Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,236 recruiting studies in this area right now.
By phase
- Not applicable3,144
- Phase 21,066
- Phase 1823
- Phase 1/Phase 2446
- Phase 3426
- Phase 4238
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis345
- Multiple Myeloma334
- Asthma194
- Lymphoma183
- Rheumatoid Arthritis141
- Type 1 Diabetes131
- Atopic Dermatitis129
- Systemic Lupus Erythematosus126
- Acute Lymphoblastic Leukemia123
- HIV Infections117
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 170
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Mantle Cell Lymphoma62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)91
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama179
- Arizona141
- Florida141
- New York122
- Massachusetts120
- Texas119
- Illinois82
- Colorado77
Recruiting studies6,236 total
- NCT07760662Recruiting
Oxidative stress and heart risk in rheumatoid arthritis
This study looks at how oxidative stress (an imbalance of harmful molecules in the body) relates to cardiovascular risk in people with rheumatoid arthritis. It aims to see if these factors are linked, which could help in better managing heart health for RA patients.
Santa Cruz de Tenerife, Canary IslandsAges 18 years+ - NCT07011810RecruitingPhase 2
Axatilimab for sclerotic chronic graft-versus-host disease
This study tests a new drug called axatilimab for people with a specific type of chronic graft-versus-host disease (cGVHD) that causes hardening or thickening of the skin or joints. cGVHD is a complication after a stem cell transplant where the donor's immune cells attack your body. The study aims to see if axatilimab can improve these sclerotic symptoms. If you have this condition and it was recently diagnosed (within the last year), you might qualify to participate.
Tampa, FloridaAges 18 years+ - NCT06323044Recruiting
Support program for parents giving daily leukemia medicine
This study tests a support program that helps parents give their child's daily leukemia medicine (6-MP) on schedule and overcome any barriers. It aims to make it easier for families to stick with treatment.
Buffalo, New YorkAges Any age - NCT05478707RecruitingPhase 2
Treating small blood vessel problems in type 1 diabetes
This study tests whether two different treatment strategies can improve the function of the tiny blood vessels in people with type 1 diabetes. It aims to find a way to prevent or reduce diabetes-related complications.
Orlando, FloridaAges 18–40 - NCT07675811RecruitingPhase 3
Study of a new treatment for cat allergy related eye symptoms
This trial tests an injectable treatment that may help manage eye allergy symptoms caused by cat allergies. It aims to see if the treatment is safe and effective for adults and children, and includes a controlled cat exposure challenge.
Andover, MassachusettsAges 8 years+ - NCT07754890RecruitingPhase 1/Phase 2
Study of two drugs for advanced skin lymphoma
This trial tests two medications (golidocitinib and chidamide) for people with a type of lymphoma that affects the skin. The combo may help control the disease when other treatments haven't worked or have stopped working.
Beijing, Beijing MunicipalityAges 18–75 - NCT07094750Recruiting
Comparing treatment intensities for less fit adults with AML
This study compares different treatment intensities for adults with acute myeloid leukemia (AML) who are less able to handle strong chemotherapy. It aims to find the best approach for people with health issues like heart or lung problems that make standard chemo riskier.
Seattle, WashingtonAges 18 years+ - NCT06929299RecruitingPhase 1/Phase 2
Testing STSA-1301 for immune thrombocytopenia (ITP)
This trial tests a new drug called STSA-1301 for people with immune thrombocytopenia (ITP), a condition where the immune system attacks platelets. The study has two parts: one for healthy volunteers to check safety, and one for ITP patients to see if the drug can raise platelet counts and reduce bleeding risk.
Bengbu, AnhuiAges 18–75 - NCT07570316RecruitingPhase 3
Testing efgartigimod for Graves' disease hyperthyroidism
This study tests whether efgartigimod, an injectable medication given under the skin, can help control overactive thyroid (Graves' disease) in adults already taking methimazole or carbimazole. The goal is to see if it reduces thyroid antibodies and improves thyroid hormone levels.
Orange, CaliforniaAges 18 years+ - NCT07754968Recruiting
Probiotic for formula-fed babies with colic
This study tests whether adding a probiotic called Bifidobacterium bifidum to formula can help reduce colic symptoms in babies who are not breastfed. It may also help if the baby has eczema (atopic dermatitis).
Roma, RMAges 1 week–5 months - NCT06897930RecruitingPhase 1/Phase 2
Testing a new drug for adults with lupus
This trial tests an investigational drug called AZD0120 in adults with lupus that hasn't improved with standard treatments. The goal is to see if it's safe and works well for people with lupus-related organ problems.
San Francisco, CaliforniaAges 18–70 - NCT05444348Recruiting
Communication and care-planning support for blood cancer patients
This study tests an approach to help people with certain blood cancers and their main caregiver plan ahead and communicate more clearly about end-of-life care. It may help patients feel more supported and better prepared for difficult decisions.
AalborgAges 18 years+ - NCT04700657Recruiting
Study dryness patterns in eye graft-vs-host disease
This study looks at how common and how severe corneal nerve-related dryness is in people with chronic graft-vs-host disease (GVHD) after a stem cell transplant. It may help doctors understand which eye problems are most typical and how best to recognize them early.
Indianapolis, IndianaAges 18 years+ - NCT07455396RecruitingPhase 2
Dexamethasone vs methylprednisolone for children with severe asthma
This trial compares two steroids, dexamethasone and methylprednisolone, to see which works better for children in the intensive care unit with severe asthma. The goal is to find the best treatment with fewer side effects.
St. Petersburg, FloridaAges 3–17 - NCT07490925Recruiting
Breathing Machine Strategy to Protect the Heart in ARDS
This trial tests a special breathing machine strategy that uses pressure measurements from a small tube in your esophagus (food pipe) to protect your heart's right side while treating ARDS caused by pneumonia. It may help if you have severe lung failure and need a ventilator.
BeijingAges 18 years+ - NCT04307576RecruitingPhase 3
Study for newly diagnosed ALL children and young adults
This Phase 3 trial studies a treatment plan for people up to age 45 who are newly diagnosed with B-cell or T-cell acute lymphoblastic leukemia (ALL). The goal is to see whether the study treatment improves outcomes compared with standard approaches.
BrusselsAges birth–45 years - NCT07037901RecruitingPhase 2
Testing IMG-007 for moderate-to-severe eczema
This study tests a new medicine called IMG-007 for adults with moderate-to-severe eczema (atopic dermatitis) that hasn't gotten better with standard creams. The goal is to see if it safely reduces itching and skin symptoms.
Lancaster, CaliforniaAges 18–74 - NCT07220915RecruitingPhase 3
Study of Panzyga to prevent infections in people with weak immune systems
This trial tests if a medication called Panzyga can help prevent infections in people with autoimmune conditions who have low antibody levels after B-cell therapy. It may be an option if you have a condition like multiple sclerosis, rheumatoid arthritis, or lupus.
Scottsdale, ArizonaAges 18 years+ - NCT02595255Recruiting
Testing a hormone marker to predict infertility risk after childhood cancer
This study looks at whether a blood test (a hormone marker) can predict a child’s future risk of infertility after cancer treatment. If it works, it could help families and doctors plan earlier fertility and puberty-related care.
Montegnée, LiègeAges 3–14 - NCT07732660Recruiting
Building skills and reducing stigma for young people with HIV in Zambia
This trial helps young people aged 18 to 24 living with HIV in three districts of Zambia. It aims to reduce stigma and build job skills to improve their lives.
Lusaka, Lusaka ProvinceAges 18–24 - NCT06584448Recruiting
Drinking, acetate, and stress study
This study looks at how acetate (a substance produced when the body breaks down alcohol) affects stress and drinking. It tests if giving acetate can help people with alcohol use disorder (AUD) reduce their drinking.
New Haven, ConnecticutAges 18–60 - NCT07535008Recruiting
Dental Cleaning to Prevent Graft-Versus-Host Disease
This study tests whether professional dental cleaning after a stem cell transplant can help prevent chronic graft-versus-host disease (GVHD), a condition where transplanted immune cells attack your body. You'll receive dental cleanings and be followed for one year to see if this simple preventive step reduces GVHD complications.
Seattle, WashingtonAges 18 years+ - NCT07194850RecruitingPhase 2/Phase 3
Study of Efgartigimod for teens with chronic ITP
This trial tests an IV medicine called efgartigimod for teenagers (ages 12 to under 18) who have had chronic immune thrombocytopenia (ITP) for more than a year. The goal is to see if it can safely help raise platelet counts.
BordeauxAges 12–17 - NCT07194980RecruitingPhase 2
Study of a pill and CAR T-cell therapy for CLL/SLL
This study tests a combination of two treatments: a targeted pill (nemtabrutinib) and a special immune cell therapy (lisocabtagene maraleucel, or liso-cel) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or has not responded to previous treatment. The goal is to see if giving the pill first helps the cell therapy work better.
Seattle, WashingtonAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,236 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,675 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.