Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07701135Recruiting
Antibiotic guidance for positive stool test results
This study tests whether adding easy-to-understand comments to lab reports helps doctors use antibiotics more wisely for certain gut infections. If your stool sample tested positive for one of the listed bacteria, you can participate.
AucklandAges 6 months+ - NCT07704177RecruitingPhase 2
A study of trastuzumab rezetecan plus two other drugs for advanced bile duct cancer
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) for people with advanced bile duct or gallbladder cancer that has HER2 protein on its cells. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18–80 - NCT07700992Recruiting
A blood test to find pancreatic cancer early
This study uses stored blood samples from people at higher risk for pancreatic cancer (due to family history or certain pancreatic cysts) to see if a simple blood test can detect the disease early or help monitor it over time.
Milan, MIAges 18–99 - NCT07699185RecruitingPhase 2
Immunotherapy plus chemoradiation before surgery for esophageal cancer
This study tests whether giving a combination of chemotherapy, radiation, and an immunotherapy drug (cadonilumab) before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a specific type of esophageal cancer that has not spread to other parts of the body.
Wuhan, HubeiAges 18–75 - NCT07703709Recruiting
Colorectal cancer treatment study in real-world care
This study looks at how well treatments work for colorectal cancer in everyday medical practice. It may help doctors understand which therapies are most effective for people like you.
TaichungAges 20 years+ - NCT07705880Recruiting
Predicting cancer in large flat colon polyps
This study tests a new tool to help doctors decide if a large, flat colorectal polyp might contain cancer. It involves doctors who use the tool during colonoscopy to better guide treatment.
GhentAges 18 years+ - NCT07699666Recruiting
Cord clamping timing for preterm babies
This study compares waiting a bit before clamping the umbilical cord versus clamping it right away for babies born between 32 and 37 weeks of pregnancy. It helps determine which approach may be better for preterm infants.
Tunis, Tunis GovernorateAges birth+ - NCT07700420RecruitingPhase 1
Chemo and personalized radiation for esophageal cancer before and after surgery
This trial tests combining chemotherapy (FLOT) with a new type of personalized radiation (PULSAR) before and after surgery for esophageal cancer. It aims to see if this approach is safe and effective.
Dallas, TexasAges 18 years+ - NCT07705139Recruiting
Listening to bowel sounds after colorectal surgery
This study listens to your bowel sounds after colorectal cancer surgery to see if they can help doctors know when your gut is working again. You will have a small device placed on your belly to record sounds for a few days.
Wuhan, HubeiAges 18–90 - NCT07697872Recruiting
The Dirty Nappy Study for babies with liver problems
This study looks at babies with possible liver problems (cholestasis) who have been referred to the Birmingham Liver Unit. Researchers want to collect information from nappy (diaper) samples to better understand these conditions.
BirminghamAges Up to 11 years - NCT07703813Recruiting
Energy use and nutrition after pancreas surgery
This study measures how your body uses energy after pancreas surgery to improve nutrition care. It may help doctors better support your recovery.
Athens, AtticaAges 18–75 - NCT05546346Recruiting
Wearable magnet tracking for capsule endoscopy
This trial checks how well a wearable magnet tracking system can guide a capsule camera through your digestive tract. It may help doctors see where the capsule is in real time without changing the basic capsule endoscopy process.
Jinan, ShandongAges 18–75 - NCT05224960RecruitingPhase 2
Stem cell treatment for worsening liver cirrhosis
This trial tests umbilical-cord stem cells to see if they can improve outcomes in people with decompensated (worsening) cirrhosis. You may be considered if your liver disease is moderate to severe (MELD 15–30) and you do not have certain high-risk problems right now.
Lanzhou, GansuAges 18–75 - NCT06353126RecruitingPhase 4
Chemoembolization before liver transplant for liver cancer
This trial tests whether using chemotherapy beads delivered directly to the liver (DEB-TACE) before a living donor liver transplant improves outcomes for people with liver cancer. If you have a tumor in the right side of the liver that fits certain size and number limits, and you are already scheduled for a transplant, this study may be an option.
ShanghaiAges 18–75 - NCT06041009Recruiting
Pancreatic cancer screening with a new enzyme test
This study is testing if measuring a substance called elastase-1, along with standard tests, can help find pancreatic cancer earlier. It may benefit people who already have signs of pancreatic disease or are at high risk.
Jinan, ShandongAges 18 years+ - NCT06649474Recruiting
Oxaliplatin side effects linked to HMGB1 blood levels
This study checks if a substance called HMGB1 in your blood is linked to nerve damage and liver side effects from the chemotherapy drug oxaliplatin. It is for people with a specific type of stomach or pancreas cancer that can be surgically removed.
Clermont-FerrandAges 18 years+ - NCT06648083Recruiting
How very premature babies learn to eat by mouth
This study looks at how very premature babies (born at 28 weeks or earlier) learn to eat by mouth and whether they develop any feeding or mouth problems later. Researchers will review medical records from past years to see what helped or hindered their progress.
LyonAges Up to 6 months - NCT05744219RecruitingPhase 3
Iron after major abdominal surgery to improve recovery
This Phase 3 study tests whether giving iron (as ferric carboxymaltose) after complex major surgery can improve recovery by helping your body rebuild blood and oxygen levels after blood loss. It may help patients who are having certain types of aortic, liver, or pancreas operations.
Uppsala, SverigeAges 18 years+ - NCT06648551Recruiting
Nutrition screening tool for inflammatory bowel disease
This study checks if a simple nutrition test can accurately identify malnutrition in people with ulcerative colitis. It may help doctors better monitor your nutritional health.
Mexico City, CuauhtemocAges 18–80 - NCT05784311RecruitingPhase 4
Longer vs shorter antibiotic prevention after pancreatoduodenectomy
This trial compares a standard length of preventive antibiotics versus a longer course after Whipple surgery to see if it lowers infection risk without causing extra side effects. It targets people considered higher risk for contamination of bile during surgery.
Leiden, South HollandAges 18–90 - NCT06207656RecruitingPhase 2
Targeted therapy for BRAF V600E mutated colorectal cancer
This trial tests if combining three targeted drugs (cetuximab, encorafenib, and binimetinib) before surgery can shrink or control cancer in people with a specific BRAF V600E mutation and a stable (MSS) tumor. It focuses on colorectal cancer that is either already able to be removed or could become removable with treatment.
MadridAges 18 years+ - NCT06650332RecruitingPhase 1/Phase 2
Cadonilimab combo for first-line HER2-positive gastric cancer
This trial tests a new combination treatment (cadonilimab plus chemotherapy) as the first therapy for people with advanced gastric or gastroesophageal junction cancer that has a certain amount of HER2 protein. It aims to see if this combination can shrink tumors and help people live longer.
Hangzhou, ZhejiangAges 18–75 - NCT06650683Recruiting
Nursing support for parents of babies with Hirschsprung disease
This trial is for parents of babies with Hirschsprung disease who need daily nursing care before surgery. It studies whether extra nursing support can help reduce parents' stress while taking care of their baby at home.
MarseilleAges Any age - NCT07692165RecruitingPhase 1/Phase 2
Testing INT-210 capsules for active ulcerative colitis
This trial tests an experimental capsule called INT-210 for people with active ulcerative colitis (UC) who haven't improved enough with standard treatments. It aims to see if the drug can help control symptoms and improve the condition.
Guangzhou, GuangdongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.