Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07328971RecruitingPhase 3
Vancomycin taper to prevent C. diff from coming back
This trial tests whether a gradual decrease (taper) of vancomycin can stop C. diff infections from returning. It’s for adults with their first or second C. diff infection who can take pills by mouth.
Montreal, QuebecAges 18 years+ - NCT07329036Recruiting
Liver support therapy for acute liver failure
This trial tests two different blood-filtering treatments for people with severe liver failure who are waiting for or unable to receive a liver transplant. It aims to see how these treatments affect blood clotting, inflammation, and organ function.
PragueAges 18–75 - NCT07329894RecruitingPhase 1
XH001 and vaccine-activated T cells for advanced GI cancer
This trial tests a two-part treatment: an injection called XH001 plus a custom vaccine that trains your immune cells to attack tumors. It's for people with advanced stomach or bowel cancer that hasn't responded to at least two prior treatments.
BeijingAges 18–70 - NCT07330284Recruiting
Cold water rinse to prevent pancreatitis after ERCP
This trial tests whether rinsing the pancreas with cold water during ERCP can reduce the risk of pancreatitis, a common complication. The treatment is added to the standard medicine (indomethacin) to see if it offers extra protection.
Kansas City, KansasAges 20 years+ - NCT07331883RecruitingPhase 2
Sintilimab and bevacizumab after surgery for ruptured liver cancer
This trial tests whether combining two immune-based drugs (sintilimab and a bevacizumab biosimilar) after surgery can prevent liver cancer from returning in people whose tumor had ruptured. It’s for patients who have had a complete surgical removal of a ruptured hepatocellular carcinoma and are now cancer-free on imaging.
Sanming, FujianAges 18–75 - NCT07333144Recruiting
Bleeding from the gut while on blood thinners
This study collects information from patients who come to the emergency room with gastrointestinal bleeding while taking certain newer blood thinners. It aims to better understand and manage this type of bleeding.
StrasbourgAges 18 years+ - NCT07333716RecruitingPhase 2
Desloratadine for mild to moderate UC
This trial tests whether desloratadine, an allergy medicine (antihistamine), can help reduce inflammation in people with mild to moderate ulcerative colitis. All participants must already be taking mesalamine and cannot be on other stronger UC treatments.
Shibīn al Kawm, MenofiaAges 18–65 - NCT07334119RecruitingPhase 1
Testing MT-304 for advanced HER2-positive tumors
This trial tests a new drug, MT-304, for people with advanced cancers that have high levels of a protein called HER2. It aims to see if the drug is safe and helps shrink tumors.
Darlinghurst, New South WalesAges 18 years+ - NCT07334431RecruitingPhase 1/Phase 2
A trial of fruquintinib, trastuzumab, and chemo for HER2-positive stomach cancer
This study tests a combination of three drugs (fruquintinib, trastuzumab, and XELOX chemotherapy) as the first treatment for people with advanced HER2-positive stomach or gastroesophageal junction cancer. The goal is to see if this combination is safe and effective for shrinking tumors.
Zhengzhou, HenanAges 18–75 - NCT07335042Recruiting
Heart injury risk after major liver or bile duct surgery
This study looks at whether certain patients have heart muscle injury (called MINS) after major liver or bile duct surgery. If you are having this type of surgery, your doctors will check your heart with a special blood test before and after. The goal is to find out who is at risk and help prevent problems.
BeijingAges 18–85 - NCT07335055RecruitingPhase 2
Testing HSK47388 for moderate to severe ulcerative colitis
This study tests an experimental drug called HSK47388 for people with moderate to severe ulcerative colitis who have not had good results from other treatments. The goal is to see if it can reduce inflammation and improve symptoms.
HangzhouAges 18–75 - NCT07335705Recruiting
Factors affecting bowel prep in IBD patients
This study looks at factors that affect how well the bowel is cleaned before a colonoscopy in people with IBD. The goal is to improve preparation so the colonoscopy can be more effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07337421RecruitingPhase 2
Chemo infusion after liver cancer surgery to lower recurrence risk
This trial tests whether a targeted chemotherapy infusion directly into the liver's main artery (HAIC) after surgery can prevent liver cancer from coming back. It is for people with certain high-risk features, like a large tumor or cancer in blood vessels, who have had their tumor completely removed.
Yangzhou, JiangsuAges 18–75 - NCT07337460RecruitingPhase 2
Icaritin plus chemotherapy for high-risk liver cancer after surgery
This trial tests combining a natural compound (Icaritin) with standard chemotherapy (mFOLFOX) after liver cancer surgery to lower the chance of the cancer coming back. It is for patients whose cancer had certain high-risk features, like a large tumor or cancer in blood vessels.
Yangzhou, JiangsuAges 18–75 - NCT07337590Recruiting
New device to monitor healing after colorectal cancer surgery
This trial tests a new system that monitors healing inside the body after surgery for colorectal cancer. It is designed to help doctors detect problems early and keep you safe.
Louisville, KentuckyAges 21 years+ - NCT07337850Recruiting
Testing 68Ga-FAPI PET scan in biliary cancers
This trial is testing a new type of PET scan (called 68Ga-FAPI) to see if it can better detect biliary tract cancers, including advanced or recurring gallbladder cancer and intrahepatic cholangiocarcinoma. It may help doctors find cancer more accurately, which could guide better treatment decisions.
Mumbai, MaharashtraAges 18–90 - NCT07337876RecruitingPhase 2
Avoiding surgery for rectal cancer with precise radiation
This trial tests a new way to give high-dose radiation to rectal cancer tumors while avoiding the bladder and bowels. The goal is to cure the cancer without removing the rectum, so you may keep normal bowel function.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07337902Recruiting
Comparing pain medicines for menstrual cramps in Crohn’s disease
This study tests two common over-the-counter pain relievers (ibuprofen and acetaminophen) to see which works better for menstrual cramps in women who also have Crohn's disease while in remission. If you have Crohn's and painful periods, this may help you find a safer option.
Chapel Hill, North CarolinaAges 18–44 - NCT07338565Recruiting
Magnesium study for gut conditions
This trial looks at magnesium levels in people with inflammatory bowel disease, an ileostomy, or bile acid diarrhea, compared to healthy volunteers. It aims to understand how these conditions affect magnesium in the body.
Aarhus NAges 18 years+ - NCT07339488RecruitingPhase 2
Low-dose radiation plus immunotherapy to shrink esophageal cancer before surgery
This trial tests whether a combination of low-dose radiation and immunotherapy can shrink advanced esophageal cancer enough to make it removable by surgery. It is for people whose cancer is considered borderline resectable or unresectable due to its location or spread.
Shantou, GuangdongAges 18–75 - NCT07339904Recruiting
Bowel Function After Rectal Cancer Surgery
This study follows people with rectal cancer who have surgery to remove part of the rectum. It looks at how bowel function changes over time, and whether different treatments before surgery affect recovery.
Edegem, AntwerpAges 18 years+ - NCT07340307Recruiting
Acupuncture for pain after anal surgery
This trial tests whether a special wrist-ankle acupuncture technique can reduce pain after perianal surgery. It may be an option for people who have at least moderate pain and want to avoid stronger painkillers.
PutianAges 18–75 - NCT07342231Recruiting
FAPi PET scan for pancreatic cancer
This trial uses a special PET scan (FAPi PET) to see if it can help spot pancreatic ductal adenocarcinoma better than standard scans. It may offer a more precise way to check the extent of the disease.
Mumbai, MaharashtraAges 18 years+ - NCT07342920Recruiting
Smoking and vaping in adults with cystic fibrosis
This study looks at how many adults with cystic fibrosis smoke or vape (use e-cigarettes). It aims to understand how common these habits are in this group.
StrasbourgAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.