Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05417958Recruiting
Tube-feeding formula thickness trial for stomach symptom relief
This trial studies whether changing how thick your tube-feeding formula is can improve stomach symptoms like nausea, bloating, feeling full too soon, and early fullness. It may help people who mostly receive nutrition through a feeding tube and have moderate upper-GI symptoms.
Boston, MassachusettsAges 1 year+ - NCT05450237Enrolling by invitation
Testing thinking and memory questionnaires in people with brain injury
This study checks how well certain questionnaire and testing tools work for people who have brain damage from neurologic conditions and ongoing brain inflammation. It may help future patients by improving which tests are most accurate and easy to use.
Pozzilli, IserniaAges 18–80 - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT05452031Recruiting
Sleep program for people with dementia and their caregiver
This study tests a “dyadic” sleep health approach, meaning it works with both you and your caregiver together. It aims to improve sleep when dementia is causing frequent sleep problems, and to see whether a caregiver-involved plan helps both of you.
La Jolla, CaliforniaAges 18 years+ - NCT05434130RecruitingPhase 1/Phase 2
Testing the right exercise amount to help concussion recovery
This study tests whether adjusting how much exercise you do can improve recovery after a concussion. You may be screened to make sure symptoms are still present, and then assigned to an exercise plan that matches the study’s goals.
Aurora, ColoradoAges 13–18 - NCT05446805Recruiting
Depression study for older people who drive
This study looks at how depression relates to the brain by using blood tests and either a spinal fluid test or brain scans. It may help researchers better understand depression in older drivers and how to measure it.
St Louis, MissouriAges 65 years+ - NCT05432349Recruiting
Rett syndrome genetic registry for MECP2 changes
This trial is a registry that collects health and genetic information from people with Rett syndrome. It may help researchers better understand how MECP2 loss-of-function changes lead to symptoms and how to support patients.
Birmingham, AlabamaAges birth–99 years - NCT05446584RecruitingPhase 2
Study memory changes in people with past mild head injury
This Phase 2 study looks at how memory problems (amnestic mild cognitive impairment) may relate to a history of a mild traumatic brain injury. It compares people with a past mild head injury to people without one to better understand what might be driving memory symptoms.
Dallas, TexasAges 55 years+ - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05427123Recruiting
Study for kids and teens with bipolar or cyclothymic disorder
This trial is testing treatments for children and teens (ages 9–19) who have been diagnosed with bipolar disorder or cyclothymic disorder. It also requires regular participation from a caregiver so the team can track symptoms and response over time.
Los Angeles, CaliforniaAges 9–19 - NCT05447689Recruiting
Group mind-body skills for anxious graduate students
This trial offers a weekly group program teaching mind-body skills to help reduce anxiety. It’s for graduate students who screen as having moderate or higher anxiety and can attend meetings regularly.
White Plains, New YorkAges 18 years+ - NCT05452772RecruitingPhase 2
Psilocybin plus niacin to help quit smoking
This Phase 2 study tests whether a psilocybin “session” with niacin can help people quit smoking. It’s for adults who smoke daily and want to quit but have tried and struggled before.
Birmingham, AlabamaAges 21 years+ - NCT05419895Recruiting
Early autism screening follow-up after a high-risk test score
This study looks at an “early diagnostic response” approach for toddlers who screen high-risk for autism. It aims to help families get timely follow-up and evaluation based on screening results.
Atlanta, GeorgiaAges 1.3 years–3 years - NCT05447325Recruiting
Brain scans to study vaping to smoking risk
This study uses brain imaging to better predict who might start smoking cigarettes and who might increase nicotine use among young adult e-cigarette (vaping) users. It may help researchers find early warning signals so support can be targeted sooner.
Athens, GeorgiaAges 18–29 - NCT05457985Recruiting
Adaptive app coaching for PTSD in community health clinics
This study tests a flexible (adaptive) approach using a mobile app to help improve treatment outcomes for posttraumatic stress disorder (PTSD) for people getting care at participating community health clinics. It may help you get more tailored support between visits.
Baldwin, MichiganAges 18 years+ - NCT05445804RecruitingPhase 1
Oral cannabidiol (CBD) to help you quit tobacco
This Phase 1 study tests whether taking oral CBD can help people quit tobacco. It also checks safety and helps researchers learn how people respond to the treatment while they practice quitting.
Baltimore, MarylandAges 18–65 - NCT05458323Recruiting
Vision testing and glasses change to improve thinking
This study checks whether better distance and near vision (through eye exams and correct glasses) can improve thinking and memory. You may be randomly assigned to receive eye care, and your ability to see and think will be measured.
Hyderabad, TelanganaAges 60 years+ - NCT05457998Enrolling by invitation
Study of Alzheimer’s brain markers using memory testing
This trial looks for signs of Alzheimer’s disease in the brain by using memory and thinking tests, and related study procedures. It may help researchers find better ways to identify Alzheimer’s-related changes earlier.
Providence, Rhode IslandAges 50–80 - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT05426057Recruiting
Mental health support for Hispanic teens with caregiver involvement
This study looks at improving mental health in primary care by involving both a teen and an adult caregiver. It may help families who are struggling with communication, depression or anxiety symptoms, or past suicidal thoughts or behaviors.
Miami, FloridaAges 12–16 - NCT05423444Recruiting
Therapy for PTSD in teens using brain connectivity imaging
This study looks at how well PTSD-focused therapy changes brain “connectivity” patterns in adolescents. It may help your care team understand which teens benefit most from therapy.
San Antonio, TexasAges 12–17 - NCT05427500Enrolling by invitationPhase 3
Nerve block treatment for PTSD with strong stress-and-alertness symptoms
This Phase 3 study tests whether a procedure called a stellate ganglion block can reduce PTSD symptoms, especially feeling highly “on edge” (hyperarousal). You may join if you have PTSD despite appropriate usual treatments and are able to go through the procedure safely.
Ottawa, OntarioAges 18–69 - NCT05448768Enrolling by invitation
Testing brain stimulation in people with mild memory problems
This study tests a brain stimulation approach (TBS) to see if it can improve thinking and memory in people with mild cognitive impairment. It may also explore why it works by looking at brain-related measurements after TBS.
TaoyuanAges 50–90
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
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- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.