Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07162948Recruiting
Home monitoring technology for ICU recovery
This study tests a smart technology box that helps monitor your health at home after a stay in the ICU. It may help you and your doctors keep track of your recovery more easily.
Leiden, South HollandAges 18 years+ - NCT07156110Recruiting
Dental implant study for back teeth
This trial is testing a type of dental implant for people missing one or more teeth in the back of the jaw. It aims to see how well the implant holds up over time and whether the surrounding bone stays healthy.
Roma, RMAges 18 years+ - NCT07160231RecruitingPhase 4
Lowering dose of JAK inhibitors for rheumatoid arthritis or psoriatic arthritis
This trial tests if reducing the dose of a JAK inhibitor can keep your inflammatory arthritis under control. If you have rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis and are in a stable remission, you may be able to take a lower dose.
Nijmegen, GelderlandAges 16 years+ - NCT07162311Enrolling by invitation
Home brain stimulation for rheumatoid arthritis pain
This trial tests if a gentle, home-based brain stimulation device (tDCS) can reduce chronic pain in people with rheumatoid arthritis who have low inflammation. It may offer a drug-free way to manage pain.
Porto Alegre, Rio Grande do SulAges 18–70 - NCT07163117Recruiting
Back exercises for female university students with back pain
This study tests two different types of back exercises to see which works better for reducing mechanical low back pain (pain not caused by injury or disease) in female university students. It may help you find a good exercise routine if you have had this type of back pain for a while.
CairoAges 18–24 - NCT07161232Recruiting
When to start rehab after UBE spine surgery
This study looks at whether starting rehabilitation exercises earlier or later after a specific type of minimally invasive back surgery (UBE) for a slipped disc improves your recovery. It's for people who have had leg pain for less than a year and are scheduled for this surgery.
Beijing, Beijing MunicipalityAges 19–65 - NCT07157852Recruiting
Testing pregabalin vs mirogabalin for fibromyalgia pain
This study tests two medications, pregabalin and mirogabalin, for people with fibromyalgia who have not yet tried prescription drugs. It aims to see which one works better for pain relief.
BeijingAges 18 years+ - NCT07161726RecruitingPhase 1/Phase 2
Cocoa and exercise for older adults
This trial tests whether eating cocoa can boost the benefits of a supervised exercise program for older adults who walk a bit more slowly. You could help find out if this natural product makes exercise work better.
Birmingham, AlabamaAges 55 years+ - NCT07159178Enrolling by invitation
Shoulder problems and balance in stroke survivors
This study looks at how shoulder problems after a stroke affect balance. Understanding this link could help improve therapy for better stability and fall prevention.
Istanbul, KÜÇÜKÇEKMECEAges 40–80 - NCT07162168Recruiting
Using AI to measure bone age from abdominal CT scans
This study uses artificial intelligence to estimate bone age from standard abdominal CT scans. It may help researchers understand how bone age relates to health conditions without extra X-rays.
BeijingAges 18 years+ - NCT07157319Recruiting
Zadek osteotomy for Haglund's syndrome
This trial tests a surgery called Zadek osteotomy for people with Haglund's syndrome (a painful heel condition). It may help those who haven't gotten better after at least six months of non-surgical treatments.
SohagAges 18–60 - NCT07155967Enrolling by invitation
Blood flow restriction training for leg strength in older women
This trial tests whether a type of strength training that partly uses blood flow restriction can help older women build leg strength on one side, which may also benefit the other leg. It's for women who are generally healthy and have not had recent leg injuries or surgeries.
Presidente Prudente, São PauloAges 60 years+ - NCT07161336RecruitingPhase 2
Methotrexate for knee arthritis with swelling seen on ultrasound
This trial tests if methotrexate (a medicine that reduces inflammation) can improve knee pain and swelling in people with knee osteoarthritis. It is for patients who have signs of synovitis (inflammation inside the joint) that can be seen on an ultrasound.
Dhaka, Dhaka DivisionAges 40–70 - NCT07160205RecruitingPhase 2/Phase 3
Study of ULSC for dermatomyositis and polymyositis
This trial tests a new treatment called ULSC to see if it can improve muscle strength and skin symptoms, and help reduce steroid use in people with dermatomyositis or polymyositis. It may be an option if standard treatments haven't worked well enough.
Gainesville, FloridaAges 18 years+ - NCT07160634RecruitingPhase 3
Gene therapy for ambulant males with Duchenne muscular dystrophy
This trial tests a new gene therapy called SGT-003 in boys and men with Duchenne muscular dystrophy who are still able to walk. The treatment aims to deliver a working version of the dystrophin gene to help muscle cells produce the protein they are missing.
Little Rock, ArkansasAges 7–11 - NCT05538416Recruiting
Back surgery approach trial for mild slip and leg pain
This trial compares a newer, “cortical bone trajectory” method with more traditional open surgery and a minimally invasive approach for treating certain low-back slips. It looks at short-term outcomes to see which approach helps patients recover better and relieve leg symptoms.
GroningenAges 18–75 - NCT02257229Recruiting
Study for treating clubfoot in Spanish-speaking patients
This study looks at treatment for children with clubfoot (a foot that turns inward or upward). If you speak Spanish, the study may be easier to join and could help doctors improve how clubfoot is treated.
Dallas, TexasAges Up to 18 years - NCT06906783Recruiting
Comparing two ways to fix a shifted meniscus in the knee
This trial compares two surgical techniques to see which better treats a meniscus that has moved out of place (extruded) in the knee, which can cause pain and limited movement. It aims to find the best approach to relieve symptoms and improve knee function.
Erzurum, YakutiyeAges 18–65 - NCT06956729Recruiting
Guided hip growth for children with cerebral palsy
This trial tests a surgery to help guide the growth of the hip bone in children with cerebral palsy whose hips are at risk of slipping out of place. The goal is to prevent hip dislocation and avoid more complex surgery later.
A Coruña, A CoruñaAges 3–8 - NCT06956222Recruiting
Home vs in-person rehab for knee osteoarthritis
This study compares doing physical therapy exercises at home through a video call (tele-rehab) versus doing them in person at a clinic. It is for people with mild to moderate knee osteoarthritis to see if home rehab works just as well.
JeddahAges 40–80 - NCT07151417RecruitingPhase 2/Phase 3
Steroid injection during total knee replacement
This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.
Bethesda, MarylandAges 18 years+ - NCT07146256Recruiting
OPMD Natural History Registry Study
This study is building a national registry (a database) for people with Oculo-Pharyngeal Muscular Dystrophy (OPMD) in Israel. Joining will help researchers understand how OPMD progresses over time and may lead to better care.
Ramat GanAges 18 years+ - NCT07150221Enrolling by invitation
10-year follow-up of vitamin E hip liner
This study follows people who received a special vitamin E infused plastic hip liner (Vivacit-E) during a first-time total hip replacement about 10 years ago. It checks how the implant is holding up over time.
South Bend, IndianaAges 18 years+ - NCT07145229RecruitingPhase 2
Testing a new drug for acute gout flares
This trial tests a new medication, ABP-745, for people having an acute gout flare. It aims to see if the drug is safe and helps reduce pain and inflammation.
Peoria, ArizonaAges 18–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.