Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07355634Recruiting
Terraflora daily care for gut health
This trial tests if a daily probiotic supplement, Terraflora, can improve gut health in people with an imbalance of gut bacteria (dysbiosis). You may join if you're an adult with a stool test showing dysbiosis and are not taking certain other medications or supplements.
Richmond, VirginiaAges 25 years+ - NCT05678023Recruiting
Study of contrast dye in certain bowel blockage cases
This trial studies whether using contrast dye (a special substance seen on scans) helps in treating people with a specific type of small-bowel blockage. It may help doctors make better decisions without needing emergency surgery.
Tartu, TartuAges 18 years+ - NCT06619548Recruiting
Ear magnet for loss of appetite in kids
This study tests if a small magnet placed on the ear can help improve appetite in children with poor eating or stomach discomfort. It may offer a drug-free option for kids who have lost weight or feel too full too quickly.
TaichungAges 2–6 - NCT05680246Recruiting
Study of long-term outcomes after special donor-liver preservation
This study looks at how well people do in the long run after liver transplant using donor livers that were preserved in a specific machine called DHOPE for more than 4 hours. It may help doctors understand whether this preservation method leads to better transplant outcomes over time.
GroningenAges 18 years+ - NCT06551194Recruiting
Studying hard-to-treat inflammatory bowel disease
This study looks at people with inflammatory bowel disease (IBD) that is hard to manage. Researchers want to understand how common it is, how it is treated, and what happens over time.
MilanAges 18–69 - NCT06550908Recruiting
Training doctors to spot polyp patterns in colon images
This trial teaches physicians to identify polyp features using AI-generated images. It aims to improve cancer detection skills.
WürzburgAges 18 years+ - NCT07346248Enrolling by invitation
Complications after pre-surgery treatment for advanced rectal cancer
This study looks at complications that happen after surgery in patients with advanced rectal cancer who got radiation or chemo-radiation before their operation. Researchers want to learn how different pre-surgery treatments affect recovery.
Rozzano, MilanAges 18 years+ - NCT06550453RecruitingPhase 4
Immunotherapy plus chemo before surgery for RAS-mutated colorectal cancer
This trial tests a combination of immunotherapy (pembrolizumab) plus targeted therapy (bevacizumab) and chemotherapy (CapeOX) given before surgery for a specific type of locally advanced colorectal cancer. It is designed for patients whose tumors have a RAS mutation, are BRAF normal, and are microsatellite stable.
Xi'an, ShaanxiAges 18 years+ - NCT04824053Recruiting
Dairy products study for people at high risk of colon cancer
This trial studies whether specific dairy products (UNICLA-A2) can help lower the risk of future colon problems in people considered high risk for colorectal cancer. You may be asked to keep using dairy consistently and undergo colon checks as part of usual follow-up.
Zaragoza, ZaragozaAges 18–80 - NCT06918808RecruitingPhase 2
Stem cell therapy for Crohn's fistula healing
This trial tests if a special stem cell treatment (called DB-3Q bmMSC-EVs) can help heal fistulas caused by Crohn's disease. It's for people who have already tried other treatments and still have actively draining fistulas.
Aurora, ColoradoAges 18–75 - NCT06787183RecruitingPhase 2
Short-course radiation with chemoimmunotherapy for rectal cancer that has spread to the liver
This trial tests whether combining short-course radiation with a chemotherapy regimen (CAPOX) and an immunotherapy drug (QL1706) can help treat rectal cancer that has spread to the liver. It is designed for patients who have not had any prior cancer treatment.
Fuzhou, FujianAges 18–75 - NCT07336160Recruiting
Nutrition before knee replacement surgery
This trial studies a special nutrition plan before knee replacement surgery to see if it helps recovery. Participants follow enhanced recovery guidelines for eating and drinking before their operation.
Istanbul, IstanbulAges 18 years+ - NCT07335406Recruiting
H. pylori infection registry study in Shandong
This study is creating a registry of people with Helicobacter pylori (H. pylori) infection in Shandong Province who choose to have treatment. It will gather information to improve how H. pylori infections are managed.
Jinan, ShandongAges 18–80 - NCT03417336Recruiting
Radiation for prostate cancer using smaller, targeted doses
This trial studies a specific radiation schedule for prostate cancer (with an extra “boost” dose) and checks whether it works well and is tolerable. It may help people with higher-risk, localized prostate cancer by aiming at the cancer while limiting side effects to surrounding tissues.
DijonAges 18–85 - NCT07330830Recruiting
Genetics and fatty liver disease in Caribbean and Indian Ocean populations
This study looks at how a specific gene (PNPLA3) might affect non-alcoholic fatty liver disease (MASLD) in people from Guadeloupe, French Guiana, and Réunion Island. It aims to understand genetic differences that could explain why some people get the disease.
CayenneAges 18 years+ - NCT06607107RecruitingPhase 2
Combination therapy for liver cancer beyond Milan criteria
This trial tests a combination of chemotherapy (mFOLFOX7) plus two targeted/immunotherapy drugs (camrelizumab and apatinib) for people with liver cancer that has grown beyond standard transplant criteria. It aims to shrink tumors and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06876935Recruiting
Avocado for healthy growth in Hispanic infants
This study tests if feeding avocado to Hispanic infants when they start solids helps their gut health and development. We need families who are ready to offer avocado regularly for about 6 months, starting when their baby is around 6 months old.
Phoenix, ArizonaAges 3 months–6 months - NCT07328880Recruiting
Two bowel prep methods before colonoscopy study
This trial compares two ways to clean the bowel before a colonoscopy: a 4-liter split-dose of a laxative plus two other medications versus a 2-liter split-dose with a gas-relief medication. The goal is to see which works better and is easier to tolerate.
Tanta, GharbyeaAges 18–70 - NCT07328698Recruiting
Ozonated oil dressing after hernia surgery pilot
This study tests whether a special oil dressing (ozonated oil) can help heal the surgical wound better after open inguinal hernia repair. It compares the oil dressing to a standard dressing to see if it reduces pain, infection, or other complications.
Niğde, Niğde ProvinceAges 18–75 - NCT06364384RecruitingPhase 2
Chemo, radiation, and immunotherapy for rectal squamous cell carcinoma
This trial tests a combination of chemotherapy (cisplatin and 5-FU), radiation, and an immunotherapy drug (PD-1 antibody) for people with a rare type of rectal cancer that hasn't spread. The goal is to see if this treatment can shrink or eliminate the cancer.
Guangzhou, GuangdongAges 18–75 - NCT06791408Recruiting
AI-assisted endocytoscopy for small colorectal polyps
This trial uses artificial intelligence to help doctors look at small growths in the colon or rectum. It aims to see if the AI can accurately tell what they are while you are still undergoing the procedure.
Changchun, JilinAges Any age - NCT07600073Recruiting
Comparing two sedation medications for endoscopy procedures
This trial tests whether remimazolam, a newer sedative, works as well as midazolam (a common sedative) for keeping patients comfortable during endoscopy procedures that examine the stomach and pancreas. The study aims to see which medication has fewer side effects.
Lecco, LeccoAges 18 years+ - NCT06883422Recruiting
Pre-surgery immune drink for colorectal surgery recovery
This trial tests whether taking a special immune-boosting drink before and after colorectal surgery helps patients recover better. It compares this 'immunonutrition' to standard care.
Mexico City, TlalpanAges 18 years+ - NCT07318493Recruiting
Antiseptic-coated sutures to lower pancreatic fistula risk
This trial tests if using antiseptic-coated stitches during pancreatic surgery can reduce the chance of a pancreatic leak (fistula) afterward. If you are scheduled for a Whipple procedure (pancreatoduodenectomy), this study may help improve your recovery.
Akron, OhioAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.