Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06768164RecruitingPhase 3
Comparing two stomach reconnection methods after cancer surgery
This trial compares two different ways to reconnect the stomach after removing the lower part for stomach cancer. It looks at which surgery leads to a better quality of life for patients.
ParisAges 18 years+ - NCT06768463Recruiting
Stomach cancer surgery after chemo for limited spread
This trial tests if surgery to remove the stomach and some tumors, after a few months of chemo, helps people whose stomach cancer has spread to only a few nearby spots (like the lining of the belly, liver, or lymph nodes) live longer compared to chemo alone.
Ho Chi Minh City, Ho Chi MinhAges 18–75 - NCT06769061Recruiting
Acupuncture for Chemo Nerve Pain in Gynecologic Cancers
This study tests whether acupuncture can help reduce nerve pain, numbness, or tingling in hands and feet caused by chemotherapy for gynecologic cancers. You may join if you finished certain chemo at least 3 months ago and still have these symptoms.
Hong KongAges 18 years+ - NCT06769113RecruitingPhase 2
Study of HLX43 for advanced esophageal cancer
This trial tests a new drug, HLX43, for people with advanced esophageal squamous cell carcinoma that has stopped responding to or cannot tolerate standard treatments. It aims to see if HLX43 can help shrink or control the cancer.
Jinan, ShandongAges 18–75 - NCT06769425RecruitingPhase 1
Combination treatment for advanced solid tumors
This trial tests a new combination treatment for people with advanced solid tumors that have not responded to standard therapy. It aims to find a safe dose and see if the combination can shrink tumors.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06769828Recruiting
Ga-68-FAPI-46 PET scan for colorectal cancer recurrence with rising CEA
This trial tests a new type of PET scan called Ga-68-FAPI-46 to help find if your colorectal cancer has returned when your CEA levels are rising. It might offer a more accurate way to detect recurrence early.
Taipei, BeitouAges 20–100 - NCT06770270RecruitingPhase 2
Immunotherapy with radiation and chemo before rectal cancer surgery
This trial tests adding an immunotherapy drug (pucotenlimab) to standard radiation and chemotherapy before surgery for locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor more effectively and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT06770452RecruitingPhase 2
HRS-4642 combo for first-line advanced pancreatic cancer
This trial tests a new targeted drug (HRS-4642) combined with nimotuzumab and chemotherapy for people with advanced pancreatic cancer that has a specific gene change called KRAS G12D. It's for those who haven't had treatment for advanced disease yet.
Hangzhou, ZhejiangAges 18–75 - NCT06771011Recruiting
Comparing two ways to diagnose liver injury causes
This study compares two methods (RUCAM and RECAM) to better identify what caused a recent liver injury. It may help doctors find the right cause and treatment faster.
Beijing, Beijing MunicipalityAges 18–85 - NCT06771102Recruiting
New single-use gastroscope compared to standard for bedside use
This trial tests a single-use gastroscope used at the bedside versus the standard reusable gastroscope used in the endoscopy unit. It aims to see if the bedside scope works as well for patients who are already in the hospital and need an upper endoscopy without general anesthesia.
KøgeAges 18 years+ - NCT06771505Recruiting
New quality of life tool for short bowel patients
This study aims to create a new tool to measure quality of life in people with short bowel syndrome. By comparing it to a standard questionnaire, researchers hope to better understand how the condition affects daily life and well-being.
Pierre-BéniteAges 18–99 - NCT06773312RecruitingPhase 1
Study of BC001 plus Sintilimab and XELOX for advanced stomach cancer
This trial tests a combination of three drugs (BC001, Sintilimab, and XELOX chemotherapy) for people with advanced or metastatic HER-2 negative stomach cancer or cancer where the stomach meets the esophagus. The goal is to see if this combination works better than standard treatments.
Beijing, Beijing MunicipalityAges 18–75 - NCT06773507RecruitingPhase 1
Study of BC008-1A for advanced solid tumors
This trial tests a new drug called BC008-1A for people with advanced esophageal cancer or non-small cell lung cancer that has not responded to standard treatments. The goal is to see if the drug is safe and effective.
TianjinAges 18 years+ - NCT06773650Recruiting
Managing lactose intolerance with diet and enzyme supplements
This trial tests whether diet tracking and lactase enzyme supplements help people with lactose intolerance manage their symptoms. It uses an online survey to gather information.
MilanAges 18 years+ - NCT06774001Recruiting
Global study of appendectomy outcomes for appendicitis
This study follows people around the world who have their appendix removed for appendicitis. It aims to track outcomes and improve care for this common surgery.
CotonouAges Any age - NCT06774079RecruitingPhase 4
GLP-1 drug and diet study for Crohn's disease patients
This study tests a drug that helps with weight loss and blood sugar (called a GLP-1 receptor agonist) combined with a special diet to see if it can improve symptoms in people with mild Crohn's disease. You may join if you have Crohn's, a BMI of 27 or higher, and are already on a stable dose of a TNF blocker.
Miami, FloridaAges 18 years+ - NCT06774690Recruiting
Arterial treatments for primary liver cancer
This study is watching how treatments that deliver medicine or tiny beads directly into the liver's blood supply work for people with liver cancer. If you have liver cancer and are getting or have gotten one of these treatments, this study wants to learn from your experience.
BolognaAges 18 years+ - NCT06774963RecruitingPhase 1
Study of LNCB74 for advanced solid tumors
This trial tests a new drug called LNCB74 for people with advanced solid tumors that have not responded to other treatments. It aims to see if the drug is safe and effective.
Newport Beach, CaliforniaAges 18 years+ - NCT06775080RecruitingPhase 2
Testing propranolol before and after surgery for stomach or colon cancer
This trial tests if taking a medicine called propranolol around the time of surgery can improve outcomes for people with stomach or colon cancer that can be removed with an operation. Propranolol is a type of drug that blocks certain stress signals in the body and may help with recovery.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06776029RecruitingPhase 2
Fecal transplant for radiation-induced rectal bleeding
This study tests whether a fecal (stool) transplant can help heal rectal damage caused by pelvic radiation. The treatment may decrease bleeding and improve symptoms for people whose supportive care hasn't worked well.
Guangzhou, GuangdongAges 18–75 - NCT06776757RecruitingPhase 1/Phase 2
Sintilimab plus cetuximab and chemo for first-line advanced colorectal cancer
This trial tests a combination of immunotherapy (sintilimab), a targeted therapy (cetuximab), and chemotherapy as a first treatment for advanced colorectal cancer that hasn't spread or come back after earlier treatment. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and show signs of immune activity (PD-L1 or CD8+ TILs).
Shenzhen, GuangdongAges 18–75 - NCT06776770RecruitingPhase 1/Phase 2
Study of adebrelimab with chemo for stomach cancer
This trial tests a new combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (capecitabine and oxaliplatin) for people with stomach cancer or cancer where the stomach meets the esophagus. It aims to see if this combination is safe and effective for patients who have not had prior treatment for advanced disease.
Shenzhen, GuangdongAges 18 years+ - NCT06777030Recruiting
Study of exosomes in pancreatic cancer
This study looks at tiny particles called exosomes in pancreatic cancer. Researchers want to understand how exosomes may help the cancer grow, which could lead to better treatments in the future.
BolognaAges 18 years+ - NCT06777017Recruiting
Can liver stiffness predict cancer return after ablation?
This trial studies if measuring liver and spleen stiffness can help predict the risk of liver cancer coming back after radiofrequency ablation (RFA), a treatment that uses heat to destroy tumors. It aims to improve follow-up care for people with chronic liver disease and early-stage liver cancer.
BolognaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.