Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06346093Recruiting
Fecal transplant for advanced stomach cancer
This trial tests whether a fecal transplant (a stool donation from a healthy person) can help patients with advanced stomach cancer respond better to treatment. If you qualify, you would receive the transplant through a colonoscopy, possibly along with other standard therapies.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07420231Recruiting
Prebiotic and Postbiotic for Digestive Comfort
This trial tests whether taking a prebiotic and a postbiotic together can help reduce intestinal discomfort such as bloating, gas, or stomach pain. If you have ongoing mild to moderate digestive symptoms, this study may offer a new approach to feeling better.
Louvain-la-Neuve, Brabant WallonAges 18–75 - NCT07378839Recruiting
Alternate nostril breathing for early pregnancy nausea
This study tests if a simple breathing technique can help reduce nausea and vomiting during early pregnancy. You would practice alternate nostril breathing daily and track your symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT07492693RecruitingPhase 2
Preventing low platelets from chemo in GI cancers
This trial tests if hetrombopag can prevent low platelet counts caused by chemotherapy in people with gastrointestinal cancers. It may help reduce the risk of bleeding and the need for platelet transfusions.
ShanghaiAges 18 years+ - NCT06930157RecruitingPhase 4
Shenling Baishu Granule to prevent low-risk colon polyp return
This study tests if a Chinese herbal medicine (Shenling Baishu Granule) can help prevent low-risk colon polyps from coming back after they've been removed. It is for people who have had a good colonoscopy and had their polyps taken out within the last 3 months.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05934331RecruitingPhase 2
Study for CLDN18.2-positive advanced gut cancers after first treatment
This Phase 2 trial tests a combination anti-cancer medicine (LM-302) plus other anti-tumor treatments for advanced gastrointestinal cancers. It’s designed for people whose tumors test positive for CLDN18.2 and who have already tried standard first-line treatment but didn’t respond or couldn’t tolerate it.
ShanghaiAges 18–80 - NCT05773274RecruitingPhase 2
Retreating with 177Lu-DOTATATE radiation versus usual treatment
This trial tests whether repeating a targeted radioactive treatment (177Lu-DOTATATE) works better than standard options in people with metastatic gastroenteropancreatic neuroendocrine tumors. It may help by controlling tumor growth after the first round of this therapy stops working.
Birmingham, AlabamaAges 18 years+ - NCT07520734Recruiting
Laser Treatment for Internal Hemorrhoids: Treatment Outcomes
This study tracks how well laser treatment works for people with symptomatic internal hemorrhoids (swollen blood vessels in the lower rectum that cause bleeding, itching, or pain). You would undergo the laser procedure and be followed to see how your symptoms improve.
Sanliurfa, ŞanlıurfaAges 18 years+ - NCT04989985RecruitingPhase 2
SOX chemotherapy plus immunotherapy for junction stomach-esophagus cancer
This trial studies whether adding an immunotherapy drug (sintilimab) to standard chemotherapy (S-1 and oxaliplatin) can better treat locally advanced cancer at the junction of the esophagus and stomach. It may help shrink the tumor and control the cancer before or around surgery.
Guangzhou, GuangdongAges 18–75 - NCT06972199Recruiting
Foot massage or warm water bath for pain after colon cancer surgery
This trial tests whether a foot massage or a warm water foot bath can help reduce pain and improve recovery after laparoscopic surgery for colon cancer.
Istanbul, IstanbulAges 18 years+ - NCT07005752RecruitingPhase 4
CnU capsule for cholesterol gallstones
This trial tests if CnU capsules shrink cholesterol gallstones in people who have stones smaller than 15 millimeters. It aims to help people dissolve stones without surgery.
Ansan, Gyeonggi-doAges 19 years+ - NCT06908382RecruitingPhase 2
Neoadjuvant QL1706 therapy for esophageal cancer before surgery
This trial tests a new immunotherapy drug, QL1706, given before surgery for esophageal squamous cell cancer. The goal is to see if it helps shrink tumors and improve outcomes for patients who are healthy enough for the treatment.
Jinan, ShandongAges 18–75 - NCT07452744Enrolling by invitation
Picroliv for non-alcoholic fatty liver disease
This study tests a plant-based medicine called Picroliv for people with non-alcoholic fatty liver disease (NAFLD). It aims to see if it is safe and can reduce fat in the liver.
Chandigarh, ChandigarhAges 18–60 - NCT05667987Recruiting
Lidocaine to help prevent pancreas inflammation after ERCP
This study tests whether giving lidocaine during an ERCP procedure can lower the risk of a painful complication called pancreatitis. If you’re scheduled for ERCP with a “never-treated” opening, this trial may see if lidocaine helps you avoid post-procedure pancreas inflammation.
ParisAges 18 years+ - NCT07218523RecruitingPhase 3
Bowel cleansing study for children having a colonoscopy
This study tests a bowel-cleansing medicine called PLENVU against another medicine (sodium picosulfate) in children aged 1 to under 18 who need a colonoscopy. The goal is to see which one works better at cleaning the bowel before the procedure.
Edegem, AntwerpAges 1–17 - NCT07365436Enrolling by invitation
Better colon imaging with a new probe
This trial tests a new camera probe that works with a standard colonoscope to take better images of the colon. It may help doctors find polyps or other issues more clearly during a routine colonoscopy.
Boston, MassachusettsAges 45–75 - NCT06914804Enrolling by invitation
Stomasense: New leak detection for ileostomy pouches
This trial tests a new device called Stomasense that aims to detect and manage leaks from an ileostomy pouch earlier. It's for people who have had their ileostomy for at least 18 months and experience frequent leaks (more than once a week).
Coleraine, Co. DerryAges 18 years+ - NCT06967272RecruitingPhase 2
Oral rotavirus vaccine trial for healthy infants
This trial tests an oral vaccine given as drops to protect babies against rotavirus, a common cause of severe diarrhea. It is for healthy infants aged 6 to 12 weeks who have not had the rotavirus vaccine or infection before.
Wuhan, HubeiAges 1 month–3 months - NCT05671822RecruitingPhase 2
Study of targeted drugs for HER2-positive advanced stomach cancer
This Phase 2 trial tests whether SHR-A1811—given with other medicines—works safely and effectively for people with advanced stomach or gastroesophageal junction cancer that has high HER2. It may help shrink tumors or slow cancer growth, especially if previous treatment didn’t work.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07361614Recruiting
Colorectal cancer education program
This study tests a program to help people learn about colorectal cancer screening. If you are 45 to 75 and due for screening, you may be able to join.
New York, New YorkAges 45–75 - NCT06557629Recruiting
Gastric sonar vs aspiration for feeding tube placement in ICU
This trial tests whether using a special ultrasound device (gastric sonar) to check stomach contents is as good as the standard method of suctioning stomach fluid to make sure feeding tubes are in the right place in critically ill patients.
Kfar SabaAges 18–99 - NCT07359443RecruitingPhase 1
Chemo plus MRI-guided radiation before esophageal cancer surgery
This trial tests combining chemotherapy (FLOT) with a special type of MRI-guided radiation before surgery for esophageal adenocarcinoma. It aims to improve treatment results for patients with a specific type and stage of the disease.
Utrecht, UtrechtAges 18 years+ - NCT04908566RecruitingPhase 2
PD-1 immunotherapy plus chemotherapy before and after gastric surgery
This trial studies whether adding a PD-1 immune therapy to chemotherapy around the time of surgery can improve outcomes for people with locally advanced stomach or stomach–esophagus junction cancer. It aims to better control the cancer before and reduce the chance it comes back after surgery.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07427680RecruitingPhase 1/Phase 2
Study of TGM-312-SC01 for MASH patients
This trial tests a new drug called TGM-312-SC01 to see if it can help people with MASH (a type of fatty liver disease that causes inflammation and damage). It is for adults aged 18 to 70 who are otherwise healthy or have MASH.
LondonAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.