Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07089940RecruitingEarly Phase 1
OMO-103 for advanced pancreatic cancer
This trial tests a new drug called OMO-103 in people with advanced pancreatic cancer that has spread or cannot be removed by surgery. It may be an option whether you have had treatment before or not, as long as it's been at least 2 weeks since your last therapy.
Portland, OregonAges 18 years+ - NCT07093294Recruiting
Predicting vedolizumab success with ultrasound in early Crohn's
This study uses intestinal ultrasound to see if vedolizumab can heal the gut in people recently diagnosed with Crohn's disease. It aims to find early signs that the treatment is working.
Changsha, HunanAges 18–80 - NCT07093359RecruitingPhase 3
LINX vs fundoplication for acid reflux surgery
This trial compares two surgical treatments for acid reflux (GERD) that isn't well controlled with medication. It tests if the LINX device (a magnetic ring around the esophagus) works as well or better than fundoplication (a stomach wrap). It may help people who need surgery for reflux.
Oxford, OxfordshireAges 18 years+ - NCT07095517RecruitingPhase 1
Preventing early-onset colorectal tumors with tirzepatide
This study tests if tirzepatide can help prevent early-onset colorectal tumors in people aged 18-50 who have had certain types of polyps removed. It aims to find risk factors and ways to stop colorectal cancer before it starts.
Boston, MassachusettsAges 18–50 - NCT07093346Recruiting
Pectin supplement for fatty liver disease
This study tests whether a pectin supplement (a fiber found in fruits) can reduce inflammation and improve liver and metabolic health in people with fatty liver disease (MASLD). You might be eligible if you have MASLD, a healthy weight range, and can avoid certain medications and foods.
Nottingham, United KingdomAges 18 years+ - NCT07091526Recruiting
Does controlling uric acid help after pancreatic cancer surgery?
This study is checking if controlling uric acid (a normal body waste product) can help people with pancreatic cancer live longer after surgery. If you have had successful surgery and are otherwise healthy, this trial might be for you.
Lanzhou, GansuAges 18–85 - NCT07089030Recruiting
Capsule endoscopy for unexplained anemia on blood thinners
This study uses a capsule endoscopy (a pill-sized camera you swallow) to look for hidden sources of bleeding in the small intestine of people who have iron deficiency anemia and take blood thinners. Finding the cause may help manage your anemia and avoid unnecessary repeat tests.
Trois-Rivières, QuebecAges 18–90 - NCT07091032Recruiting
Building connections for better health
This study tests if helping people address obesity, cancer screenings, or mental health struggles can improve their overall health. You may qualify if you have obesity, are behind on colon or cervical cancer screening, or have depression or anxiety.
Boston, MassachusettsAges 18–75 - NCT07086833Recruiting
Diet, gut bacteria, and colon cancer risk study
This study looks at how diet and gut bacteria affect colon cancer risk in Black and Non-Hispanic White adults aged 45 to 75 who are at higher risk. You would donate mouth and stool samples and complete food recalls.
Indianapolis, IndianaAges 45–75 - NCT07087561Recruiting
Nutrition and health education after colorectal cancer surgery
This trial tests whether a short-term nutritional supplement combined with health education can improve recovery after surgery for colorectal cancer. It is for people with stage IIa, IIb, or IIIa colon or rectal cancer who have completed surgery and are able to engage in follow-up.
Xi'an, ShaanxiAges 18 years+ - NCT01551563Recruiting
Study for people newly diagnosed with inflammatory bowel disease
This trial studies treatment approaches for inflammatory bowel disease (IBD) in people who are newly diagnosed. It may help researchers find better care by learning how well the study treatment works early in the disease.
StavangerAges 16–80 - NCT03061435Recruiting
Screening for anal cancer after high-grade vulvar changes
This trial checks whether anal cancer screening is useful for women age 40 and older who previously had high-grade vulvar pre-cancer (VIN 2/3) or vulvar cancer. It may help find serious problems earlier in people at higher risk.
Toronto, OntarioAges 40 years+ - NCT06251115Recruiting
Study of QY-1-T for advanced HBV-related liver cancer
This study tests a new treatment called QY-1-T for people with advanced liver cancer related to hepatitis B. It is for patients who have already tried other standard treatments and have a certain genetic marker (HLA-A*11:01).
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05854368Recruiting
Blood tests to detect early stomach changes and cancer
This study looks for a blood “signature” that can spot early, risky stomach changes (before cancer) and stomach cancer. It may help clinicians diagnose earlier and decide who needs closer follow-up.
Boulogne-BillancourtAges 18 years+ - NCT06668454Recruiting
Chemoimmunotherapy before surgery for limited spread esophageal cancer
This trial tests a treatment plan that combines chemotherapy with immunotherapy, followed by surgery, for people whose esophageal or stomach cancer has spread to a few areas (oligometastatic). The goal is to see if this approach can shrink the cancer and improve outcomes.
Toronto, OntarioAges 18–80 - NCT06772064Recruiting
Rifaximin for bloating caused by SIBO
This study tests whether the antibiotic rifaximin can relieve bloating in people with small intestinal bacterial overgrowth (SIBO). If you have chronic bloating and a positive SIBO breath test, this trial may be a good fit.
Jinan, ShandongAges 18–70 - NCT06959758RecruitingPhase 4
Probiotics for childhood constipation
This study tests whether a probiotic supplement (BioKid LR) can help children with functional constipation — a condition where a child has hard, infrequent bowel movements with no other medical cause. The probiotic contains nine different types of good bacteria, including L. reuteri.
AfulaAges 6 months–17 years - NCT06974695Recruiting
Study on bile duct stone treatment success
This trial looks at why some bile duct stones don't clear after a special procedure using a tiny camera (cholangioscopy) to break them up. The goal is to help doctors predict who will have better results.
Vandœuvre-lès-Nancy, LorraineAges 18 years+ - NCT06975579Recruiting
Liver MRI scatter correction study
This study tests a new way to improve liver MRI images by reducing scatter. It includes healthy volunteers and patients with fatty liver disease (steatosis) having a regular liver MRI.
London, Greater LondonAges 18 years+ - NCT07081100Recruiting
Probiotics for stomach and bowel health improvement
This trial tests whether a probiotic supplement can help people with common stomach or bowel issues like indigestion or constipation that are not caused by another disease. You take the probiotic daily to see if it improves your symptoms.
Suzhou, JiangsuAges 18–65 - NCT07077681Recruiting
Switching from Stelara to a biosimilar for Crohn's disease
This study checks if it's acceptable for people with Crohn's disease to switch from the biologic medicine Stelara to a similar, lower-cost version called Uzpruvo. If you have been stable on Stelara for at least 6 months without needing steroids, you may be able to participate.
AmiensAges 18 years+ - NCT07082673Recruiting
Sea buckthorn supplement for chronic constipation
This study tests a food supplement made from sea buckthorn to see if it helps people with chronic constipation have more regular and comfortable bowel movements.
NaplesAges 18–70 - NCT07080034RecruitingPhase 2
Testing BCD-261 for moderate to severe ulcerative colitis
This trial tests a new drug called BCD-261 for people with moderate to severe ulcerative colitis that hasn't gotten better with standard treatments. It aims to see if the drug can improve symptoms and how safe it is.
Barnaul, Altayskiy KrayAges 18–75 - NCT07079228RecruitingPhase 3
Comparing a new drug with chemo for pancreatic cancer
This trial tests a new treatment called QLS31905 plus chemotherapy against a placebo plus chemotherapy for people with advanced pancreatic cancer that hasn't been treated yet. It aims to see if the new combination works better.
BeijingAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.