Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07606339Recruiting
Guselkumab for moderate-to-severe Crohn's or ulcerative colitis
This study tests guselkumab, a medication that reduces inflammation in the gut, for people with moderate-to-severe Crohn's disease or ulcerative colitis who haven't previously tried certain similar biologic drugs. The goal is to see how well it works and is tolerated in real-world use.
ViennaAges 18 years+ - NCT07610798RecruitingPhase 1/Phase 2
Testing INV-8989 for Advanced Cancers With KRAS G12D Mutation
This early-stage trial tests a new drug called INV-8989 designed to target a specific genetic mutation (KRAS G12D) found in some advanced solid cancers. The study will evaluate whether the drug is safe and if it can help shrink tumors in patients who haven't responded to standard treatments.
Guangzhou, GuangdongAges 18 years+ - NCT07607769Recruiting
Tremelimumab and Durvalumab for Untreated Advanced Liver Cancer
This Italian study follows patients with advanced liver cancer (hepatocellular carcinoma) who receive a combination immunotherapy treatment called STRIDE for the first time. The trial tracks how well the treatment works, how it affects quality of life, and its safety in people with moderate to severe liver disease.
AnconaAges 18–100 - NCT05654649RecruitingPhase 1/Phase 2
Dexamethasone to prevent bowel blockage after C-section
This trial studies whether a medicine called dexamethasone can help prevent bowel “slow-down” (ileus) after a C-section done with spinal anesthesia. If you qualify, you may receive the study medicine to see if it helps you recover your bowel function faster.
AsyutAges 18–40 - NCT06112704RecruitingPhase 2
HS-20093 for advanced esophageal and other solid tumors
This trial tests an investigational drug called HS-20093 for people with advanced esophageal cancer or other solid tumors that have not responded to prior treatment. The drug targets a protein on cancer cells called B7-H3, and the study aims to see if it can shrink tumors or slow their growth.
Hefei, AnhuiAges 18 years+ - NCT05933122Recruiting
Sexual health support after rectal cancer surgery
This study looks at how common sexual difficulties are in women after rectal cancer surgery, and whether a sexologist-led support program can help. If you qualify, you may be asked about sexual well-being and take part in counseling support.
Brive-la-GaillardeAges 18 years+ - NCT06310564Recruiting
SBRT for limited metastatic colorectal cancer
This trial tests whether focused radiation (SBRT) can treat 1 to 3 metastases in people with colorectal cancer that has spread but is still low or intermediate risk. It may be an option if you are starting first or second line systemic therapy and your primary tumor is under control.
Negrar, VeronaAges 18 years+ - NCT07608653Recruiting
Minimally invasive surgery for recurrent groin hernias
This trial tests a keyhole (laparoscopic) surgical technique to repair inguinal hernias that have returned after previous surgery. The goal is to evaluate how well this approach works and what outcomes patients experience.
SohagAges Any age - NCT07605481Recruiting
Managing Dumping Syndrome After Esophageal Cancer Surgery
This study looks at dumping syndrome—a condition where food moves too quickly from your stomach after esophageal cancer surgery—and tests ways to help manage its symptoms like sweating, dizziness, and abdominal discomfort.
Seoul, Gangnam-gu Irwon-Ro 81Ages 18 years+ - NCT07608055Recruiting
Pancreas Removal and Metabolic Health in Non-Diabetic Patients
This study follows patients who are having part or all of their pancreas removed due to disease. Researchers want to understand how this surgery affects blood sugar control, weight, and overall health in people without diabetes before surgery.
RomeAges 18 years+ - NCT07607353Recruiting
Biodegradable Stents for Primary Sclerosing Cholangitis
This trial tests a new type of stent (a small tube placed in bile ducts) that dissolves on its own over time in patients with primary sclerosing cholangitis (PSC), a rare disease affecting the bile ducts. The goal is to widen narrowed ducts and reduce the need for repeated procedures.
LondonAges 18 years+ - NCT07612163Recruiting
Antibiotic levels and effectiveness in patients with liver cirrhosis
This study measures how antibiotic drugs called beta-lactams work in people with cirrhosis (liver damage). Researchers will check antibiotic blood levels to see if standard doses are right for cirrhotic patients or need adjustment.
Nanjing, JiangsuAges 18 years+ - NCT07604415Recruiting
Active vs. Passive Pelvic Floor Training for Fecal Incontinence
This study compares two types of at-home pelvic floor exercises—one where you actively squeeze your muscles and one that uses gentle stimulation—to help reduce accidental stool leakage. The goal is to find which approach works better for controlling bowel movements.
MartinAges 18 years+ - NCT07610356Recruiting
Understanding gut blood-flow problems in ICU patients
This study helps doctors better predict and understand a serious condition where the bowel doesn't get enough blood flow while patients are in the ICU. By identifying warning signs early, the research aims to improve diagnosis and treatment decisions.
Tallinn, TallinnAges 18 years+ - NCT07611266Recruiting
Predicting colorectal adenoma recurrence using combined medicine approach
This study helps predict which patients with colorectal adenomas (pre-cancerous growths) are at higher risk of them coming back or turning into cancer. Researchers will use both Western medical tests and Traditional Chinese Medicine patterns to create a prediction tool that may guide your follow-up care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07607119Recruiting
PULSAR radiation plus immunotherapy for advanced gastric cancer
This trial tests combining PULSAR (a type of radiation therapy) with immunotherapy drugs to treat gastric (stomach) cancer that cannot be surgically removed. You must have already completed at least 3 months of chemotherapy with immunotherapy and shown no cancer growth to qualify.
Seoul, Select Province/StateAges 19 years+ - NCT07611825RecruitingPhase 2
Gut Bacteria Treatment for Advanced Kidney Cancer Resistant to Immunotherapy
This study tests whether modifying your gut bacteria can help immunotherapy work again in advanced kidney cancer that has stopped responding to initial immune-checkpoint inhibitor treatment. Researchers will give you a special bacterial preparation along with a new immunotherapy drug to see if this combination can slow or shrink your cancer.
Nanjing, JiangsuAges 18–90 - NCT07610551Recruiting
Combination therapy for advanced liver cancer
This trial studies whether combining three treatments—an immunotherapy drug (Atezo), a blood-vessel-blocking drug (Bev), and a radioactive bead treatment (SIRT-Y90)—can help patients with advanced liver cancer that cannot be surgically removed. The goal is to see if using all three together works better than using fewer treatments.
Xi’an, ShanxiAges 18 years+ - NCT07612046Recruiting
MRI of the pancreas for cancer screening
This study uses MRI scans to screen for pancreas cancer in people at high risk due to family history or certain gene mutations. It aims to see if MRI can help find cancer early.
Basking Ridge, New JerseyAges 18 years+ - NCT07606547Recruiting
Swallowing Strength Training for Parkinson's Disease
This study tests whether a mouth and throat muscle-strengthening device called EMST helps people with Parkinson's disease who have difficulty swallowing. Stronger throat muscles may make swallowing safer and easier.
MünsterAges 18 years+ - NCT07607873Recruiting
Transplant vs surgery after chemo for liver-only colorectal cancer
This trial compares liver transplant versus liver surgery for people whose colorectal cancer has spread only to the liver and cannot be removed initially. You would first receive chemotherapy to shrink the tumors, and if they become removable, you may be randomly assigned to have a liver transplant or standard liver surgery.
MilanAges 18 years+ - NCT07609641Recruiting
Surgery for Bile Duct Cancer: Two Surgical Approaches
This trial compares two different surgical approaches for treating bile duct cancer (cholangiocarcinoma) to see which method works better and is safer. You would undergo surgery and have your recovery and outcomes closely monitored.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07607158Recruiting
How Blueberries Work in Your Body
This study explores how your gut bacteria (the healthy microbes in your digestive system) affect how your body processes beneficial compounds in blueberries. Researchers want to understand this natural process by studying healthy adults.
Fort Collins, ColoradoAges 18 years+ - NCT07607249Enrolling by invitation
Floating Needle Treatment for Stomach Issues After Knee Surgery
This trial tests whether a traditional Chinese acupuncture technique called 'floating needle' can help with stomach and bowel problems that sometimes happen after knee surgery under general anesthesia. You would receive this treatment along with standard post-surgery care to see if it reduces nausea, constipation, or other digestive issues.
Guangzhou, GuangdongAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.