Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06604052Recruiting
Comparing new stoma surgery techniques for temporary ileostomy
This trial tests a newer, less invasive stoma surgery method against the traditional approach. It aims to see if the new method works better for people who need a temporary ileostomy during colorectal cancer surgery.
Shanghai, ChinaAges 18 years+ - NCT07425249Recruiting
Chewing gum after stomach or bowel surgery
This trial tests if chewing gum after open stomach or bowel surgery can help your intestines start moving again sooner. It is for people undergoing open gastrointestinal surgery who do not have certain health conditions or take specific medicines.
Peshawar, KPKAges 17–85 - NCT06601075Recruiting
FDG and FAPI PET Scans for Advanced Colorectal Cancer
This trial uses two types of PET/CT scans (FDG and FAPI) to better see and track colorectal cancer that has spread to the belly lining (peritoneum). It aims to help doctors choose the best treatment by improving how they detect and monitor the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07439640Recruiting
PEG laxatives for bowel prep and gut health after gallbladder removal
This study looks at how a common bowel prep medicine (PEG laxatives) affects gut bacteria in people who have had their gallbladder removed compared to those who still have one. It involves collecting stool samples before and after a colonoscopy to track changes over time.
Wuhan, HubeiAges 18–65 - NCT07439445Recruiting
Simplified treatment for H. pylori guided by a stool test
This trial tests a simpler two-drug treatment for H. pylori infection, chosen based on a stool test that checks if the bacteria are resistant to clarithromycin. It may help people who have not been treated before avoid unnecessary antibiotics.
Beijing, Beijing MunicipalityAges 18–70 - NCT06596759Recruiting
Breathing exercise for bloating relief
This trial tests if a simple breathing technique can help reduce bloating and belly swelling. You may join if your doctor has already sent you for a breath test because of bloating.
Jacksonville, FloridaAges 18 years+ - NCT07436013Recruiting
Comparing two types of weight-loss revision surgery after sleeve gastrectomy
This trial compares two surgical options for people who have regained weight or didn't lose enough after a sleeve gastrectomy. It tests whether adding a ring to the standard revision surgery helps with long-term weight loss.
Alexandria, Alexandria GovernorateAges 18–65 - NCT05830136Recruiting
Bicarbonate fluid during laparoscopic liver surgery
This trial tests whether giving a specific salt-water fluid (sodium bicarbonate in Ringer’s solution) during laparoscopic liver surgery can improve safety or outcomes. You may be eligible if you’re an adult planning this type of minimally invasive liver operation and can provide consent.
Nanjing, JiangsuAges 18 years+ - NCT07407530Recruiting
Sipping fluids before planned c-section
This trial tests whether drinking small amounts of clear fluids up until surgery is safe for women having a planned c-section. It uses an ultrasound to check the stomach before the procedure.
Dublin, Ireland/County DublinAges 18 years+ - NCT07434687Recruiting
Comparing two keyhole surgeries for belly button hernia
This trial tests two minimally invasive surgical methods for fixing a hernia near the belly button. It aims to find which approach works better and has fewer complications.
Lahore, Punjab ProvinceAges 18–65 - NCT07146165Recruiting
New tool for removing large growths in the rectum and lower colon
This trial tests a new platform to help doctors remove large polyps or early-stage cancers from the rectum and lower colon using a scope (endoscope). The goal is to see if this tool makes the removal process safer and more effective.
Freiburg im BreisgauAges 18 years+ - NCT07027605Recruiting
Testing a computer tool for colorectal liver metastasis prognosis
This trial is testing a computer program that helps doctors predict outcomes for people with colorectal cancer that has spread to the liver. It is for patients who have had surgery to remove both the colon and liver tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06588855RecruitingPhase 3
Study of afimkibart for moderate to severe ulcerative colitis
This trial is testing a new medication called afimkibart (RO7790121) for people with moderate to severe ulcerative colitis. It aims to see if this treatment can help reduce inflammation and improve symptoms in people who haven't had success with other therapies.
Dothan, AlabamaAges 16–80 - NCT07430579Recruiting
Adebrelimab with chemo for esophageal cancer
This trial tests adding adebrelimab (an immunotherapy drug) to standard chemotherapy for people with a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this combination helps shrink tumors before surgery.
JinanAges 18–80 - NCT07427992Recruiting
Study of zolbetuximab for stomach cancer with claudin 18.2
This trial is looking at a drug called zolbetuximab, given with chemotherapy, for people with a certain type of stomach or gastroesophageal junction cancer that has spread and has high levels of a protein called claudin 18.2. The goal is to see how well it works in real-world settings.
MilanAges 18–100 - NCT06590454RecruitingPhase 2
Reversing stomach lining changes to lower cancer risk
This trial tests whether a treatment can reverse stomach lining changes called GIM that increase cancer risk. It's for people who have had a past H. pylori infection but no current stomach cancer, and whose GIM has certain high-risk features.
Durham, North CarolinaAges 18 years+ - NCT07428226Recruiting
Bile acid tests in pregnancy with liver issues
This study looks at bile acid levels in pregnant women who have intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes itching and can affect the baby. It also includes two control groups: healthy pregnant women and healthy non-pregnant women for comparison.
Jena, ThuringiaAges 18–45 - NCT07425067Recruiting
Upper GI endoscopy in HIV patients
This study looks at the findings of upper endoscopy (a camera exam of the stomach and esophagus) in people living with HIV. It may help doctors understand if routine screening is helpful.
BrusselsAges 18–99 - NCT07400237Recruiting
New imaging for tough gallbladder removal
This study compares two advanced imaging methods—laparoscopic ultrasound and fluorescence cholangiography—to help surgeons see bile ducts more clearly during a difficult gallbladder removal. It aims to make the surgery safer for patients like you.
Sant Joan Despí, BarcelonaAges 18 years+ - NCT06587646Recruiting
Virtual reality for perianal Crohn's surgery
This trial is testing whether using virtual reality (VR) technology can help doctors better plan surgery for people with Crohn's disease around the bottom. It aims to improve how fistulas and abscesses are managed.
NottinghamAges 18–75 - NCT07422584Recruiting
Cytokine response after hernia repair surgery
This study looks at how the body's immune system (cytokines) responds to a specific type of hernia repair called open retromuscular ventral hernia repair. It may help patients understand inflammation after surgery.
Chicago, IllinoisAges 18 years+ - NCT07407231Recruiting
Chemo and radiation for advanced inoperable pancreatic cancer
This trial tests a combined treatment of chemotherapy followed by a precise type of radiation therapy (SBRT) for people with pancreatic cancer that cannot be surgically removed. It is designed for those who have not yet started treatment for locally advanced disease.
LjubljanaAges 18 years+ - NCT05823636Recruiting
Tracking why new indigestion turns into functional indigestion
This study follows adults with new indigestion symptoms to understand what factors make symptoms persist and possibly develop into functional dyspepsia. It may help future care by identifying who is more likely to get worse and why.
Xi'an, ShaanxiAges 18 years+ - NCT07362186RecruitingPhase 3
LM-108 with Toripalimab vs Paclitaxel for advanced stomach cancer
This trial tests a new combination of two immunotherapy drugs (LM-108 and Toripalimab) against a standard chemotherapy drug (Paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has a specific marker called CCR8. It may be an option if you have already tried a first-line therapy and your cancer has progressed or you had side effects from chemotherapy.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.