Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07200297Recruiting
Comparing three mouth care methods for ICU patients on non-invasive ventilation
This study compares three different mouth care methods for patients in the intensive care unit who are using a non-invasive ventilator (a mask or mouthpiece). The goal is to find the best way to keep the mouth clean and comortable during their stay.
Erzurum, MerkezAges 18 years+ - NCT04960904Recruiting
Long-term study of Global D dental implant systems
This study looks at how safe and well certain Global D dental implant systems work over many years. You may be able to join if you received one of these implants during specific dates and can do long-term follow-up visits.
Andrézieux-BouthéonAges 18 years+ - NCT04098146Recruiting
Registry for jawbone reconstruction after jaw cancer and jaw bone death
This study collects real-world information from people undergoing jaw reconstruction after their jaw bone was damaged (from cancer and certain medicines). It may help improve future treatment planning by tracking surgical choices and outcomes.
Jacksonville, FloridaAges 18 years+ - NCT05821140Recruiting
Assessing jaw and bite function in children with oral health issues
This study looks at how a child’s mouth, jaw, and biting function work in different dental and oral health situations. It may help clinicians better understand what support or treatments children need.
Clermont-FerrandAges 3–17 - NCT03966131Recruiting
Study of tongue and palate effects on speech comfort
This study looks at how the tongue and roof of the mouth (palate) work together when wearing a new dental prosthesis. It may help improve comfort and how well people speak while using dentures.
LyonAges 18 years+ - NCT04227314RecruitingPhase 3
Apremilast vs placebo for severe recurrent mouth ulcers
This Phase 3 trial tests whether apremilast can reduce severe, recurring mouth ulcers compared with an inactive placebo. It aims to improve ulcer frequency and pain while carefully checking safety.
AmiensAges 18 years+ - NCT04276246Recruiting
Dental implant supports for removable dentures in back-tooth gaps
This trial tests whether small “supporting” implants can help hold a removable partial denture more securely. It’s for adults missing back teeth on both sides (a specific dental gap pattern) and may improve comfort and fit.
BaselAges 18 years+ - NCT05296291Recruiting
Compare titanium, zirconia, and another frame for missing teeth
This study compares three types of dental support frames (titanium, zirconia, and another material) for people missing teeth behind the canine. It may help find which frame works best for stability and successful treatment in that specific area.
GothenburgAges 18–100 - NCT05473858RecruitingPhase 3
Compare sedation dentist injections with laser treatment for children
This trial compares two ways of giving dental pain control for children who need a specific injection near a back lower tooth. It aims to see which approach works better and is more comfortable for kids during treatment under anesthesia.
CairoAges 6–10 - NCT05073952Recruiting
Guided implant placement: grafted gum tissue versus flapless
This study compares two surgical approaches for placing dental implants in the back of the mouth. It aims to see which method works better for healing and implant success when you have enough jaw bone and no active inflammation.
Milan, MIAges 18 years+ - NCT04544839Enrolling by invitation
Test two ways to attach dentures or implants
This trial compares two different attachment systems for people who have major problems with their upper and/or lower dentures, or who want implant-supported replacement teeth. It may help your smile and chewing by improving how the replacement teeth stay firmly in place.
PuneAges 18 years+ - NCT04367766Recruiting
Tested treatment for a fresh tooth socket after front tooth extraction
This trial studies how to care for a just-removed tooth’s socket in the front of the mouth, where appearance matters. It may help improve healing and stability by using socket treatments based on the amount of remaining bone.
RomaAges 18 years+ - NCT04319042Recruiting
Same-day versus 4-week dental implant crown placement study
This study compares placing a crown on a dental implant either the same day as the implant or 4 weeks later. It may help decide which timing leads to better healing and tooth function after an implant.
Bern, Canton of BernAges 20 years+ - NCT04007783Recruiting
Test of a new plan for jaw reconstruction and implants
This study checks whether the “O-bridge protocol” helps people who need jaw surgery—either for osteonecrosis of the jaw or for oral/jaw tumors—followed by dental implant placement to support fixed teeth (not removable dentures). The goal is to improve your ability to eat, speak, and get a stable tooth replacement plan after surgery.
AntwerpAges 18 years+ - NCT02397824Recruiting
Teeth photo study for people with rare diseases
This study looks at how rare diseases can show up in the mouth and teeth, using pictures of your teeth. It may help doctors recognize dental signs earlier and better describe these rare conditions.
Strasbourg, AlsaceAges Any age - NCT02137824Recruiting
Sinus bone lift procedure for people with limited jaw bone
This pilot study tests a modified technique to add bone in the upper jaw area (the sinus floor) so dental implants may be possible. You may be considered if you have a small amount of remaining bone height and enough bone width, and you do not have certain infections or risk factors.
ViennaAges 18–100 - NCT07666100Recruiting
Study of medication side effects in a periodontology clinic
This study looks at side effects from medications prescribed in a gum disease clinic. It aims to understand what types of side effects patients experience, which can help doctors choose safer medicines.
SivasAges 16 years+ - NCT03580785Recruiting
Study of delayed tooth eruption in children and teens
This study looks at how doctors diagnose delayed tooth eruption and how that affects treatment. It focuses on people with a condition called Primary Failure of Eruption (PFE) and tries to refine the best diagnostic checks.
StrasbourgAges 6 years+ - NCT02874625Recruiting
Test of dental fillings for compatibility in baby teeth
This trial compares how well resin-based tooth fillings work (how well they “match” with the tooth and don’t cause problems) in children’s back baby teeth. You may be invited if you have a cavity that needs treatment and none of the listed situations apply.
LeuvenAges 4–10 - NCT07160660Enrolling by invitation
Comparing two types of partial denture anchors
This study looks at how patients feel about two ways to hold a removable partial denture in place: one uses small sticky attachments called 'extracoronal adhesive attachments' and the other uses clips called 'clasps'. It aims to see which patients prefer and how well each works over time.
Basel, BaselAges 18 years+ - NCT07177378Enrolling by invitation
Double flap closure for jaw bone damage from medication
This trial tests a surgical technique using a double tissue flap to close the jawbone in patients with medication-related osteonecrosis of the jaw (MRONJ). The goal is to improve healing and reduce complications.
TantaAges Any age - NCT07658144Enrolling by invitation
Immediate dental implant for upper back teeth
This trial tests a new way to place a dental implant right away after removing a damaged upper molar. It aims to see if placing the implant using the tooth's natural root as a guide is accurate and effective.
TantaAges 18–60 - NCT02891967Recruiting
Compare two tooth-filling methods for back teeth
This trial tests whether a newer “bulk-fill” way of placing tooth filling works as well as the usual step-by-step method for restoring back teeth with cavities. It aims to see which approach best meets dental quality standards over one year.
Cairo, Cairo GovernorateAges 18–38 - NCT06643468Enrolling by invitation
ALB-PRF with bone grafts for immediate dental implants
This trial tests whether using a special protein-rich blood product (ALB-PRF) with two different types of putty-like bone grafts helps improve the success of dental implants placed right after a tooth is removed in the front upper jaw. It may help people who need a tooth replaced in the 'smile zone' and have good oral health.
Al MansurahAges 20–60
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.