Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07608120Recruiting
Electrolyte drink with bowel cleansing solution for colonoscopy prep
This study tests whether combining an electrolyte beverage (a drink with salts and minerals) with polyethylene glycol—a standard bowel-cleaning solution—helps prepare your colon better for colonoscopy. The goal is to see if this combination makes the preparation easier to tolerate while still cleaning your bowel effectively.
Guangzhou, GuangdongAges 18–75 - NCT07607158Recruiting
How Blueberries Work in Your Body
This study explores how your gut bacteria (the healthy microbes in your digestive system) affect how your body processes beneficial compounds in blueberries. Researchers want to understand this natural process by studying healthy adults.
Fort Collins, ColoradoAges 18 years+ - NCT07609641Recruiting
Surgery for Bile Duct Cancer: Two Surgical Approaches
This trial compares two different surgical approaches for treating bile duct cancer (cholangiocarcinoma) to see which method works better and is safer. You would undergo surgery and have your recovery and outcomes closely monitored.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07607873Recruiting
Transplant vs surgery after chemo for liver-only colorectal cancer
This trial compares liver transplant versus liver surgery for people whose colorectal cancer has spread only to the liver and cannot be removed initially. You would first receive chemotherapy to shrink the tumors, and if they become removable, you may be randomly assigned to have a liver transplant or standard liver surgery.
MilanAges 18 years+ - NCT07604909RecruitingPhase 2
Serplulimab plus chemotherapy for early-relapsed colorectal cancer
This trial tests a new immunotherapy drug called serplulimab combined with standard chemotherapy or targeted therapy for colorectal cancer that has come back within a year after surgery. The goal is to see if adding this immune-boosting drug helps control the cancer better than chemotherapy alone.
ShanghaiAges 18 years+ - NCT06711471RecruitingPhase 2
Combination therapy for advanced stomach cancer after prior treatments
This trial tests a combination of three drugs — trifluridine/tipiracil (a chemotherapy pill), bevacizumab (avastin, a targeted therapy), and camrelizumab (an immunotherapy) — as a later treatment option for people with advanced stomach cancer who have already tried other therapies. It may help patients whose cancer has not responded to previous treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06711211Recruiting
Digestive cancer registry study
This study collects information from patients with different types of digestive cancers to better understand these diseases and improve future care. It does not test a new treatment, but helps doctors learn more about digestive cancers over time.
Madrid, MadridAges 18 years+ - NCT06042127Recruiting
Achalasia POEM study for adults types I–II
This study tests a procedure called POEM-F for achalasia types I–II or III. It may help people who haven't had treatment or who've had balloon dilation before.
Baltimore, MarylandAges 18–65 - NCT04502719Recruiting
Testing nutrition screening in people with liver cirrhosis
This study compares different ways of checking nutrition problems in people with liver cirrhosis. It may help doctors choose the best screening tool to spot risk earlier and guide care.
Barcelona, CataloniaAges 18–100 - NCT06212921Recruiting
Biomarkers to predict acute mesenteric ischemia
This trial is looking for biomarkers (clues in your blood) that can help doctors predict acute mesenteric ischemia, a condition where blood flow to your gut is suddenly blocked. It may help find better ways to diagnose this serious condition early.
TartuAges 18 years+ - NCT06609850Recruiting
Comparing TACE plus lenvatinib with or without ablation for recurrent liver cancer
This trial compares two treatments for people whose liver cancer has come back (recurrent intermediate-stage hepatocellular carcinoma). One group gets TACE plus lenvatinib (a targeted therapy), the other gets TACE plus lenvatinib plus ablation (a procedure that destroys tumors with heat or cold). The goal is to see which combination works better.
Beijing, None SelectedAges 18–75 - NCT06298188Recruiting
Studying risankizumab in children with Crohn's disease
This study follows children with Crohn's disease who have already started taking risankizumab. It aims to see how well the treatment works in real-world use.
JerusalemAges 6–18 - NCT06609876Recruiting
Donafenib after ablation for recurrent liver cancer
This trial tests whether taking the drug donafenib after a procedure called ablation (which destroys liver tumors) can help keep your liver cancer from returning. It is for people whose liver cancer has come back within the past year and who have small, treatable tumors.
Beijing, None SelectedAges 18–75 - NCT06609863Recruiting
Triple therapy for large liver cancer tumors
This trial tests combining a special type of chemo delivered directly to the liver (dTACE-HAIC) with two immunotherapy drugs (bevacizumab and atezolizumab) for people with huge liver cancer tumors (10 cm or larger). The goal is to see if this combination can shrink tumors and improve outcomes.
Beijing, None SelectedAges 18–75 - NCT06709209Recruiting
AI tool for grading colitis during colonoscopy
This study uses a special AI system that analyzes images from a colonoscopy to help doctors better understand how active your ulcerative colitis is and predict how it might progress. If you are scheduled for a routine colonoscopy, this AI tool may help your doctor make more precise treatment decisions.
LeuvenAges 18–75 - NCT06714604RecruitingPhase 3
Comparing standard vs. longer chemo before pancreatic cancer surgery
This trial tests whether taking chemotherapy for a longer period before surgery can help people with borderline or locally advanced pancreatic cancer. It aims to see if a longer treatment course leads to better outcomes.
Gothenburg, VGRAges 18–90 - NCT03916809Recruiting
Voice and swallowing therapy device during head and neck cancer treatment
This trial tests whether using a mouth-based training device (called EMST150) during planned radiation (with or without chemotherapy) can help people with head and neck cancer with swallowing and related muscle function. It may be useful if you’re starting radiation for a cancer in the mouth, throat, or voice box area.
Milwaukee, WisconsinAges 18 years+ - NCT04971577RecruitingPhase 2/Phase 3
Simvastatin for alcohol-related liver scarring in stable adults
This trial studies whether simvastatin (a cholesterol medicine) can improve or slow scarring of the liver caused by long-term alcohol use. Participants must have confirmed liver fibrosis on biopsy and be in a stable (compensated) phase of liver disease.
BarcelonaAges 18 years+ - NCT05165706Recruiting
Study of how obesity affects insulin resistance over time
This study follows adults over time to understand how weight and body chemistry relate to insulin resistance. It may help researchers learn why insulin resistance happens and what could prevent or improve it.
Stanford, CaliforniaAges 35–65 - NCT05916040Recruiting
MRI-guided treatment for locally advanced rectal cancer
This trial studies a total “before-surgery” treatment plan for locally advanced rectal cancer, using MRI (a detailed scan) to help guide radiation. It may help patients by aiming to shrink the tumor and improve the chance of successful surgery.
Jette, Brussels CapitalAges 18 years+ - NCT06614036RecruitingPhase 4
Remimazolam vs. Midazolam for sedation during upper GI endoscopy
This study compares two different sedative medicines, remimazolam and midazolam, to see which works better for people having a routine upper GI endoscopy (a camera test to look at your stomach and esophagus). If you are scheduled for this procedure and need sedation, you may be able to join.
Apeldoorn, GelderlandAges 18 years+ - NCT07603336Recruiting
Heart Monitoring Methods During Pancreas Surgery
This study compares two ways of monitoring your heart function during Whipple surgery (pancreas removal). Doctors will use different monitoring approaches to guide fluid and medication during your operation to help you recover better.
Çankaya, AnkaraAges 18–80 - NCT07602504Recruiting
Metastatic Liver Cancer Patient Registry Study
This study collects health information from patients with cancer that has spread to the liver. Researchers will track your medical history and outcomes to better understand how metastatic liver cancer develops and progresses.
Bengbu, AnhuiAges 18–80 - NCT06694012Recruiting
Ohtori Study Part 2 heart health
This study looks at heart and metabolic health in the general population. It helps researchers understand how to prevent conditions like diabetes and heart disease.
Sakai, OsakaAges 20 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.