Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07128108Recruiting
Testing a new ultrasound for liver fat and scarring
This study tests a new ultrasound technique called Visual Transient Elastography (ViTE) to measure fat and scarring in the liver. If you recently had a liver biopsy, this noninvasive test could help check your liver health without another needle procedure.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06597227Recruiting
Partial vs total stomach removal for upper stomach cancer after chemo
This trial compares two types of surgery for upper stomach cancer after chemotherapy or radiation. It aims to see if removing only part of the stomach (proximal gastrectomy) works as well as removing the whole stomach (total gastrectomy) to help you recover better.
Wuhan, HubeiAges 18–75 - NCT06814080Recruiting
Stomach Content Study for GLP-1 Users Before Surgery
This study looks at whether a common diabetes medication (GLP-1) affects how much food stays in your stomach before surgery. It aims to make anesthesia safer by understanding stomach content.
Little Rock, ArkansasAges 18 years+ - NCT07450950Recruiting
Learning from patients before and after major cancer surgery
This trial looks at how people understand health information and what they expect before and after major cancer surgery. The goal is to help doctors better support patients by learning about their hopes and possible regrets.
Copenhagen, CopenhagenAges 18 years+ - NCT07467980Recruiting
Measuring oxygen in the colon during bowel surgery
This study tests a new way to measure oxygen levels inside the colon during surgery, right after the surgeon reconnects the bowel. It may help doctors see if the new connection is healing well.
Nashville, TennesseeAges 18 years+ - NCT07424586RecruitingEarly Phase 1
Better recovery for older adults with ostomy surgery
This study tests a program to help adults aged 65 and older recover well after ostomy surgery (a surgery that creates an opening on the belly for waste to leave the body). It also involves their healthcare providers.
Boston, MassachusettsAges 18 years+ - NCT07465614Recruiting
Nerve stimulation study for children with cyclic vomiting syndrome
This study tests whether a gentle nerve stimulation device placed on the ear can reduce vomiting episodes in children with cyclic vomiting syndrome (CVS). It aims to find a safe, non-drug option for managing symptoms.
Milwaukee, WisconsinAges 5–18 - NCT07463287Recruiting
Fatty liver and colorectal polyp risk study
This study looks at whether certain gene activity in people with fatty liver disease can predict the risk of developing colorectal polyps. It may help doctors find high-risk patients earlier.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07454629Recruiting
BIS monitoring and recovery after gallbladder surgery
This trial tests whether a special monitor that tracks your brain activity during anesthesia can improve how quickly and well you recover after gallbladder removal surgery.
Sakarya, SerdivanAges 18–65 - NCT07462481Recruiting
Probiotic study for constipation relief
This trial tests whether a probiotic can help people with constipation. You may be eligible if you have fewer than 3 bowel movements per week or hard, lumpy stools.
Suzhou, JiangsuAges 18–65 - NCT07461558Recruiting
Watchful waiting vs fixing a hidden hernia found during surgery
This study compares two approaches for people who have a hidden hernia on the opposite side during groin hernia repair. One option is to watch and wait, and the other is to fix it right away.
Chicago, IllinoisAges 18 years+ - NCT05257993RecruitingPhase 1/Phase 2
Pancreatic cancer trial testing JPI-547 with standard chemo
This study tests whether adding JPI-547 to standard chemotherapy (modified FOLFIRINOX or gemcitabine with nab-paclitaxel) is safe and tolerable in people with advanced pancreatic cancer. If it works, it may improve treatment options for cancers that have spread or cannot be removed with surgery.
Gyeonggi-doAges 19–79 - NCT06454955RecruitingEarly Phase 1
PET scan imaging study for solid tumors using a new probe
This trial tests a new imaging agent that targets a protein called B7-H3 found on many solid tumors. It uses PET/CT to help doctors see and stage tumors more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07407777Recruiting
Can a daily drink improve your gut health and mood?
This trial tests a powder made from mushrooms and algae that you mix into a drink once a day for 30 days. Researchers want to see if it helps with minor tummy troubles and how you feel emotionally.
San Francisco, CaliforniaAges 18 years+ - NCT07010744Enrolling by invitation
Comparing 3 vs 4 drugs for H. pylori infection
This study compares two treatment plans for H. pylori infection (a stomach bacteria). It looks at whether a 3-drug combination works as well as a 4-drug combination to clear the infection.
DhakaAges 18 years+ - NCT06611176Recruiting
Pain relief after esophageal lesion removal using a numbing medication
This trial tests whether injecting a long-acting numbing medicine (levobupivacaine) into the esophagus after removing a large lesion can reduce pain. If you're scheduled for this procedure, you may experience less discomfort afterward.
GroningenAges 18 years+ - NCT07451470Recruiting
Comparing two airway devices for stomach air in children during short surgeries
This trial compares two devices used to help children breathe during surgery (LarySeal Pro and Ambu AuraGain). It measures how much air gets into the stomach, which can cause discomfort. It is for children aged 6–12 having short elective surgeries (1 hour or less).
Cairo, Cairo GovernorateAges 6–10 - NCT07449208Recruiting
Esophagectomy leak risk registry study
This study follows people having surgery to remove part of the esophagus (esophagectomy) who are at higher risk for a leak where the esophagus is reconnected. The goal is to learn more about who develops leaks and how to prevent them.
Basking Ridge, New JerseyAges 18 years+ - NCT06610760RecruitingPhase 4
Ursodeoxycholic acid for stomach precancer reversal
This trial tests if ursodeoxycholic acid can reverse intestinal metaplasia (a precancerous stomach condition) in patients who have no H. pylori infection. The goal is to see if this medication can help lower the risk of stomach cancer.
Pingdingshan, HenanAges 18–75 - NCT06639828RecruitingPhase 4
Safety study of Sonazoid for liver ultrasound in children
This trial tests a contrast agent called Sonazoid, which is used during an ultrasound to get clearer pictures of the liver. It is for children and teens who have one or more spots in the liver that need to be checked. The goal is to see if Sonazoid is safe and works well for children.
MünchenAges Up to 18 years - NCT07435610Recruiting
Acupuncture for children with stomach pain and related issues
This study tests whether acupuncture can help children with stomach pain or other gut-brain interaction disorders. It may be a good option if your child's current treatments aren't working well enough.
Irvine, CaliforniaAges 8–17 - NCT07443280Recruiting
Gut health supplement study for dialysis patients
This trial tests whether a special blend of probiotics and prebiotics (called a synbiotic) can improve gut health and reduce harmful waste products in the blood for people on hemodialysis.
Taichung, Wuqi DistrictAges 18 years+ - NCT06445660Recruiting
Using CT scans to find salvageable bowel in mesenteric ischemia
This trial is testing a new way to use CT scans to identify which parts of the bowel can still be saved in patients with acute mesenteric ischemia. It aims to help doctors make better decisions about whether surgery is needed.
TartuAges 18 years+ - NCT06984562Recruiting
Adaptive radiation therapy for advanced pancreatic cancer
This trial tests a new way of giving radiation therapy that adapts to changes in your cancer over time. It is for people with pancreatic cancer that cannot be removed by surgery but has not spread to other parts of the body.
Philadelphia, PennsylvaniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.