Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,371 recruiting studies in this area right now.
By phase
- Not applicable978
- Phase 2168
- Phase 399
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia73
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke20
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)17
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University59
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida30
- Massachusetts21
- Illinois20
- Texas18
- Arizona17
- Colorado16
- Alabama15
Recruiting studies1,371 total
- NCT06309225Recruiting
Adjusted Chemoradiation for HPV Throat Cancer in Older Adults
This trial tests adjusting the dose of chemotherapy and radiation for older adults (65+) with HPV-related throat cancer. The goal is to find a treatment that is effective but gentler on the body.
Jacksonville, FloridaAges 65–99 - NCT06309264Recruiting
Comparing ways to fit hearing aids for blast-exposed Veterans
This study compares two different ways of fitting hearing aids for Veterans who were exposed to blasts and now have hearing difficulties. The goal is to see which method works better for improving hearing and understanding speech.
Loma Linda, CaliforniaAges 18–60 - NCT06309602Recruiting
Testing a free water protocol for stroke or trauma patients
This trial studies whether allowing patients who are on thickened liquids to also have sips of plain water is safe. It may help people who are recovering from stroke or injury and can protect their own airway.
Loveland, ColoradoAges 18 years+ - NCT06310278Recruiting
Normal ear movement data collection study
This study collects information on how the eardrum moves in people with normal hearing. It helps doctors understand what 'normal' looks like so they can better detect hearing problems.
Halifax, Nova ScotiaAges 18 years+ - NCT06313450Recruiting
Lower radiation for nose cancer after immunotherapy and chemo
This trial tests whether giving a lower dose of radiation to the main tumor is safe and effective for people with nasopharyngeal cancer (a type of nose/throat cancer) who first receive a combination of immunotherapy (toripalimab) and chemotherapy. It aims to reduce side effects while still controlling the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06319963RecruitingPhase 1/Phase 2
Lenti-HPV-07 immunotherapy for HPV throat or cervical cancer
This trial tests a new immunotherapy called Lenti-HPV-07 for people with HPV-related throat or cervical cancer. It aims to help your immune system fight the cancer more effectively.
Orlando, FloridaAges 18 years+ - NCT06321341RecruitingPhase 4
Testing Vespireit for chronic dizziness from autonomic dysfunction
This trial tests a new medication called Vespireit (prolonged-release buspirone) for people with chronic dizziness caused by a problem with the autonomic nervous system. The study aims to see if the drug helps reduce dizziness and improve quality of life.
BryanskAges 18–65 - NCT06321939Recruiting
Tracking EBV DNA in Blood for Nasopharyngeal Cancer
This trial studies whether tracking levels of Epstein-Barr virus DNA in your blood can help guide treatment for non-metastatic nasopharyngeal cancer. You would get standard radiation and maybe chemotherapy, with extra blood tests to see how the virus levels change.
Changsha, HunanAges 18 years+ - NCT06323239RecruitingPhase 2
Radiation plus chemo and immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of two types of radiation therapy (standard SBRT and low-dose radiation) along with chemotherapy and an immunotherapy drug (PD-1 antibody) for people whose nasopharyngeal cancer has come back or spread. The goal is to see if this combination can better control the cancer.
Guangzhou, GuangdongAges 18–75 - NCT06323460RecruitingPhase 2
Less Radiation for HPV Throat Cancer Guided by a Blood Test
This study tests a way to use less radiation for HPV-related throat cancer. Doctors will adjust your treatment based on a simple blood test that tracks cancer DNA, so you may get only the treatment you need.
Columbus, OhioAges 18 years+ - NCT06340633RecruitingPhase 2
Testing SPI-1005 with cochlear implant surgery
This trial tests an oral medication, SPI-1005, given to adults receiving a cochlear implant to see if it improves hearing outcomes. It may help people with moderate to profound hearing loss who are scheduled for implant surgery.
Iowa City, IowaAges 18 years+ - NCT06349889RecruitingPhase 2
Adebrelimab with chemo and radiation for high-risk nasopharyngeal cancer
This trial tests adding the immunotherapy drug adebrelimab to standard chemotherapy and radiation for people with a high-risk type of nasopharyngeal cancer (stage IVA). The goal is to see if this combination helps control the cancer better.
Xiamen, FujianAges 18–65 - NCT06354010Recruiting
Study of Early-Onset Hearing Loss Related to GJB2 Gene
This study looks at hearing loss that starts in early adulthood (after age 16) and is linked to a specific gene change (GJB2). Researchers want to understand how this type of hearing loss changes over time.
Tampa, FloridaAges 30–55 - NCT06356272Recruiting
Oropharynx cancer biomarker study
This study looks at certain markers (called p16 and HPV) in tumor samples to better understand oropharynx cancer. It may help doctors learn more about the disease and guide future treatments.
Rochester, MinnesotaAges 18 years+ - NCT06362122Recruiting
Severe nasal polyps: links between symptoms, tissue, and blood
This study looks at people with severe nasal polyps that need surgery (ethmoidectomy) for the first time. Researchers want to understand the connection between your symptoms, nasal tissue, and blood tests.
PoitiersAges 18 years+ - NCT06364670Recruiting
Acupuncture for tinnitus: brain imaging study
This study is testing whether acupuncture can help treat tinnitus by using a special brain imaging technique (fNIRS) to see how the brain responds. It may help find out who benefits most from acupuncture.
Hangzhou, ZhejiangAges 18–60 - NCT06377215Recruiting
How well do you hear speech in noise?
This study tests how well people understand speech in noisy settings, comparing younger and older adults with normal hearing and older adults with hearing loss. It aims to improve our understanding of hearing aid benefits.
Tampa, FloridaAges 18–80 - NCT06383780RecruitingPhase 3
Tislelizumab plus chemo for nasopharyngeal cancer with bone spread
This trial tests a combination of the immunotherapy drug tislelizumab with chemotherapy for people whose nasopharyngeal cancer has spread to the bones. It may be an option if you have not had prior treatment for advanced disease.
Guangzhou, GuangdongAges 18 years+ - NCT06387004Recruiting
Predicting swallowing problems during head and neck radiation
This study uses ultrasound scans to predict which patients will develop swallowing problems during radiation therapy for head and neck cancer. The goal is to catch and manage swallowing difficulties early.
Férolles-AttillyAges 18 years+ - NCT06389201Recruiting
Hydroxychloroquine before radiation and chemo for NPC
This trial tests whether taking hydroxychloroquine (HCQ) before standard radiation and chemo can help treat advanced nasopharyngeal cancer. It is for patients who have not yet started any cancer therapy.
Nantong, JiangsuAges 20–70 - NCT06395298Recruiting
Mouth care therapy for premature babies' feeding
This study tests a gentle mouth care routine called PIOMI to help very premature babies (born at 29–30 weeks) learn to feed by mouth. It’s for babies who need a feeding tube but are otherwise stable.
Barcelona, CataloniaAges 7 months–7 months - NCT06400992Recruiting
Testing Sky hearing technology in children
This study is testing the Sky CI sound processor in children aged 6–16 who use cochlear implants and/or hearing aids. The goal is to see how well the Sky technology works for hearing in noise.
ParisAges 6–16 - NCT06401811Recruiting
Turkish swallowing questionnaire study for Sjögren's syndrome
This study tests a Turkish version of a swallowing questionnaire (EAT-10) to see if it is reliable and accurate for people with primary Sjögren's syndrome. Taking part could help doctors better understand and track swallowing problems in this condition.
AnkaraAges 18 years+ - NCT06401993Recruiting
Brain connection study of tinnitus treatment with Chinese medicine
This study tests a traditional Chinese medicine treatment called 'Dao qi Tong Luo' for chronic tinnitus. It uses a safe brain scan (fNIRS) to see how the treatment affects brain connections related to hearing.
HangzhouAges 20–55
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,371 recruiting otolaryngology studies from the U.S. registry right now, out of 2,216 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.