Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,371 recruiting studies in this area right now.
By phase
- Not applicable978
- Phase 2168
- Phase 399
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia73
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke20
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)17
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University59
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida30
- Massachusetts21
- Illinois20
- Texas18
- Arizona17
- Colorado16
- Alabama15
Recruiting studies1,371 total
- NCT06406725Recruiting
Detecting vocal cord issues with noninvasive breathing test
This study tests whether a noninvasive breathing support device can detect vocal cord movement problems in children who had heart or airway surgery. It may avoid the need for a scope test.
Queens, New YorkAges 1 day–18 years - NCT06407102Recruiting
Nose or sinus tissue collection during surgery
This trial collects a small sample of tissue from your nose or sinus during a planned surgery. The sample is used for research to better understand diseases of the nose and sinuses.
ToursAges 18–90 - NCT06408363Recruiting
Ear pressure maneuvers for first hyperbaric session
This trial looks at whether doing a specific sequence of ear pressure-equalization moves helps people during their first hyperbaric oxygen therapy session. It might help you if you're about to start this treatment.
Belo Horizonte, Minas GeraisAges Any age - NCT06427577Recruiting
Study of ZhenQiFuZheng for allergic rhinitis
This trial tests if a traditional Chinese medicine called ZhenQiFuZheng can help people with allergic rhinitis by changing their gut bacteria. Researchers will collect samples to understand how it works.
Nanjing, JiangsuAges 18–65 - NCT06438627RecruitingPhase 3
New triple therapy vs standard for advanced nasopharyngeal cancer
This trial tests a new combination of three drugs (TPC, apatinib, and camrelizumab) against the standard two-drug regimen (GP plus camrelizumab) for people with high-risk nasopharyngeal carcinoma that has spread to neck lymph nodes. The goal is to see if the three-drug combination works better and is safe.
Guangzhou, GuangdongAges 18–65 - NCT06439290Recruiting
Voice Changes After Vocal Cord Surgery
This study looks at how different types of voice surgery affect the voice. Researchers will record and analyze voices before and after surgery to understand the results better.
Ghent, East-FlandersAges 18–70 - NCT06439927Recruiting
New method for closing a hole in the nasal septum
This trial is testing a new way to close a hole in the nasal septum (the wall inside your nose) during surgery. It may be a better option for people who need this repair.
CairoAges 18–58 - NCT06441136Recruiting
Study on age-related voice changes and social life
This trial studies how age-related voice changes (presbyphonia) affect social interactions and daily life. You may be eligible if you have thinning of the vocal cords and can complete voice assessments and questionnaires.
Iowa City, IowaAges 65 years+ - NCT06445088Recruiting
Testing a new EBV DNA test for nasopharyngeal cancer
This trial is testing a new way to diagnose nasopharyngeal cancer using a special test that looks at a change in the EBV virus DNA. It is for people who may have symptoms of this cancer or have tested positive for EBV, but have not yet been treated.
Fuzhou, FujianAges Any age - NCT06445114RecruitingPhase 2
Blood-Guided Chemoradiation for HPV-Positive Throat Cancer
This study tests whether a blood test that looks for circulating HPV DNA (ctDNA) can help doctors decide if you need chemotherapy after surgery for HPV-positive throat cancer. After you have surgery to remove the cancer, you receive radiation (possibly with chemotherapy) — the results of the blood test guide whether or not to add chemo.
Beverly Hills, CaliforniaAges 18 years+ - NCT06446713RecruitingPhase 1
Higher-dose proton therapy for advanced throat cancer
This trial is testing a higher, more precise dose of proton beam radiation for people with advanced throat cancer that is not connected to HPV. It aims to improve tumor control while protecting healthy tissue.
GroningenAges 18 years+ - NCT06453343Recruiting
Comparing two surgical approaches for cochlear implants
This study compares two different surgical methods for placing a cochlear implant (a device that helps with hearing). It is for adults who have lost hearing after learning to speak and are eligible for a specific type of implant. The goal is to see which approach works best.
NijmegenAges 18 years+ - NCT06455410RecruitingPhase 2
GP plus adebrelimab vs. chemo alone for nasopharyngeal cancer
This trial tests a new combination of chemotherapy drugs (GP) plus an immunotherapy drug (adebrelimab) before standard treatment for nasopharyngeal cancer. It aims to see if this combination works better than chemotherapy alone for shrinking tumors.
Foshan, GuangdongAges 18–65 - NCT06456255RecruitingPhase 2/Phase 3
Numbing injection study for first-time sinus surgery
This study tests a numbing medication (bupivacaine with epinephrine) injected during your first sinus surgery to see if it helps reduce pain after the procedure. It may be an option if you have not had sinus surgery before and are generally healthy.
Vancouver, British ColumbiaAges 19 years+ - NCT06457503RecruitingPhase 4
Toripalimab plus chemo for advanced nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy (cisplatin and gemcitabine) can help people whose nasopharyngeal cancer has come back or spread. It is for those who haven't yet received other treatments for this advanced stage.
Little Rock, ArkansasAges 12 years+ - NCT06462417Recruiting
Testing arbidol for allergic rhinitis
This trial tests if arbidol, an antiviral medicine, can safely treat allergic rhinitis (hay fever). It might help if your nasal symptoms like sneezing or stuffiness are moderate to severe.
Wuhan, HubeiAges 18–65 - NCT06463392Recruiting
Deep learning tool to diagnose post-radiation nasopharyngeal changes
This trial tests a new computer-based tool (deep learning) to help diagnose a condition called sbORN (suspected benign or recurrent nasopharyngeal carcinoma) after radiation therapy. It aims to see if the tool can accurately tell if a suspicious spot is a recurrence or something harmless.
Guangzhou, GuangdongAges 18 years+ - NCT06463756Recruiting
AI Predicts Thyroid Cartilage Invasion in Laryngeal Cancer
This study uses AI to analyze CT scans and predict if laryngeal cancer has spread to the thyroid cartilage. It may help doctors plan better treatment without needing extra invasive procedures.
ChongqingAges 18–81 - NCT06464757Recruiting
Laryngomalacia and breathing in children: before and after treatment study
This trial is for children with laryngomalacia (a floppy voice box) who have noisy breathing and trouble breathing. It will check how they are doing before and after treatment, and follow up for one year to see how their quality of life improves.
OsloAges 1 week–12 months - NCT06465979Recruiting
How do people with hearing loss understand speech in different settings?
This study looks at how people with healthy hearing or hearing loss understand speech in different listening environments. You might join if you have normal hearing, mild hearing loss, or use a cochlear implant, and are a competent adult English speaker.
Minneapolis, MinnesotaAges 18–65 - NCT06472713RecruitingPhase 2
Liposomal mitoxantrone with immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of a chemotherapy drug (mitoxantrone liposome) with an immunotherapy (PD-1 blocker) for people whose nasopharyngeal cancer has come back or spread and hasn't responded to previous treatments. The goal is to see if this combination can shrink tumors or slow cancer growth.
Zhuhai, GuangdongAges 18–70 - NCT06472739RecruitingPhase 2
GM-CSF to prevent mouth sores during radiation for head and neck cancer
This study tests if a mouth rinse with GM-CSF (a protein that helps healing) can prevent mouth sores caused by radiation therapy for nasopharyngeal carcinoma. If you are about to start radiation, this may help reduce pain and trouble eating.
Guangzhou, GuangdongAges 18–65 - NCT06475651Recruiting
DNA patterns in rare prenatal diseases
This study looks at DNA patterns in fetuses or children with rare genetic conditions. It aims to better understand how these patterns relate to diseases that start before birth, which could help with diagnosis and future care.
ParisAges birth–18 years - NCT06479811RecruitingPhase 1
Radioactive drug for advanced neuroendocrine and other cancers
This trial tests a new radioactive drug, [212Pb]VMT-Alpha-NET, that targets a protein on certain cancer cells. It is for people with specific types of advanced cancers that have gotten worse and are not responding to standard treatments.
Bethesda, MarylandAges 18–120
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,371 recruiting otolaryngology studies from the U.S. registry right now, out of 2,216 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.