Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07250347Recruiting
AI-assisted detection of gastric cancer on CT scans
This trial uses artificial intelligence to analyze contrast-enhanced CT scans of patients with gastric cancer. It aims to improve how doctors detect and stage the disease, which may lead to better treatment decisions.
Nanjing, JiangsuAges 18–85 - NCT07250854RecruitingEarly Phase 1
Using a dye to help diagnose blocked bile ducts in newborns
This study tests if a special dye (ICG) and a camera can help doctors see blocked bile ducts in newborns with jaundice, so they can diagnose biliary atresia faster and without extra procedures.
Birmingham, AlabamaAges 2 weeks–4 months - NCT06101277Recruiting
Local therapy for limited new cancer growth in digestive cancers
This trial tests a cancer treatment that uses local therapies (like radiation or targeted heat) to destroy a small number of growing spots. It is for people with certain gastrointestinal cancers whose main treatment is working well except for a few new spots, so they can avoid switching to a different drug right away.
Sacramento, CaliforniaAges 18 years+ - NCT05183126RecruitingPhase 4
Paclitaxel dose study using a 1-hour muscle-area infusion
This trial studies how paclitaxel (a chemotherapy medicine) behaves in the body when given by a specific 1-hour infusion approach. It may help refine dosing for people with cancer using measurements from scans, and it includes a medicine schedule you must match.
Ann Arbor, MichiganAges 18 years+ - NCT07367516RecruitingPhase 1/Phase 2
A study of TQB6411 for advanced esophageal cancer
This trial tests an investigational drug called TQB6411 for people with advanced esophageal cancer that has worsened after prior treatment. The hope is that it may shrink tumors or slow the cancer's growth.
Hefei, AnhuiAges 18–75 - NCT07678541Recruiting
Gallbladder infection treatment for people 75 and older
This study compares two ways to treat a gallbladder infection in older adults: surgery or a less invasive procedure using an endoscope and ultrasound. The goal is to see which option leads to better outcomes.
Oulu, OuluAges 75 years+ - NCT06843148Recruiting
Does niacin help move fat from liver to fat tissue?
This study tests if niacin (a B vitamin) can help the body store fat safely in fat tissue instead of letting it build up in the liver. It may be an option for people with fatty liver linked to belly fat, without serious liver damage or other health issues.
Sherbrooke, QuebecAges 20–80 - NCT07682363Recruiting
Survey on MASLD management by Chinese doctors
This study surveys doctors in China about how they manage Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), a type of fatty liver disease. It aims to understand current practices and improve patient care.
BeijingAges 18 years+ - NCT07681128Recruiting
Studying a new surgical stitch to help stomach emptying after pancreas surgery
This trial is testing whether adding a special connection (Braun anastomosis) between two parts of the small intestine during pancreas surgery can reduce delayed stomach emptying, a common problem after the procedure.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07169734RecruitingPhase 1/Phase 2
ALE.P03 for advanced CLDN1-positive solid tumors
This trial tests a new drug, ALE.P03, for people with advanced or metastatic solid tumors that have a certain protein (CLDN1). The drug is given alone (monotherapy) to see if it can shrink tumors or slow their growth.
Phoenix, ArizonaAges 18 years+ - NCT07223255Recruiting
Mediterranean diet study for children with cystic fibrosis
This study tests whether a Mediterranean-style diet can improve gastrointestinal health in children with cystic fibrosis. It requires families to follow the diet for 6 months and attend regular clinic visits.
Lebanon, New HampshireAges 3–18 - NCT06057714Recruiting
MRI study of airway function in cystic fibrosis
This study uses a special MRI technique (19F MRI) to look at how well your lungs are working and where any blockages are. The goal is to understand airway problems in cystic fibrosis better.
Chapel Hill, North CarolinaAges 18–99 - NCT07389044RecruitingPhase 1
Safety study of IB-001 injection in healthy people and hepatitis B patients
This study tests a new injection called IB-001 in two groups: healthy people and people with chronic hepatitis B. The goal is to see if it's safe and how the body handles it at different doses. It might offer a new treatment option for hepatitis B in the future.
ChisinauAges 18–70 - NCT06016842RecruitingPhase 3
Long-term study of elafibranor for primary biliary cholangitis
This trial tests a drug called elafibranor for people with primary biliary cholangitis (PBC), a liver disease. It aims to see if the drug is safe and works well over a long time.
Tucson, ArizonaAges 18 years+ - NCT07545317Recruiting
IL-23 Inhibitors for Active Crohn's Disease
This study follows patients with moderate-to-severe Crohn's disease who are starting a newer type of biologic medication called IL-23 inhibitors (guselkumab or risankizumab). Researchers want to understand how well these drugs work in real-world clinical practice and compare their effectiveness to other treatments.
Guangzhou, GuangdongAges 18–75 - NCT07059884Recruiting
Exercise program to help people with cancer stay active
This trial tests a distance-based exercise program designed to help people on chemotherapy maintain their physical function and prevent disability. It is for patients with certain cancers who are working full-time and can participate in moderate physical activity.
Dublin, CaliforniaAges 18 years+ - NCT07312734Recruiting
Testing new ways to find lung germs in CF
This study tests a new method to detect bacteria in the lungs of people with cystic fibrosis (CF) by analyzing mucus samples. It aims to improve how we diagnose and treat lung infections.
La Jolla, CaliforniaAges 16 years+ - NCT07541261Recruiting
Real-World Study of Guselkumab for Ulcerative Colitis and Crohn's Disease
This study tracks how guselkumab (a biologic medication that reduces inflammation) works in patients with moderate-to-severe ulcerative colitis or Crohn's disease in Saudi Arabia. Researchers want to understand how the medication helps patients in everyday clinical practice, not in a controlled research setting.
JeddahAges 18 years+ - NCT07561814Recruiting
Predicting Pancreatic Cancer Treatment Outcomes Using Medical Images and Data
This study builds a computer model to predict how well pancreatic cancer patients will respond to surgery and what their long-term outcomes might be. Researchers use CT scans, blood tests, and medical records from patients who had pancreatic cancer surgery to teach the model to recognize patterns that help predict outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07251114Recruiting
AI help for early esophageal cancer depth check during endoscopy
This trial tests if artificial intelligence can help doctors more accurately determine how deep early esophageal cancer goes during an endoscopic ultrasound. It may lead to better treatment decisions for people with early signs of esophageal cancer.
Fuzhou, FujianAges 18 years+ - NCT07251140Recruiting
Swallowing study with a new microphone device
This study tests a new microphone device to see if it can help find swallowing problems in people who have had a stroke. If you are already scheduled for a swallowing test, you may be able to take part.
Atlanta, GeorgiaAges 40–85 - NCT07252102Recruiting
High-flow oxygen during sedation for critical patients having GI endoscopy
This trial tests whether high-flow nasal oxygen (HFNC) reduces low oxygen levels during sedated gastrointestinal procedures. It is for patients with higher health risks (ASA grade III–IV) who need an endoscopy or treatment.
Shenzhen, GuangdongAges 18–80 - NCT07252115Recruiting
Comparing two surgeries for hiatal hernia and stubborn GERD
This trial compares two surgical approaches (a 'partial wrap' and a 'full wrap' of the stomach around the esophagus) to fix a hiatal hernia and treat severe, hard-to-control reflux (GERD). It may be a good option if your reflux hasn't improved with medication and you have a hiatal hernia.
BeijingAges 18–85 - NCT07252323Recruiting
Carbon ion radiotherapy for liver cancer after TARE
This trial tests a new type of radiation therapy (carbon ion radiotherapy) for people with liver cancer that has not been fully controlled after prior TARE treatment. It aims to see if it is safe and effective for treating the remaining or returning cancer.
SeoulAges 20 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.