Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06181656Recruiting
Pneumonia Vaccine Study for Esophageal and Liver Cancer Patients
This trial studies how well the pneumonia vaccine works in people with esophageal or liver cancer who have low white blood cell counts after chemoradiation. It aims to see if the vaccine can still protect them from infection.
Houston, TexasAges 18 years+ - NCT06184152Recruiting
Comparing two scans to find liver cancer early
This trial compares two types of imaging scans (CEUS and AMRI) to see which one is better at finding liver cancer (HCC) in patients who have an unclear spot on their liver (an indeterminate nodule). It is for people with cirrhosis who have at least one such nodule but no confirmed liver cancer yet.
Ann Arbor, MichiganAges 18 years+ - NCT06184698RecruitingPhase 2
Liposomal irinotecan, chemotherapy, and bevacizumab for advanced colorectal cancer
This trial tests a combination of liposomal irinotecan, two chemotherapy drugs (leucovorin and 5-fluorouracil), and bevacizumab as a second-line treatment for people with colorectal cancer that has spread and cannot be removed by surgery.
Shijiazhuang, HebeiAges 18–75 - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06185621Recruiting
Aspirin to prevent recurrent pancreatitis
This trial tests if taking aspirin daily can prevent repeated attacks of acute pancreatitis. It's for people who have had at least two episodes of pancreatitis in the past year that were not caused by a medical procedure.
Xi'an, ShaanxiAges 14–80 - NCT06186089Recruiting
How stomach surgery affects gut bacteria and your thinking
This study looks at how having stomach cancer surgery changes your gut bacteria and thinking abilities. Researchers want to understand if these changes affect memory or brain function after the operation.
Wuhan, HubeiAges 40–80 - NCT06186609RecruitingPhase 2
PD-1 Inhibitor and Radiation for Elderly Esophageal Cancer
This trial tests whether combining a PD-1 inhibitor (a type of immunotherapy) with radiation therapy can help older adults (70+) with esophageal squamous cell cancer who cannot have surgery. The goal is to see if this treatment is safe and effective for those with limited options.
Nantong, JiangsuAges 70 years+ - NCT06186752Recruiting
Action planning test for teens with IBD
This study tests if a planning tool helps teenagers with Crohn's disease or ulcerative colitis manage their condition. It's for patients aged 13 to 19 who have had their diagnosis for at least 3 months and are seen at UNC.
Chapel Hill, North CarolinaAges 13–19 - NCT06186869Recruiting
Diet and exercise for fatty liver disease
This study tests whether combining diet with two different exercise programs can help people who are overweight or obese and have fatty liver disease. The goal is to see which program works best to reduce liver fat and improve health.
Castellana Grotte, BariAges 18–65 - NCT06187597RecruitingPhase 2
Toripalimab after chemoradiation for older esophageal cancer
This study tests whether adding a drug called toripalimab after standard chemoradiation can help older adults with esophageal cancer. The goal is to see if this treatment can keep the cancer from coming back after initial therapy.
Guangzhou, GuangdongAges 70–85 - NCT06188585Recruiting
New blue dye vs standard treatment for upper GI bleeding
This study tests a new blue dye spray (UI-EWD) versus standard endoscopy treatment for people with active upper GI bleeding. The goal is to see if the dye helps doctors find and stop bleeding more effectively.
New Haven, ConnecticutAges 22 years+ - NCT06189898Recruiting
Using scans to find radiation-sensitive esophageal cancer
This study tests whether a special imaging scan (functional imaging) can identify which esophageal cancers respond best to radiation. If you have stage II–IVA esophageal cancer and meet the health criteria, joining may help personalize your treatment.
BerlinAges 18 years+ - NCT06189859RecruitingPhase 3
Comparing electrical tools for POEM surgery
This trial compares two types of electrical tools used during a POEM procedure to treat swallowing problems. It aims to find which tool works better for patients with esophageal motility disorders.
CairoAges 18 years+ - NCT06190171Recruiting
Breathing strength training for heart transplant patients
This trial tests whether a special breathing and muscle-strengthening exercise program can help people waiting for a heart transplant. It is designed to improve your respiratory strength and overall conditioning before surgery.
Nashville, TennesseeAges 18–90 - NCT06190847Recruiting
Oral bacteria and response to chemoradiotherapy in esophageal cancer
This study looks at how the bacteria in your mouth might affect how well chemoradiotherapy (a combination of chemotherapy and radiation) works for esophageal cancer that cannot be removed by surgery. The goal is to see if the oral microbiome can predict treatment response.
Hefei, AnhuiAges 18–85 - NCT06190626Recruiting
A study of eye disease in Zellweger spectrum disorder over time
This study follows people with Zellweger spectrum disorder (ZSD) to understand how their eye condition develops over time. It aims to help doctors treat the disease better in the future.
Rochester, New YorkAges Any age - NCT06190665Recruiting
Bead type comparison for liver cancer TACE
This trial compares two types of tiny beads used in a liver cancer treatment called TACE to see which works better. If you have liver cancer that needs TACE and your liver is still working fairly well, you may be able to join.
Beijing, Beijing MunicipalityAges 18–80 - NCT06190639RecruitingPhase 2
Sintilimab after surgery for node-positive esophageal cancer
This trial tests whether giving the immunotherapy drug Sintilimab after surgery can help prevent esophageal cancer from coming back. It is for people whose cancer had spread to lymph nodes and who have already had their tumor removed.
Hangzhou, ZhejiangAges 18 years+ - NCT06190730Recruiting
Remote symptom collection for better recovery after surgery
This trial uses a phone or computer app to track your symptoms after gastrointestinal tumor surgery. It aims to improve your recovery by keeping your care team informed remotely.
Baltimore, MarylandAges 18 years+ - NCT06190782RecruitingPhase 3
Local therapy for limited metastatic esophageal cancer
This trial tests whether adding targeted radiation or other local treatments can help people with esophageal cancer that has spread to only a few spots (up to 4) after they've been treated with a PD-1 inhibitor. It aims to control the cancer better and improve outcomes.
ShanghaiAges 18 years+ - NCT06191120Recruiting
FAPI PET scan for aggressive colorectal cancer liver metastases
This trial uses a special PET scan (FAPI) to detect a specific, more aggressive type of colorectal cancer (CMS4) in people who have liver tumors that can be surgically removed. The goal is to see if the scan can help doctors choose the best treatment for you.
Utrecht, UtrechtAges 18 years+ - NCT06191432Recruiting
Testing an ancient grain for people sensitive to wheat
This study tests how well people with non-celiac wheat sensitivity tolerate a special ancient grain. Researchers want to see if this grain causes fewer or less bothersome symptoms than modern wheat.
Palermo, SicilyAges 18–65 - NCT06191640Recruiting
Study of sinus disease in young children with cystic fibrosis
This study looks at sinus problems in young children with cystic fibrosis. One group of children starts a new medicine called a highly effective modulator (like Trikafta), and the other group does not take this medicine. The goal is to see how the medicine affects sinus health over time.
Aurora, ColoradoAges 2–8 - NCT06192719Recruiting
Study of gallbladder cancer, dysplasia, and gallstones
This trial is studying people with gallbladder cancer, abnormal cell changes (dysplasia), or gallstones. It aims to learn more about these conditions, possibly before or after treatment, or before gallbladder removal surgery.
SaltaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.