Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,146
- Phase 21,063
- Phase 1820
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma183
- Rheumatoid Arthritis140
- Type 1 Diabetes134
- Atopic Dermatitis130
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections113
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California494
- Maryland195
- Alabama176
- Florida145
- Arizona141
- New York122
- Massachusetts119
- Texas118
- Illinois81
- Colorado76
Recruiting studies6,230 total
- NCT07524244Recruiting
Ketogenic and carnivore diets for IBD and rheumatoid arthritis
This study tests whether special diets (ketogenic or carnivore/meat-based) can help reduce inflammation and symptoms in people with inflammatory bowel disease or rheumatoid arthritis. You'll follow dietary guidelines for 3 weeks, then continue in the study while researchers track how you respond.
Charlottesville, VirginiaAges 18–64 - NCT07524543Recruiting
Severe asthma registry study in Hong Kong
This study collects health information from adults with severe asthma to better understand the condition and improve treatment. Your participation involves sharing medical data to help researchers learn more about what works best for severe asthma.
Hong KongAges 18–120 - NCT07525505Recruiting
Nigella Sativa Oil for Itchy, Inflamed Ear Canal
This trial tests whether Nigella sativa (black seed) oil can safely treat eczematous otitis externa—a condition causing itching, discomfort, and drainage in the ear canal. Researchers want to see if this natural oil works as well as standard treatments.
Istanbul, FatihAges 18 years+ - NCT07526350RecruitingEarly Phase 1
MTS109 for Hard-to-Treat Autoimmune Diseases
This early-stage trial tests a new treatment called MTS109 for autoimmune diseases (like lupus, muscle inflammation, scleroderma, vasculitis, or Sjögren's syndrome) that haven't responded well to standard medications. The goal is to see if MTS109 can help control disease that keeps flaring or getting worse despite current treatments.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07526493RecruitingPhase 1
QH103 Cell Therapy for Resistant Autoimmune Nerve and Brain Diseases
This Phase 1 trial tests whether QH103 cell injections can help patients with serious autoimmune diseases affecting nerves and the brain (like MS, NMOSD, myasthenia gravis, and others) that haven't responded well to standard treatments. The goal is to evaluate safety and whether the treatment helps reduce symptoms.
Wuhan, HubeiAges 18–75 - NCT07527923RecruitingPhase 1
Testing REGN20423 for healthy people and atopic dermatitis
This early-stage trial tests a new experimental medicine called REGN20423 in two groups: healthy volunteers and people with atopic dermatitis (a chronic skin condition causing itching and inflammation). The trial aims to assess whether the medicine is safe and well-tolerated.
Leuven, Vlaams-BrabantAges 18–65 - NCT07528105RecruitingEarly Phase 1
CAR-T Cell Therapy for Early-Stage Type 1 Diabetes
This early-stage trial tests a new type of immune cell therapy (CAR-T cells) designed to stop the body's immune system from attacking insulin-producing cells in type 1 diabetes. The goal is to help preserve remaining pancreas function in people with early-stage disease.
ShanghaiAges 18–40 - NCT07528352RecruitingPhase 1
Radiation Plus Antibody Therapy for Difficult-to-Treat Lymphoma
This trial tests a combination of radiation therapy to specific tumor sites followed by a bispecific antibody (a type of immunotherapy that targets cancer cells). It's designed for people with diffuse large B-cell lymphoma that has not responded to or has come back after at least two prior treatments.
Salt Lake City, UtahAges 18 years+ - NCT07528781Recruiting
New 3D Ultrasound Method for Measuring Heart Valve Leakage
This study tests a new way to measure leakage in the mitral valve (a valve in your heart) using advanced 3D ultrasound. If you have moderate or severe mitral valve leakage, this research may help doctors better understand and treat the condition.
Badalona, BarcelonaAges 18–95 - NCT07529782RecruitingPhase 1
Safety and Efficacy of HDP-101 in Relapsed or Refractory Multiple Myeloma
This trial tests a new drug called HDP-101 in patients with multiple myeloma that has come back or stopped responding to previous treatments. The study aims to find the safest and most effective dose and to see if this drug can help control the cancer.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT07529847Recruiting
Breathing Techniques to Help Asthma Control
This study compares two special breathing techniques—alternating which nostril you breathe through and a method called Buteyko breathing—to see which helps asthma patients breathe easier and improve lung function. You'll practice these techniques and we'll measure how well they work for you.
IslamabadAges 18–45 - NCT07530198RecruitingPhase 1
HIV DNA vaccine test for people on stable treatment
This study tests a new DNA vaccine (ICVAX) designed to help your immune system better control HIV. You'll receive injections over several months if your HIV is well-controlled with current medications.
Shatin, New TerritoriesAges 18–60 - NCT07530770Recruiting
Benralizumab for Severe Asthma with Aspergillus Allergy
This study tests whether benralizumab, a biologic medicine, works well in real-world settings for people with severe asthma caused by an allergic reaction to a common mold called Aspergillus. You may qualify if you have hard-to-control asthma despite strong medications and recent asthma flare-ups.
Jinan, ShandongAges 18–75 - NCT07535554RecruitingPhase 2/Phase 3
New PET scan to detect inflammation in three conditions
This study tests a new type of PET scan (a medical imaging test) that may better detect inflammation in the body compared to the standard scan currently used. Researchers will compare the two scans in patients with fever of unknown origin, IgG4-related disease, or inflammatory back pain.
LeuvenAges 18 years+ - NCT07536152RecruitingPhase 4
Antihistamine to prevent allergic reactions during heart surgery
This study tests whether giving an antihistamine (a common allergy medication) before heart surgery can prevent allergic-type reactions that sometimes happen during the surgery itself. The trial includes children with certain types of congenital heart disease (heart problems present from birth).
Giza, OctoberAges 1–7 - NCT07536256Recruiting
Youth Resilience Through Native Hawaiian Culture in Wai'anae
This program connects young people in the Wai'anae community with culturally rooted activities and support to build resilience and improve physical and mental health. You'll work with other youth and community organizations that use Native Hawaiian values to help you thrive.
Waianae, HawaiiAges 12–25 - NCT07536503Recruiting
How Sleep Quality Affects Thinking and Function in MS
This study looks at whether better sleep helps people with multiple sclerosis (MS) think more clearly and stay more physically active. Researchers will measure your sleep quality and test your memory and everyday abilities to see if they're connected.
Ankara, AnkaraAges 18–65 - NCT07536529Recruiting
Oxidative Stress in Autoimmune Joint Diseases
This study looks at a type of cellular damage called oxidative stress in people with autoimmune joint diseases like rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Researchers want to understand how this damage relates to your disease and may help develop better treatments.
Larissa, ThessalyAges 18 years+ - NCT07536841Recruiting
Testing New Criteria for Autoimmune Pancreas Inflammation
This study validates a new diagnostic tool (Odesa Criteria 2026) to help doctors accurately identify autoimmune pancreatitis—a rare condition where the body attacks the pancreas. If you're being evaluated for possible pancreas inflammation, this trial may help confirm whether you have this specific type.
OdesaAges 18 years+ - NCT07537738Recruiting
Blood test to predict outcomes in MLL acute myeloid leukemia
This study uses a special blood test to see if it can predict which patients with a specific type of acute myeloid leukemia (AML with MLL changes) are more likely to relapse or have better survival. The test may help doctors plan better treatment.
BeijingAges 6–60 - NCT07540910RecruitingPhase 1
Safety study of EDP-978 in healthy adults
This is an early-stage study testing a new experimental drug called EDP-978 in healthy volunteers to see if it is safe and how the body processes it. Researchers will give participants single or multiple doses and monitor for side effects and how the drug moves through the body.
San Antonio, TexasAges 18–65 - NCT07541391RecruitingPhase 1
CAR T-cell therapy for relapsed kappa myeloma
This trial tests a new treatment called CAR T-cells (your own immune cells engineered in the lab) designed to fight kappa-restricted multiple myeloma that has come back or stopped responding to standard drugs. The goal is to see if this treatment can help patients whose cancer has progressed despite previous therapies.
Melbourne, VictoriaAges 18 years+ - NCT07544303Recruiting
Fatigue and Mental Well-Being in MS Patients
This study explores how fatigue and mental health are connected in people with multiple sclerosis. Researchers will use audio sessions through headphones to understand your experiences and may help improve care for MS-related tiredness and mood.
VanAges 18–80 - NCT07544394Recruiting
Understanding Fatigue in Sjögren's Syndrome
This study explores why people with Sjögren's syndrome experience fatigue and what factors predict it. Researchers will follow you for 3 months to better understand your fatigue patterns and potentially improve treatment.
KahramanmaraşAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,786 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.