Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,229 recruiting studies in this area right now.
By phase
- Not applicable3,142
- Phase 21,065
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4237
- Phase 2/Phase 394
Top conditions
- Multiple Sclerosis341
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes133
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)65
- Leukemia64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals63
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona141
- New York123
- Massachusetts119
- Texas117
- Illinois82
- Colorado77
Recruiting studies6,229 total
- NCT04427189Recruiting
Diabetes registry for children and teens with better care
This study builds a diabetes “registry” to better understand how diabetes is managed in children and teens. Your information helps create reference centers and improve care, and you must be willing to follow study instructions.
Hanover, Low SaxonyAges Any age - NCT04428658Recruiting
Telehealth coaching for kids to improve blood sugar control
This trial tests whether extra diabetes coaching delivered through online video and online messages can lower blood sugar levels in children with type 1 diabetes. It may help your child improve diabetes control by combining real-time and non-real-time support.
Sacramento, CaliforniaAges 5–18 - NCT04430257Recruiting
PrEP for people at higher risk of HIV
This study checks whether taking HIV prevention medicine called PrEP can help protect people who are not living with HIV but have recent risk of HIV exposure. You may qualify if you have ongoing risk and are not already taking PrEP.
Cambridge, MassachusettsAges 18 years+ - NCT04435990RecruitingPhase 3
Allergy shots for dust mites in teens and adults
This Phase 3 study tests whether dust-mite allergy treatment (likely allergy shots) can reduce allergy symptoms and improve safety. It focuses on people whose nose/eye allergy is triggered by house dust mites and who may also have controlled asthma.
Santiago de Compostela, A CoruñaAges 12–65 - NCT04440267RecruitingPhase 2
Tested leukemia treatment for mixed-type acute leukemia
This Phase 2 study tests a leukemia-based treatment for people with acute leukemia that doesn’t clearly belong to one type. It aims to improve outcomes for patients who meet specific health and heart/lab requirements.
Tianjin, Tianjin MunicipalityAges 14 years+ - NCT04442412RecruitingPhase 3
Prednisone and vitamin D before chemo for certain lymphomas
This Phase 3 study tests whether a short “pre-treatment” with prednisone, with or without vitamin D, can improve outcomes when followed by standard lymphoma chemo. It aims to see if adding vitamin D early can help older adults tolerate or benefit from treatment for specific lymphoma types.
Brescia, BSAges 65 years+ - NCT04442646Recruiting
Asthma education program for better self-management
This study looks at an “Asthma School,” an education and support program, to help adults manage their asthma day to day. It may help you learn practical ways to control symptoms and know what to do when asthma flares.
Tradate, LombardyAges 18–85 - NCT04448951Recruiting
Study of immune response in early sepsis or septic shock
This trial looks at how the immune system behaves in the first day after septic shock begins. It may help researchers find better ways to support the body’s immune balance during sepsis, but you must be enrolled very quickly.
Pilsen, Česká RepublikaAges 18 years+ - NCT04449198RecruitingEarly Phase 1
Study for mitochondrial and blood-vessel issues in type 1 diabetes
This early study looks at how a new approach may affect energy-making (mitochondria) and blood-vessel signaling in people with insulin-dependent type 1 diabetes. It may help researchers understand whether these pathways can be improved in type 1 diabetes.
Augusta, GeorgiaAges 18 years+ - NCT04449991Recruiting
Repeat kidney biopsy in new lupus kidney disease
This study looks at whether doing a planned second kidney biopsy about 12 months later helps doctors understand and guide treatment for people with newly diagnosed lupus nephritis. You may be put on standard lupus-kidney medications, and the main “test” is the repeat biopsy timing.
StockholmAges 18 years+ - NCT04452305Recruiting
Frozen testicle tissue transplant to restore fertility
This study tests using previously frozen (cryopreserved) testicle cells or tissue to regrow testicular tissue. If you’ve had cancer treatment that can harm fertility, this may help restore natural fertility potential using your own tissue.
Pittsburgh, PennsylvaniaAges Any age - NCT04455906Recruiting
Study why some people with eczema get more severe
This study looks at why disease tends to be more severe in some people with atopic dermatitis (eczema), especially those with a specific genetic change in the IL-4 receptor (IL-4Ra). The results may help explain what drives flare-ups and could guide better treatments in the future.
Boston, MassachusettsAges 6–65 - NCT04458688Recruiting
Ocrelizumab study for relapsing MS in African Americans and Caucasians
This study looks at how ocrelizumab works in people with relapsing-remitting multiple sclerosis (MS), and it specifically includes African American and Caucasian participants. Your neurologist may already be choosing ocrelizumab as the best standard treatment for you, and the study then follows you with medical visits and MRI scans.
Detroit, MichiganAges 18–60 - NCT04459689Recruiting
COVID-19 study for people with primary immune deficiencies
This study looks at COVID-19 experiences in people who have a primary immune deficiency (a long-term immune problem) and who have had COVID-19. It may help researchers better understand how COVID-19 affects people with these conditions.
ParisAges birth+ - NCT04460235RecruitingPhase 4
Compare two pneumococcal vaccines in adults treated for lymphoma
This trial compares two vaccination plans to see which one works better for preventing pneumococcal infections after lymphoma chemotherapy. You may be randomly assigned to one of the vaccine strategies, and the study checks your immune response.
AngersAges 18 years+ - NCT04461821Recruiting
Breath test to study disease in children
This study uses a special machine to analyze exhaled breath to learn about different illnesses in children and teens. It may help researchers find breathing “signals” that reflect conditions like breathing problems, nervous system issues, or new/worsening type 1 diabetes.
BaselAges Up to 22 years - NCT04466059Recruiting
AI tool for leukemia diagnosis using blood or marrow samples
This study tests whether an AI (computer system) can help improve leukemia and related blood cancer diagnoses. You may be able to help if your doctor is already evaluating you for a possible blood disorder and your sample is high enough quality for testing.
Munich, BavariaAges 18 years+ - NCT04477928Recruiting
Checking type 1 diabetes risk using routine child care
This study estimates the chance of developing type 1 diabetes in children by using information gathered during regular well-child visits. It may help identify children who could benefit from earlier monitoring.
Bemidji, MinnesotaAges birth–17 years - NCT04477967Recruiting
Creating a liver transplant biobank for children
This trial sets up a long-term collection of medical information and samples from children who have had a liver transplant. It helps doctors study outcomes over time and improve care for future patients.
Chongqing, Chongqing MunicipalityAges 1 month–18 years - NCT04480853RecruitingPhase 4
Fingolimod start study for adults with relapsing MS
This study checks how safe and effective fingolimod is when adults with relapsing-remitting multiple sclerosis start it for the first time. It may help confirm whether this treatment works well and is tolerated in newly treated patients.
Kaohsiung CityAges 20–100 - NCT04483206RecruitingPhase 1
Personalized stem cell transplant for multiple myeloma
This Phase 1 study tests a personalized (tailored) autologous stem cell transplant for people with multiple myeloma or related plasma cell diseases. The goal is to see how safe it is and how well it works, using your own stem cells.
Atlanta, GeorgiaAges 18 years+ - NCT04484012RecruitingPhase 2
CAR T cells plus acalabrutinib for mantle cell lymphoma
This trial tests whether modified immune cells (CD19 CAR T cells) given with the medicine acalabrutinib can help people with mantle cell lymphoma that has come back or did not respond. It may help by attacking lymphoma cells more strongly and improving disease control after prior treatment.
Duarte, CaliforniaAges 18–75 - NCT04491370RecruitingPhase 1/Phase 2
Stem cell transplant then polatuzumab for certain lymphomas
This trial tests whether doing your own stem cell transplant, followed by polatuzumab, can improve outcomes in people with specific B-cell non-Hodgkin or Hodgkin lymphomas that did not fully respond or has come back. It aims to add a targeted medicine after transplant to help control the lymphoma.
Valhalla, New YorkAges 12–70 - NCT04494503RecruitingPhase 1/Phase 2
Study drug for hard-to-treat CLL or SLL after relapse
This Phase 1/2 study tests APG2575 alone or combined with other treatment in people whose CLL/SLL has come back or did not respond to prior therapy. The goal is to see how well the treatment works and how safe it is.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,229 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,721 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.