Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06219226Enrolling by invitation
Mouthwash for bad breath study
This study tests if two special mouthwashes, chlorine dioxide and chlorhexidine, can reduce bad breath. You'd be asked to use one of these rinses and have your breath checked.
Budapest, BudapestAges 18 years+ - NCT07657364Recruiting
Comparing zirconia vs titanium for full-arch dental implants
This study compares two types of material (zirconia or titanium) used as a frame in full-arch screw-retained implant bridges. It aims to find which material has fewer complications, helps patients who have lost all teeth in one or both jaws.
CairoAges 18–70 - NCT06476574Recruiting
Comparing Retainers: Bonded Wire vs Clear Tray vs Both
This study compares three types of retainers (a bonded wire, a clear plastic tray, and a combination of both) to see which one holds your teeth in place best after braces. It is for adults who have finished non-extraction orthodontic treatment and are generally healthy with good oral hygiene.
CairoAges 18–35 - NCT06275087Recruiting
Recovery speed after anesthesia for mouth surgery
This trial compares how quickly people recover from anesthesia after mouth surgery. It may help if you are having a soft-tissue procedure inside your mouth that takes 30 minutes to 2 hours.
ZagrebAges 18 years+ - NCT06500845Recruiting
Study of a new tooth crown made of high-performance polymer
This trial tests a new type of dental crown made of a strong plastic called PEEK for a back molar that has had a root canal. It looks at how well the crown fits, and may be a good option if your tooth is still mostly intact.
CairoAges 18–50 - NCT06496828Recruiting
Dental crown study using biologically friendly technique
This study tests a new way of preparing teeth for dental crowns that is gentler on the gums. If you need at least two crowns and have healthy gums, this might be an option for you.
DamascusAges 19–80 - NCT07655349Recruiting
Comparing two ways to attach gum grafts after surgery
This study tests if using small titanium tacks to hold a gum graft in place causes less pain than the usual stitches. It might help people who need more attached gum around their teeth.
Cairo, Cairo GovernorateAges 18 years+ - NCT06347679Recruiting
Can aromatherapy ease anxiety and pain during dental work?
This study tests whether smelling certain essential oils (aromatherapy) can help reduce anxiety and pain during dental treatments. If you are an adult having a dental procedure, this may be a way to feel more comfortable without medication.
Chengdu, SichuanAges 18–40 - NCT06347640Recruiting
Blood clot treatment for dead permanent teeth
This trial is testing a new way to save a dead tooth by using a special blood clot (platelet-rich fibrin) to help the tooth heal itself. It is for adults who have a permanent tooth that is dead and infected at the root tip, but still has a good chance of being saved.
IrbidAges 12–60 - NCT06406751Enrolling by invitation
MI Paste and mouth bacteria in older denture wearers
This study tests whether a special paste (MI Paste) used for several months can change the natural bacteria in the mouth of older adults who wear dentures. It may help keep your mouth healthier.
Iowa City, IowaAges 65–105 - NCT07664488Recruiting
AI vs. Manual Analysis of Skull X-rays
This trial tests whether a computer program using artificial intelligence can measure skull and jaw landmarks from X-rays as accurately as a human expert. It may help improve future orthodontic care.
Pavia, ItalyAges Any age - NCT07648654Recruiting
Hall Technique vs. Traditional Crowns for Decayed Baby Molars
This study compares two ways to treat decayed baby molars in children ages 5–8: the Hall Technique (a newer method) and traditional stainless-steel crowns. Researchers will measure which method works better, reduces anxiety, takes less time, and costs less.
CairoAges 5–8 - NCT06630819Recruiting
Comparing different volumes of numbing medicine for tooth removal
This study tests whether using a smaller amount of a numbing medicine (articaine) works as well as the usual amount for numbing the area before removing a lower back tooth. It aims to make the procedure more comfortable and efficient.
Buraidah, Al QassimAges 18 years+ - NCT06436638Recruiting
CPAP mask vs. nasal tube for breathing during molar extraction
This trial compares two ways to help you breathe during deep sedation for a molar extraction: a CPAP mask over your nose or a small tube placed in your nostril. The goal is to see which method keeps your oxygen levels more stable.
KayseriAges 18–60 - NCT07698158Recruiting
Growing Well Study: healthy growth study for young children
This study looks at how children aged 6 months to 4 years grow and develop. It involves families in Leeds, Doncaster, or East London. Researchers want to understand what supports healthy growth in early childhood.
Doncaster, West YorkshireAges 6 months–4 years - NCT07638358RecruitingEarly Phase 1
Bone filler to preserve jaw structure after tooth removal
This early-stage trial tests a bone-filling material called Neobone® placed in the socket after tooth extraction to help maintain jawbone volume. This is important because losing bone after tooth removal can make future implants or dentures difficult to fit.
Caparica, Monte Da CaparicaAges 18 years+ - NCT06388395Enrolling by invitation
Comparison of PEEK and Conventional Dental Prostheses
This study compares two types of full-arch dental prostheses (PEEK and conventional) placed on four implants in the lower jaw, to see which works better. It may be an option if you need all lower teeth replaced and have healthy jawbone.
Sharjah cityAges 18 years+ - NCT07649239Recruiting
Gum Grafting Methods for Dental Implants in Front Teeth
This trial compares two techniques to improve the appearance and health of gum tissue around dental implants in your front teeth. One uses a special blood product (PRF), and the other uses a traditional gum graft. The goal is to see which gives better-looking results.
Ajman, Ajman EmirateAges 20–70 - NCT06433297Recruiting
Direct vs. indirect pulp capping for deep cavities in lower molars
This study compares two ways to treat deep cavities in lower back teeth when the nerve is exposed. The goal is to see which method better protects the nerve and avoids the need for a root canal.
Rohtak, HaryanaAges 18 years+ - NCT07311772RecruitingPhase 3
Testing houyanqing liquid for mouth sores during radiation
This trial tests a liquid medicine (houyanqing) to prevent or treat mouth sores caused by radiation therapy for nasopharyngeal cancer. You swish it in your mouth during radiation to see if it helps reduce pain and healing time.
Beijing, Beijing MunicipalityAges 18–75 - NCT06277791RecruitingPhase 2
Adebrelimab plus chemo before surgery for advanced oral cancer
This trial is testing a new combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (paclitaxel and carboplatin) given before surgery for advanced oral cancer. The goal is to see if this treatment can shrink the tumor and improve outcomes.
Hubei, WuhanAges 18–75 - NCT05741749Recruiting
Immediate dental implant placed right after tooth removal
This study tests a way to place a dental implant immediately after removing a hopeless back tooth, and to help the gums and bone heal better. It may help people who have enough healthy gum and bone and can follow strict mouth-care rules.
LiègeAges 18–99 - NCT07649226Enrolling by invitation
Laser gum contouring for a more balanced smile
This study compares two minimally invasive laser techniques to reshape your gums and reduce a gummy smile (excessive gum show). The goal is to see which approach—without cutting or with a small tunnel cut—gives better results with less discomfort and faster healing.
Alexandria, Alexandria GovernorateAges 21 years+ - NCT06221306Recruiting
Comparing narrow vs standard dental implants for jaw bone loss
This trial tests whether narrow dental implants can preserve jaw bone better than standard implants with bone grafting in people missing back teeth. If you have a narrow jawbone, this study may help determine which option works best for you.
Cairo, Greater CairoAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.