Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07707609Recruiting
Pain and brain changes in chronic pancreatitis
This study looks at how chronic pancreatitis pain affects the nervous system and mental health. It aims to understand pain better and may help develop new ways to manage it.
Hyderabad, TelanganaAges 18–60 - NCT07710352Recruiting
Comparing gas pressure settings for robotic surgery
This study compares two different gas pressure levels used during robotic surgery to see if one is better for patients. If you are having robotic surgery, it may help doctors improve safety and recovery.
New York, New YorkAges 18 years+ - NCT07707258Recruiting
Remimazolam with oliceridine for sedation in older adults during GI endoscopy
This trial tests two medicines, remimazolam (a sedative) and oliceridine (a pain reliever), to see if they work well together for sedation during a painless gastrointestinal (GI) endoscopy in people aged 65 to 80. It aims to find a safe and effective option for older adults.
Shanghai, Shanghai MunicipalityAges 65–80 - NCT07713433Recruiting
Antibiotics versus none for pediatric colorectal surgery
This trial tests whether giving oral antibiotics before surgery is better than giving no antibiotics for children who are having their colostomy closed or a pull-through procedure. It aims to reduce infections and improve recovery in children with conditions like anorectal malformation or Hirschsprung's disease.
Lahore, Punjab ProvinceAges 1–15 - NCT07714499Recruiting
Energy use in healthy people vs. those with intestinal failure
This study looks at how the body uses energy (calories) in people with intestinal failure compared to healthy controls. The results may help improve nutritional care.
LjubljanaAges 18–65 - NCT07714850Recruiting
Endoscopy in acute pancreatitis study
This study looks at whether an upper endoscopy (a camera test to look inside your stomach and the first part of your small intestine) done within 24-48 hours of being admitted to the hospital can help guide treatment for acute pancreatitis. You may be able to join if you are an adult with a confirmed case of acute pancreatitis and are able to safely undergo this procedure.
KielceAges 18 years+ - NCT07709702Recruiting
Enhanced recovery after surgery for children with bile duct issues
This trial tests an enhanced recovery program (ERAS) to help children heal faster after surgery for two bile duct conditions: choledochal cyst and biliary atresia. The program includes steps to improve recovery, like better pain control and early eating.
Lahore, Punjab ProvinceAges 1 month–14 years - NCT07710287Recruiting
Using a protein test to measure inflammation in IBD
This study looks at a protein called claudin 2 in tissue samples from people with inflammatory bowel disease (IBD). The goal is to see if it can help doctors tell whether inflammation is active or inactive. This could lead to a more accurate way to check disease activity.
San Donato Milanese, MiAges 18 years+ - NCT07708220Recruiting
Laparoscopic treatment for acid reflux in children
This trial tests a minimally invasive surgery to treat gastroesophageal reflux disease (GERD) in children. It aims to reduce symptoms and improve quality of life for kids who have not had prior reflux surgery.
TantaAges 2–18 - NCT07714278Enrolling by invitation
Video-based rehab for chemotherapy nerve damage
This study tests a personalized rehab program using video analysis to help people with chemotherapy-induced nerve damage (numbness, tingling, weakness) improve their walking and daily life.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT07707011Enrolling by invitation
Comparing two test-guided treatments for acid reflux
This trial compares two ways to choose the best treatment for people with frequent acid reflux. It tests whether using a simple test (called PCAB-guided) is as good as a more detailed test (called physiologic test-guided) for deciding on the right medicine. The goal is to find a more practical and effective approach.
Bangkok Noi, BangkokAges 18–70 - NCT06642883Recruiting
A supplement for gut health in ulcerative colitis remission
This study tests a supplement called ProLife 10 FORTE to see if it affects the natural balance of gut bacteria in people with ulcerative colitis (UC) that is in remission. If you have UC that is not active and you meet other health criteria, you may be able to join.
Padua, PaduaAges 18–75 - NCT04183712RecruitingPhase 2
Targeted drug treatment after gallbladder surgery using blood test monitoring
This Phase 2 trial tests a targeted treatment (GEMOX) given after gallbladder cancer surgery. It uses a blood test that looks for cancer-related DNA to monitor recurrence and guide care, aiming to improve outcomes for people with higher-risk disease.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05197387Recruiting
Study of pregnancy cholestasis and placental inflammation
This study looks at whether a pregnancy liver condition called intrahepatic cholestasis of pregnancy is linked with chronic inflammation in the placenta. It may help doctors better understand risks and what to monitor during pregnancy.
AngersAges 18–60 - NCT05882370RecruitingPhase 2
Immunotherapy plus TIPS for liver cancer with blocked portal vein
This study tests whether adding the immunotherapy drug cadonilimab (and a related treatment plan) plus TIPS can help people with advanced liver cancer that has a tumor clot causing portal vein pressure problems. It aims to improve disease control while managing the circulation pressure in the liver.
Guangzhou, GuangdongAges 18–75 - NCT06275958RecruitingPhase 3
Lower starting chemo dose for older adults with metastatic colorectal cancer
This study tests whether starting with a lower dose of chemotherapy works as well as the standard dose for people aged 70 and older with metastatic colorectal cancer. The goal is to find a treatment that is effective but gentler, with fewer side effects.
's-HertogenboschAges 70 years+ - NCT06643325Recruiting
Gastric emptying after traumatic injuries
This study looks at how quickly the stomach empties after a traumatic injury. It may help doctors understand digestion in injured patients.
WinterthurAges 18 years+ - NCT06633133Recruiting
Virtual ileostomy vs. diverting ileostomy for rectal cancer surgery
This trial compares a virtual ileostomy (a system that monitors leaks without creating a temporary opening) to a traditional diverting ileostomy (a temporary bag) in people having rectal cancer surgery. The goal is to see if the virtual method is safer and avoids a second surgery.
ChongqingAges 18 years+ - NCT02246634Recruiting
MRI screening to find liver metastases in bowel cancer
This study checks whether a special MRI scan (DW-MRI) can spot liver metastases early in people with high-risk colorectal cancer. Finding metastases sooner may help doctors choose the right treatment path.
Macclesfield, CheshireAges 16 years+ - NCT02222844Recruiting
MRI checks for treatment planning in sigmoid colon cancer
This study uses MRI scans to better plan “curative” treatment (aimed at cure) for sigmoid colon cancer before surgery. It is for people who may still be deciding on the radical (major, curative) treatment plan and who can safely have an MRI.
Huntingdon, CambridgeshireAges 16 years+ - NCT02579278Recruiting
Tests blood DNA and scans in early colon cancer surgery
This study looks at a blood test that detects cancer DNA (ctDNA) and compares it with CT scan findings before surgery. It may help doctors understand how aggressive the cancer is and how scan features relate to blood test results.
Margate, KentAges 16 years+ - NCT03303547Recruiting
Matching scans and biopsy results in colon and rectal cancer
This study looks at how well cancer found on scans matches the actual cancer seen under the microscope after surgery. It may help improve how doctors plan treatment for colon, sigmoid, or rectal adenocarcinoma.
London, SurreyAges 16 years+ - NCT02704520Recruiting
MRI scoring test for rectal cancer response to treatment
This study looks at how an MRI “score” (mrTRG) matches how well locally advanced rectal cancer shrinks after pre-surgery chemotherapy and radiation. The goal is to use MRI results to better predict treatment response and guide care.
Aberdeen, AberdeenshireAges 16 years+ - NCT04547166RecruitingPhase 2/Phase 3
New targeted immune drug plus bevacizumab and chemo for colon cancer
This trial studies serplulimab (an immune-related drug) together with bevacizumab and chemotherapy to treat metastatic colorectal (colon) cancer that cannot be removed with surgery. It aims to see whether this combination improves outcomes and is safe.
Guangzhou, GuangdongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.