Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06316245Recruiting
Recovery after major gastrointestinal surgery
This study looks at how well you recover after major or intermediate surgery on your stomach, intestines, colon, or rectum. It measures your ability to do daily activities and how many days you spend at home (instead of the hospital) in the first 30 days after surgery.
Istanbul, FatihAges 18 years+ - NCT06538610Recruiting
Portable heart monitor for people on FOLFOX chemo
This study will use a small portable heart monitor (Holter) to track your heart rhythm while you receive FOLFOX chemotherapy. The goal is to learn more about how the chemotherapy drug 5-FU affects the heart.
AucklandAges 18 years+ - NCT06954675Recruiting
Ketone drink study: how it affects gut bacteria in healthy adults
This study tests how a ketone ester drink changes the bacteria in your gut. You'll drink the supplement and fill out questionnaires online. It's for healthy adults who want to help researchers understand gut health.
San Francisco, CaliforniaAges 18–40 - NCT06514300Enrolling by invitation
Study of muscle fat in fatty liver disease
This study looks at how fat in the muscles may affect liver disease in people with fatty liver and related conditions like obesity or diabetes. It aims to better understand the connection between muscle fat and liver health.
BrusselsAges 18–75 - NCT06529159Recruiting
Treating H. pylori with argon plasma during endoscopy
This trial tests a new way to treat H. pylori infection using argon plasma (a kind of energy) during an upper endoscopy. It may help people who haven't yet taken antibiotics for H. pylori and are already having an endoscopy.
Boston, MassachusettsAges 18 years+ - NCT06577415RecruitingPhase 1
Study of RAY1225 in people with reduced liver function
This study tests a new medicine called RAY1225 in people with mild or moderate liver problems compared to those with healthy livers. It helps researchers understand how the liver affects the medicine, which could lead to safer dosing.
Guangzhou, GuangdongAges 18–75 - NCT07101679RecruitingPhase 2
Study of radiation, chemo, and immunotherapy for advanced pancreatic cancer
This trial tests a combination of chemotherapy (GnP), an immunotherapy drug (serplulimab), and targeted radiation (SBRT) as a first treatment for locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this triple therapy can shrink the tumor and improve outcomes.
Chengdu, SichuanAges 18–75 - NCT02647177Recruiting
Blood and cyst fluid study for pancreatic cyst conditions
This study looks for “biomarkers,” or measurable lab signals, in blood and (when available) cyst fluid to understand pancreatic cyst problems and related conditions. It may help doctors better predict what these conditions are and how to manage them.
Houston, TexasAges 18–100 - NCT06519500Recruiting
Growing tumor models from gastrointestinal neuroendocrine tumor surgery
This study takes tumor tissue from people having surgery for a certain type of gut or pancreas cancer (neuroendocrine tumors). The tissue is used to grow tiny 3D models called organoids in the lab, which can help researchers learn more about the tumor and find better treatments.
RomeAges 18 years+ - NCT06517407Recruiting
Comparing two stoma placement methods to reduce complications
This trial is comparing two ways to place a stoma (a new opening for waste) during abdominal surgery, to see which method leads to fewer problems like leaking or skin issues.
AsyutAges Any age - NCT06514911Recruiting
Laparoscopic surgery for common bile duct stones
This study tests a keyhole surgery technique to remove stones from the common bile duct (the tube that carries bile from the liver to the intestine). It may help people who have stones that need to be removed and are healthy enough for surgery.
SohagAges Any age - NCT07313007Recruiting
Gut bacteria chemicals in fatty liver disease
This study looks at whether the natural chemicals made by your gut bacteria from the food you eat could affect liver fat and health. If you have MASLD (a fatty liver condition), researchers want to measure these gut-produced substances to better understand the disease.
Pierre-BéniteAges 18–80 - NCT06512428RecruitingPhase 2
Simmitinib plus irinotecan for advanced esophageal cancer
This trial tests a new combination of two drugs—simmitinib (a targeted therapy) and irinotecan (a chemotherapy)—for people with advanced esophageal cancer that has stopped responding to one prior treatment. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Heilongjiang, HarbinAges 18–70 - NCT06507527Recruiting
Frailty in older adults having outpatient digestive endoscopy
This study looks at frailty in older adults (70+) who are having an outpatient digestive endoscopy. It aims to understand how frailty affects the procedure and recovery.
BarcelonaAges 70–100 - NCT02471443Recruiting
Laparoscopic surgery for severe endometriosis involving bowel
This trial studies how well a minimally invasive (laparoscopic) surgery works for people with severe endometriosis that affects the bowel. It may help improve symptoms and quality of life, and it focuses on planned surgery for this specific type of endometriosis.
Guildford, SurreyAges Any age - NCT06507410Recruiting
Clonidine with propofol for sedation during colonoscopy
This trial tests if adding clonidine to the sedative propofol makes colonoscopy more comfortable and safer. If you are having a colonoscopy and are generally healthy, this study may help improve your sedation experience.
Tanta, El-GharbiaAges 18–65 - NCT07282093RecruitingPhase 1
Olverembatinib in people with liver problems
This trial tests how a drug called olverembatinib is processed by the body in people with different levels of liver impairment. It looks at how the liver condition affects the drug levels and safety, which may help find the right dose.
Suzhou, JiangsuAges 18–75 - NCT05631964RecruitingPhase 1
Early trial of BL-M07D1 for advanced HER2-positive digestive tumors
This early-phase trial tests BL-M07D1 in people with advanced digestive tract (and other solid) cancers that can’t be removed with surgery and have already tried or can’t use standard treatment. It’s studying whether the drug works and how safe it is, and whether HER2 tumor results are linked to benefit.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06497569Recruiting
Support program for people with gastroesophageal cancer
This study offers remote nutrition guidance and support for people with gastroesophageal cancer who are starting chemotherapy or radiation. The goal is to help you stay strong and manage side effects during treatment.
Tampa, FloridaAges 18 years+ - NCT06297993Recruiting
Global study following adults with PSC
This study follows adults with primary sclerosing cholangitis (PSC) over time to learn more about the condition. It is observational, meaning no new treatments are tested—just regular checkups and data collection to better understand PSC.
Sacramento, CaliforniaAges 18–75 - NCT06959758RecruitingPhase 4
Probiotics for childhood constipation
This study tests whether a probiotic supplement (BioKid LR) can help children with functional constipation — a condition where a child has hard, infrequent bowel movements with no other medical cause. The probiotic contains nine different types of good bacteria, including L. reuteri.
AfulaAges 6 months–17 years - NCT06497777Recruiting
DNA nanomachine blood test for pancreatic cancer diagnosis
This trial uses a tiny DNA-based machine to detect tumor signals in your blood. It aims to improve how doctors diagnose pancreatic cancer, especially at an early stage.
TaipeiAges 20 years+ - NCT06496958Recruiting
Better colonoscopy with water, CO2, and a belly compression belt
This study tests a new approach to make colonoscopy easier and more comfortable by using water, carbon dioxide gas, and a soft belly compression device instead of the standard air. The goal is to help patients need less manual pushing from the doctor during the procedure.
Kaohsiung CityAges 45–80 - NCT02784119Recruiting
Temporary bypass during liver transplant to help extended-donor livers
This trial studies a temporary surgical bypass during liver transplantation to improve how well the new liver works, especially when the donor liver is “extended criteria.” It may help patients whose transplant plan includes a higher-risk donor liver by testing whether the bypass better protects the graft.
BordeauxAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.