Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT06927011Recruiting
Loose stools after colon cancer surgery: a study
This study looks at why some people have chronic loose stools after right-sided colon cancer surgery, possibly due to bile acid problems or bacterial overgrowth. It uses a new device to sample the small intestine.
Houston, TexasAges 20–85 - NCT07283770RecruitingPhase 1
Safety study of VX-581 in healthy people
This trial tests the safety of a new medicine called VX-581. It is given to healthy volunteers to see how the body processes the drug and if it causes any side effects.
Overland Park, KansasAges 18–55 - NCT06840977Recruiting
Low dose chemo for older adults with colorectal cancer
This trial tests a lower-dose chemotherapy regimen for adults aged 70 or older with metastatic colorectal cancer that has not been treated yet. It aims to see if a gentler approach can still be effective and easier to tolerate.
Genova, GEAges 70–99 - NCT07707011Enrolling by invitation
Comparing two test-guided treatments for acid reflux
This trial compares two ways to choose the best treatment for people with frequent acid reflux. It tests whether using a simple test (called PCAB-guided) is as good as a more detailed test (called physiologic test-guided) for deciding on the right medicine. The goal is to find a more practical and effective approach.
Bangkok Noi, BangkokAges 18–70 - NCT06388967Recruiting
Pancreatic cancer detection study
This study is looking at blood or tissue samples from people with pancreatic cancer and from those without it. The goal is to find ways to detect the cancer earlier.
Phoenix, ArizonaAges 18 years+ - NCT06948448RecruitingPhase 2
New treatment for advanced colorectal cancer with PD-L1 biomarker
This trial tests a new drug (ONO-4578) combined with standard chemotherapy and immunotherapy for people with advanced colorectal cancer that has not been treated before and has a specific marker called PD-L1. The goal is to see if this combination works better than the usual treatment.
Phoenix, ArizonaAges 18 years+ - NCT07224113Recruiting
Reducing ultra-processed foods in teens with IBD
This study looks at whether a simple educational program can help teens with IBD eat less ultra-processed foods (like fast food and sugary snacks). Participants will learn about healthier food choices during their regular infusion visits.
Hartford, ConnecticutAges 10–21 - NCT07704047RecruitingPhase 2
Study of FT1 for short bowel syndrome
This study tests a new treatment called FT1 for people with short bowel syndrome. It aims to help you absorb more nutrients and fluids from food, potentially reducing the need for IV nutrition.
Nanjing, JiangsuAges 18 years+ - NCT07704177RecruitingPhase 2
A study of trastuzumab rezetecan plus two other drugs for advanced bile duct cancer
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) for people with advanced bile duct or gallbladder cancer that has HER2 protein on its cells. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18–80 - NCT06937177RecruitingPhase 2
Testing mifomelatide to help maintain weight during chemo
This trial tests an investigational drug called mifomelatide (TCMCB07) to see if it can help people with newly diagnosed colorectal or pancreatic cancer maintain a healthy weight while receiving certain types of chemotherapy. You would give yourself a daily injection under the skin.
Tucson, ArizonaAges 18 years+ - NCT07704489Recruiting
Liver and bile duct cancer registry study
This registry collects information from people with liver cancer or bile duct cancer to learn more about the disease and its treatment. Anyone 18 or older with any stage of these cancers can join.
MilanAges 18 years+ - NCT05810480Recruiting
Predicting steroid-dependent liver injury with blood test
This study looks at whether a specific blood marker can predict which patients with liver inflammation will need long-term steroid treatment. It may help doctors decide the best treatment for you if you have unexplained liver injury.
AachenAges Any age - NCT06478719RecruitingPhase 1/Phase 2
FB-1603 plus TACE for liver cancer patients
This trial tests a new medicine (FB-1603) given along with standard TACE procedure for people with liver cancer. It aims to see if the combination is safe and works better than TACE alone.
Taipei, TaiwanAges 18–85 - NCT07705139Recruiting
Listening to bowel sounds after colorectal surgery
This study listens to your bowel sounds after colorectal cancer surgery to see if they can help doctors know when your gut is working again. You will have a small device placed on your belly to record sounds for a few days.
Wuhan, HubeiAges 18–90 - NCT07705880Recruiting
Predicting cancer in large flat colon polyps
This study tests a new tool to help doctors decide if a large, flat colorectal polyp might contain cancer. It involves doctors who use the tool during colonoscopy to better guide treatment.
GhentAges 18 years+ - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT05053971RecruitingPhase 1/Phase 2
Entinostat plus ZEN003694 for advanced solid tumors
This Phase 1/2 study tests a new combination anti-cancer treatment (entinostat plus ZEN003694) in people with advanced solid tumors that can’t be controlled with standard care. It aims to find a safe dose and see whether the treatment can shrink tumors or control the disease.
New Haven, ConnecticutAges 18 years+ - NCT05243966Recruiting
Registry for soft tissue repair using a special matrix
This study is a registry that collects information from people who had soft tissue repair using a specific matrix and/or morcell material. It may help researchers understand how this approach performs in real-world care and patient outcomes over time.
Phoenix, ArizonaAges 18 years+ - NCT07275905RecruitingPhase 1
Phage therapy for adults with cystic fibrosis and achromobacter infection
This trial tests a cocktail of viruses (bacteriophages) that target achromobacter bacteria in the lungs of adults with cystic fibrosis. It aims to see if the phages are safe and can reduce the infection.
San Diego, CaliforniaAges 18 years+ - NCT07010497RecruitingPhase 2
Study of a three-drug combo for advanced liver cancer
This trial tests a new combination of three drugs (Irpagratinib, Atezolizumab, and Bevacizumab) for people with advanced liver cancer that cannot be removed by surgery. It aims to see if this combination is safe and effective.
SeoulAges 19 years+ - NCT07104604RecruitingPhase 2
New combo before surgery for low rectal cancer
This trial tests a new combination of treatments (radiation, immunotherapy, and two chemotherapy drugs) given before surgery for people with a specific type of locally advanced rectal cancer that is close to the anus. The goal is to see if this approach is safe and effective.
Shantou, GuangdongAges 18–75 - NCT07702292RecruitingPhase 2
68Ga-BED003 PET scan for certain cancers
This trial tests a new PET imaging agent that targets a protein called FAP, which appears in many solid tumors. The goal is to see if this scan can better find and measure cancer in the body.
Bergamo, LombardyAges 18–79 - NCT07185009RecruitingPhase 3
Testing duvakitug for long-term ulcerative colitis control
This study tests the long-term safety and effectiveness of an experimental drug called duvakitug in people with moderate to severe ulcerative colitis. It is for those who have already responded well to treatment in a previous study and need ongoing care.
Tucson, ArizonaAges 16–80 - NCT02965326Recruiting
Testing blood and swab markers to track new cystic fibrosis treatments
This study looks for simple signals (markers) that may show whether cystic fibrosis treatments are working. It includes people who take CF “modulator” medicines like ivacaftor, people who don’t, and people whose cystic fibrosis was ruled out after testing.
ParisAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.