Clinical trials
Thyroid clinical trials
Below are recruiting thyroid clinical trials, each written for real people, not researchers. We’re tracking 324 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06785987Enrolling by invitationPhase 4
Lidocaine Drip During Thyroid Surgery with Nerve Monitoring
This study tests whether giving a continuous lidocaine drip during open thyroid surgery can improve pain control and recovery. Lidocaine is a numbing medicine, and researchers want to see if it helps without interfering with the nerve monitor used during surgery.
Kaohsiung, TaiwanAges 20–75 - NCT06738888Recruiting
Better predicting easy thyroid removal through mouth or under chin
This study compares two approaches for thyroid removal surgery—one through the mouth and one under the chin—to find which is easier to perform. It is for people with thyroid nodules or early thyroid cancer that hasn't spread.
ShanghaiAges Any age - NCT06458036RecruitingPhase 2
Selpercatinib before radioactive iodine for RET-positive thyroid cancer
This study tests whether a targeted drug called selpercatinib, taken before radioactive iodine therapy, can help treat thyroid cancer in children and young adults who have a specific genetic change (RET fusion or mutation). The drug may make the cancer more sensitive to the radioactive iodine treatment that follows.
San Francisco, CaliforniaAges 2–25 - NCT06426563Recruiting
Comparing microwave vs radiofrequency for benign thyroid nodules
This study compares two heat-based treatments—microwave ablation (MWA) and radiofrequency ablation (RFA)—for shrinking benign thyroid nodules that are moderate in size. If you have a non-cancerous, solid nodule at least 2 cm wide, this trial may help you avoid surgery.
Hong Kong, Hong KongAges 18 years+ - NCT06316895Recruiting
Thermal ablation for small, low-risk thyroid cancer
This trial is studying a treatment called thermal ablation (using heat to destroy cancer cells) for people with small, low-risk papillary thyroid cancer. It aims to see how well it works and to predict outcomes.
BeijingAges 18–80 - NCT06261190Enrolling by invitation
Active monitoring for low-risk thyroid cancer
This trial tests whether it is safe to avoid immediate surgery and instead monitor small thyroid cancers that are considered low-risk. If you join, doctors will check regularly to make sure the cancer does not grow or spread.
Goyang-siAges 18 years+ - NCT06235216RecruitingPhase 2
Sacituzumab govitecan for advanced thyroid cancer
This trial tests a new drug called sacituzumab govitecan for people with advanced thyroid cancer that has stopped responding to standard treatments. It may be an option for those with differentiated thyroid cancer (after certain prior therapies) or anaplastic thyroid cancer (first-line or after one prior treatment).
BarcelonaAges 18 years+ - NCT06220656Recruiting
Thyroid nodule observation and biopsy study
This study looks at how doctors talk with patients who have a thyroid nodule that may need a biopsy. It aims to improve communication and help patients feel more involved in their care.
Lebanon, New HampshireAges 18 years+ - NCT06146764Recruiting
Better ultrasound for thyroid cancer diagnosis
This study uses a special ultrasound method called contrast-enhanced ultrasound (CEUS) to see if it can improve accuracy of diagnosing thyroid cancer. If you have a thyroid nodule and have had certain tests, this trial may help doctors better understand your condition.
Guangzhou, GuangdongAges 18 years+ - NCT05264857Recruiting
Decision aid for managing suspicious thyroid nodules
This trial studies a decision-support tool to help people make choices about care for thyroid nodules that look indeterminate to cancer on biopsy. It may help you understand options and decide next steps more confidently.
Stony Brook, New YorkAges 18 years+ - NCT05783323RecruitingPhase 2
Larotrectinib plus radiation for thyroid cancer with NTRK fusion
This Phase 2 trial tests larotrectinib (a targeted medicine) to help radioactive iodine (RAI) work better in people with differentiated thyroid cancer that has an NTRK gene fusion. It may improve how much thyroid cancer the RAI can reach and shrink.
San Francisco, CaliforniaAges 2–99 - NCT03841617RecruitingPhase 2
Measure radiation in thyroid cancer using a special PET-CT scan
This trial tests how much radiation a specialized whole-body PET/CT scan delivers in patients with differentiated thyroid cancer. It may help doctors better plan treatment for cancer that persists, returns, or has spread—especially when radioactive iodine (RAI) may or may not work.
Bethesda, MarylandAges 18–90 - NCT03647358RecruitingPhase 1
Iodine scan planning for metastatic thyroid cancer treatment
This early-stage study tests how well a special iodine scan (using iodine-124) can help plan treatment with radioactive iodine (iodine-131) for thyroid cancer that has spread. It may help doctors decide the right way to measure and target radioiodine-avid (radioiodine-absorbing) metastases.
New York, New YorkAges 18 years+ - NCT03676647Recruiting
Test DNA methylation from thyroid FNA samples to diagnose cancer
This study looks at a molecular test (DNA methylation pattern) using samples taken during fine-needle aspiration (FNA) of thyroid nodules. It aims to help identify which thyroid nodules that looked “unclear” after the first test may be cancer.
Duarte, CaliforniaAges 19 years+ - NCT03177902Recruiting
Monitoring thyroid health during breast cancer chemotherapy
This study checks whether chemotherapy for breast cancer affects thyroid function. It follows patients during treatment to see if thyroid problems develop.
Bengbu, AnhuiAges 18–85 - NCT05229341Recruiting
Testing DNA “methylation” to evaluate thyroid nodule samples
This study looks at patient tissue from needle biopsies to see if DNA “methylation” patterns can help diagnose and guide treatment for thyroid nodules. You might benefit by helping improve how these nodules are evaluated, using information from your biopsy sample and medical data.
Duarte, CaliforniaAges 18 years+ - NCT06007924RecruitingPhase 2
Study of two drugs for advanced thyroid cancer
This trial tests two oral medications, avutometinib and defactinib, for people with advanced thyroid cancer that has specific genetic changes. The goal is to see if these drugs can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT02869620Recruiting
Thyroid cancer patient database study
This study collects information from people who have been diagnosed with thyroid cancer. It helps researchers understand thyroid cancer and may support future research or treatments.
Marseille, Bouches-du RhôneAges 18–95 - NCT05830500RecruitingPhase 4
Anlotinib for advanced medullary thyroid cancer
This trial studies anlotinib in people with advanced or metastatic medullary thyroid cancer that has been getting worse. It aims to see how well the treatment controls the cancer and how safe it is for patients who can’t have curative surgery.
Hefei, AnhuiAges 18–75 - NCT05994365Recruiting
Testing anlotinib for advanced thyroid cancer that resists radioactive iodine
This trial tests a targeted therapy pill (anlotinib) for people with advanced thyroid cancer that stopped responding to radioactive iodine. It may slow tumor growth or shrink tumors.
Beijing, Beijing MunicipalityAges 18–75 - NCT06079333RecruitingPhase 2
Targeted therapy before and after surgery for BRAF-mutant anaplastic thyroid cancer
This trial tests whether giving a targeted therapy pill (which attacks cancer cells with a BRAF mutation) before and after surgery can help treat anaplastic thyroid cancer that hasn't spread to other organs. It's for people whose cancer has a specific gene change (BRAF V600E or V600K) and who are healthy enough for surgery.
Leiden, South HollandAges 18 years+ - NCT06082180RecruitingPhase 3
Preventive neck lymph node removal in low-risk thyroid cancer
This trial is for people with low-risk papillary thyroid cancer. It compares two surgical approaches: one that removes just the thyroid gland, and another that also removes some lymph nodes in the center of the neck as a preventive measure. The goal is to see if removing these lymph nodes helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–70 - NCT06087068RecruitingPhase 2
Thyroid hormone therapy after lobectomy for low-risk thyroid cancer
This trial is testing whether thyroid hormone replacement after surgery is safe for people with low-risk papillary thyroid cancer. It may help maintain normal hormone levels after part of the thyroid is removed.
Beijing, Beijing MunicipalityAges 1.5 years–70 years - NCT05962892Recruiting
Study of thyroid cancer return risk after heat ablation
This study looks at what makes papillary thyroid cancer come back after a heat-based treatment called thermal ablation. It may help doctors better predict recurrence risk and guide follow-up after treatment.
BeijingAges 18 years+
Hear when a new Thyroid trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for thyroid?
- Yes. Clin2 currently lists 324 recruiting thyroid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a thyroid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a thyroid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.