Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06192771Recruiting
Swallowing and speech therapy after tongue cancer surgery
This trial tests whether starting speech and swallowing therapy early after surgery helps people with tongue cancer recover their ability to eat and talk. It is for patients having part of their tongue removed and rebuilt with a tissue flap.
Toronto, OntarioAges 18 years+ - NCT06193356Recruiting
Can endoscopists learn to spot scar after polyp removal?
This study tests whether endoscopists can learn to see scarring and find any remaining tissue after polyp removal. It may help improve how doctors check for cancer coming back.
GhentAges 18 years+ - NCT06193928Recruiting
Long-term safety study of Livmarli in ALGS or PFIC
This study is following patients who are already taking Livmarli (maralixibat) for Alagille syndrome or PFIC to see how safe and effective it is over the long term.
Los Angeles, CaliforniaAges Any age - NCT06194708Recruiting
Why some temporary stomas are never reversed after rectal cancer surgery
This trial looks at why some people who had a temporary stoma (a bag for waste) after rectal cancer surgery never get it reversed. It collects information from medical records to find patterns that might explain this.
Beijing, Beijing MunicipalityAges 18–100 - NCT06194734RecruitingPhase 3
KC1036 vs. chemo for advanced esophageal cancer
This study compares a new drug, KC1036, to standard chemotherapy options for people with advanced esophageal squamous cell cancer that has progressed after immunotherapy and at least one chemo. It aims to see if KC1036 works better or has fewer side effects.
BeijingAges 18–75 - NCT06196294RecruitingPhase 1
Engineered immune cells for cancers with GPC3 or mesothelin
This trial tests a new type of immune cell therapy made from your own cells (gamma-delta T cells) that are engineered to find and attack cancers that have GPC3 or mesothelin proteins. It may be an option for people with advanced cancer who have not had gene therapy before and are in generally good health.
Guangzhou, GuangdongAges 18–75 - NCT06196788RecruitingPhase 2
Artery infusion chemo for advanced pancreatic cancer
This trial tests a treatment called transcatheter arterial infusion, where chemotherapy drugs are delivered directly to the tumor through a thin tube in an artery. It's for people with advanced pancreatic cancer who haven't had other treatments yet.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06197334Recruiting
Recording stomach and gut signals with skin sensors
This study uses small sensors placed on your belly to record electrical signals from your stomach and intestines. It may help doctors better understand conditions like Crohn's disease and other digestive issues without using needles or inside-the-body tests.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18 years+ - NCT06197308RecruitingEarly Phase 1
Testing a mouth bacteria treatment for PSC
This study tests whether a treatment made from mouth bacteria can help people with primary sclerosing cholangitis (PSC). It aims to see if it's safe and improves health.
Minneapolis, MinnesotaAges 18–76 - NCT06198296RecruitingPhase 1
Armored CAR T cells for GPC3-positive solid tumors
This trial tests a new type of immunotherapy called CAR T cells that are trained to find and attack cancer cells with a specific marker (GPC3). The CAR T cells are also 'armored' with extra proteins (IL-15 and IL-21) to help them work better. It might be an option for adults with advanced solid tumors, especially liver cancer, that have not responded to standard treatments.
Houston, TexasAges Up to 21 years - NCT06198400Recruiting
Dye test for blood flow after pancreas surgery
This trial uses a special dye to check blood flow in the remaining part of your pancreas after surgery. It helps doctors see if the tissue is getting enough blood, which can improve healing and reduce complications.
Prague, Czech RepublicAges 18 years+ - NCT06199895RecruitingPhase 2
Study of paclitaxel for patients with taxane-resistant solid tumors
This trial tests paclitaxel given as tiny micelle particles for people whose cancer (pancreatic, bile duct, lung, stomach, esophagus, or breast) stopped responding to taxane chemotherapy or did not shrink. The goal is to see if this treatment can help when standard taxanes no longer work.
Wuhan, HubeiAges 18 years+ - NCT06200961Recruiting
Trans-nasal endoscopy for bariatric patients
This study tests a thinner, more comfortable endoscope that goes through the nose instead of the mouth for patients who need an upper GI exam. It may be a gentler option for weight-loss surgery patients.
Boston, MassachusettsAges 18–90 - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT06201065RecruitingPhase 3
Targeted therapy and immunotherapy for advanced liver cancer
This trial tests a combination of two drugs (lenvatinib and toripalimab, a type of immunotherapy) plus a special chemotherapy infusion directly into the liver artery for people with advanced liver cancer that has not been treated before. The goal is to see if adding the immunotherapy helps shrink tumors better than the standard combination.
Guangzhou, GuangdongAges 18–75 - NCT06202001RecruitingPhase 1/Phase 2
Three-drug combo for metastatic colorectal cancer as second treatment
This trial tests a combination of three drugs (irinotecan, TAS-102, and bevacizumab) for people with metastatic colorectal cancer that has already been treated with oxaliplatin-based chemotherapy. The goal is to see if this three-drug combination works better as a second treatment option.
BeijingAges 18–70 - NCT06202105Recruiting
Laparoscopic vs open total gastrectomy for advanced stomach cancer
This trial compares two types of surgery for stomach cancer that has grown into deeper layers but has not spread to distant organs. The goal is to see if a keyhole (laparoscopic) approach is as safe and effective as traditional open surgery.
Bien Hoa, Dong NaiAges 18–80 - NCT06202131Recruiting
Blood test for tumor DNA in gastrointestinal cancers
This trial uses a blood test (ctDNA) to look for genetic material from tumors in patients with gastrointestinal cancers. It may help doctors understand and track your cancer better.
Rome, LazioAges 18–85 - NCT06203548Recruiting
Tracking liver fat with a continuous monitor
This study looks at a new way to track how much fat is in your liver using a simple, continuous device. It may help people with fatty liver disease and related metabolic issues (like being overweight or having high blood sugar) avoid frequent MRI scans.
Hong KongAges 18–65 - NCT06203327Recruiting
Can atrophic gastritis predict stomach cancer risk?
This trial studies whether a condition called atrophic gastritis (thinning of the stomach lining) can help predict who is more likely to develop stomach cancer. It may help with early detection and prevention.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06203782Recruiting
Comparing two treatments for Crohn's disease strictures
This trial compares two ways to treat narrowed areas (strictures) in the gut caused by Crohn's disease: endoscopic strictureplasty versus balloon dilation. It aims to see which method works better for people whose strictures are manageable with a scope.
Hangzhou, HangzhouAges 18–75 - NCT06204094RecruitingPhase 2
Preserving the anus with chemo, immunotherapy, and radiation for rectal cancer
This trial tests a treatment plan that combines chemotherapy, immunotherapy, and radiation before surgery for patients with middle or low rectal cancer. The goal is to shrink the tumor enough to avoid removing the anus, preserving bowel function.
Jinhua, ZhejiangAges 18–75 - NCT06203951Recruiting
Better STI testing during pregnancy in Kenya
This study tests a simpler way to check for sexually transmitted infections (STIs) and HIV/syphilis during pregnancy in Kenyan clinics, to help keep both you and your baby healthy.
Homa BayAges Any age - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.