Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT07810101Enrolling by invitationPhase 3
Freezing and vitamin C for gum discoloration
This trial tests two treatments for dark spots on the gums: freezing them with liquid nitrogen or applying vitamin C. Both aim to reduce gum discoloration and improve the appearance of your smile.
Asyut, Asyut GovernorateAges 18–40 - NCT07810452Recruiting
Numbing methods for baby tooth nerve treatment
This study tests different numbing methods to stop bleeding during a dental procedure (pulpotomy) on baby molars. It aims to find the most effective technique to improve comfort and outcomes for children.
Afyonkarahisar, AfyonkarahisarAges 6–9 - NCT07809334Enrolling by invitation
Surgical treatment for infected dental implants in smokers
This trial tests a surgical treatment for dental implant infections (peri-implantitis) in patients who smoke. It aims to see how well the implant survives after surgery to fix the infected area.
TorinoAges 18 years+ - NCT07814092Enrolling by invitation
Radiomics for bone health after tooth removal
This trial uses a special imaging technique called radiomics to check how well your jawbone heals after a tooth is removed and the socket is preserved. It may help doctors predict bone quality for future dental implants.
Trieste, TriesteAges 18–75 - NCT07813910Recruiting
Two-step sinus lift for upper jaw implants
This study tests a two-stage method to build up bone in the upper jaw for dental implants using either donor bone or a mix of your own bone and donor bone. It may help people with very little bone in the back of the upper jaw get implants successfully.
Giza, Giza GovernorateAges 18–70 - NCT07812259RecruitingEarly Phase 1
Pain relief injection after parotid gland surgery
This trial tests whether injecting a numbing medicine plus an anti-inflammatory steroid into the parotid gland area after surgery can reduce pain and improve recovery for people having a benign parotid tumor removed.
NîmesAges 18 years+ - NCT07812883Recruiting
Preserving jawbone after tooth removal
This study tests a technique to preserve the jawbone after a tooth is removed, so there is enough bone left to place a dental implant later. It may help people who need a tooth extraction and want to get a dental implant in the future.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07810699Recruiting
Laser or LED light for moving upper canine teeth
This study compares two types of light therapy, laser and LED, to see which one helps move your upper canine teeth faster and more comfortably during orthodontic treatment. It may help reduce treatment time and pain.
Can ThoAges 15–40 - NCT07814716Recruiting
Dental bands for treating soft enamel in children's back teeth
This study tests whether special metal bands around children's back teeth help protect teeth with soft, weak enamel (from a condition called hypomineralization) and improve the success of fillings. It compares this approach to standard dental care to see which works better.
Natal, Rio Grande do NorteAges 5–10 - NCT07815522RecruitingPhase 2
Abiraterone with dalpiciclib for salivary gland cancer
This trial tests a combination of two targeted drugs for advanced salivary gland cancer that has spread or cannot be removed with surgery. The drugs may block hormones and slow cancer growth, potentially helping people whose tumors have specific markers.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06312085Recruiting
Root canal study with new filling material
This study tests a new material for filling root canals after cleaning out an infection. It aims to see if the material helps the tooth heal successfully. You may qualify if you have an infected tooth that has never had a root canal before.
IstanbulAges 18–75 - NCT05426616Recruiting
Compare two dental membranes to help new bone grow
This trial tests two types of protective membranes placed during a bone-grafting procedure to help your upper-front jaw (anterior maxilla) rebuild bone. You might benefit if you have a tooth gap where a tooth was removed at least 3 months ago.
Ghent, Oost-VlaanderenAges 21 years+ - NCT06383780RecruitingPhase 3
Tislelizumab plus chemo for nasopharyngeal cancer with bone spread
This trial tests a combination of the immunotherapy drug tislelizumab with chemotherapy for people whose nasopharyngeal cancer has spread to the bones. It may be an option if you have not had prior treatment for advanced disease.
Guangzhou, GuangdongAges 18 years+ - NCT06438627RecruitingPhase 3
New triple therapy vs standard for advanced nasopharyngeal cancer
This trial tests a new combination of three drugs (TPC, apatinib, and camrelizumab) against the standard two-drug regimen (GP plus camrelizumab) for people with high-risk nasopharyngeal carcinoma that has spread to neck lymph nodes. The goal is to see if the three-drug combination works better and is safe.
Guangzhou, GuangdongAges 18–65 - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT07803510Recruiting
Pictures before wisdom tooth surgery to reduce stress
This study tests whether showing patients pictures of their surgery before it happens can lower their stress, measured by a stress hormone in saliva. It may help you feel calmer about having your lower wisdom tooth removed.
Al Mansurah, AddakahlyiaAges 18–32 - NCT07802639Recruiting
Botulinum toxin injections for uneven lower lip in children
This study tests a weekly injection of botulinum toxin type A (a muscle-relaxing medication, like Botox) to see if it can improve the appearance and movement of an uneven lower lip in children with craniofacial microsomia. If successful, this treatment might reduce the visible asymmetry when smiling or baring teeth.
BeijingAges 5–18 - NCT07802340Recruiting
Asiaticoside for immature teeth with dead pulp
This study tests if a gel made from Asiaticoside helps immature permanent teeth with a dead pulp (nerve) heal better during a root canal procedure. It might help the tooth root finish forming and avoid complications.
Al MansurahAges 8–18 - NCT07801339Enrolling by invitation
Dental implants for patients 80 and older
This study looks at placing dental implants right after removing a tooth in people who are 80 or older. It aims to see how well these implants work in very elderly patients and if they can improve quality of life.
Gotemba, ShizuokaAges 80 years+ - NCT07808424Recruiting
Comparing two ways to place MTA in root-end surgery for back teeth
This study compares two ways of placing a special filling material (MTA) at the root tip during a surgical procedure called apicoectomy (removing the tip of the root). One method is done from the top of the tooth (orthograde), and the other is done from the bottom (retrograde). The goal is to see which method works better for saving a tooth with a persistent infection after a root canal.
Rohtak, HaryanaAges 18–55 - NCT07800949RecruitingPhase 2
Comparing regular vs narrow dental implants for lower dentures
This study tests whether regular or narrow dental implants work better for supporting a lower denture in people who have no teeth. It may help improve how well the denture fits and feels.
CairoAges 55–65 - NCT07801573Recruiting
Immediate dental implants with custom healing caps for back teeth
This trial tests placing a dental implant right after removing a damaged back tooth, using a custom healing cap. It may help people who need a tooth extraction and want a faster path to a replacement tooth.
PlovdivAges 18 years+ - NCT07807813Recruiting
Facial nerve safety in jaw fracture surgery
This study tests a new surgical approach to fix jaw fractures while protecting the facial nerve, which controls facial movement. It aims to reduce nerve damage during surgery.
Al Mansurah, AddakahlyiaAges 20–45 - NCT06510881Recruiting
One surgery vs. multiple surgeries for cleft nose and gum repair
This trial compares doing a single surgery to fix both the nose and gum problems caused by a cleft lip and palate, versus doing multiple surgeries over time. It aims to find out which approach works better for children and teens.
AsyutAges 5–18
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.