Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,069 recruiting studies in this area right now.
By phase
- Not applicable3,003
- Phase 21,060
- Phase 1795
- Phase 1/Phase 2443
- Phase 3437
- Phase 4232
- Phase 2/Phase 399
Top conditions
- Multiple Sclerosis331
- Multiple Myeloma329
- Asthma194
- Lymphoma179
- Type 1 Diabetes132
- Rheumatoid Arthritis131
- Atopic Dermatitis121
- Systemic Lupus Erythematosus120
- Acute Lymphoblastic Leukemia118
- HIV Infections105
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Mantle Cell Lymphoma63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- City of Hope Medical Center50
- Mayo Clinic50
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California498
- Maryland198
- Alabama178
- Florida152
- Arizona150
- Massachusetts116
- New York115
- Texas112
- Illinois86
- Colorado81
Recruiting studies6,069 total
- NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT02479698RecruitingPhase 2
Immune cells for BK or JC virus infections
This trial tests a treatment using special immune cells (called cytotoxic T lymphocytes) to fight BK or JC virus infections in people with weakened immune systems, such as cancer patients or organ transplant recipients. It may help control the virus and reduce related complications.
Houston, TexasAges Any age - NCT02646839Enrolling by invitationPhase 2
Testing a gene-matched transplant approach for childhood leukemia
This trial studies a specific type of partially matched (haploidentical) stem cell transplant in children with ALL, AML, or MDS. It looks at whether using certain immune system gene patterns (KIR) and measuring leftover disease after treatment can improve outcomes and cost-effectiveness.
Los Angeles, CaliforniaAges Up to 21 years - NCT02356653RecruitingEarly Phase 1
Stem cell transplant help for children lacking a matching sibling
This expanded-access study offers a specific type of stem cell transplant preparation that removes certain immune cells (CD3 and CD19) from donor stem cells. It is for children who need a transplant but do not have a fully matched sibling donor and whose team cannot use the hospital’s usual matching device protocol.
Philadelphia, PennsylvaniaAges Up to 30 years - NCT02310867RecruitingPhase 2
Immunotherapy to help grafts heal for people with limb loss
This Phase 2 study tests an immune-targeting treatment to help a transplanted tissue “graft” integrate and heal better after limb loss. It may help by reducing problems with healing and rejection, but you must be able to complete frequent follow-up visits and testing.
Durham, North CarolinaAges 18–65 - NCT01206920Recruiting
DC study following HIV prevention and care experiences over time
This study follows people who receive HIV care in Washington, DC and people using HIV prevention medicines (like PrEP) to understand health needs and outcomes over time. It may help improve how HIV care and prevention are delivered in local clinics.
Washington D.C., District of ColumbiaAges Any age - NCT02343042RecruitingPhase 1/Phase 2
Selinexor with standard therapies for multiple myeloma
This trial tests a new drug called selinexor (KPT-330) combined with various standard treatments for patients whose multiple myeloma has come back or stopped responding to therapy. The goal is to see if adding selinexor helps control the cancer better than current options, and to find the safest dose for different drug pairings.
Gilbert, ArizonaAges 18 years+ - NCT02332668RecruitingPhase 1/Phase 2
Pembrolizumab for children with advanced, hard-to-treat cancer
This trial tests pembrolizumab (an immunotherapy that helps the body recognize and attack cancer) in children with advanced solid tumors or lymphoma that can’t be cured. It’s designed for kids who have already tried standard treatments or don’t have standard treatment options.
Aurora, ColoradoAges 6 months–17 years - NCT01402661Enrolling by invitation
Rheumatoid arthritis drug safety and effectiveness registry
This registry collects real-world information about people with rheumatoid arthritis (RA) to help doctors understand how RA medicines work and their safety. You may be able to join if you’re newly diagnosed or starting certain RA treatments and you’re willing to share consent and basic personal details.
Waltham, MassachusettsAges 18 years+ - NCT01351545Recruiting
Cryopreserved cord blood access program for transplant patients
This trial studies an organized way to obtain and distribute unlicensed (not FDA-approved for general use) stored cord blood units that have been frozen and kept. It may help people who need a cord blood transplant but don’t fit the “licensed cord blood only” options.
Birmingham, AlabamaAges Any age - NCT01790152Recruiting
Dexrazoxane study to monitor heart damage in cancer survivors
This study tests dexrazoxane (DRZ) to see how it affects blood and heart-related “biomarkers,” or measurable signs of heart damage, after cancer treatment. It mainly targets survivors who may be at risk for cardiomyopathy (heart muscle weakness) or related heart failure.
Birmingham, AlabamaAges Any age - NCT02147405Recruiting
PET scans and lymph node checks for HIV immune rebound
This study looks at people with HIV who either have not started HIV medicines yet or who recently started/changed them and may develop immune rebound (IRIS). It uses blood tests and optional PET/CT scans and lymph node biopsies to understand what’s happening in the body and to guide care.
Bethesda, MarylandAges 18–100 - NCT01799538RecruitingPhase 1/Phase 2
Inhaled albuterol for lung disease LAM
This Phase 1/2 study tests whether breathing in albuterol can improve symptoms or lung function in people with lymphangioleiomyomatosis (LAM). It’s mainly about safety and early signs of benefit by targeting airflow problems.
Bethesda, MarylandAges 18–100 - NCT01730131Recruiting
Study of PML in patients, at-risk people, and healthy volunteers
This study follows people with suspected or confirmed progressive multifocal leukoencephalopathy (PML), people at higher risk, and healthy volunteers. It uses visits, brain imaging (MRI), and stored biological samples to better understand how PML progresses and who is at risk.
Bethesda, MarylandAges 2–120 - NCT01425892Recruiting
Study of how Sjogren’s disease starts and changes over time
This study follows people with Sjogren’s disease to understand how it develops and how symptoms naturally change over time. The goal is to improve understanding and future care rather than provide a new immediate treatment.
Bethesda, MarylandAges 16–100 - NCT01419561RecruitingPhase 2
Studying KSHV inflammatory syndrome (KICS)
This study tracks people with KICS, a condition caused by KSHV (a virus related to Kaposi sarcoma). It aims to understand the syndrome better and may lead to future treatments.
Bethesda, MarylandAges 18–120 - NCT01386437Recruiting
Study immune problems and fungal infections
This study looks at how immune system problems relate to fungal infections, using medical records and lab tests on blood and tissue. It may help researchers understand the cause of these infections—especially for people with inherited immune conditions—and improve future care.
Bethesda, MarylandAges 1 day–99 years - NCT02140255RecruitingPhase 1/Phase 2
Intensive early HIV treatment in newborns to aim for remission
This study gives very early, intensive HIV medicine to infants diagnosed with HIV and follows them closely to see if HIV can go into remission (stop being detectable without ongoing treatment). It may help families understand whether treating right after birth can change a child’s long-term HIV outlook.
La Jolla, CaliforniaAges Up to 2 days - NCT02015013RecruitingPhase 2
Blood cell collection study for immune system disorders
This study collects blood-forming cells from people with low CD4 counts and healthy volunteers to learn how the immune system works. It may help researchers better understand and treat conditions like idiopathic CD4 lymphocytopenia.
Bethesda, MarylandAges 18–65 - NCT01422694Recruiting
Understanding spondyloarthritis over time
This study follows people with spondyloarthritis (an inflammatory arthritis that often affects the spine and joints) and their family members over time to better understand how the disease develops and progresses. It also includes a research stool sample test to learn about gut bacteria.
Bethesda, MarylandAges 2–99 - NCT01676805Recruiting
Collecting tissue samples for lymphoma research
This study collects leftover tissue samples from patients with or without lymphoma to help researchers better understand lymph system cancers. It may be an option if you are already having a biopsy or surgery.
Bethesda, MarylandAges 18 years+ - NCT01861106RecruitingPhase 2
Bone marrow transplant for GATA2 mutations
This trial tests a bone marrow transplant (called allogeneic hematopoietic stem cell transplant) as a treatment for people with GATA2 mutations or MonoMAC. The goal is to replace faulty immune cells with healthy donor cells, which may reduce infections and improve immune function.
Bethesda, MarylandAges 6–70 - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT01441089Recruiting
Donate blood for genetic testing in an NIH research study
This study collects blood from people already in an NIH (National Institutes of Health) clinical research program to run genetic tests. It may help researchers understand cancer and related inherited conditions by studying DNA changes.
Bethesda, MarylandAges 3 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,069 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,273 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.