Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07420309Recruiting
Colonoscopy training with or without AI assistance for residents
This trial tests whether using artificial intelligence (AI) during colonoscopy training helps endoscopy trainees find polyps better. It involves adult patients getting a colonoscopy for screening, diagnosis, or follow-up.
LarissaAges Any age - NCT06902116Recruiting
Bowel preparation for colostomy reversal in children
This study compares two approaches for preparing the bowel before reversing a colostomy (closing the opening in the belly) in children. The goal is to see if using a bowel-cleansing regimen for three days leads to fewer complications than skipping prep entirely.
Lahore, Punjab ProvinceAges 1–15 - NCT04113382RecruitingPhase 1/Phase 2
A bowel prep study for children having a colonoscopy
This trial tests a bowel-cleansing liquid called CLENPIQ in children ages 1 to 9 who need a colonoscopy. It aims to see if it works well and is safe for preparing the colon before the procedure.
Mobile, AlabamaAges 1–8 - NCT07416760Recruiting
Gut bacteria study after intestinal surgery
This study looks at how gut bacteria change after surgery to reconnect the intestines (anastomosis). It may help doctors understand complications and improve recovery.
MadridAges 18 years+ - NCT06433310RecruitingPhase 4
A dietary supplement's effect on gut fungi in healthy adults
This study tests whether a dietary supplement (L-phenylalanine) can affect the natural balance of fungi in the gut. Healthy volunteers take the supplement for a short time, and researchers check how it changes their gut fungi.
New York, New YorkAges 18 years+ - NCT05596357Recruiting
Study during hernia surgery to understand patient experience
This trial enrolls adults who are scheduled for planned hernia/abdominal wall surgery to learn more about patients’ experiences and follow-up through questionnaires. If you qualify and agree, your study participation may help improve how care is planned around surgery.
Colombes, Île-de-France RegionAges 18–79 - NCT05904665Recruiting
Blood methylation test to guide follow-up after colon cancer surgery
This study checks a special blood test (circulating tumor DNA methylation) to help guide follow-up after surgery for non-metastatic colon cancer. It may help find whether additional treatment or closer monitoring is needed based on the test results.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07122024RecruitingPhase 4
Testing a dual therapy for H. pylori treatment
This trial tests a two-drug treatment (keverprazan and amoxicillin) for people who have H. pylori and have not been treated for it before. The goal is to see if this newer combination works well and is safe.
Hangzhou, ZhejiangAges 18–65 - NCT06306976Enrolling by invitation
Shear-wave test before hernia surgery
This trial uses a special ultrasound (shear-wave elastography) to measure tissue stiffness before and after hernia repair. It aims to see if this test can predict complications and help choose the best surgical approach.
Greenville, South CarolinaAges 18 years+ - NCT07611825RecruitingPhase 2
Gut Bacteria Treatment for Advanced Kidney Cancer Resistant to Immunotherapy
This study tests whether modifying your gut bacteria can help immunotherapy work again in advanced kidney cancer that has stopped responding to initial immune-checkpoint inhibitor treatment. Researchers will give you a special bacterial preparation along with a new immunotherapy drug to see if this combination can slow or shrink your cancer.
Nanjing, JiangsuAges 18–90 - NCT07398222Recruiting
Stomach contents in tirzepatide users and fasting volunteers
This study uses an ultrasound to look at the stomach contents of people who are taking tirzepatide compared to those who are not. It will help doctors understand how this medication affects stomach emptying during fasting.
São Paulo, São PauloAges 18 years+ - NCT06575400RecruitingPhase 1
Testing tolerance of BI 3804379 in healthy people and MASH patients
This study tests how well different doses of a new drug (BI 3804379) are tolerated. It is for healthy people and for patients with MASH (a type of fatty liver disease) who have advanced liver scarring.
EdegemAges 18–65 - NCT07393074Recruiting
Liver cancer and nervous system study
This study looks at how the nervous system works in people with liver cancer (hepatocellular carcinoma) or liver scarring (cirrhosis) who need a liver biopsy. It aims to see if there is a link between the nervous system and liver tumors.
LyonAges 18 years+ - NCT07392268Recruiting
Testing AI to help during endoscopic surgery
This trial tests an AI system to help guide doctors during a minimally invasive procedure to remove early-stage lesions in the esophagus, stomach, or colon. If you're scheduled for this surgery, the AI may help make it safer and more precise.
Hong KongAges 18–85 - NCT07391618RecruitingPhase 2
First treatment for advanced colorectal cancer with combo chemo
This trial tests a combination of two chemotherapy drugs, levozolinate and 5-FU, given together as a first treatment for advanced colorectal cancer that cannot be surgically removed. It aims to see if giving them at the same time works better for patients who have never received treatment for this stage of cancer.
BeijingAges 18–75 - NCT07388420Recruiting
Evolocumab for pancreatitis from high triglycerides
This trial tests adding evolocumab, a medicine that lowers fats in the blood, to standard treatment for people hospitalized with pancreatitis caused by very high triglycerides. The goal is to see if it helps improve recovery.
Shenyang, LiaoningAges 18–75 - NCT05950438Recruiting
Study of outcomes after planned robotic esophagus surgery
This study looks at what happens after a planned (elective) robotic surgery to remove part or all of the esophagus. It may help doctors understand recovery and outcomes, and compare results among patients having this operation.
Chicago, IllinoisAges 18–89 - NCT07388121Recruiting
Vitamin C and gut health in healthy adults
This trial tests whether taking vitamin C supplements changes the bacteria in your gut and how well your gut works. If you are a healthy adult, you may be able to join.
GlasgowAges 18–65 - NCT06571097Recruiting
Levofloxacin for constipation from PIB bacteria
This study tests whether the antibiotic levofloxacin can help people with chronic constipation caused by a specific gut bacteria (PIB). If you have this bacteria and meet the other criteria, you may be able to join this trial to see if the treatment improves your symptoms.
Nanjing, JiangsuAges 18–70 - NCT07387952Recruiting
Fecal transplant with nutrition help for chronic constipation
This trial tests if a fecal microbiota transplant combined with nutritional support can improve chronic constipation that hasn't gotten better with standard treatments. It's a small early study to see if the approach is safe and works.
BeijingAges 18–70 - NCT06624098Recruiting
Early TIPS for Advanced Liver Cancer with Vein Blockage
This study tests whether placing a small tube (TIPS) early in people with advanced liver cancer and a vein blockage helps their other treatments work better. It is for patients who are already taking lenvatinib and immunotherapy.
Beijing, Beijing MunicipalityAges 18–75 - NCT05872685RecruitingPhase 2
Perioperative chemo plus serplulimab for specific stomach cancers
This Phase 2 trial tests whether adding serplulimab (an immune medicine) to standard chemotherapy before and/or around surgery can improve outcomes for people with certain locally advanced stomach cancer. You may get serplulimab or a placebo, and researchers will compare results to see if the immune add-on helps.
Hangzhou, ZhejiangAges 18–80 - NCT07378631Recruiting
Radiation rectal injury subtypes and outcomes study
This study looks at different types of radiation rectal injury to understand how they affect recovery. It may help you if you have been diagnosed with this condition and are not currently undergoing cancer treatment.
Guangzhou, GuangdongAges 18–80 - NCT07381192Recruiting
AI system for diagnosing solid pancreatic lesions via endoscopy
This trial is testing an artificial intelligence (AI) system that helps doctors identify solid masses in the pancreas using images from a special endoscope (endoscopic ultrasound). The goal is to see if the AI can make a more accurate diagnosis than the standard approach.
Jinan, ShandongAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.