Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,367 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2168
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia71
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Sensorineural Hearing Loss18
- Stroke18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California63
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,367 total
- NCT06955884Recruiting
Awake breathing tube: mouth vs. nose
This trial compares two ways of placing a breathing tube in patients who have a difficult airway and need surgery. One method goes through the mouth, the other through the nose, both while you are awake. The goal is to see which method you prefer.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT05736198Recruiting
Compare two sedation options for awake intubation
This trial compares two different sedation choices for people who have airway conditions that make breathing tubes harder to place, and who still need an awake fiberoptic intubation. It may help find a sedation approach that’s safer and more comfortable during the procedure.
Chicago, IllinoisAges 18 years+ - NCT04923763Recruiting
Video tongue exam analysis study
This study uses recordings from a tongue (mouth) exam to see what tongue features can be identified from video. It may help improve how tongue exams are done and interpreted later.
TaichungAges 20 years+ - NCT07070089Recruiting
Stent implant for severe heartbeat-synchronized ear ringing
This trial tests whether placing a small mesh tube (stent) in a narrowed brain vein can stop severe, pulse-synchronous tinnitus—a whooshing sound that matches your heartbeat. It is for people whose tinnitus is very bothersome and has not improved with other treatments.
Ottawa, CanadaAges 18–80 - NCT07281417RecruitingPhase 2
Testing adding cemiplimab to chemo before surgery for sinus cancer
This trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps treat sinonasal squamous cell carcinoma. The goal is to see if this combination reduces tumors more effectively than chemotherapy alone.
Irvine, CaliforniaAges 18 years+ - NCT07149428Enrolling by invitation
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT07027826Recruiting
String test for eosinophilic esophagitis in African patients
This study tests a new, less invasive way (the Esophageal String Test) to look for signs of eosinophilic esophagitis—an allergic condition that can make swallowing painful or difficult. It is for people of African descent who have trouble swallowing and are already having an endoscopy.
Bethesda, MarylandAges 18–65 - NCT07038343RecruitingPhase 1/Phase 2
Testing a new drug for advanced solid tumors
This trial tests a new drug called AVZO-1418, either alone or with other treatments, for people with advanced solid tumors that have spread or cannot be removed. The goal is to see if the drug is safe and effective against certain types of cancer.
Gilbert, ArizonaAges 18–75 - NCT06589804RecruitingPhase 3
Testing cetuximab plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding cetuximab to the standard drug pembrolizumab works better for head and neck cancer that has spread or come back after treatment. It is for people whose cancer did not respond to platinum chemotherapy and whose tumors have a certain immune marker (PD-L1).
Little Rock, ArkansasAges 18 years+ - NCT06449443RecruitingTeam says not enrolling
New MRI for Upper Jaw and Sinus Images
This study tests a new type of MRI (called zero echo time) to see if it can take clear pictures of the sinuses and teeth in the upper jaw, without using radiation. It may be an option for people who are missing back teeth and already have a CT scan of that area.
AnkaraAges 18 years+ - NCT07790679Recruiting
Microbial testing for severe outer ear infections
This study is looking at people with a severe outer ear infection called malignant otitis externa, which often affects those with diabetes or weakened immune systems. The goal is to test for bacteria or fungi in the infection to guide better treatment.
Sohag, Sohag GovernorateAges Any age - NCT07789665Recruiting
Auditory nerve implant for deaf adults who cannot use cochlear implants
This study is testing a new way to use an inner ear implant (called an auditory nerve implant, or ANI) to help people who are deaf in both ears and cannot use a cochlear implant. The researchers want to see how well people perceive sounds with this device.
HanoverAges 18–85 - NCT07195734RecruitingPhase 2
Adding chemo or immunotherapy before surgery for advanced head and neck cancer
This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
Tucson, ArizonaAges 18 years+ - NCT07130136Recruiting
Switching from Baha Connect to Osia for bone conduction implant users
This study is for people who already have a Baha Connect bone conduction hearing implant but are having problems with it, like skin irritation. It tests switching to a newer device called Osia, which may work better for them.
LondonAges 18 years+ - NCT07137052Recruiting
Precise adaptive radiotherapy for nasopharyngeal cancer
This trial tests a more precise form of radiation therapy (adaptive radiotherapy) for nasopharyngeal cancer. It is designed for patients who have not yet had any treatment and whose cancer is limited to the head and neck area.
XiamenAges 18–70 - NCT07499791RecruitingPhase 2
Absorbable stent for recurrent tear duct infection
This trial tests a new type of dissolvable stent that slowly releases medicine to treat chronic tear duct infections that have come back after previous surgery. It may help people who need another treatment option.
Beijing, Beijing MunicipalityAges 18–65 - NCT05288790RecruitingPhase 2
Study how gut chemicals and alcohol affect heart risk in HIV
This Phase 2 study looks at how “microbiome metabolites” (chemicals from gut bacteria) and alcohol may affect heart and blood vessel risk in people living with HIV. If you qualify, you may be asked to follow a study plan to see how these factors change health markers related to cardiovascular disease.
Nashville, TennesseeAges 18–89 - NCT07627971RecruitingPhase 1/Phase 2
Gene therapy for GJB2-related hearing loss in young children
This study tests an experimental gene therapy (SKY-GJB2) designed to treat hearing loss caused by mutations in the GJB2 gene. The therapy is given directly to children ages 9 months to 7 years who have significant bilateral hearing loss, and researchers will monitor safety and whether hearing improves.
Bethesda, MarylandAges 9 months–7 years - NCT07788638Recruiting
Neurofeedback training for tinnitus relief
This study tests a non-invasive brain training method called neurofeedback to help reduce the distress caused by tinnitus, which is a constant ringing or buzzing in the ears. If you have bothersome tinnitus, this treatment might help you feel better.
Urbana, IllinoisAges 18–70 - NCT07787312Recruiting
Ultrasound for swallowing and muscle loss in intensive care patients
This study uses ultrasound to check the muscles that help you swallow and move. It aims to see if measuring these muscles can predict swallowing problems and muscle loss after being on a breathing machine.
Madrid, MadridAges 18 years+ - NCT05494346Recruiting
Seawater nasal spray with essential oils for blocked nose
This trial tests whether a seawater nasal spray (with essential oils) is safe and works well for people ages 12+ who have sudden (acute) cold- or allergy-related nasal blockage. You may be able to join if you can use the spray as instructed and complete simple monitoring and questionnaires.
Blainville-sur-OrneAges 12 years+ - NCT07484841Recruiting
Comparing ways to insert a breathing tube while awake
This study compares different methods for placing a breathing tube while you are awake. It is for people who are having planned surgery and might have a difficult airway—for example, if doctors expect challenges with a face mask, a breathing tube, or if you have a short time before you stop breathing.
İzmit, KocaeliAges 18 years+ - NCT06693258Recruiting
Robotic vs. open thyroid surgery comparison study
This study compares two ways to remove the thyroid gland: a newer robotic method through the armpit (transaxillary robotic thyroidectomy) versus the traditional open surgery through a neck incision. It aims to see which approach leads to better recovery and fewer complications.
ParisAges 18 years+ - NCT05983666Recruiting
Using ultrasound to check breathing tube placement
This study tests whether an ultrasound scan on the neck can help doctors confirm that a breathing tube is in the right place (the windpipe) instead of the food pipe during surgery.
Madrid, MadridAges 18–90
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,367 recruiting otolaryngology studies from the U.S. registry right now, out of 2,201 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.