Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,367 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2168
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia71
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Sensorineural Hearing Loss18
- Stroke18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California63
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,367 total
- NCT05963113Recruiting
Exercise and extra protein for swallowing and aging strength
This study tests whether a swallowing exercise program plus a higher-protein intake can improve function in older adults at risk for swallowing problems. It may help by strengthening muscles used for swallowing and supporting overall physical health.
New York, New YorkAges 65 years+ - NCT06580210Recruiting
Seawater spray with essential oils for stuffy nose
This trial tests a seawater and essential oil spray to clear a stuffy nose caused by a cold, sinus infection or allergies. The spray is meant to help you breathe easier without strong medicines.
BayeuxAges 12 years+ - NCT06860022Recruiting
Sentence Shaping for deaf or hard of hearing children
This trial tests a new way to help children who are deaf or hard of hearing improve their sentence writing skills. It focuses on children who use both spoken English and American Sign Language and need extra help with word order and grammar.
Nashville, TennesseeAges 9–15 - NCT07633158Recruiting
Real-world study of tezepelumab for chronic nasal polyps
This study follows patients with chronic rhinosinusitis with nasal polyps (CRSwNP)—a condition causing blocked sinuses and nasal growths—who are starting a new biologic medication called tezepelumab. Researchers will track how symptoms and quality of life improve over time in everyday medical practice.
DortmundAges 18–130 - NCT07780981Recruiting
Body position study for endoscopy pressure measurements
This study looks at whether lying on your back or side affects a measurement taken during a routine endoscopy procedure to check how well your esophagus and stomach opening are working. It may help doctors get more accurate readings to guide your care.
Baltimore, MarylandAges 5–21 - NCT05434637Recruiting
Somatosensory tinnitus treatment study
This study tests a physical therapy approach for people whose tinnitus (ringing in the ears) can be changed by moving their head, neck, or jaw. It aims to see if this treatment can reduce the bothersome nature of the sound.
Portland, OregonAges 18 years+ - NCT07781358RecruitingPhase 2
Testing a new drug combination for recurrent nasopharyngeal cancer
This trial tests a new drug combination for people whose nasopharyngeal cancer has come back in the same area or nearby lymph nodes. The goal is to see if this treatment can shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05156398RecruitingPhase 3
Rimegepant to prevent migraine attacks in children
This trial studies whether rimegepant can reduce how often migraine attacks happen in children and teens. It also looks at safety and how well the treatment fits day-to-day life and school activities.
Fort Smith, ArkansasAges 6–17 - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT04664634RecruitingPhase 3
Digital treatment for drooling and swallowing in Parkinson’s
This trial tests a smartphone/tablet digital program meant to help with drooling (sialorrhea) and swallowing problems in people with Parkinson’s disease. If you’re eligible, you’ll use the platform during clinic study visits to see whether it can improve symptoms and safety.
Evanston, IllinoisAges 22 years+ - NCT04901234RecruitingPhase 2
Adaptive radiation for advanced throat cancer
This study tests an approach called “adaptive radiotherapy,” where the radiation plan may be adjusted based on how your tumor and anatomy look during treatment. It is for adults with biopsy-proven oropharyngeal (throat) squamous cell carcinoma who are planning curative radiation, with or without chemotherapy.
MelbourneAges 18 years+ - NCT07278232Recruiting
Voice test to predict difficult breathing tube placement
This study uses a simple voice recording to see if your voice can help predict whether placing a breathing tube during surgery might be more difficult. It aims to make anesthesia safer for you.
ShanghaiAges 15–70 - NCT07515781Recruiting
VivaStent for Pulsatile Tinnitus Caused by Vein Narrowing
This study tests a stent (a small metal tube) placed in a narrowed vein in the brain to treat pulsatile tinnitus—a rhythmic ringing or whooshing sound in one ear that matches your heartbeat. The stent may improve blood flow and reduce or stop the sound.
ParisAges 18 years+ - NCT07780760Recruiting
Numbing throat spray to ease pain after tonsil removal in children
This study tests whether a numbing mist sprayed into the throat before surgery can reduce sore throat pain children feel after having their tonsils removed. It compares two numbing medicines to see if one works better than the other.
Al FayyumAges 3–15 - NCT07690995Recruiting
Testing a new software to guide cochlear implant surgery
This trial tests a new software called OTOGUIDE that helps doctors monitor the insertion of a cochlear implant electrode during surgery. It may help make the procedure more precise and safer for patients.
Innsbruck, TyrolAges 18 years+ - NCT06563362RecruitingPhase 2
Personalized radiation for oropharyngeal cancer
This trial tests a personalized approach to radiation therapy for oropharyngeal cancer. The goal is to safely reduce the amount of radiation to healthy lymph nodes, which may lower side effects while still effectively treating the cancer.
Zurich, Canton of ZurichAges 18 years+ - NCT07225855Recruiting
Support for older adults with head and neck cancer and their caregivers
This trial tests whether a special geriatric assessment (a check-up for older adults) and extra support can help people aged 60+ with head and neck cancer feel better during chemotherapy and radiation. It also looks at how this helps their family or friend caregivers.
Duarte, CaliforniaAges 18 years+ - NCT07661771RecruitingPhase 3
Personalized radiation therapy for nasopharyngeal cancer
This trial tests a new way to plan radiation treatment for nasopharyngeal cancer, where the target area is tailored to each patient's tumor spread. It aims to improve effectiveness while reducing side effects.
Dongguan, GuangdongAges 18–65 - NCT02734537RecruitingPhase 2
Radiation with or without cisplatin after head and neck surgery
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
Birmingham, AlabamaAges 18 years+ - NCT07772973Enrolling by invitation
Two rotating chairs for diagnosing vertigo
This study compares two rotating chairs used to diagnose benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. If you have typical vertigo symptoms, this trial may help find the best way to diagnose your condition.
Aalborg, North JutlandAges 18 years+ - NCT05527652Recruiting
Breathing tube device to help blocked upper airways in children
This study tests a self-supporting breathing tube placed through the nose during sleep to reduce upper airway blockage and improve breathing in children. It may help children who have sleep apnea symptoms, especially after tonsil/adenoid treatment or when tonsil removal isn’t possible.
Ann Arbor, MichiganAges 3–21 - NCT06980038RecruitingPhase 2
Testing two immunotherapy drugs before surgery for advanced head and neck cancer
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Irvine, CaliforniaAges 18 years+ - NCT05136196RecruitingPhase 2
Cabozantinib plus nivolumab for advanced melanoma or head-neck cancer
This trial tests whether combining two immunotherapy medicines—cabozantinib and nivolumab—can shrink advanced melanoma or certain head-and-neck squamous cell cancers. It is mainly for people whose cancer has grown after prior PD-1 treatment.
Phoenix, ArizonaAges 18 years+ - NCT06064097RecruitingPhase 2
Nivolumab plus chemo for young people with nasopharyngeal cancer
This trial tests combining the immunotherapy drug nivolumab with standard chemotherapy to treat newly diagnosed nasopharyngeal cancer in children and young adults. The goal is to see if adding this immune-boosting medicine can help shrink tumors and prevent the cancer from coming back.
Birmingham, AlabamaAges Up to 21 years
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,367 recruiting otolaryngology studies from the U.S. registry right now, out of 2,201 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.