Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06983639Recruiting
Fecal test vs. colonoscopy follow-up after polyp removal
This trial compares using a simple stool test (FIT) versus a repeat colonoscopy to check for new polyps in people who have already had an advanced adenoma removed. It aims to see if the stool test is a safe and effective alternative for routine follow-up.
Arendal, AgderAges 40–75 - NCT06984679Recruiting
Physical function study for kids with cystic fibrosis
This trial compares physical abilities between children with cystic fibrosis and healthy children. It aims to find differences that could lead to better care and therapies.
IzmirAges 6–18 - NCT06984952Recruiting
ERAS program for recovery after minimally invasive stomach cancer surgery
This study tests whether a special care program called ERAS (Enhanced Recovery After Surgery) helps people recover better and faster after keyhole surgery for stomach cancer. It aims to improve your hospital experience and reduce complications.
BusanAges 19 years+ - NCT06988215Recruiting
Taping and swallowing exercises for stroke patients with swallowing difficulty
This trial tests whether kinesiology taping (a special tape placed on the skin) combined with swallowing exercises can help people who have had a stroke and have trouble swallowing. It may improve muscle thickness and swallowing function.
Istanbul, bahçelievlerAges 50–80 - NCT06988475RecruitingPhase 2/Phase 3
Capmatinib for cancers with MET gene changes
This study tests an oral drug called capmatinib for people whose cancers have specific changes in the MET gene (except for one type of lung cancer). It aims to see if the drug can shrink tumors or slow their growth.
BelfastAges 18 years+ - NCT06988956RecruitingPhase 2
Nimotuzumab Plus Chemoradiation for Older Adults with Esophageal Cancer
This trial tests adding nimotuzumab, a targeted therapy, to standard chemoradiation for elderly patients with esophageal squamous cell cancer. It aims to see if the combination improves outcomes.
NanjingAges 75 years+ - NCT06989723RecruitingPhase 4
Pioglitazone and empagliflozin for fatty liver in type 2 diabetes
This trial tests two diabetes pills (pioglitazone and empagliflozin) to see if they can reduce liver fat in people with type 2 diabetes and fatty liver disease. It may help if your diabetes is not well controlled and you have a fatty liver confirmed by a special ultrasound scan.
Seongnam-siAges 20 years+ - NCT06989814Recruiting
Liquid biopsy test for Lynch syndrome cancer patients
This trial tests a simple blood test to measure tumor DNA in people with Lynch syndrome who have been newly diagnosed with cancer but haven't started treatment yet. It aims to see if this test can help monitor the cancer.
Leiden, South HollandAges 18 years+ - NCT06991348RecruitingPhase 4
Comparing two heartburn medicines: tegoprazan vs pantoprazole
This study tests whether a newer medicine, tegoprazan, works better than an older one, pantoprazole, for treating heartburn and acid reflux. Both are stomach acid reducers. You may be able to join if you have been diagnosed with GERD and your symptoms have lasted for at least three months.
Mexico City, Mexico CityAges 18 years+ - NCT06991465RecruitingPhase 2
Organ preservation trial for rectal cancer using shorter radiation
This trial tests a shorter course of radiation to the pelvis to treat rectal cancer, with the goal of avoiding surgery and preserving the rectum. It may be an option for people with advanced rectal cancer that has not spread to other organs.
Montreal, QuebecAges 18–90 - NCT06991881Recruiting
Better management for eosinophilic esophagitis
This study looks at how to improve care for people with eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus. It may help you if you have or are being checked for EoE.
BergenAges Up to 17 years - NCT06992648RecruitingPhase 3
Two drug combos for advanced colorectal cancer
This trial tests a two-drug combination (trifluridine/tipiracil plus regorafenib) against a standard pair (trifluridine/tipiracil plus bevacizumab) for people with advanced colorectal cancer that has stopped responding to prior treatments. It aims to find which combination works better.
Hangzhou, ZhejiangAges 18 years+ - NCT06993974RecruitingPhase 2
Nitazoxanide for mild to moderate ulcerative colitis
This trial tests if a medication called nitazoxanide can help people with mild to moderate ulcerative colitis (UC). It may be a treatment option for those not already on strong UC medications.
AlexandriaAges 18–65 - NCT06995170Recruiting
Polyamines and IBD progression study
This study looks at how certain natural chemicals called polyamines relate to the activity of inflammatory bowel disease (IBD). It aims to understand if these chemicals can help predict disease progression.
Xi'an, ShaanxiAges 18–65 - NCT06995924Recruiting
Improving follow-up care for colorectal cancer survivors
This study tests whether a navigator and online education can help colorectal cancer survivors get the recommended follow-up tests after surgery. If you've had surgery for stage I-III colorectal cancer in the last 3 months, this program may support you in staying on track with your surveillance.
Seattle, WashingtonAges 18 years+ - NCT06996756RecruitingPhase 1
Gene therapy for alpha-1 antitrypsin deficiency
This trial tests a gene therapy to fix the genetic cause of alpha-1 antitrypsin deficiency, aiming to stop or slow emphysema. It is for people with the most common harmful gene variants who have mild to moderate lung damage and are otherwise healthy enough to take steroids safely.
New York, New YorkAges 18–70 - NCT06996951RecruitingPhase 3
Sinus treatments in cystic fibrosis with modern modulator therapy
This study looks at how different sinus treatments affect people with cystic fibrosis who are taking modern modulator therapy. It aims to understand which rinses work best for chronic sinus problems.
Indianapolis, IndianaAges 18 years+ - NCT06997055Recruiting
Study of Steqeyma® biosimilar in Crohn's and psoriasis
This study follows people with Crohn's disease or plaque psoriasis who are switching from the reference Ustekinumab to a biosimilar (Steqeyma®). It aims to see how well the biosimilar works in real-world settings.
AmiensAges 18 years+ - NCT06998043RecruitingPhase 2
Phage therapy for cystic fibrosis with pseudomonas lung infection
This trial tests a new treatment using phages (viruses that kill bacteria) for people with cystic fibrosis who have a chronic pseudomonas lung infection. It aims to see if adding phages to your usual care can help control the infection.
Birmingham, AlabamaAges 18 years+ - NCT06998940RecruitingPhase 3
Chemotherapy with or without panitumumab for pancreatic cancer
This trial tests whether adding a targeted drug called panitumumab to standard chemotherapy can help people with a certain type of pancreatic cancer that has spread. It is for patients whose tumors do not have a KRAS mutation and who have already had one line of chemotherapy.
Anchorage, AlaskaAges 18 years+ - NCT06999174Recruiting
Using MRI to Study Liver Cancer Treatment
This trial uses special MRI scans to learn more about liver cancer (hepatocellular carcinoma) before and during treatment with TACE or SIRT. It may help doctors better understand how the tumor responds to therapy.
MünsterAges 18 years+ - NCT06999187RecruitingPhase 1
Study of DR-0202 for advanced solid tumors after multiple treatments
This trial tests a new drug, DR-0202, for people with certain advanced cancers that have not responded to at least two prior treatments. It may be an option if standard treatments are no longer working.
Denver, ColoradoAges 18 years+ - NCT06999577RecruitingPhase 4
The Mechanism Versus PPI Trial for throat reflux
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
San Deigo, CaliforniaAges 18–89 - NCT06999707RecruitingPhase 2
Radiation plus immunotherapy for advanced liver cancer
This trial tests a combination of targeted radiation (photon radiotherapy) with two immunotherapy drugs (tremelimumab and durvalumab) for people with intermediate or advanced liver cancer that can't be surgically removed. The goal is to see if this combination can shrink tumors and improve outcomes.
Taoyuan City, TaiwanAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.