Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,227 recruiting studies in this area right now.
By phase
- Not applicable3,140
- Phase 21,067
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4236
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis342
- Multiple Myeloma333
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes132
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona140
- New York122
- Massachusetts119
- Texas118
- Illinois82
- Colorado77
Recruiting studies6,227 total
- NCT04438525Recruiting
BAT test to replace sting challenge in venom allergy care
This study looks at whether a BAT (a blood test) can stand in for sting/venom “challenges” for people already receiving venom immunotherapy. If it works, it could help patients avoid more risky or uncomfortable challenge procedures while still checking whether treatment is working.
GrazAges 18–70 - NCT06821100RecruitingPhase 1
Thymalfasin to Boost COVID-19 Vaccine Response in Older Adults
This trial tests whether a drug called thymalfasin (thymosin alpha 1) can help older adults (65+) get a stronger immune response from their COVID-19 booster shot. It may be especially helpful for those whose immune systems have weakened with age.
Houston, TexasAges 65–100 - NCT03000244Recruiting
Long-term follow-up after stem cell or gene therapy
This study checks how people do long-term after stem cell transplant, cellular therapy, or gene therapy. It may help doctors track longer-term health effects and recovery and improve future care.
Bethesda, MarylandAges 4–120 - NCT03357172Recruiting
Study immune changes after a stem cell transplant
This study looks at how the immune system changes after an allogeneic stem cell transplant (using a donor’s stem cells). It may help researchers understand what controls immune recovery and transplant-related complications.
Vandœuvre-lès-NancyAges 18 years+ - NCT05351216Recruiting
Sirolimus safety with routine vaccines for a rare blood vessel tumor
This trial studies how the medicine sirolimus affects children’s response to routine vaccines during treatment for kaposiform hemangioendothelioma (KHE). It compares vaccinated KHE patients taking sirolimus with healthy children getting the same vaccines.
Shanghai, Shanghai MunicipalityAges Up to 12 years - NCT03153527RecruitingPhase 4
Testing slow steroid taper versus stopping suddenly
This trial studies whether it’s safer or works better to slowly reduce steroids versus stopping them abruptly after long-term use. It may help people who are currently on daily steroid tablets and don’t medically need a taper just to treat their underlying condition.
FrankfurtAges 18 years+ - NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80 - NCT03356054RecruitingPhase 1/Phase 2
Test drug for CD30-positive lymphoma after first treatment fails
This early-phase study tests a lymphoma treatment in adults whose diffuse large B-cell lymphoma (DLBCL) is “CD30-positive” and who didn’t respond well to first-line chemotherapy (like R-CHOP) or had an early relapse. It aims to see if the treatment can shrink the lymphoma and is safe enough to move forward.
RotterdamAges 18 years+ - NCT03741023Enrolling by invitation
Blood tests after trauma or surgery to study body stress response
This study looks at how your body’s inflammation and “stress response” changes after major injury or certain surgeries. Doctors may use the results to better understand who is at risk for complications and how to respond sooner.
Nashville, TennesseeAges 2 months+ - NCT01551563Recruiting
Study for people newly diagnosed with inflammatory bowel disease
This trial studies treatment approaches for inflammatory bowel disease (IBD) in people who are newly diagnosed. It may help researchers find better care by learning how well the study treatment works early in the disease.
StavangerAges 16–80 - NCT03253705Recruiting
Donate small blood samples to study heart and inflammation health
This study collects small blood samples (and sometimes samples during treatment) to help researchers understand diseases involving the heart, inflammation, and blood vessel function. It may help improve future tests and treatments by giving scientists usable human data.
Bethesda, MarylandAges 18–100 - NCT06933537Recruiting
Personalized brain stimulation for emotional disorders in MS and NMOSD
This trial tests if a gentle brain stimulation technique can help with anxiety in people with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). It uses a mild electrical current through the scalp to regulate mood, and the treatment is customized to each person.
Beijing, Beijing MunicipalityAges 18–65 - NCT02653079Recruiting
Blood testing and low-dose radiation for painful joint conditions
This study collects blood samples and treats certain painful joint/soft-tissue problems with low-dose local radiation therapy. It aims to understand disease features and how patients may respond to this treatment.
Erlangen, BavariaAges 18 years+ - NCT02055105Recruiting
Study tests a blood test pattern in children with sepsis
This trial studies how a specific pattern in blood (called “molecular fingerprinting”) changes in children with suspected or developing sepsis. The goal is to help doctors better recognize sepsis early and understand how it progresses, which may improve care.
Phoenix, ArizonaAges 1–18 - NCT07672522Recruiting
Infections and the aging immune system in older adults
This study is looking at how infections and the aging immune system affect older adults. It compares people with an infection to healthy volunteers to understand how the body fights germs as we age.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT01163578Recruiting
Using test results to improve outcomes after organ or marrow transplant
This study looks at “biomarkers,” which are measurable lab signals, in people who have had an organ or bone marrow transplant. The goal is to use these test results to better predict and improve transplant outcomes.
Pittsburgh, PennsylvaniaAges Any age - NCT06075745RecruitingPhase 2
CMV Vaccine Study for Liver Transplant Candidates
This trial tests a vaccine to prevent cytomegalovirus (CMV) infection in people awaiting a first liver transplant. You may be eligible if you have never been infected with CMV and are scheduled to receive a liver transplant within the next 1 to 12 months.
Birmingham, AlabamaAges 18 years+ - NCT02836158RecruitingPhase 2/Phase 3
Test drug plus spinal chemotherapy for older PCNSL
This trial studies whether adding R-IDARAM and medication delivered into the spinal fluid can improve treatment for primary central nervous system lymphoma (PCNSL) in newly diagnosed older adults. It may help by targeting lymphoma cells in the brain, covering membranes, and spinal fluid.
Beijing, Beijing MunicipalityAges 60–75 - NCT03681964Recruiting
Check tests for suspected Sjögren’s syndrome
This study follows people who have signs that might mean Sjögren’s syndrome and looks at how well a standardized work-up identifies the condition. It may help doctors confirm the diagnosis earlier and more consistently.
BrestAges 18 years+ - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT03684018RecruitingPhase 4
Testing two doses of Privigen for children with CIDP
This study tests whether two different dose levels of Privigen (a type of immune blood treatment) are safe and effective for children and teens with CIDP. It may help improve nerve-related symptoms in people whose CIDP has been confirmed or is being evaluated as likely.
Phoenix, ArizonaAges 2–17 - NCT07159074RecruitingPhase 2
Testing tilmanocept for heart inflammation in sarcoidosis
This study tests whether a tracing agent called tilmanocept can help doctors see inflammation in the heart caused by sarcoidosis. It may provide a new way to diagnose and monitor cardiac sarcoidosis without invasive procedures.
Durham, North CarolinaAges 18 years+ - NCT07134491Recruiting
B Cells in Kidney Transplant Rejection Study
This study looks at certain immune cells (B cells) in the blood and kidney to better understand antibody-mediated rejection in kidney transplant patients. It might help doctors find new ways to diagnose or treat this type of rejection.
ParisAges 18 years+ - NCT06196996Recruiting
Donor islet transplant for brittle type 1 diabetes
This study tests a one-time transplant of insulin-making cells from a donor to treat brittle type 1 diabetes—a condition where blood sugar swings wildly and dangerously low. The goal is to help people who still have severe low blood sugar episodes despite intensive insulin therapy.
Shanghai, Shanghai MunicipalityAges 6–65
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,227 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,696 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.