Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05447325Recruiting
Brain scans to study vaping to smoking risk
This study uses brain imaging to better predict who might start smoking cigarettes and who might increase nicotine use among young adult e-cigarette (vaping) users. It may help researchers find early warning signals so support can be targeted sooner.
Athens, GeorgiaAges 18–29 - NCT05456503RecruitingPhase 3
PET scan study of tau buildup in memory and brain disorders
This Phase 3 study uses a PET/CT scan to measure whether a brain protein called tau (and related disease patterns) builds up in different dementia conditions. The goal is to better match which disorders have which brain changes and how they progress.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05450237Enrolling by invitation
Testing thinking and memory questionnaires in people with brain injury
This study checks how well certain questionnaire and testing tools work for people who have brain damage from neurologic conditions and ongoing brain inflammation. It may help future patients by improving which tests are most accurate and easy to use.
Pozzilli, IserniaAges 18–80 - NCT05419895Recruiting
Early autism screening follow-up after a high-risk test score
This study looks at an “early diagnostic response” approach for toddlers who screen high-risk for autism. It aims to help families get timely follow-up and evaluation based on screening results.
Atlanta, GeorgiaAges 1.3 years–3 years - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05423444Recruiting
Therapy for PTSD in teens using brain connectivity imaging
This study looks at how well PTSD-focused therapy changes brain “connectivity” patterns in adolescents. It may help your care team understand which teens benefit most from therapy.
San Antonio, TexasAges 12–17 - NCT05446805Recruiting
Depression study for older people who drive
This study looks at how depression relates to the brain by using blood tests and either a spinal fluid test or brain scans. It may help researchers better understand depression in older drivers and how to measure it.
St Louis, MissouriAges 65 years+ - NCT05448768Enrolling by invitation
Testing brain stimulation in people with mild memory problems
This study tests a brain stimulation approach (TBS) to see if it can improve thinking and memory in people with mild cognitive impairment. It may also explore why it works by looking at brain-related measurements after TBS.
TaoyuanAges 50–90 - NCT04729504Recruiting
Caregivers of young children with anxiety for a new program
This study adapts an anxiety-helping program so it fits families better. You may be invited to take part as a caregiver of a child ages 4 to 10.
Miami, FloridaAges 18 years+ - NCT03923374Recruiting
Study of buprenorphine for opioid use during pregnancy
This study looks at pregnancy and baby outcomes for people who are pregnant and taking buprenorphine for opioid use disorder. It may help doctors understand what to expect long-term for both parent and child when opioid treatment continues during pregnancy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05277558Recruiting
MRI and brain testing in teens at risk for type 2 diabetes
This study looks at brain health in teens with normal weight, overweight, or obesity who are at risk for type 2 diabetes. It may help researchers understand how weight and diabetes risk affect the brain, using MRI scans and learning/memory tests.
St Louis, MissouriAges 12–17 - NCT05380050Recruiting
Comparing online and in-person memory training for veterans with mild brain injury and PTSD
This study compares two ways of delivering a memory and thinking skills program to veterans with both mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). The goal is to see if doing the training online is as effective as doing it in person, which could make it easier for more veterans to get help.
Gainesville, FloridaAges 30–55 - NCT05393622Recruiting
Brain stimulation trial for severe, treatment-resistant depression
This study tests an implanted form of brain stimulation for people with severe depression that has not improved with multiple medication trials. If you qualify, you would have brain scans and surgery planning, then follow a treatment-and-safety plan for several months.
Boston, MassachusettsAges 21–80 - NCT05400824Recruiting
Health study in La Réunion
This study looks at how metabolism and infections affect people in La Réunion. Participants will provide consent for genetic analysis and answer health questions.
La Réunion, Saint-PierreAges 18–67 - NCT05395949Enrolling by invitation
Treat breast inflammation with support for mental health
This study looks at a non-surgical (“conservative”) approach to treating granulomatous lobular mastitis, along with help for mental health symptoms. It may help people whose breast inflammation and mental health concerns happen together.
Wuhan, HubeiAges 18–60 - NCT05402761Recruiting
Nurse-guided sleep program for insomnia after brain injury
This trial studies whether nurse-guided behavioral sleep therapy can improve insomnia in people recovering after a traumatic brain injury (TBI). It may help you sleep better by targeting sleep habits and insomnia symptoms.
TaipeiAges 20–65 - NCT05400382Recruiting
Mindfulness for depression and pain after cesarean delivery
This study tests whether a mindfulness program can help new mothers manage pain and depression after a planned cesarean delivery. You might be eligible if you are a woman of color or non-Hispanic White with a history of depression and are scheduled for a planned C-section.
Champaign, IllinoisAges 18–45 - NCT05393830Recruiting
Study tests how sleep loss affects emotion control
This study looks at how losing sleep changes a person’s ability to manage emotions. You may need to do brain scans (fMRI), and you would be asked to avoid alcohol and recreational drugs during the study.
Boston, MassachusettsAges 18–40 - NCT05388565Recruiting
Support program for early pregnancy after intimate partner violence
This trial tests an enhanced perinatal care (pregnancy and newborn support) program for people who are pregnant early and have been screened positive for intimate partner violence. It may help by offering extra support and care tailored to safety and pregnancy needs.
Jinan, ShandongAges 18 years+ - NCT05372172Recruiting
Tennessee Alzheimer’s study for people 60 and older
This study is looking at how brain and memory changes show up in people across the Alzheimer’s spectrum—from normal thinking to mild memory problems to Alzheimer’s disease. You might join if you can do study visits and an MRI and have a reliable study partner available.
Nashville, TennesseeAges 60 years+ - NCT05396248Recruiting
Memory training study for older adults with mild memory problems
This trial tests an approach to improve learning and memory in people age 60+ with amnestic mild cognitive impairment (a specific type of early memory problem). It may help by supporting memory and learning skills, but it also has medication and health-history requirements.
Ann Arbor, MichiganAges 60 years+ - NCT05386394RecruitingPhase 2
Brain stimulation to help primary progressive aphasia speech
This trial tests a non-painful brain stimulation method to improve language and speech problems caused by primary progressive aphasia. It may help some people communicate more clearly by targeting specific brain regions.
Baltimore, MarylandAges 50–90 - NCT05368493Enrolling by invitation
Study how air pollution affects youth development
This study looks at whether exposure to air pollution during youth is linked to how children grow, learn, or develop. You may be invited if your family is already part of an earlier birth cohort study and can complete questionnaires and (if needed) brain imaging safely.
New York, New YorkAges 6 months–11 years - NCT05390918Recruiting
Trial for teen sleep and suicidal thoughts risk
This study aims to see if treating insomnia (sleep problems) can lower overall risk related to suicidal behavior in teens. You may be eligible if you’ve had both recent sleep issues and recent suicidal thoughts, with some important safety exclusions.
Columbus, OhioAges 11–18
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
- Mouth & dental
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.