Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07284186RecruitingPhase 1
Study of PLX-61639 for advanced SMARCA4-mutant solid tumors
This trial is testing a new drug called PLX-61639 for people with advanced solid tumors that have a specific SMARCA4 gene change. The drug aims to stop cancer growth by targeting the cells that lack this gene.
Scottsdale, ArizonaAges 18 years+ - NCT07284277RecruitingPhase 1/Phase 2
TTFields and chemo for metastatic pancreatic cancer
This trial tests a wearable device (TTFields) combined with a specific chemotherapy (mFOLFIRINOX) for people whose pancreatic cancer has spread to the liver and other organs. The device sends gentle electrical fields to disrupt cancer cell growth, and the chemo attacks cancer cells throughout the body.
Pamplona, NavarreAges 18 years+ - NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT07284992RecruitingPhase 2
Comparing short vs long radiation with immunotherapy for rectal cancer
This trial tests whether a short course of radiation followed by an immunotherapy drug (PD-L1 inhibitor) plus chemotherapy works as well as or better than a longer radiation course for locally advanced rectal cancer. The goal is to shrink tumors before surgery.
Jinan, ShandongAges 18–80 - NCT07285044RecruitingPhase 2
Home cancer treatment program for Florida panhandle residents
This study tests whether people with certain cancers can safely receive their regular intravenous treatments at home instead of coming to the clinic. It aims to make treatment more convenient and improve satisfaction, especially for those living in the Florida Panhandle.
Jacksonville, FloridaAges 18 years+ - NCT07285356Recruiting
Surgical gloves to prevent nerve damage from oxaliplatin
This trial tests whether wearing special surgical gloves during oxaliplatin chemotherapy can help prevent nerve damage (numbness or tingling) in people with advanced colon cancer.
São Paulo, São PauloAges 18 years+ - NCT07285850RecruitingPhase 2/Phase 3
Sequential treatment for advanced liver cancer with fatty liver
This trial tests a combination of two medications, bevacizumab and atezolizumab, given one after the other to treat advanced liver cancer that cannot be surgically removed. It is specifically for people whose liver cancer is linked to a fatty liver condition (MASLD). The goal is to see if this approach helps shrink tumors or control the disease.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07285863RecruitingPhase 4
How Secretin Changes Pancreatic Fluid in Healthy People
This study tests how a drug called secretin affects the fluid in your pancreas. It is for healthy people who are already having an endoscopic ultrasound for another reason.
Rochester, MinnesotaAges 18–80 - NCT07286643Recruiting
Ultrasound-guided sepsis care for patients with cirrhosis
This study tests whether using a special ultrasound of the heart can guide treatment for sepsis-related low blood pressure in patients with cirrhosis. It aims to improve care and outcomes for critically ill patients.
ChandigarhAges 18–65 - NCT07287943Recruiting
Medtronic pump study for diabetes and gastroparesis
This study tests whether the Medtronic 780G insulin pump helps people with type 1 diabetes and gastroparesis (slowed stomach emptying) control their blood sugar better than their usual care. It requires continuous glucose monitoring and certain blood sugar levels.
Indianapolis, IndianaAges 18 years+ - NCT07289100Recruiting
Smart home monitoring for lung flare-ups in CF and bronchiectasis
This trial tests if a smart home monitoring system (using sensors and AI) can detect sudden lung flare-ups early in people with cystic fibrosis or bronchiectasis. It may help you get treatment sooner when you are admitted to the hospital for IV antibiotics.
Cambridge, CambridgeshireAges 18 years+ - NCT07290010RecruitingPhase 2
Iparomlimab plus chemotherapy for advanced esophageal cancer
This trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) with chemotherapy as a first treatment for advanced esophageal squamous cell carcinoma. It aims to see if this combination is safe and effective for people whose cancer cannot be removed by surgery or has spread.
Shijiazhuang, HebeiAges 18 years+ - NCT07290257RecruitingPhase 4
Long-term safety study of Livmarli for Alagille syndrome or PFIC
This study looks at the long-term safety and effects of Livmarli (maralixibat) in children with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC). It may help understand how well the medicine works over time for itching and other symptoms.
BrusselsAges 2 months+ - NCT07290309Recruiting
Remote exercise program for cancer survivors
This study tests a remote guided exercise program for cancer survivors to see if it helps with recovery and well-being. It is designed for people who have finished their main cancer treatments and are not already exercising a lot.
Fort Collins, ColoradoAges 18 years+ - NCT07291141Recruiting
MRI vs. Ultrasound for Liver Cancer Detection in Cirrhosis
This study compares MRI and ultrasound to see which is better at finding liver cancer early in people with liver cirrhosis. It also looks at body composition and other factors that could lead to worsening liver function.
Linköping, Select A State Or ProvinceAges 18 years+ - NCT07291180Recruiting
Personalized heated chemo for advanced appendix or colon cancer
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
New Haven, ConnecticutAges 18–81 - NCT07291414Recruiting
Tracking cancer medication safety with a self-monitoring platform
This trial tests a platform where you can track your experiences and concerns about cancer medications. It aims to help you and your care team manage medication safety.
Ann Arbor, MichiganAges 18 years+ - NCT07291700Recruiting
Talcid for acid rebound after stopping long-term PPI therapy
This study tests whether Talcid chewable tablets can relieve the acid reflux symptoms that often happen when you stop taking a long-term daily acid-reducing medicine (like omeprazole). It is for people whose doctor says they no longer need that medicine.
LeverkusenAges 18 years+ - NCT07292012RecruitingPhase 4
Mirikizumab to heal intestinal damage in Crohn's disease
This trial tests if mirikizumab can reduce deep inflammation in the intestine walls in people with active Crohn's disease. It may help heal damage that shows up on an MRI scan.
BrestAges 18–75 - NCT07292298RecruitingPhase 2
Rectal cancer brachytherapy after treatment to avoid surgery
This trial tests a special type of internal radiation (brachytherapy) for people with low-lying rectal cancer that did not fully go away after standard chemoradiation and chemotherapy. The goal is to shrink the remaining tumor enough to avoid major surgery like removing the rectum or colostomy.
Aurora, ColoradoAges 18–100 - NCT07293468RecruitingPhase 2/Phase 3
Comparing two treatments for advanced liver cancer
This trial tests two different ways to treat liver cancer that can't be removed with surgery. It compares stereotactic body radiation therapy (targeted high-dose radiation) with selective internal radiation therapy (tiny radioactive beads delivered through a blood vessel), both combined with immunotherapy (medicines that help your immune system fight cancer).
Hong KongAges 18–80 - NCT07293897Recruiting
Study of Livmarli for Alagille Syndrome and PFIC
This study looks at how well Livmarli works for people with Alagille syndrome or a liver disease called PFIC. It uses data from prescriptions to understand the treatment's effects.
Tokyo, TokyoAges Any age - NCT07294638Recruiting
New imaging method to find cancer spread in early gastric cancer
This trial tests a new dye that helps surgeons see if early gastric cancer has spread to nearby lymph nodes. It might help guide the extent of surgery needed.
Guangzhou, GuangdongAges 18 years+ - NCT07295275Recruiting
Fluorescence-guided surgery for liver cancer
This trial tests a new way to remove liver cancer during surgery. A special dye called ICG is injected into the artery leading to the liver, which makes the tumor glow under a special camera, helping the surgeon remove just the right area. This study checks if this technique is both safe and effective for people with a common type of liver cancer (hepatocellular carcinoma).
Beijing, Beijing MunicipalityAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.