent the cancer from coming back.
Graz, StyriaAges 18 years+ - NCT06112704RecruitingPhase 2
HS-20093 for advanced esophageal and other solid tumors
This trial tests an investigational drug called HS-20093 for people with advanced esophageal cancer or other solid tumors that have not responded to prior treatment. The drug targets a protein on cancer cells called B7-H3, and the study aims to see if it can shrink tumors or slow their growth.
Hefei, AnhuiAges 18 years+ - NCT06113419Recruiting
Timing of gallbladder surgery after severe pancreatitis
This study looks at the best time to remove the gallbladder in people who have had a severe bout of pancreatitis caused by gallstones. It aims to see if removing the gallbladder earlier or later after recovery helps patients heal better.
Bogota, CundinamarcaAges 18 years+ - NCT06113913RecruitingPhase 4
Switching from IV to under-the-skin infliximab after dose increase
This study tests if switching from a high-dose infliximab IV infusion to a daily or weekly injection under the skin works just as well. It is for people with inflammatory bowel disease who are already stable on IV infliximab.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06116019Recruiting
Online adaptive radiotherapy for cancer patients
This trial tests a new radiation therapy machine that adjusts the radiation plan in real-time based on changes in your body. It may help make treatment more precise and reduce side effects.
BerlinAges 18 years+ - NCT06115876Recruiting
Kuwait diabetes long-term follow-up study
This study checks in on people with prediabetes or type 2 diabetes who were part of an earlier Kuwait diabetes study. It aims to understand how their condition has changed and what health care they may need.
Kuwait CityAges 21–75 - NCT06117241Recruiting
Reducing metabolic risk in couples after colon polyp diagnosis
This study tests a program to improve metabolic health in couples where one person had colon polyps. You and your partner may join if you both are overweight or obese, live together, and share meals.
Columbia, South CarolinaAges 9–55 - NCT06117735Recruiting
Covered stent for portal hypertension
This trial tests a special stent to treat high blood pressure in the liver caused by cirrhosis. It may help patients who need a procedure called TIPS to improve blood flow.
Fuzhou, FujianAges 18–85 - NCT06118762RecruitingPhase 4
Study of fruquintinib plus raltitrexed for advanced colorectal cancer
This trial tests two drugs, fruquintinib and raltitrexed, for people with metastatic colorectal cancer that has stopped responding to or is no longer tolerable after standard treatments like fluorouracil, oxaliplatin, and irinotecan. The goal is to see if this combination can help shrink or control the cancer.
Nanchang, JiangxiAges 18 years+ - NCT06119997Recruiting
Liver fibrosis screening using simple blood tests in primary care
This trial uses a blood test (FIB-4) to find liver scarring (fibrosis) in people who haven't been tested before. It aims to catch advanced liver disease early, which can help you get treatment sooner.
GrenobleAges 18–70 - NCT06121089Recruiting
Surgery for early-stage cecal cancer
This trial is testing different surgical approaches for people with cecal cancer that hasn't spread. The goal is to find the best treatment option for patients whose tumors are at a stage where surgery can be curative.
MoscowAges 18 years+ - NCT06121700RecruitingPhase 2
Chemoimmunotherapy and radiation before surgery for limited spread stomach cancer
This trial tests combining chemotherapy, immunotherapy, and radiation before surgery for stomach or gastroesophageal junction cancer that has spread to a limited number of sites. The goal is to see if this approach can improve outcomes by shrinking tumors before they are removed.
ShanghaiAges 18–75 - NCT06121622Recruiting
Personalized 3D models for pancreatic neuroendocrine tumors
This study is testing a new way to make 3D models in the lab that look like your specific tumor. The goal is to better understand pancreatic neuroendocrine tumors and find personalized treatments.
Milan, MIAges 18 years+ - NCT06122285Recruiting
Bulevirtide for chronic hepatitis delta
This study tests a daily shot of Bulevirtide for people with long-term hepatitis delta and early-stage cirrhosis. It aims to see if the medicine is safe and works well.
Milan, MIAges 18 years+ - NCT06122493RecruitingPhase 2
Better treatment for advanced esophageal cancer
This trial tests a new treatment plan for people with advanced esophageal squamous cell carcinoma that has spread to lymph nodes but not to other organs. It aims to find the best way to treat this cancer using radiation and other therapies.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06122896RecruitingEarly Phase 1
Screening for pancreatic cancer in high-risk people
This trial uses MRI and endoscopic ultrasound to look for early signs of pancreatic cancer in people who have a high risk due to their genes or family history. Finding it early may lead to better treatment options.
Boston, MassachusettsAges 18 years+ - NCT06123117Recruiting
Nerve block vs local painkiller for gallbladder surgery recovery
This study compares two ways of giving pain relief after gallbladder removal surgery. It tests if a nerve block (STALL) works better than injecting numbing medicine directly into the surgery site. The goal is to find which method reduces pain and the need for painkillers.
Espoo, UusimaaAges 18 years+ - NCT06123156RecruitingPhase 3
Early erectile rehabilitation after rectal cancer treatment
This trial tests if sildenafil (Viagra) given soon after surgery and radiation for rectal cancer can help preserve erectile function. It is for men with normal erectile function before treatment who have a regular partner.
AmiensAges 18–70 - NCT06123338RecruitingPhase 2
Pembrolizumab plus chemo and trastuzumab for HER2+ stomach cancer
This trial tests adding pembrolizumab to standard trastuzumab and chemotherapy for people with HER2-positive stomach or esophageal cancer that can be fully removed with surgery. The goal is to see if this combination improves outcomes before and after surgery.
Boston, MassachusettsAges 18 years+ - NCT06123650Recruiting
Magnetic brain stimulation plus therapy for swallowing after stroke
This study tests whether adding a gentle magnetic brain stimulation (called rTMS) to standard swallowing therapy can help prevent pneumonia in people who have trouble swallowing after a stroke. It might reduce the risk of getting a lung infection.
Giza, Giza GovernorateAges 49–65 - NCT06124287Recruiting
Can MRI predict Crohn's relapse after stopping biologics?
This study looks at whether MRI scans can predict when Crohn's disease will come back after stopping biologic medications. If you are in remission and recently stopped a biologic, researchers want to see if your MRI results can help understand your risk of relapse.
LondonAges 16 years+ - NCT06124261Recruiting
Hormones and fatty liver study
This study looks at how hormones (androgens) relate to fatty liver disease (MASH) in women, especially those with PCOS. It aims to understand why some women develop worse liver problems and might help find new ways to treat or prevent them.
San Francisco, CaliforniaAges 18–42 - NCT06124456Recruiting
Vigorous vs. moderate exercise for liver fat reduction
This study compares high-intensity exercise to moderate-intensity exercise to see which is better at reducing fat in the liver for people with obesity and fatty liver disease.
Hong KongAges 18–69 - NCT06124833Recruiting
Gut and mouth microbiome study for Korean IBD patients and their family
This study looks at the bacteria in your gut and mouth to understand more about inflammatory bowel disease (IBD). It compares patients with their close family members who do not have IBD to see what might be different.
SeoulAges 13–85
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.