Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT04209816Enrolling by invitation
Genetics study on fatty liver and cholesterol problems
This is a research study testing whether specific gene changes are linked to fatty liver and a cholesterol pattern that raises heart risk. It may help researchers understand who is most likely to develop these conditions and why, which could guide future prevention.
HelsinkiAges 18–70 - NCT04205604RecruitingPhase 2
FDOPA PET scan to locate excess insulin in infancy
This Phase 2 study uses an FDOPA PET scan to find where insulin overproduction is coming from in focal congenital hyperinsulinism (FoHI) or related conditions. The goal is to help doctors better detect and localize the “source” so treatment can be more targeted.
San Francisco, CaliforniaAges birth–18 years - NCT04149613Enrolling by invitation
Blood marker study for new stage IV colon cancer
This study looks at blood tests (inflammatory markers and small RNA molecules called microRNAs) to better predict how stage IV colon cancer may progress. It may help doctors identify who is likely to do better or worse and tailor future care.
BeirutAges 18 years+ - NCT04115826Enrolling by invitation
Stones treatment comparison for chronic pancreas pain
This trial compares two ways to break and remove pancreatic duct stones in people with long-term pancreas pain caused by calcified stones. It looks to see which approach helps reduce pain more effectively and safely.
Aurora, ColoradoAges 18–89 - NCT04074356Enrolling by invitation
Tests for esophagus function using noninvasive body measurements
This study looks for noninvasive ways to measure how well your esophagus is moving. It may help doctors better evaluate swallowing and esophagus movement without relying only on invasive testing.
Nashville, TennesseeAges 18 years+ - NCT04066608Enrolling by invitation
Screening for advanced liver scarring in people with HIV
This study looks at how common advanced liver scarring (advanced fibrosis) is in people living with HIV. It may help doctors better understand liver risk in everyday care and guide future prevention.
MainzAges 18 years+ - NCT04065516Enrolling by invitation
Test for reflux treatment after POEM for achalasia
This study looks at a specific treatment (“ARAT”) to help people who develop acid reflux after a procedure called POEM for achalasia. It may help reduce reflux symptoms and abnormal acid levels in the stomach/esophagus after the original procedure.
Mexico City, Mexico CityAges 18 years+ - NCT03793335Enrolling by invitation
Personalized prevention plan for stomach and colon cancer in the community
This trial tests personalized prevention strategies to help lower the risk of stomach (gastric) and colon (colorectal) cancer in community members. It may help by tailoring screening and prevention steps to your individual health and risk factors.
TaipeiAges 50–75 - NCT03756649Enrolling by invitation
IBD biobank study for adults and young adults
This study collects and stores information and samples from people with inflammatory bowel disease (IBD) to help researchers learn more and improve care. Your participation mainly helps build a “biobank,” which can support future studies.
Rochester, MinnesotaAges 18–85 - NCT03713229Enrolling by invitation
Seville study of people with HIV at risk for anal cancer
This study follows people living with HIV who may be at higher risk for anal cancer. It aims to better understand risk and outcomes, which could help guide future screening or prevention.
SevilleAges 18 years+ - NCT03692455Enrolling by invitation
Compare two weight-loss surgeries for reflux over 8 years
This study follows people for up to 8 years to see how two different weight-loss surgeries affect ongoing heartburn and acid reflux. You would join only if you were already enrolled in an earlier related study and can complete required follow-up visits and tests.
Passo Fundo, Rio Grande do SulAges 18–78 - NCT03632616Enrolling by invitation
Testing how endoscopy affects quality of life in chronic pancreatitis
This study looks at how different endoscopic procedures (procedures done using a scope) affect quality of life in people with painful chronic pancreatitis. It may help doctors better choose treatments that improve day-to-day well-being.
Aurora, ColoradoAges 18 years+ - NCT03407833Enrolling by invitation
Study changes in the body after weight, gut, or liver treatment
This study looks at how the body’s insulin-sensitivity (how well your body uses sugar/insulin) and organ function change after certain medical procedures. It may help researchers understand why some people improve after surgery or liver transplant and guide future care.
Nashville, TennesseeAges 18 years+ - NCT03369353Enrolling by invitation
Personalized immune testing study for bowel and transplant patients
This study looks at whether a precise lab test can help understand inflammatory bowel disease, functional gut disorders, and immune changes after stem cell transplant or cell therapy. It may help doctors choose better monitoring and treatments based on your immune and gut test results.
Boston, MassachusettsAges Any age - NCT03319446Enrolling by invitation
Sharing anonymous samples for a diagnostic test
This trial collects and stores anonymous samples from consenting adults. It helps researchers evaluate or improve diagnostic testing without using your personal identity.
Salt Lake City, UtahAges 18–99 - NCT03308773Enrolling by invitation
Prevention program for people at risk of type 2 diabetes
This trial looks at a personalized prevention approach for people who are at risk of developing type 2 diabetes. It may help by targeting your specific health factors before diabetes starts.
Ages 18–100 - NCT03234296Enrolling by invitation
Antibiotics versus placebo for uncomplicated appendicitis
This trial tests whether taking antibiotics alone can treat acute uncomplicated appendicitis, compared with a placebo. If antibiotics work, it may help some people avoid surgery or reduce treatment intensity.
TurkuAges 18–60 - NCT03162549Enrolling by invitation
Inflammatory bowel disease registry for adults on biologics or JAKs
This study is a real-world registry that collects information about people with Crohn’s disease or ulcerative colitis who take certain medicines (biologics or tofacitinib). It helps researchers better understand how these treatments are used and how people are doing over time.
Waltham, MassachusettsAges 18 years+ - NCT03136731Enrolling by invitation
Screening strategies for celiac disease in families and patients
This study tests practical, evidence-based screening approaches for celiac disease—either for family members of people with celiac disease or for people who already have it diagnosed. It may help improve how celiac disease is checked earlier and more accurately.
TampereAges 6 months–100 years - NCT03103789Enrolling by invitation
Testing a device that measures esophagus lining health
This study tests a new sensor to check how healthy the lining of your esophagus is during a routine upper endoscopy. It may help researchers understand esophageal lining injury and how well it recovers over time.
Nashville, TennesseeAges 18–99
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.