Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT05260385RecruitingPhase 1/Phase 2
Study drug KC1036 for advanced digestive cancers
This early-phase study tests whether KC1036 can treat advanced digestive system cancers that have come back or spread after standard treatment. It may help people by shrinking tumors or slowing growth, and it will also check safety and side effects.
BeijingAges 18–75 - NCT06060990Recruiting
Copper and trace elements in biliary tract cancer
This study looks at levels of copper and other minerals in the blood of people with biliary tract cancer (cancer of the bile ducts or gallbladder). If you have not had treatment yet, this trial may help doctors understand how these elements relate to your cancer.
LjubljanaAges 18–80 - NCT07701811Recruiting
AI help for chronic anal fissure education
This study tests whether AI-written educational materials can help people with chronic anal fissure. It's for patients who are beginning simple treatments (like diet or cream) and can read Turkish.
SanliurfaAges 18 years+ - NCT07703735Enrolling by invitation
Survival after ABO-mismatch living donor liver transplant for liver cancer
This trial looks at how well patients with liver cancer do after receiving a living donor liver transplant that is not the same blood type. It compares survival and cancer return for these patients.
Ages 18 years+ - NCT07702799Recruiting
Low-fiber diet vs enema before laparoscopic endometrial cancer surgery
This trial compares two colon preparation methods — a low-residue diet versus a rectal enema — before laparoscopic surgery for endometrial cancer. The goal is to find which approach is easier and works better for bowel preparation.
IstanbulAges 18–90 - NCT07701798Recruiting
AI-written information for hemorrhoid care
This study tests whether AI-written educational information helps people with hemorrhoids who are getting first-line (non-surgical) care. It aims to see if this information improves your understanding and symptoms.
Sanliurfa, ŞanlıurfaAges 18 years+ - NCT07702292RecruitingPhase 2
68Ga-BED003 PET scan for certain cancers
This trial tests a new PET imaging agent that targets a protein called FAP, which appears in many solid tumors. The goal is to see if this scan can better find and measure cancer in the body.
Bergamo, LombardyAges 18–79 - NCT07705334RecruitingPhase 1
Study of SHY-ONC6 for advanced solid tumors
This trial tests a new drug called SHY-ONC6 that targets and breaks down cancer cells. It's for people with advanced solid tumors that haven't responded to standard treatments.
Scottsdale, ArizonaAges 18 years+ - NCT07700342Recruiting
Could an evening gel improve sleep for nighttime reflux?
This trial tests a topical therapy you apply at night to see if it can improve sleep for people with non-erosive GERD who still have nighttime symptoms even while taking a morning acid reducer.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07700667RecruitingPhase 2
Testing a new drug combo for advanced esophageal cancer
This trial tests a new drug combination (SKB500 plus other treatments) for people with advanced esophageal squamous cell carcinoma. It aims to see if the combination is safe and effective for those who have had little or no prior treatment.
ChangchunAges 18–75 - NCT07701993RecruitingPhase 3
Testing efimosfermin for MASH with compensated cirrhosis
This trial tests whether efimosfermin, an experimental drug, can safely help people with MASH (a fatty liver disease) that has led to cirrhosis (liver scarring) but the liver is still working well (compensated). Participants will be randomly assigned to receive the drug or a placebo.
Little Rock, ArkansasAges 18–75 - NCT07704892RecruitingPhase 3
Study of efimosfermin for adults with cirrhosis from MASH
This trial tests a new drug, efimosfermin, to see if it is safe and effective for people with cirrhosis caused by MASH (a type of fatty liver disease). It may help improve liver health compared to a placebo.
Little Rock, ArkansasAges 18–75 - NCT07704047RecruitingPhase 2
Study of FT1 for short bowel syndrome
This study tests a new treatment called FT1 for people with short bowel syndrome. It aims to help you absorb more nutrients and fluids from food, potentially reducing the need for IV nutrition.
Nanjing, JiangsuAges 18 years+ - NCT07702032RecruitingPhase 3
Study of petosemtamab plus chemo for left-sided colorectal cancer
This trial tests a new drug (petosemtamab) plus standard chemo to see if it works better than the current standard (cetuximab plus chemo) for people with advanced left-sided colorectal cancer that has not been treated yet. It is for patients whose cancer cells have no RAS or BRAF mutations.
Hot Springs, ArkansasAges 18 years+ - NCT07700979RecruitingPhase 3
Testing a new drug combo for stomach cancer
This trial tests a new immunotherapy drug called cadonilimab combined with chemotherapy for people with advanced stomach cancer that hasn't been treated yet. It compares this combination to chemotherapy with or without another immunotherapy drug, nivolumab.
Phoenix, ArizonaAges 18 years+ - NCT07700381Recruiting
Fermented dairy and gut bacteria study
This study tests if a fermented dairy product can increase the amount of a healthy gut bacteria called Bifidobacterium. If you are healthy, age 45-60, and willing to follow the diet rules, you may be able to join.
DijonAges 45–60 - NCT07701486RecruitingPhase 1/Phase 2
Testing more frequent VCN-01 with standard chemo for new pancreatic cancer
This study tests a more frequent schedule of the experimental drug VCN-01 along with standard chemotherapy (nab-paclitaxel and gemcitabine) for people newly diagnosed with pancreatic cancer that has spread. The goal is to see if the virus-based therapy can help shrink tumors better.
Madrid, MadridAges 18 years+ - NCT06646198RecruitingPhase 2
TIPS with half-dose Donafenib for liver cancer with portal hypertension
This trial tests a treatment that combines a procedure called TIPS with a targeted therapy drug (Donafenib) at half strength. It is for people with advanced liver cancer that has spread into the portal vein and caused high blood pressure in the liver (portal hypertension). The goal is to see if this combination can help control the cancer and reduce complications.
Guangzhou, GuangdongAges 18–75 - NCT06646588RecruitingPhase 2
Study of fruquintinib, tislelizumab, and radiation for esophageal cancer
This trial tests a combination of two drugs (fruquintinib and tislelizumab) followed by radiation therapy for people with advanced esophageal squamous cell carcinoma. The goal is to see if this approach can help shrink tumors and improve outcomes.
Shijiazhuang, HebeiAges 18 years+ - NCT07703813Recruiting
Energy use and nutrition after pancreas surgery
This study measures how your body uses energy after pancreas surgery to improve nutrition care. It may help doctors better support your recovery.
Athens, AtticaAges 18–75 - NCT07697872Recruiting
The Dirty Nappy Study for babies with liver problems
This study looks at babies with possible liver problems (cholestasis) who have been referred to the Birmingham Liver Unit. Researchers want to collect information from nappy (diaper) samples to better understand these conditions.
BirminghamAges Up to 11 years - NCT07704255RecruitingPhase 4
Fecal transplant for stubborn H. pylori infection
This study tries a fecal microbiota transplant (placing healthy donor stool into your gut) to get rid of stubborn H. pylori infection that hasn't been cured by standard treatments. It's for people who have failed several rounds of therapy and have a stomach condition that makes eradication important.
Chengdu, SichuanAges 18–80 - NCT07703709Recruiting
Colorectal cancer treatment study in real-world care
This study looks at how well treatments work for colorectal cancer in everyday medical practice. It may help doctors understand which therapies are most effective for people like you.
TaichungAges 20 years+ - NCT07705919RecruitingPhase 1/Phase 2
MRI scans to monitor borderline resectable pancreatic cancer treatment
This study uses MRI scans to see how well chemotherapy and radiation work in people with borderline resectable pancreatic cancer – a type where surgery might be possible but is risky. The goal is to find the best way to measure tumor response so doctors can make better treatment decisions.
Columbus, OhioAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.