Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06610799RecruitingPhase 1
Study of IBI363 for first-line advanced gastric cancer
This trial tests a new drug called IBI363 in patients with advanced gastric or gastroesophageal junction cancer who have not yet received any treatment. The goal is to see if the drug can help shrink tumors or slow the cancer's growth.
Hangzhou, ZhejiangAges 18–75 - NCT06609980RecruitingPhase 1
Fecal transplant to restore gut health in infants
This study tests whether giving a baby’s own stool back to them (after it was stored before antibiotics) can help restore healthy gut bacteria. It’s for healthy infants and toddlers up to 4 years old who haven’t recently taken antibiotics.
New Brunswick, New JerseyAges 1 month–4 years - NCT06604572Recruiting
TAPP vs open repair for repeat groin hernia
This study compares two surgical methods — TAPP (a laparoscopic, or keyhole, surgery) and open repair — to fix a hernia in the groin that has come back after a previous surgery. The goal is to see which technique works better for this type of repeat hernia.
Kunming, YunnanAges 18–80 - NCT06601829Recruiting
Liver and kidney disease study in children
This study looks at children with congenital hepatic fibrosis and autosomal recessive polycystic kidney disease. It aims to learn more about these conditions and how they affect children.
SohagAges Any age - NCT06685289RecruitingPhase 2
Donafenib and capecitabine after surgery for biliary cancer with high risk of return
This trial tests whether taking donafenib and capecitabine pills after surgery can help prevent biliary cancer from coming back in people who have a high risk of recurrence. It is for patients whose cancer was completely removed but had certain features that make recurrence more likely.
Nanjing, JiangsuAges 18–75 - NCT07384234RecruitingPhase 2
Testing a new drug plus chemo for stomach cancer with belly spread
This trial tests a new immunotherapy drug (SHR-1701) combined with chemotherapy for people with stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen (peritoneal metastasis) but not to other organs like the liver or lungs. The goal is to see if this combination can help shrink or control the cancer before any surgery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06023758RecruitingPhase 2
Study of two drugs with or without chemo for HER2-positive stomach cancer
This study tests two new immunotherapy drugs (KN026 and KN046) with or without chemotherapy (XELOX) for people with a specific type of advanced stomach cancer that makes too much HER2 protein. The goal is to see if this combination can shrink tumors or slow the cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT07736963Recruiting
Stopping GLP-1 drugs before colonoscopy: a trial in Taiwan
This study looks at whether stopping GLP-1 receptor agonists (a type of diabetes or weight-loss medication) before a colonoscopy can help improve the procedure. It compares how well the bowel is cleaned in people who stop these drugs for a certain time versus those who continue them.
New Taipei, TaiwanAges 18–90 - NCT07405125Recruiting
Robotic surgery for stomach tumors in tricky spots
This trial tests the safety of using a robot to remove small stomach tumors (GISTs) that are in hard-to-reach places. It aims to see if robotic surgery is a good option for you.
Nanjing, JiangsuAges 18–75 - NCT05969171RecruitingPhase 2
Surufatinib plus chemotherapy for advanced pancreatic cancer
This Phase 2 study tests whether adding surufatinib to first-line treatment (either AG or a similar AG-based regimen) can improve outcomes for people with locally advanced or metastatic pancreatic cancer. You may be considered if your cancer cannot be removed by surgery and you’ve already had a short course of similar treatment with a response.
ShanghaiAges 18–75 - NCT06595628Recruiting
Comparing two hernia repair methods in men
This trial compares two ways to repair an inguinal hernia (a bulge in the groin). The goal is to see which technique works better and has fewer problems.
CairoAges 18 years+ - NCT06595537Recruiting
Ultrasound check for feeding tube placement
This study uses an ultrasound of the stomach to see if a feeding tube is in the right place. It's for people who are on a breathing tube and need a stomach feeding tube.
Leiden, South HollandAges 18 years+ - NCT06595108Recruiting
Targeted therapy and radiation for advanced liver cancer
This trial tests a combination of immunotherapy (atezolizumab), targeted therapy (bevacizumab), and targeted radiation for advanced liver cancer that cannot be surgically removed. The goal is to see if this approach helps control the cancer.
Yongin-siAges 19–80 - NCT07736911RecruitingPhase 3
Should you pause your diabetes medication before a stomach scope?
This trial is testing whether stopping GLP-1 receptor agonists or tirzepatide one week before an upper endoscopy (a scope that looks at your stomach and esophagus) is safe and effective. It's designed for people who are already taking these medications and have an upcoming procedure.
New Taipei City, TaiwanAges 18–90 - NCT05472259RecruitingPhase 2
Testing two chemotherapy combos for metastatic pancreatic cancer
This Phase 2 study compares two chemotherapy combinations to treat metastatic pancreatic cancer that has progressed after gemcitabine (with or without Abraxane). It aims to see which combination works better and is tolerable for people with measurable disease.
Antwerp, AntwerpAges 18 years+ - NCT05978050RecruitingPhase 3
Nimotuzumab plus paclitaxel for recurring stomach cancer
This Phase 3 trial tests whether adding nimotuzumab (an anti-EGFR antibody) to paclitaxel can improve outcomes for people with stomach or stomach-junction cancer that has returned and spread. It targets tumors with high EGFR (“EGFR high” on a pathology test) to see if this combination works better than standard treatment.
Guangzhou, GuangdongAges 18–75 - NCT06583577Recruiting
Ostomy simulation education for urologic surgery patients
This study tests a hands-on simulation to help you learn about living with an ostomy before your surgery. It aims to make you more confident and prepared for your recovery.
Minneapolis, MinnesotaAges 18 years+ - NCT07658716Recruiting
Colonoscopy surveillance recommendation study
This study tests a tool to help doctors make better recommendations for colonoscopy follow-up. It may improve how often patients get the right screening.
New York, New YorkAges 18 years+ - NCT06566872Recruiting
Collecting endoscopy videos to test a computer tool
This trial records videos of routine colonoscopy and gastroscopy procedures to help test a new computer system (ME-APDS) that may assist doctors in detecting polyps or other findings. It is for adults already scheduled for these exams.
Be’er Ya‘aqovAges 18 years+ - NCT06562179Recruiting
Robotic surgery for stomach, pancreas, liver, bile duct, and esophagus conditions
This study is testing a new robotic system for several types of abdominal surgeries. Depending on your diagnosis, you may qualify for a specific part of this trial that looks at how well this robot can help with your operation.
Tampa, FloridaAges 18–80 - NCT06561698RecruitingPhase 4
High-dose dual therapy vs minocycline quadruple therapy for H. pylori
This trial compares two treatments for H. pylori infection: a high-dose two-drug regimen and a four-drug regimen containing minocycline. It aims to find which is more effective and better tolerated.
Hebi, HenanAges 18–70 - NCT07730229Recruiting
Plant-based drink study for healthy adults
This trial looks at how plant-based drinks affect the bacteria in your gut. You would drink a plant-based beverage daily and provide stool samples to see how your gut microbiome changes.
Lund, Skåne CountyAges 18–65 - NCT06544915Recruiting
Synbiotic vs. probiotic for heart and gut health
This study tests whether a synbiotic (a combination of probiotics and prebiotics) is better than a probiotic alone or a placebo for improving gut health and heart health. If you are a healthy adult who hasn't taken antibiotics recently and has few heart disease risk factors, you may be able to join.
Saratoga Springs, New YorkAges 18–60 - NCT05144152Recruiting
Testing M3 and FIT to predict polyp return in colon exams
This study checks how well two lab tests (M3 and FIT) can predict whether advanced colon polyps (adenomas) will come back. If you’ve had adenomas found on a prior colonoscopy, these results may help plan future surveillance.
Shatin, New TerritoriesAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.