Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07066540Recruiting
Trial of Reamberin for Viral Stomach Infections in Children
This trial tests if the drug Reamberin, given through an IV, can help children aged 1 to 6 recover faster from a viral stomach infection. It's for kids who need fluids through a vein and have symptoms like vomiting, fever, and tiredness.
ChelyabinskAges 1–6 - NCT07069556Recruiting
ColoSense stool test study before colonoscopy
This study is testing a new stool-based screening test for colorectal cancer. You provide a stool sample before having a colonoscopy, and researchers compare the test results with what the colonoscopy finds.
St Louis, MissouriAges 18 years+ - NCT07069569RecruitingPhase 2
AHB-137 injection combined with other hepatitis B drugs
This study tests a new injection called AHB-137 combined with other hepatitis B drugs. It aims to see if the combination can better control the virus in people with chronic hepatitis B who are already on antiviral pills.
Beijing, Beijing MunicipalityAges 18–65 - NCT07070518RecruitingPhase 1/Phase 2
Study of GV20-0251 for advanced solid tumors
This trial tests a new study drug, GV20-0251, for people with advanced solid tumors that no longer respond to standard therapies. It aims to see if the drug can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07066098RecruitingPhase 3
New drug IBI343 for advanced pancreatic cancer with CLDN18.2 protein
This study tests a new drug called IBI343 compared to a placebo (inactive substance) for people with advanced pancreatic cancer that has a specific protein (CLDN18.2) and has not responded to earlier treatments. The goal is to see if IBI343 can help slow the cancer's growth.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07070115Recruiting
OviTex mesh for hiatal hernia repair
This trial tests a special mesh (OviTex) used during hiatal hernia repair to see how well it helps the hernia stay closed. It may be a good option if you are having a robotic or laparoscopic hernia repair and do not smoke or have a very high BMI.
Mobile, AlabamaAges 22 years+ - NCT07069673Recruiting
Abbott Cephea mitral valve disease registry
This study tracks people with mitral valve disease who receive the Cephea valve through a tube in an artery rather than open-heart surgery. It looks at how well the valve works over time.
Birmingham, AlabamaAges 18 years+ - NCT07070232RecruitingPhase 1/Phase 2
Testing a new drug BNT326 for advanced cancers
This trial tests a new medicine called BNT326, alone or with another drug BNT327, for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and might help shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT07073079Recruiting
Study of upadacitinib and risankizumab for Crohn's after first therapy
This study tests two oral/ injectable medicines (upadacitinib and risankizumab) in adults with moderate-to-severe Crohn's who have already tried a TNF-blocker. It aims to see how well these treatments work in everyday practice.
Castellana Grotte, BariAges 18 years+ - NCT07069712RecruitingPhase 2
New drug combinations before and after surgery for stomach or esophageal cancer
This study tests new drug combinations given before and after surgery for people with stomach or gastroesophageal cancer that can be removed but is locally advanced (has grown into nearby tissue). The goal is to see if these combinations can shrink the tumor and improve outcomes.
Newark, DelawareAges 18 years+ - NCT04328948RecruitingPhase 3
Preventive radiation for early esophagus cancer after chemoradiation
This Phase 3 trial tests whether giving preventive (prophylactic) radiation reduces cancer coming back in people with early esophagus cancer after standard chemoradiation. It may help by lowering the chance that microscopic cancer spreads to nearby areas.
TokyoAges 20 years+ - NCT04742881Recruiting
Laparoscopic colon surgery comparison for bowel tumors or disease
This trial studies a low-impact approach to colon or upper-rectum surgery using small cameras (laparoscopy) to see if it works well and is safe. You may be eligible if you are scheduled for a specific type of colon/rectal operation and can safely be monitored during the study.
BayonneAges 18 years+ - NCT05180578Recruiting
Goat milk protein study for children with milk-triggered esophagus inflammation
This trial tests whether goat milk protein is tolerated and safe for kids with eosinophilic esophagitis (EoE) whose symptoms improve when cow milk is stopped and come back when cow milk is added again. It may help some families find an alternative to cow milk, but you must meet specific “milk trigger” and allergy-safety requirements.
JerusalemAges Up to 18 years - NCT04803916Recruiting
Balloon dilation study for Crohn’s bowel strictures
This study looks at inflammation just before a narrowed section of the bowel in people with Crohn’s disease, using planned endoscopic balloon dilation. It may help doctors better understand what drives narrowing and inflammation so treatment can be timed and chosen more effectively.
JerusalemAges Any age - NCT06382519Recruiting
Thalidomide for Very Early-Onset IBD in Kids
This study tests whether the drug thalidomide can help children with very early-onset inflammatory bowel disease (VEOIBD) when their symptoms are moderate to severe. It aims to see if thalidomide can calm the inflammation and improve quality of life.
Shanghai, Shanghai MunicipalityAges 4 weeks–6 years - NCT07071961RecruitingPhase 2
Treatment for colorectal cancer with signs of remaining disease after therapy
This trial tests a combination of two drugs, regorafenib and lorigerlimab, for people with colorectal cancer that has a positive blood test for cancer DNA after they have finished standard treatments. The goal is to see if this treatment can delay or prevent the cancer from coming back.
Houston, TexasAges 18 years+ - NCT07071987Recruiting
Acupuncture for bowel recovery after colon cancer surgery
This trial tests if thread embedding acupuncture can help your bowels start working again faster after surgery for colorectal cancer. It may reduce discomfort and speed up recovery.
Yangzhou, JiangsuAges 18–80 - NCT07070362Recruiting
Digital early warning system for lung injury after liver surgery
This trial tests a digital early warning system to detect acute lung injury after liver surgery. It may help doctors catch breathing problems early so they can treat them faster.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07069127Recruiting
Home treatment for tooth sensitivity in celiac disease
This study tests a special toothpaste-like treatment for adults with celiac disease who have sensitive teeth and enamel problems. You apply it at home, and it may help reduce tooth pain and protect your teeth.
Pavia, LombardyAges 18 years+ - NCT07074379Recruiting
Treating painless chronic pancreatitis with stones
This study tests two procedures—endotherapy and shockwave lithotripsy—to break up and remove stones blocking the main pancreatic duct. It aims to relieve duct blockage and prevent complications in people who have painless chronic pancreatitis.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07066995RecruitingPhase 1/Phase 2
Dual-target CAR-T cell therapy for advanced pancreatic cancer
This trial tests a new type of cell therapy (CAR-T) that targets two markers on pancreatic cancer cells. It's for people with advanced pancreatic cancer who have already tried standard chemotherapy.
Beijing, Beijing MunicipalityAges 21–90 - NCT07068191Recruiting
Gepaktiv vs other drugs for fatty liver with enlarged liver
This study tests a new drug, Gepaktiv, compared to two other treatments (UDCA and ademetionine) for people with metabolic fatty liver disease who also have an enlarged liver. You may be able to join if you meet specific test results showing moderate liver fat and scarring.
Tyumen, Tyumen OblastAges 18–65 - NCT07067983Recruiting
Gastric cancer screening study with the GRAPE model
This trial is testing a new model called GRAPE to see if it can help find gastric cancer earlier using routine CT scans. If you are between 18 and 80 and having a chest and abdomen CT, you might be able to join.
Hangzhou, ZhejiangAges 18–80 - NCT07069842Recruiting
Gastric cancer immunotherapy prediction model
This study looks at markers in your tumor to predict how well immunotherapy might work for you. It aims to create a model that helps doctors choose the best treatment for advanced gastric cancer.
Changzhi, ShanxiAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.