Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06534996Recruiting
Chinese Herbal Medicine for Constipation in Older Adults
This trial tests a Chinese herbal medicine formula (SCD-2101) to see if it can help older adults with chronic constipation. It aims to improve bowel movement frequency and comfort without the need for laxatives.
Kowloon TongAges 60 years+ - NCT06895200Recruiting
Smart reminders for safer gallbladder surgery
This trial tests a smart reminder system to help surgeons follow safety steps during laparoscopic gallbladder removal. It aims to reduce risks and improve outcomes for patients with non-cancerous gallbladder disease.
StrasbourgAges 18 years+ - NCT07315204Recruiting
Liver viability test during machine perfusion
This trial tests a new way to check if a donated liver is healthy while it is kept on a machine that keeps it alive before transplant. Doctors measure a substance called FMN in the fluid that flows through the liver and in bile. This could help them know how well the liver might work after transplant.
Cleveland, OhioAges 18 years+ - NCT07599930Recruiting
Novel Snack for Perimenopausal Symptoms and Wellness
This study tests whether a specially designed snack can help reduce hot flashes, night sweats, mood changes, and other symptoms that happen during perimenopause (the years leading up to menopause). You'll eat the snack regularly and answer questions about how you feel.
London, LondonAges 40–55 - NCT06494917Recruiting
Manual therapy and pelvic floor exercises for constipation
This trial tests whether manual therapy (hands-on muscle work) and pelvic floor exercises can help people with constipation. It's a chance to try a non-medication approach for better bowel function.
ŞırnakAges 18–55 - NCT06894329Recruiting
A new test for pancreatic cysts using cyst fluid
This study tests a new lab test called PanCystPro that looks at fluid taken from a pancreatic cyst during an endoscopic ultrasound. It aims to help doctors better manage your condition.
Indianapolis, IndianaAges 18 years+ - NCT07312890Recruiting
Ultrasound to check stomach fullness in ICU patients
This trial tests whether a bedside ultrasound can measure how full the stomach is in patients on a breathing machine who are receiving liquid nutrition through a tube. If it works, doctors may avoid complications and feed patients more safely.
LyonAges 18 years+ - NCT07309315Recruiting
Testing a bacteria pill to prevent diarrhea from chemotherapy
This trial tests if a pill made from a harmless bacteria can prevent diarrhea caused by certain chemotherapy treatments. It is for people with advanced colorectal cancer or breast cancer who are about to start specific treatments.
Shenzhen, GuangdongAges 18 years+ - NCT06906952Enrolling by invitation
Robotic surgery through the anus vs. standard robotic surgery for rectal cancer
This trial compares two robotic surgery methods for high rectal and sigmoid colon cancer—one that removes the tumor through the anus (NOSES-IV) and the traditional assisted approach. It aims to see which way may lead to better recovery.
NanchangAges 18–80 - NCT06525428RecruitingPhase 2
Adding radiation and immunotherapy to standard care for advanced colorectal cancer
This trial is testing a combination of standard chemotherapy, radiation therapy, and an immunotherapy drug (toripalimab) for people with metastatic colorectal cancer. It aims to see if adding radiation therapy and immunotherapy can help shrink tumors and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07176715Recruiting
Same-day discharge after robotic colon surgery: is it safe?
This study tests whether it is safe for patients to go home the same day after robotic colon surgery. If you are healthy enough and have help at home, you may be able to recover there instead of staying in the hospital overnight.
Phoenix, ArizonaAges 18–70 - NCT07303738RecruitingPhase 4
Testing bile-lowering foods for kids with feeding tubes
This trial tests if certain foods can lower bile acid levels in the upper part of the stomach for children who get most nutrition through a feeding tube. It may help understand and manage reflux symptoms related to bile.
Boston, MassachusettsAges 5–21 - NCT07303153Recruiting
Quality of life after acute mesenteric ischemia treatment
This study looks at how acute mesenteric ischemia (a condition where blood flow to the intestine is suddenly reduced) and its treatment affect quality of life. It aims to understand the long-term effects on patients treated between 2010 and 2022.
StrasbourgAges 18 years+ - NCT06798948RecruitingPhase 2
Can a mix of herbs improve mild fatty liver?
This study is testing if a combination of four herbs (artichoke, milk thistle, turmeric, and licorice root) can help people with non-alcoholic mild to moderate fatty liver disease (also called metabolic-associated fatty liver disease). It's a randomized trial, meaning participants are assigned to either the herbal mix or a comparison group. This may offer a natural option to support liver health.
Hangzhou, Select...Ages 18–65 - NCT07586111Recruiting
Plant Foods for Better Gut and Heart Health
This study tests whether eating more plant-based foods improves your gut bacteria, digestion, and heart health markers. You'll follow a structured diet plan for several weeks while providing blood, stool, and urine samples to measure changes.
LondonAges 30–70 - NCT07300423Recruiting
Parent views on physical activity in kids with constipation
This study asks parents of children with constipation to share their views on their child's physical activity. It aims to understand how physical activity relates to constipation in children.
AlingsåsAges 18 years+ - NCT06800833Recruiting
Mango or cookie study for gut, mental, sexual, and skin health
This study is testing whether eating mangoes or low-fat cookies every day for 4 weeks can improve your gut health, and in turn affect your mood, sex life, and skin. If you are generally healthy, not pregnant, and not taking certain medications or supplements, you may be able to join.
San Diego, CaliforniaAges 18–50 - NCT02886104Recruiting
Surgery versus local ablation for certain liver metastases
This trial compares two ways to treat colorectal cancer that has spread to the liver: removing liver tumors with surgery versus destroying them in place with local ablation. It may help doctors learn which approach works best for people whose disease can be fully treated and who have enough healthy liver left.
Guangzhou, GuangdongAges 18–80 - NCT06802276Recruiting
Smart underwear measures gas from diet
This study tests special underwear that can measure gas produced by digestion after eating different foods. Researchers want to see if the underwear can track how diet affects gas production.
Aurora, ColoradoAges 18 years+ - NCT07293624Enrolling by invitation
Diet and inflammation after weight-loss surgery
This study looks at how your diet affects inflammation and stomach symptoms after weight-loss surgery. You'll fill out food records and have blood tests to see how your eating habits relate to your health.
Istanbul, UskudarAges 18–65 - NCT06510010RecruitingPhase 2
Chemo plus H. pylori treatment for advanced stomach cancer
This trial tests whether adding H. pylori bacteria treatment to standard chemotherapy (before and after surgery) can improve outcomes for people with locally advanced stomach cancer. It combines oxaliplatin and S-1 chemo with antibiotics to clear the infection.
GuangzhouAges 18–75 - NCT07165886RecruitingPhase 2/Phase 3
Study of sirolimus and octreotide for advanced neuroendocrine tumors
This trial tests a combination of two drugs, sirolimus and octreotide, for people with advanced neuroendocrine tumors in the digestive system that cannot be removed by surgery and are not making excess hormones. The goal is to see if this combination can help control the tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05729646RecruitingPhase 2
Pre-surgery chemotherapy with toripalimab for dMMR stomach cancer
This trial studies whether adding toripalimab (an immune therapy) to chemotherapy before and around surgery can improve outcomes for people with certain mismatch repair–deficient stomach cancers. It mainly targets tumors that are dMMR and not HER2-positive.
Hangzhou, ZhejiangAges 18–80 - NCT06969872Recruiting
Probiotics for Constipation Relief
This trial tests whether taking probiotics can help relieve constipation in adults. If you have chronic constipation but no serious health issues, you may be able to join.
Taichung, SouthAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.