Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06023446Enrolling by invitation
Can eye photos detect early Alzheimer's disease?
This study uses a special camera (OCT) to take pictures of the retina (the back of your eye) to see if it can detect Alzheimer's disease very early. You may be eligible if you are either cognitively normal or have mild cognitive impairment, and have already had a test for Alzheimer's-related brain changes.
Sacramento, CaliforniaAges 50–89 - NCT06011460Enrolling by invitation
Observing clozapine safety for bipolar depression
This study is testing whether clozapine, a medication usually used for schizophrenia, is safe for treating hard-to-treat depression in people with bipolar disorder. It may help if you have not found relief from other treatments.
Gdansk, Pomeranian VoivodeshipAges 18–65 - NCT06018389Enrolling by invitation
Preventing risky drinking in Danish high schools
This trial tests a program called 'Our Choice' to help prevent risky drinking among Danish high school students. It is for students and staff at 16 specific high schools starting in August 2023.
AarhusAges 15 years+ - NCT06002919Recruiting
MindWalk for older South Asian caregivers of people with cognitive disabilities
This study tests a program that combines physical activity and mindfulness practices to help reduce stress in older South Asian caregivers. Participants will get a Fitbit tracker and receive text messages to support their well-being.
Bolingbrook, IllinoisAges 45 years+ - NCT06014125Recruiting
Tele-education for moderate depression
This study tests a remote education program (tele-education) for people with moderate depression who recently started an antidepressant. The program helps you learn skills to manage your mood, and you can take part from home.
Toulouse, OccitanieAges 18 years+ - NCT06019247Enrolling by invitation
Job support program for people with mental illness
This study tests a program that helps people with serious mental illness find and keep competitive jobs. It provides individualized support to match you with employment that fits your goals.
New York, New YorkAges 18–60 - NCT06017505Enrolling by invitation
Using eSAGE for early detection of cognitive decline
This study uses a simple computer-based self-assessment (eSAGE) to detect early signs of memory or thinking problems. It may help identify cognitive impairment sooner and track changes over time.
Columbus, OhioAges 50 years+ - NCT06021548Recruiting
Opioid addiction markers study
This study looks at physical, psychological, and social factors that may be linked to opioid addiction. It aims to better understand addiction to help improve future treatments.
BronAges 18 years+ - NCT06029114Enrolling by invitation
Brain scan study for memory problems
This study uses a special MRI to look at brain stiffness in people with normal memory, mild memory problems, or Alzheimer's disease. The goal is to see if this scan can help tell the difference between these groups.
Rochester, MinnesotaAges 18–100 - NCT06020261Recruiting
Parent training for kids with irritability
This study tests if a parent management training program can help reduce irritability in children. You and your child will work together with a therapist to learn new ways to handle challenging behaviors.
Aurora, ColoradoAges 10–14 - NCT06014424RecruitingPhase 2
CBD medication study for agitation in Alzheimer's
This study tests if a CBD medication can help reduce agitation in people with Alzheimer's disease. It's for adults 55 and older who have significant agitation and mild to moderate dementia.
Calgary, AlbertaAges 55 years+ - NCT06002633Recruiting
Alcohol effects and brain responses in PTSD
This study explores how people with PTSD respond to alcohol and how their brains handle approach or avoidance situations. You may participate if you drink alcohol occasionally and are between 21 and 60 years old.
Austin, TexasAges 21–60 - NCT06027554RecruitingPhase 2
MitoQ for frailty, walking, memory, and blood flow in older adults
This trial tests whether a supplement called MitoQ can improve blood vessel health, walking speed, and thinking skills in older adults who are frail or have mild memory problems. It aims to see if MitoQ helps maintain independence and quality of life.
Farmington, ConnecticutAges 65–80 - NCT06003127Recruiting
Recovery from dexmedetomidine-induced unconsciousness
This study explores how people recover after being given a common sedative called dexmedetomidine. It may help doctors better understand and manage recovery from sedation.
Boston, MassachusettsAges 18–65 - NCT06005285Recruiting
Testing a therapy program for young children with autism
This study looks at whether a therapy called the Early Start Denver Model (ESDM) works well in community programs. It includes children ages 1 to 5 with autism, their therapists, and supervisors.
Sacramento, CaliforniaAges 1 year+ - NCT06007755Recruiting
Finding blood markers for confusion after heart surgery
This study is looking for certain substances in the blood that may show up if a person becomes confused or delirious after heart surgery. The goal is to find early warning signs so doctors can help prevent or treat this confusion.
Wuhan, HubeiAges 18 years+ - NCT06013579Recruiting
Exercise study for older adults with HIV
This study tests whether high-intensity exercise can help improve thinking and memory, and build lasting exercise habits, in older adults living with HIV who feel tired and are not very active.
Birmingham, AlabamaAges 50–80 - NCT06002191Recruiting
A text-based safety program for teens bullied online
This study tests a texting program called imHere4U to help teens who have been cyberbullied and feel distressed or think about suicide. The program aims to provide support and reduce suicide risk.
Pittsburgh, PennsylvaniaAges 12–17 - NCT06003725Recruiting
Drug treatment for Black youth on probation
This study is testing a drug treatment program that is made for Black youth involved with the justice system. It aims to see if a more culturally fitting approach can help reduce substance use and related problems.
San Francisco, CaliforniaAges 13–17 - NCT06023407Enrolling by invitation
Heat therapy for blood sugar and Alzheimer's prevention
This study tests whether regular heat therapy (like sitting in a hot tub) can help improve blood sugar control and lower the risk of Alzheimer's disease in older women who have metabolic problems.
Kansas City, KansasAges 65 years+ - NCT06002100Enrolling by invitation
Predicting depression treatment response with brain imaging
This study uses a special headband (TD-fNIRS) that measures brain activity to see if it can predict how well different depression treatments work. You would be starting a new treatment for depression (like ketamine, SPRAVATO, TMS, or antidepressants) and wear the headband before and during treatment.
Costa Mesa, CaliforniaAges 18–75 - NCT04882839RecruitingPhase 2
Therapy with psilocybin for severe OCD symptoms
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
BeershebaAges 18–65 - NCT05974553Recruiting
Dialectical behavior therapy for justice-involved veterans
This study tests whether dialectical behavior therapy (DBT, a structured therapy skills program) can help veterans with stress or behavior challenges related to justice system involvement. It may help by teaching practical coping skills in a group setting.
Aurora, ColoradoAges 18 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.