Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07076524Recruiting
Muscle wasting and swallowing in critically ill patients
This study looks at muscle loss and swallowing problems in very ill patients on breathing machines in the intensive care unit. It aims to understand these issues better, which could help improve care for future patients.
LondonAges 18 years+ - NCT07077356RecruitingPhase 1
mRNA vaccine for liver cancer patients awaiting transplant
This trial tests an mRNA vaccine for people with liver cancer who are waiting for a liver transplant. The vaccine is given to help control the cancer while they wait.
ChengduAges 18 years+ - NCT07078136Recruiting
AI study for upper GI tumor diagnosis
This study uses artificial intelligence to help diagnose tumors in the upper stomach or esophagus. It looks at images from endoscopy and ultrasound to improve how doctors identify these growths.
Wuhan, HubeiAges 18 years+ - NCT07083596Recruiting
Fermented milk drink for constipation relief in Filipino adults
This study tests if a special fermented milk drink can help relieve constipation symptoms like hard or lumpy stools. Researchers want to see if it works for adults who have constipation without a known medical cause.
Manila, ManilaAges 18–59 - NCT05655780Recruiting
Irinotecan care guided by tumor genes and gut bacteria
This study looks at whether a patient’s tumor genetic makeup and gut bacteria activity can predict how well irinotecan-based treatment works and what side effects they might have. It may help personalize treatment to improve survival and quality of life for people with metastatic or unresectable colon cancer.
Maastricht, LimburgAges 18 years+ - NCT06206564RecruitingPhase 2
Artesunate ointment for anal precancer in HIV-negative adults
This trial tests an artesunate ointment to treat high-grade anal precancer (HSIL) in people who do not have HIV. The goal is to see if the ointment can clear the abnormal cells caused by HPV.
Chicago, IllinoisAges 18 years+ - NCT06655051Recruiting
Plastic versus metal stent for bile duct blockage from chronic pancreatitis
This study compares two types of stents (plastic vs. metal) to see which works better for treating bile duct narrowing caused by chronic pancreatitis. If you have a bile duct blockage from chronic pancreatitis, you may be eligible.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06978933RecruitingPhase 2
Testing two new drugs for FGF19-positive liver cancer
This trial tests two new targeted drugs (ABSK-011 and ABSK043) for people with advanced liver cancer whose tumors have high levels of the FGF19 protein and who have already tried at least one other treatment.
ShanghaiAges 18 years+ - NCT06978400RecruitingPhase 2
Targeted therapy plus chemo for BRAF mutant colorectal cancer
This trial tests a combination of targeted therapy (dabrafenib) and two other drugs (cetuximab or panitumumab) plus standard chemotherapy (FOLFOX) as a first treatment for people with a specific type of metastatic colorectal cancer that has a BRAF V600E mutation and is microsatellite stable.
MoscowAges 18 years+ - NCT04735198Recruiting
Preventive gallbladder removal for midgut neuroendocrine tumors
This trial looks at whether removing the gallbladder before it causes problems can be helpful for people with midgut neuroendocrine tumors who are already planning primary tumor surgery. It may reduce future gallbladder-related complications around the time of cancer treatment.
Badalona, BarcelonaAges 18 years+ - NCT05491434Recruiting
Study of muscle loss in colon cancer patients
This trial looks at muscle loss (called sarcopenia) in people with colon cancer to test an intervention that may help strength or recovery. If you’re age 70 or older and meet the cancer and health requirements, you may be able to take part.
L'Hospitalet de Llobregat, BarcelonaAges 70 years+ - NCT06092463Recruiting
Immune system study in newborn intestines
This study looks at how the immune system develops in the intestines of newborns, including those born early or with a blocked intestine (atresia). It may help doctors understand inflammation and improve care for sick babies.
CopenhagenAges Up to 1 year - NCT06979908RecruitingPhase 2
A study of fruquintinib plus immunotherapy for advanced colorectal cancer
This trial tests a combination of three drugs (fruquintinib, a PD-1 inhibitor, and chidamide) for people with a specific type of advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if this new combination can shrink tumors or slow the cancer's growth.
Changchun, JilinAges 18–75 - NCT06980532RecruitingPhase 1/Phase 2
Glumetinib and Fruquintinib for advanced colorectal cancer
This trial tests a combination of two targeted drugs (Glumetinib and Fruquintinib) for people with a specific type of advanced colorectal cancer that has a change in the MET gene (amplification) or too much MET protein. It is for those whose cancer has not responded to at least two prior treatments.
Wuhan, HubeiAges 18 years+ - NCT04295473Recruiting
Test of smaller-incision stomach surgery for gastric cancer
This trial studies a stomach cancer surgery done with fewer/smaller incisions (laparoscopic with reduced ports). It may help people with certain early-to-mid stage stomach cancers by comparing whether this approach is safe and effective for them.
Nanchong, SichuanAges 18–90 - NCT05999396RecruitingPhase 1
Testing a new antibody for colorectal cancer
This trial tests a new drug called CC-3, which is a type of antibody designed to help your immune system attack colorectal cancer cells. It is for people whose cancer has spread and who have already tried several standard treatments.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06214988Recruiting
Temporary stoma or not for rectal cancer surgery
This trial tests whether a temporary stoma (a bag on the belly) can be safely avoided in some people having rectal cancer surgery. The goal is to see if it's okay to skip the stoma in those with a low risk of complications.
MalmöAges 18 years+ - NCT06173947Recruiting
SSM Score for Liver Injury in Chronic Liver Disease
This study looks at how well a simple score (called SSM) can predict recovery in people with chronic liver disease who suddenly get a liver injury with jaundice. It may help your doctors understand how serious your condition is.
Guangzhou, GuangdongAges 18–80 - NCT06488001RecruitingPhase 2
Preventing nausea after gynecologic surgery with pantoprazole
This trial tests if giving pantoprazole before surgery can reduce nausea and vomiting after gynecologic procedures. It may help patients who are having gynecologic surgery under general anesthesia.
Portsmouth, VirginiaAges 18–79 - NCT06577532RecruitingEarly Phase 1
KRAS mRNA vaccine for advanced solid tumors
This early-phase trial is testing a new mRNA vaccine (ABO2102) designed to target KRAS mutations in advanced solid tumors. It may be an option if your cancer has a KRAS mutation and standard treatments are no longer working.
ShanghaiAges 18 years+ - NCT06937294RecruitingPhase 4
Metformin for diabetes from chronic pancreatitis
This trial tests if metformin is safe and effective for people who developed diabetes after being diagnosed with chronic pancreatitis. You must not have taken any diabetes medication before.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07075393Recruiting
Kidney health in Wilson's disease
This study looks at how Wilson's disease affects the kidneys. It aims to describe kidney problems in people with Wilson's disease, which may help doctors better monitor and treat this condition.
ParisAges 7 years+ - NCT07066657RecruitingPhase 1
Study of MRG007 for advanced solid tumors
This trial tests a new drug called MRG007 for people with advanced solid tumors that haven't responded to other treatments. The drug targets a protein called CDH17 on cancer cells; you need a tumor sample to check for it.
Los Angeles, CaliforniaAges 18 years+ - NCT07070518RecruitingPhase 1/Phase 2
Study of GV20-0251 for advanced solid tumors
This trial tests a new study drug, GV20-0251, for people with advanced solid tumors that no longer respond to standard therapies. It aims to see if the drug can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.