Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,227 recruiting studies in this area right now.
By phase
- Not applicable3,140
- Phase 21,067
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4236
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis342
- Multiple Myeloma333
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes132
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona140
- New York122
- Massachusetts119
- Texas118
- Illinois82
- Colorado77
Recruiting studies6,227 total
- NCT06876467Recruiting
Study of immune response to hepatitis B vaccine
This study looks at how your body's cells respond after getting a hepatitis B vaccine. It may help researchers understand how well the vaccine works.
ParisAges 18 years+ - NCT07614191RecruitingEarly Phase 1
GT801 Cell Therapy for Hard-to-Treat Autoimmune Diseases
This early-stage study tests a new cell-based treatment called GT801 for autoimmune diseases that haven't responded well to standard medicines. It aims to see if this approach is safe and helps reduce symptoms in conditions like lupus, vasculitis, and scleroderma.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07509840RecruitingPhase 3
Immune therapy to restore ovary function and fertility
This trial tests whether an immune-modulating drug can restart ovulation and improve fertility in women whose ovaries stopped working due to autoimmune disease. It is for women ages 18–38 with autoimmune premature ovarian insufficiency and certain antibodies.
StockholmAges 18–38 - NCT07641725Recruiting
Light Therapy and Steroid Rinse for Pemphigus Mouth Sores
This study tests whether a steroid mouthwash and/or light therapy (photobiomodulation) can help heal painful mouth sores caused by pemphigus vulgaris, an autoimmune disease that damages the inside of the mouth and skin.
DamascusAges 18–80 - NCT06693440Recruiting
How PD-1 antibody therapy affects immune function in cancer
This trial is studying how PD-1 antibody therapy (a type of immunotherapy that helps your immune system fight cancer) affects the immune system in people with various cancers. It may be a good fit if you have a confirmed cancer diagnosis and have your medical records and immune test results available.
Zhengzhou, HenanAges 18 years+ - NCT06303128RecruitingPhase 3
Testing penicillin allergy with one vs. two oral doses
This trial compares a single dose versus two doses of a penicillin-like drug to see if people who think they are allergic to penicillin can safely be told they are not allergic. It is for people with a low-risk penicillin allergy who want to find out if they can use these antibiotics in the future.
Lubbock, TexasAges 18–89 - NCT07533955RecruitingPhase 1
Testing JADE201 drug in rheumatoid arthritis patients
This early-stage study tests a new drug called JADE201 in people with rheumatoid arthritis (RA). Researchers want to see if it is safe and how the body handles it, which could lead to better RA treatments.
Chisinau, MoldovaAges 18–70 - NCT07534007Recruiting
Shingles vaccine response in patients on immune-modifying drugs
This study tests a new shingles vaccine in people with psoriasis or myelofibrosis, some of whom take immune-modifying medications. Researchers want to understand how well the vaccine works and how the immune system responds in these groups.
Pavia, LombardaAges 18–100 - NCT06751849RecruitingPhase 2
Vaccine, immunotherapy, and radiation for advanced lung cancer
This trial tests a combination of a personalized cancer vaccine, an immunotherapy drug (PD-1 inhibitor), and radiation therapy for people with advanced non-small cell lung cancer that has gotten worse after at least two prior treatments. The goal is to see if this approach can help shrink tumors or slow cancer growth.
Nanchang, JiangxiAges 18–70 - NCT06702566Recruiting
Study of Ferritin in Immune-Related Side Effects
This study looks at how a blood marker called ferritin relates to side effects from immunotherapy or other cancer treatments. It may help doctors predict and manage those side effects better.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06750133RecruitingPhase 1
CNK-UT cell therapy for steroid-resistant graft-versus-host disease
This trial tests a new cell therapy called CNK-UT for people with severe graft-versus-host disease (aGVHD) that hasn't improved with steroid treatment after a stem cell transplant. The goal is to see if it can help control the immune reaction.
Fuzhou, FujianAges 14–70 - NCT06716619RecruitingPhase 1
Immune cell therapy for advanced solid tumors
This trial tests a new immune cell treatment made from your own lymph nodes for advanced solid tumors that haven't responded to standard therapies or have no good treatment options. It aims to see if this personalized cell therapy is safe and can help shrink tumors.
Guangzhou, GaungdongAges 18–75 - NCT06082037RecruitingPhase 3
Testing belumosudil for chronic lung allograft dysfunction after transplant
This trial tests an oral medication called belumosudil for people with chronic lung allograft dysfunction (CLAD) after a double lung transplant. It may help slow the decline in lung function.
Birmingham, AlabamaAges 18 years+ - NCT06706102RecruitingPhase 4
Study of Tiny Blood Particles During CAR-T Therapy
This study is for people getting CAR-T cell therapy, a type of cancer treatment that uses your own immune cells. Researchers want to understand a rare side effect called neurotoxicity by looking at tiny particles in your blood called extracellular vesicles.
Saint-EtienneAges 18 years+ - NCT07033858Recruiting
Short-term effects of Advograf plus Rapamiune after kidney transplant
This trial tests a combination of two medications (Advograf and Rapamiune) given shortly after kidney transplant to see how well they work and how safe they are. It may help improve long-term transplant health.
TehranAges 18 years+ - NCT06201026Recruiting
Reducing Fatigue in New MS With Individualized Training
This trial tests if a personalized home training program can help reduce severe fatigue in people with relapsing-remitting MS who were recently diagnosed. You'll use a phone app to do exercises designed for you, and researchers will check your energy levels over time.
Saint-EtienneAges 18–60 - NCT07634640RecruitingEarly Phase 1
Testing an Inflammation Treatment for Heart Failure
This early-stage trial tests a new approach to treat heart failure with preserved ejection fraction (HFpEF)—a type of heart failure where the heart's pumping strength is normal, but it doesn't relax properly. Researchers believe inflammation plays a role and want to see if targeting it can help patients feel better and function more easily.
Gainesville, FloridaAges 18–85 - NCT07364513RecruitingPhase 1
Safety study of IMSB301 for type 1 interferon disorders
This study tests an experimental drug (IMSB301) for people with rare genetic conditions that cause too much type 1 interferon activity (a part of the immune system). The goal is to see if the drug is safe and can help reduce symptoms.
SydneyAges 12 years+ - NCT05090345Recruiting
Registry for young people getting bone marrow transplants
This trial is a registry that follows children and young adults up to age 26 who are having a bone marrow transplant, to better understand complications related to blood vessel and organ injury. It may help future patients by improving how doctors predict and prevent these problems.
Rochester, MinnesotaAges birth–26 years - NCT07622069Recruiting
Understanding Rare Autoinflammatory Diseases and Their Causes
This study helps doctors better understand rare autoinflammatory diseases—conditions where the immune system mistakenly attacks the body—by collecting information from patients being treated at a major French hospital. Your participation could help improve how these diseases are diagnosed and managed.
LyonAges 4 years+ - NCT07543380RecruitingPhase 3
RSV vaccine safety and immune response in high-risk adults
This study tests a new RSV vaccine designed to protect adults with chronic health conditions from severe RSV disease (a respiratory infection). Researchers will monitor how safe the vaccine is and how well your immune system responds to it.
Tsuchiura, IbarakiAges 18–59 - NCT06220526Recruiting
Comparing needles for chest lymph node biopsy in sarcoidosis
This trial compares two types of needles used during a breathing-tube biopsy (EBUS-TBNA) to see which one works better for diagnosing sarcoidosis in people with enlarged chest lymph nodes.
Toronto, OntarioAges 18 years+ - NCT07195552Recruiting
Quick immune effects study for healthy adults
This study tests a product that may quickly affect your immune system. It is for healthy adults who can follow a simple routine and have easy-to-find veins for blood draws.
Klamath Falls, OregonAges 18–75 - NCT05973734Enrolling by invitationPhase 1
Islet transplant with immune cells to treat type 1 diabetes
This Phase 1 study tests a new immune-system strategy around islet transplantation (or donor bone marrow therapy) to improve control of type 1 diabetes and reduce dangerous low blood sugar. It mainly aims to see if the approach is safe and helpful in people with long-standing, difficult-to-manage diabetes.
Palo Alto, CaliforniaAges 18–70
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,227 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,696 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.