Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05538871Recruiting
Testing body movement and physical capacity in scoliosis adults
This study checks how well people can move and perform physical tasks if they have scoliosis (an uneven spine), or if they’re a healthy comparison group. It may help researchers better understand how body structure and function are affected by different types of scoliosis.
Edmonton, AlbertaAges 18 years+ - NCT05540938RecruitingPhase 4
Testing WangBi granules for rheumatoid arthritis along with standard care
This trial studies whether WangBi granules help control rheumatoid arthritis symptoms when used by people already taking stable methotrexate and tofacitinib. It’s mainly for people with mild-to-moderate disease activity and specific diagnostic features.
BeijingAges 18–75 - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT05546593Recruiting
Ultrasound check for joint and tendon problems in gout
This study uses ultrasound to look for hidden changes in joints and tendons in people who have gout. It may help doctors better understand what ultrasound can show in gout, but it doesn’t sound like it’s testing a new medicine.
Boulogne-Billancourt, APHPAges 18 years+ - NCT05547451Recruiting
COVID vaccine study for teens with juvenile arthritis
This study looks at giving a COVID-19 vaccine to teens who have juvenile idiopathic arthritis, to see how they respond. It may help doctors understand vaccine safety and effectiveness for this specific age and condition group.
Nantes, Loire-AtlantiqueAges 12–18 - NCT05547984Recruiting
Ceramic hip implant study for first-time hip replacement
This trial tests a specific type of ceramic “dual mobility” hip implant for people getting their first total hip replacement (cementless). It may help reduce certain hip problems by using a designed implant that’s meant to move more safely.
Ústí nad LabemAges 18 years+ - NCT05555459Recruiting
Testing a screw system for foot and ankle surgery
This study checks how safe and well an “Inion CompressOn” screw system works during foot and ankle operations. It may help patients by improving how surgeons fix bones while also collecting safety and recovery information.
TampereAges 18 years+ - NCT05555394Recruiting
Body Awareness Therapy for Fibromyalgia Symptoms
This trial studies whether a therapy focused on body awareness can improve symptoms in people with fibromyalgia. It also checks certain biological markers to better understand how fibromyalgia may change over time.
Igualada, BarcelonaAges 18–65 - NCT05559463Recruiting
Anti-inflammatory diet for knee arthritis pain relief
This trial studies whether an anti-inflammatory eating plan (the “ITIS diet”) can improve symptoms in people with knee osteoarthritis. It is meant to see if changing what you eat can help reduce pain and improve function.
La Jolla, CaliforniaAges 18 years+ - NCT05569122RecruitingPhase 1
Studying an MRI contrast method in mitochondrial muscle disease
This Phase 1 study tests a special MRI approach (using a contrast agent) to better measure changes in muscles in people with mitochondrial diseases. It also includes some healthy volunteers and other critically ill patients to compare results and check safety.
Philadelphia, PennsylvaniaAges 10–60 - NCT05571514Recruiting
Pearl supplement study to help prevent menopause-related bone loss
This study tests whether a “mother-of-pearl” nutritional supplement can help prevent osteoporosis after menopause. You may qualify if you’re a post-menopausal woman with lower-than-normal bone density but without past fragility fractures.
Clermont-FerrandAges 50–65 - NCT05587569Recruiting
Foot surgery outcomes study for bunion and forefoot alignment
This trial studies results after a combined bunion and forefoot alignment surgery to improve foot shape and function. It may help people whose foot angles show significant bunion and front-of-foot deformity.
Greeley, ColoradoAges 14–65 - NCT05587777Recruiting
Tracking chronic conditions during standard breast cancer treatment
This study monitors health problems that can happen over time in people with breast cancer while they receive usual treatments like hormone therapy, chemotherapy, and/or radiation. It may help researchers understand which extra symptoms or complications show up and when, to improve care and follow-up.
StavangerAges 19–80 - NCT05593146RecruitingPhase 2
3D hip reconstruction surgery to prevent dislocation
This trial compares a modified hip implant positioning method to lower the chance of the hip “slipping out of place” (dislocation) after major hip tumor surgery and reconstruction. If you qualify, you may help test whether a small change in implant angle improves stability and function.
Ningbo, ZhejiangAges 16 years+ - NCT05592574Recruiting
Test of a biologic for active spondyloarthritis
This trial studies whether adding a biologic medicine (targeted therapy) can help people with active spondyloarthritis when standard anti-inflammatory pain medicines (NSAIDs) have not worked well enough. It focuses on people with ongoing symptoms despite trying at least two NSAIDs.
NiceAges 18–90 - NCT05593887Recruiting
Compare three surgeries for late hip dislocation in non-walking children with CP
This trial looks at which surgery works best for children with cerebral palsy who do not walk and have a neglected, deformed hip that has dislocated for a long time. The goal is to compare outcomes after three different hip procedures.
Cairo, AbbasiaAges Any age - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Laguna Woods, CaliforniaAges 21 years+ - NCT05607888Recruiting
Study of treatment for sinus and skull-base tumors
This study looks at how doctors manage tumors that start in the nose/sinuses and spread to the skull base. It may help improve planning of care for people with this specific type and location of tumor.
Ljubljana, LjubljanaAges Any age - NCT05610098Recruiting
Study of gene activity in spinal tuberculosis
This trial looks at patterns of gene activity (from blood/tissue samples) in adults with spinal tuberculosis. The goal is to better understand the disease and how to tell different conditions apart, which may help future care.
Cape Town, Western CapeAges 18 years+ - NCT05610878RecruitingPhase 1
Stem cell help to improve fat grafting results
This early-phase study tests whether “preconditioned” stem cells from fat tissue can improve the look of fat transferred during liposuction and grafting. If you qualify, you may receive stem cells along with fat grafting to see how well it works and how safe it is.
Lahore, Punjab ProvinceAges 18–50 - NCT05626348RecruitingPhase 4
Test immune-modulator treatments for rheumatoid arthritis with knee trouble
This Phase 4 trial studies whether immune-modulator medicines improve symptoms and function in people with rheumatoid arthritis who have knee problems. It may also compare responses in osteoarthritis and healthy volunteers, depending on the group you fit.
Jinan, ShandongAges 18–80 - NCT05629130Recruiting
Blocking blood vessel procedures for bleeding-related joint inflammation
This study looks at whether a “blocking” procedure (embolization) can improve long-lasting joint inflammation caused by inherited bleeding disorders. It focuses on people with joint lining inflammation from repeated bleeding into the joint.
São PauloAges Any age - NCT05638360RecruitingPhase 2
Test medicine for healing after wrist bone fracture surgery
This Phase 2 trial studies whether Ru-Yi-Jin-Huang-Saan (a traditional Chinese medicine) helps the wrist heal better after surgery for a Colles’ fracture. If you qualify, you may receive the medicine and be asked to complete questionnaires to track healing and outcomes.
Changhua, ChanghuaAges 20–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.